{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:01:36Z","timestamp":1791313296343,"version":"4.3.1"},"reference-count":33,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Osteoarthritis (OA) is a prevalent disease and the leading cause of pain, disability, and quality of life deterioration. Our study sought to evaluate the image quality and dose of cone-beam computed tomography arthrography (CBCT-A) and compare them to digital radiography (DR) for OA diagnoses. Overall, 32 cases of CBCT-A and DR with OA met the inclusion criteria and were prospectively analyzed. The Kellgren and Lawrence classification (KLC) stage, sclerosis, osteophytes, erosions, and mean joint width (MJW) were compared between CBCT-A and DR. Image quality was excellent in all CBCT-A cases, with excellent inter-observer agreement. OA under-classification was noticed with DR for MJW (p = 0.02), osteophyte detection (&lt;0.0001), and KLC (p &lt; 0.0001). The Hounsfield Unit (HU) values obtained for the cone-beam computed tomography CBCT did not correspond to the values for multi-detector computed tomography (MDCT), with a greater mean deviation obtained with the MDCT HU for Modeled Based Iterative Reconstruction 1st (MBIR1) than for the 2nd generation (MBIR2). CBCT-A has been found to be more reliable for OA diagnosis than DR as revealed by our results using a three-point rating scale for the qualitative image analysis, with higher quality and an acceptable dose. Moreover, the use of this imaging technique permits the preoperative assessment of extremities in an OA diagnosis, with the upright position and bone microarchitecture analysis being two other advantages of CBCT-A.<\/jats:p>","DOI":"10.3390\/tomography9060167","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T03:53:52Z","timestamp":1701230032000},"page":"2134-2147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Cone-Beam Computed Tomography CT Extremity Arthrography in the Preoperative Assessment of Osteoarthritis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-4824","authenticated-orcid":false,"given":"Marion","family":"Hamard","sequence":"first","affiliation":[{"name":"Division of Radiology, Department of Diagnosis, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sans Merce","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Diagnosis, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Gorican","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Diagnosis, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Alexandre","family":"Poletti","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Diagnosis, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Neroladaki","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Diagnosis, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-4613","authenticated-orcid":false,"given":"Sana","family":"Boudabbous","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Diagnosis, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1148\/radiol.2483062112","article-title":"Radiographic evaluation of arthritis: Degenerative joint disease and variations","volume":"248","author":"Jacobson","year":"2008","journal-title":"Radiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.rdc.2016.07.004","article-title":"Diagnosis and Longitudinal Assessment of Osteoarthritis: Review of Available Imaging Techniques","volume":"42","author":"Demehri","year":"2016","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/BOR.0000000000000163","article-title":"Conventional and novel imaging modalities in osteoarthritis: Current state of the evidence","volume":"27","author":"Demehri","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_4","first-page":"15","article-title":"Imaging in osteoarthritis: What have we learned and where are we going?","volume":"102","author":"Hayashi","year":"2011","journal-title":"Minerva Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.rehab.2015.12.003","article-title":"Imaging for osteoarthritis","volume":"59","author":"Hayashi","year":"2016","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.oooo.2017.05.514","article-title":"Evaluation of trabecular structure changes in osteoarthritis of the temporomandibular joint with cone beam computed tomography imaging","volume":"124","author":"Liang","year":"2017","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.berh.2014.02.002","article-title":"The role of imaging in osteoarthritis","volume":"28","author":"Roemer","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann. Rheum. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Seki, K., Yoshino, T., Ogisawa, S., Arai, Y., Tonogi, M., and Iinuma, T. (2023). Diagnostic Study of Mandibular Cortical Index Classification Using Dental Cone-Beam Computed Tomography Findings: A Preliminary Cross-Sectional Study. Reports, 6.","DOI":"10.20944\/preprints202309.0440.v1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3390\/tomography9050141","article-title":"Modular Neural Networks for Osteoporosis Detection in Mandibular Cone-Beam Computed Tomography Scans","volume":"9","author":"Namatevs","year":"2023","journal-title":"Tomography"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.3390\/tomography8060247","article-title":"Establishment of Diagnostic Reference Levels in Cone Beam Computed Tomography Scans in the United Arab Emirates","volume":"8","author":"Abuzaid","year":"2022","journal-title":"Tomography"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"20140235","DOI":"10.1259\/dmfr.20140235","article-title":"Temporomandibular joint diagnostics using CBCT","volume":"44","author":"Larheim","year":"2015","journal-title":"Dentomaxillofacial Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1148\/radiol.13130225","article-title":"Dedicated cone-beam CT system for extremity imaging","volume":"270","author":"Carrino","year":"2014","journal-title":"Radiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1088\/0031-9155\/60\/3\/947","article-title":"Characterization of 3D joint space morphology using an electrostatic model (with application to osteoarthritis)","volume":"60","author":"Cao","year":"2015","journal-title":"Phys. Med. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1118\/1.3633937","article-title":"Task-based modeling and optimization of a cone-beam CT scanner for musculoskeletal imaging","volume":"38","author":"Prakash","year":"2011","journal-title":"Med. Phys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1118\/1.3611039","article-title":"A dedicated cone-beam CT system for musculoskeletal extremities imaging: Design, optimization, and initial performance characterization","volume":"38","author":"Zbijewski","year":"2011","journal-title":"Med. Phys."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/art.23462","article-title":"Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees","volume":"58","author":"Sharma","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ijom.2009.02.028","article-title":"Cone-beam computerized tomography (CBCT) imaging of the oral and maxillofacial region: A systematic review of the literature","volume":"38","author":"Casselman","year":"2009","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2214\/AJR.14.13334","article-title":"Model-Based Iterative Reconstruction (MBIR) for the Reduction of Metal Artifacts on CT","volume":"205","author":"Boudabbous","year":"2015","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.joca.2006.11.009","article-title":"Atlas of individual radiographic features in osteoarthritis, revised","volume":"15","author":"Altman","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/rpd\/ncx210","article-title":"Effective Radiation Dose in the Wrist Resulting from a Radiographic Device, Two CBCT Devices and One MSCT Device: A Comparative Study","volume":"179","author":"Koivisto","year":"2018","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2307\/2529309","article-title":"General Methodology for Analysis of Experiments with Repeated Measurement of Categorical Data","volume":"33","author":"Koch","year":"1977","journal-title":"Biometrics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s13244-017-0582-1","article-title":"Cone beam CT of the musculoskeletal system: Clinical applications","volume":"9","author":"Posadzy","year":"2018","journal-title":"Insights Imaging"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00256-012-1516-0","article-title":"CT arthrography of the wrist using a novel, mobile, dedicated extremity cone-beam CT (CBCT)","volume":"42","author":"Koskinen","year":"2013","journal-title":"Skelet. Radiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00256-015-2105-9","article-title":"Using cone-beam CT as a low-dose 3D imaging technique for the extremities: Initial experience in 50 subjects","volume":"44","author":"Huang","year":"2015","journal-title":"Skelet. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jor.22521","article-title":"In vivo diagnostics of human knee cartilage lesions using delayed CBCT arthrography","volume":"32","author":"Kokkonen","year":"2014","journal-title":"J. Orthop. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40634-021-00442-y","article-title":"Radiographic vs. MRI vs. arthroscopic assessment and grading of knee osteoarthritis\u2014are we using appropriate imaging?","volume":"9","author":"Newman","year":"2022","journal-title":"J. Exp. Orthop."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Brett, A., Bowes, M.A., and Conaghan, P.G. (2023). Comparison of 3D quantitative osteoarthritis imaging biomarkers from paired CT and MR images: Data from the IMI-APPROACH study. BMC Musculoskelet. Disord., 24.","DOI":"10.1186\/s12891-023-06187-2"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1002\/jor.25557","article-title":"MRI-based synthetic CT in the detection of knee osteoarthritis: Comparison with CT","volume":"41","author":"Arbabi","year":"2023","journal-title":"J. Orthop. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bone.2018.06.006","article-title":"Quantification of bone microstructure in the wrist using cone-beam computed tomography","volume":"114","author":"Mys","year":"2018","journal-title":"Bone"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ajodo.2005.11.035","article-title":"Three-dimensional cephalometry: Spiral multi-slice vs cone-beam computed tomography","volume":"130","author":"Swennen","year":"2006","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13047-015-0067-8","article-title":"Effective radiation dose of a MSCT, two CBCT and one conventional radiography device in the ankle region","volume":"8","author":"Koivisto","year":"2015","journal-title":"J. Foot Ankle Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/rpd\/nct162","article-title":"Assessment of effective radiation dose of an extremity CBCT, MSCT and conventional X ray for knee area using MOSFET dosemeters","volume":"157","author":"Koivisto","year":"2013","journal-title":"Radiat. Prot. Dosim."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/9\/6\/167\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:33:10Z","timestamp":1760131990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/9\/6\/167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,29]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["tomography9060167"],"URL":"https:\/\/doi.org\/10.3390\/tomography9060167","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,29]]}}}