{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:29:10Z","timestamp":1780054150025,"version":"3.54.0"},"reference-count":118,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>An increasing burden of evidence is pointing toward pesticides as risk factors for chronic disorders such as obesity and type 2 diabetes, leading to metabolic syndrome. Our objective was to assess the impact of chlorpyrifos (CPF) on metabolic and bacteriologic markers. Female rats were exposed before and during gestation and during lactation to CPF (1 mg\/kg\/day). Outcomes such as weight, glucose and lipid profiles, as well as disturbances in selected gut bacterial levels, were measured in both the dams (at the end of the lactation period) and in their female offspring at early adulthood (60 days of age). The results show that the weight of CPF dams were lower compared to the other groups, accompanied by an imbalance in blood glucose and lipid markers, and selected gut bacteria. Intra-uterine growth retardation, as well as metabolic disturbances and perturbation of selected gut bacteria, were also observed in their offspring, indicating both a direct effect on the dams and an indirect effect of CPF on the female offspring. Co-treatment with inulin (a prebiotic) prevented some of the outcomes of the pesticide. Further investigations could help better understand if those perturbations mimic or potentiate nutritional risk factors for metabolic syndrome through high fat diet.<\/jats:p>","DOI":"10.3390\/toxics10030138","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T21:44:17Z","timestamp":1647207857000},"page":"138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring"],"prefix":"10.3390","volume":"10","author":[{"given":"Narimane","family":"Djekkoun","sequence":"first","affiliation":[{"name":"PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, CEDEX 1, 80054 Amiens, France"},{"name":"Laboratory of Cellular and Molecular Biology, University of the Brothers Mentouri Constantine 1, Constantine 2500, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-5104","authenticated-orcid":false,"given":"Flore","family":"Depeint","sequence":"additional","affiliation":[{"name":"Transformations & Agro-Ressources ULR7519, Institut Polytechnique UniLaSalle\u2014Universit\u00e9 d\u2019Artois, 60026 Beauvais, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Guibourdenche","sequence":"additional","affiliation":[{"name":"PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, CEDEX 1, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"El Khayat El Sabbouri","sequence":"additional","affiliation":[{"name":"PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, CEDEX 1, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-2387","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Corona","sequence":"additional","affiliation":[{"name":"PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, CEDEX 1, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-3109","authenticated-orcid":false,"given":"Larbi","family":"Rhazi","sequence":"additional","affiliation":[{"name":"Transformations & Agro-Ressources ULR7519, Institut Polytechnique UniLaSalle\u2014Universit\u00e9 d\u2019Artois, 60026 Beauvais, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5174-9308","authenticated-orcid":false,"given":"Jerome","family":"Gay-Queheillard","sequence":"additional","affiliation":[{"name":"PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, CEDEX 1, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Rouabah","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Biology, University of the Brothers Mentouri Constantine 1, Constantine 2500, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Hamdad","sequence":"additional","affiliation":[{"name":"Center for Human Biology, CHU Amiens-Picardie, 80000 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Bach","sequence":"additional","affiliation":[{"name":"PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, CEDEX 1, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Benkhalifa","sequence":"additional","affiliation":[{"name":"PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, CEDEX 1, 80054 Amiens, France"},{"name":"Center for Human Biology, CHU Amiens-Picardie, 80000 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafida","family":"Khorsi-Cauet","sequence":"additional","affiliation":[{"name":"PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, CEDEX 1, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fsi.2011.04.015","article-title":"Effects of atrazine and chlorpyrifos on the mRNA levels of IL-1 and IFN-\u03b32b in immune organs of common carp","volume":"31","author":"Wang","year":"2011","journal-title":"Fish. Shellfish Immunol."},{"key":"ref_2","unstructured":"OCSPP (2015). Opp Pesticides Industry Sales and Usage 2006 and 2007 Market Estimates, OCSPP."},{"key":"ref_3","unstructured":"World Health Organization, and Safety International Programme on Chemical (2010). The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2009."},{"key":"ref_4","first-page":"13","article-title":"Properties and uses of chlorpyrifos in the United States","volume":"231","author":"Solomon","year":"2014","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"ref_5","unstructured":"(2021, September 23). Sales of Pesticides in the EU. Available online: https:\/\/ec.europa.eu\/eurostat\/web\/products-eurostat-news\/-\/ddn-20200603-1."},{"key":"ref_6","first-page":"330","article-title":"A review: Pesticide residue: Cause of many animal health problems","volume":"6","author":"Choudhary","year":"2018","journal-title":"J. Entomol. Zool. Stud."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/cagri\/2017004","article-title":"Le plan Ecophyto de r\u00e9duction d\u2019usage des pesticides en France: D\u00e9cryptage d\u2019un \u00e9chec et raisons d\u2019esp\u00e9rer","volume":"26","author":"Guichard","year":"2017","journal-title":"Cah. Agric."},{"key":"ref_8","first-page":"23","article-title":"Les plans nationaux sant\u00e9-environnement: Conciliation ou concurrence entre deux politiques publiques?","volume":"HS","author":"Renaudie","year":"2019","journal-title":"Rev. Droit Sanit. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.crvi.2017.07.009","article-title":"Endocrine Disruptor Compounds (EDCs) and agriculture: The case of pesticides","volume":"340","author":"Combarnous","year":"2017","journal-title":"Comptes Rendus Biol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jepson, P.C., Murray, K., Bach, O., Bonilla, M., and Neumeister, L. (2019). A Global Guideline for Pesticide Selection to Reduce Risks, and Establish a Minimum Pesticides List, Social Science Research Network.","DOI":"10.2139\/ssrn.3441822"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.foodcont.2013.05.006","article-title":"Detection of the residues of nineteen pesticides in fresh vegetable samples using gas chromatography\u2013mass spectrometry","volume":"34","author":"Fakhruddin","year":"2013","journal-title":"Food Control"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1002\/etc.5620161124","article-title":"Selective toxicity of chlorpyrifos to several species of fish during an environmental exposure: Biochemical mechanisms","volume":"16","author":"Carr","year":"1997","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/tx0499259","article-title":"Organophosphate toxicology: Safety aspects of nonacetylcholinesterase secondary targets","volume":"17","author":"Casida","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"134264","DOI":"10.1016\/j.scitotenv.2019.134264","article-title":"Phthalate esters in biota, air and water in an agricultural area of western China, with emphasis on bioaccumulation and human exposure","volume":"698","author":"He","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_15","first-page":"40","article-title":"Pesticide Residues in Food Grains, Vegetables and Fruits: A Hazard to Human Health","volume":"2","author":"Grewal","year":"2017","journal-title":"J. Med. Chem. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jenvman.2012.10.032","article-title":"Microbial degradation of chlorpyrifos in liquid media and soil","volume":"114","author":"Chishti","year":"2013","journal-title":"J. Environ. Manag."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jenvman.2015.01.025","article-title":"Degradation of chlorpyrifos in tropical rice soils","volume":"152","author":"Das","year":"2015","journal-title":"J. Environ. Manag."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ecoenv.2009.09.001","article-title":"Toxicity of selected pesticides to freshwater shrimp, Paratya australiensis (Decapoda: Atyidae): Use of time series acute toxicity data to predict chronic lethality","volume":"73","author":"Kumar","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.chemosphere.2015.05.024","article-title":"The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis","volume":"135","author":"Li","year":"2015","journal-title":"Chemosphere"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1021\/acs.est.0c06579","article-title":"The Rise and Fall of Chlorpyrifos in the United States","volume":"55","author":"Hites","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11738-021-03228-y","article-title":"Role of silicon on root morphological characters of wheat (Triticum aestivum L.) plants grown under Cd-contaminated nutrient solution","volume":"43","author":"Xuebin","year":"2021","journal-title":"Acta Physiol. Plant"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e03518","DOI":"10.1016\/j.heliyon.2020.e03518","article-title":"Occurrence of organochlorine pesticide residues in biological and environmental matrices in Africa: A two-decade review","volume":"6","author":"Olisah","year":"2020","journal-title":"Heliyon"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"105124","DOI":"10.1016\/j.envint.2019.105124","article-title":"Organophosphate pesticides exposure in pregnant women and maternal and cord blood thyroid hormone concentrations","volume":"132","author":"Mulder","year":"2019","journal-title":"Environ. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2017.10.006","article-title":"Prenatal organochlorine pesticide exposure and the disruption of steroids and reproductive hormones in cord blood: The Hokkaido study","volume":"110","author":"Araki","year":"2018","journal-title":"Environ. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.envint.2017.10.025","article-title":"Assessment of human exposure to pesticides by hair analysis: The case of vegetable-producing areas in Burkina Faso","volume":"111","author":"Lehmann","year":"2018","journal-title":"Environ. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"105332","DOI":"10.1016\/j.envint.2019.105332","article-title":"Cumulative exposure to organic pollutants of French children assessed by hair analysis","volume":"134","author":"Hardy","year":"2020","journal-title":"Environ. Int."},{"key":"ref_27","unstructured":"U.S. Environmental Protection Agency (2021, June 28). Revised Human Health Risk Assessment on Chlorpyrifos, Available online: https:\/\/www.epa.gov\/ingredients-used-pesticide-products\/revised-human-health-risk-assessment-chlorpyrifos."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"109341","DOI":"10.1016\/j.envres.2020.109341","article-title":"Medium and long-term effects of low doses of Chlorpyrifos during the postnatal, preweaning developmental stage on sociability, dominance, gut microbiota and plasma metabolites","volume":"184","author":"Abreu","year":"2020","journal-title":"Environ. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1021\/tx8004746","article-title":"Metabolic profiles of serum from rats after subchronic exposure to chlorpyrifos and carbaryl","volume":"22","author":"Wang","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/acs.chemrestox.5b00054","article-title":"Metabolomics analysis and biomarker identification for brains of rats exposed subchronically to the mixtures of low-dose cadmium and chlorpyrifos","volume":"28","author":"Xu","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ntt.2007.10.004","article-title":"Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos","volume":"30","author":"Lassiter","year":"2008","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1289\/ehp.8133","article-title":"Developmental Exposure of Rats to Chlorpyrifos Elicits Sex-Selective Hyperlipidemia and Hyperinsulinemia in Adulthood","volume":"113","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2014.04.009","article-title":"A review on the molecular mechanisms involved in insulin resistance induced by organophosphorus pesticides","volume":"322","author":"Lasram","year":"2014","journal-title":"Toxicology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fct.2014.07.036","article-title":"Impaired retention in A\u03b2PP Swedish mice six months after oral exposure to chlorpyrifos","volume":"72","author":"Salazar","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.fct.2017.11.001","article-title":"Chronic chlorpyrifos exposure elicits diet-specific effects on metabolism and the gut microbiome in rats","volume":"111","author":"Fang","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10553","DOI":"10.1021\/acs.jafc.9b03602","article-title":"Chlorpyrifos Induces Metabolic Disruption by Altering Levels of Reproductive Hormones","volume":"67","author":"Li","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.envres.2015.06.036","article-title":"Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice","volume":"142","author":"Basaure","year":"2015","journal-title":"Environ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Reygner, J., Lichtenberger, L., Elmhiri, G., Dou, S., Bahi-Jaber, N., Rhazi, L., Depeint, F., Bach, V., Khorsi-Cauet, H., and Abdennebi-Najar, L. (2016). Inulin Supplementation Lowered the Metabolic Defects of Prolonged Exposure to Chlorpyrifos from Gestation to Young Adult Stage in Offspring Rats. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164614"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cbi.2005.08.004","article-title":"Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity","volume":"156","author":"Goel","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF03160916","article-title":"Weight gain associated with chronic exposure to chlorpyrifos in rats","volume":"3","author":"Meggs","year":"2007","journal-title":"J. Med. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00580-018-2750-1","article-title":"Body weight and hematological changes induced by chronic exposure to low levels of chlorpyrifos and deltamethrin combination in rats: The effect of alpha-lipoic acid","volume":"27","author":"Uchendu","year":"2018","journal-title":"Comp. Clin. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1289\/ehp.6641","article-title":"Prenatal insecticide exposures and birth weight and length among an urban minority cohort","volume":"112","author":"Whyatt","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0300-483X(02)00555-3","article-title":"Intestinal permeability of chlorpyrifos using the single-pass intestinal perfusion method in the rat","volume":"184","author":"Cook","year":"2003","journal-title":"Toxicology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuro.2017.06.003","article-title":"Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons","volume":"62","author":"Gao","year":"2017","journal-title":"NeuroToxicology"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Joly Condette, C., Khorsi-Cauet, H., Morli\u00e8re, P., Zabijak, L., Reygner, J., Bach, V., and Gay-Qu\u00e9heillard, J. (2014). Increased Gut Permeability and Bacterial Translocation after Chronic Chlorpyrifos Exposure in Rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102217"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.tem.2017.05.001","article-title":"Gut Microbiota, Endocrine-Disrupting Chemicals, and the Diabetes Epidemic","volume":"28","author":"Velmurugan","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-Bacterial Mutualism in the Human Intestine","volume":"307","author":"Ley","year":"2005","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.coph.2013.09.008","article-title":"Gut microbiota, enteroendocrine functions and metabolism","volume":"13","author":"Cani","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ismej.2014.111","article-title":"Early colonizing Escherichia coli elicits remodeling of rat colonic epithelium shifting toward a new homeostatic state","volume":"9","author":"Tomas","year":"2015","journal-title":"ISME J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MPG.0000000000000734","article-title":"Chlorpyrifos Exposure During Perinatal Period Affects Intestinal Microbiota Associated With Delay of Maturation of Digestive Tract in Rats","volume":"61","author":"Condette","year":"2015","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1007\/s11356-012-1283-4","article-title":"Impact of chronic exposure to low doses of chlorpyrifos on the intestinal microbiota in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and in the rat","volume":"20","author":"Condette","year":"2013","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Reygner, J., Joly Condette, C., Bruneau, A., Delanaud, S., Rhazi, L., Depeint, F., Abdennebi-Najar, L., Bach, V., Mayeur, C., and Khorsi-Cauet, H. (2016). Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME\u00ae Model. Int. J. Environ. Res. Public Health, 13.","DOI":"10.3390\/ijerph13111088"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.scitotenv.2018.03.053","article-title":"Chronic exposure to low concentrations of lead induces metabolic disorder and dysbiosis of the gut microbiota in mice","volume":"631\u2013632","author":"Xia","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"22529","DOI":"10.1007\/s11356-018-2332-4","article-title":"Use of a combination of in vitro models to investigate the impact of chlorpyrifos and inulin on the intestinal microbiota and the permeability of the intestinal mucosa","volume":"25","author":"Delanaud","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tiv.2006.08.015","article-title":"Effects of the pesticide clorpyrifos on an in vitro model of intestinal barrier","volume":"21","author":"Tirelli","year":"2007","journal-title":"Toxicol. Vitr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/iai.39.3.1252-1259.1983","article-title":"Relationship between cecal population levels of indigenous bacteria and translocation to the mesenteric lymph nodes","volume":"39","author":"Steffen","year":"1983","journal-title":"Infect. Immun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.3748\/wjg.v26.i23.3145","article-title":"Early exposure to food contaminants reshapes maturation of the human brain-gut-microbiota axis","volume":"26","author":"Sarron","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1007\/s00394-021-02548-6","article-title":"Chronic oral exposure to pesticides and their consequences on metabolic regulation: Role of the microbiota","volume":"60","author":"Djekkoun","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.ejcn.1602350","article-title":"Oligofructose promotes satiety in healthy human: A pilot study","volume":"60","author":"Cani","year":"2006","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.2337\/db11-0227","article-title":"Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice","volume":"60","author":"Everard","year":"2011","journal-title":"Diabetes"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ijo.2015.84","article-title":"The role of short chain fatty acids in appetite regulation and energy homeostasis","volume":"39","author":"Byrne","year":"2015","journal-title":"Int. J. Obes."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3920\/BM2012.0065","article-title":"Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: Novel insights into molecular targets and interventions using prebiotics","volume":"5","author":"Geurts","year":"2014","journal-title":"Benef. Microbes."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0278-6915(94)00124-7","article-title":"Chlorpyrifos: Hazard assessment based on a review of the effects of short-term and long-term exposure in animals and humans","volume":"33","author":"Cochran","year":"1995","journal-title":"Food Chem. Toxicol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"203678","DOI":"10.1016\/j.cdev.2021.203678","article-title":"Perinatal exposure to chlorpyrifos and\/or a high-fat diet is associated with liver damage in male rat offspring","volume":"166","author":"Guibourdenche","year":"2021","journal-title":"Cells Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"111322","DOI":"10.1016\/j.fct.2020.111322","article-title":"Does the perigestational exposure to chlorpyrifos and\/or high-fat diet affect respiratory parameters and diaphragmatic muscle contractility in young rats?","volume":"140","author":"Joumaa","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_66","unstructured":"American Society of Microbiology (2011). Manual of Clinical Microbiology, American Society of Microbiology. [10th ed.]."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1017\/S0007114511007252","article-title":"Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties","volume":"108","author":"Lecerf","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12974-016-0617-4","article-title":"Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism","volume":"13","author":"Greco","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pestbp.2019.05.018","article-title":"Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats","volume":"159","author":"Li","year":"2019","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"110467","DOI":"10.1016\/j.ecoenv.2020.110467","article-title":"Metabolomic biomarkers in urine of rats following long-term low-dose exposure of cadmium and\/or chlorpyrifos","volume":"195","author":"Xu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fct.2017.03.013","article-title":"Joint toxicity of chlorpyrifos and cadmium on the oxidative stress and mitochondrial damage in neuronal cells","volume":"103","author":"Xu","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Yang, F., Li, J., Pang, G., Ren, F., and Fang, B. (2019). Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota. Molecules, 24.","DOI":"10.3390\/molecules24102003"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.toxlet.2006.07.342","article-title":"Zinc mediates normalization of hepatic drug metabolizing enzymes in chlorpyrifos-induced toxicity","volume":"169","author":"Goel","year":"2007","journal-title":"Toxicol. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.fsi.2019.07.022","article-title":"Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp","volume":"93","author":"Zhang","year":"2019","journal-title":"Fish. Shellfish Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1007\/s11356-017-0890-5","article-title":"Effects of Exposure to Malathion on Blood Glucose Concentration: A Meta-Analysis","volume":"25","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2017.01.053","article-title":"Chlorpyrifos induces anxiety-like behavior in offspring rats exposed during pregnancy","volume":"641","author":"Silva","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.chemosphere.2012.05.059","article-title":"Chlorpyrifos acute exposure induces hyperglycemia and hyperlipidemia in rats","volume":"89","author":"Acker","year":"2012","journal-title":"Chemosphere"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.etp.2010.07.003","article-title":"Hyperglycemic and stressogenic effects of monocrotophos in rats: Evidence for the involvement of acetylcholinesterase inhibition","volume":"64","author":"Joshi","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pestbp.2008.06.006","article-title":"Effect of short-time malathion administration on glucose homeostasis in Wistar rat","volume":"92","author":"Lasram","year":"2008","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/ajcn\/33.1.51","article-title":"Enhanced lipid peroxidation in liver microsomes of zinc-deficient rats","volume":"33","author":"Sullivan","year":"1980","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_81","first-page":"1047","article-title":"Assessment of chlorpyrifos toxicity on certain organs in rat, Rattus norvegicus","volume":"30","author":"Akhtar","year":"2009","journal-title":"J. Environ. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e945439","DOI":"10.4061\/2011\/945439","article-title":"Hemotoxicity Induced by Chronic Chlorpyrifos Exposure in Wistar Rats: Mitigating Effect of Vitamin C","volume":"2011","author":"Ambali","year":"2011","journal-title":"Vet. Med. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"19605","DOI":"10.1007\/s11356-018-2185-x","article-title":"Chronic co-exposure to chlorpyrifos and deltamethrin pesticides induces alterations in serum lipids and oxidative stress in Wistar rats: Mitigating role of alpha-lipoic acid","volume":"25","author":"Uchendu","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"067007","DOI":"10.1289\/EHP2877","article-title":"Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor","volume":"126","author":"Lukowicz","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.5897\/AJB12.2797","article-title":"Effect of propolis consumption on hepatotoxicity and brain damage in male rats exposed to chlorpyrifos","volume":"12","author":"Newairy","year":"2013","journal-title":"Afr. J. Biotechnol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"122152","DOI":"10.1016\/j.jhazmat.2020.122152","article-title":"Prenatal exposure to glufosinate ammonium disturbs gut microbiome and induces behavioral abnormalities in mice","volume":"389","author":"Dong","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1289\/EHP202","article-title":"Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions","volume":"125","author":"Gao","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"110865","DOI":"10.1016\/j.fct.2019.110865","article-title":"Long-term effects of low doses of Chlorpyrifos exposure at the preweaning developmental stage: A locomotor, pharmacological, brain gene expression and gut microbiome analysis","volume":"135","author":"Colomina","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.chemosphere.2016.03.055","article-title":"Effects of chlorpyrifos on the gut microbiome and urine metabolome in mouse (Mus musculus)","volume":"153","author":"Zhao","year":"2016","journal-title":"Chemosphere"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1017\/S0029665114001700","article-title":"Gut microbiota and energy balance: Role in obesity","volume":"74","author":"Blaut","year":"2015","journal-title":"Proc. Nutr. Soc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1039\/C6FO01532H","article-title":"Dietary fibre-based SCFA mixtures promote both protection and repair of intestinal epithelial barrier function in a Caco-2 cell model","volume":"8","author":"Chen","year":"2017","journal-title":"Food Funct."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfx227","article-title":"Insights Into a Possible Influence on Gut Microbiota and Intestinal Barrier Function During Chronic Exposure of Mice to Imazalil","volume":"162","author":"Jin","year":"2018","journal-title":"Toxicol. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"10930","DOI":"10.1007\/s11356-016-6297-x","article-title":"Changes on fecal microbiota in rats exposed to permethrin during postnatal development","volume":"23","author":"Nasuti","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.envpol.2017.10.129","article-title":"Exposure to the fungicide propamocarb causes gut microbiota dysbiosis and metabolic disorder in mice","volume":"237","author":"Wu","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.3748\/wjg.v19.i43.7531","article-title":"Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications","volume":"19","author":"Carroll","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/gutjnl-2012-304119","article-title":"Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation","volume":"63","author":"Denizot","year":"2014","journal-title":"Gut"},{"key":"ref_98","first-page":"592","article-title":"Bacterial translocation in neonatal rats: The relation between intestinal flora, translocated bacteria, and influence of milk","volume":"33","author":"Yajima","year":"2001","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2174\/138161209788168164","article-title":"The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease","volume":"15","author":"Cani","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: Metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S.J., Berenjian, A., and Ghasemi, Y. (2019). Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications. Foods, 8.","DOI":"10.3390\/foods8030092"},{"key":"ref_102","first-page":"49","article-title":"Protective effects of prebiotic in zebrafish, Danio rerio, under experimental exposure to Chlorpyrifos","volume":"6","author":"Yousefi","year":"2018","journal-title":"Int. J. Aquat. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3390\/ijms11062499","article-title":"Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings","volume":"11","author":"Ooi","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/jn\/136.4.913","article-title":"Dietary Fibers Affect Viscosity of Solutions and Simulated Human Gastric and Small Intestinal Digesta","volume":"136","author":"Dikeman","year":"2006","journal-title":"J. Nutr."},{"key":"ref_105","first-page":"1730","article-title":"High Propionic Acid Fermentations and Mineral Accumulation in the Cecum of Rats Adapted to Different Levels of Inulin","volume":"121","author":"Levrat","year":"1991","journal-title":"J. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/ejcn.2016.156","article-title":"Effect of inulin-type fructans on blood lipid profile and glucose level: A systematic review and meta-analysis of randomized controlled trials","volume":"71","author":"Liu","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.gpb.2019.03.001","article-title":"Inulin Can Alleviate Metabolism Disorders in ob\/ob Mice by Partially Restoring Leptin-related Pathways Mediated by Gut Microbiota","volume":"17","author":"Song","year":"2019","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e4446","DOI":"10.7717\/peerj.4446","article-title":"Inulin-type fructan improves diabetic phenotype and gut microbiota profiles in rats","volume":"6","author":"Zhang","year":"2018","journal-title":"PeerJ"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/gut.28.10.1221","article-title":"Short chain fatty acids in human large intestine, portal, hepatic and venous blood","volume":"28","author":"Cummings","year":"1987","journal-title":"Gut"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1038\/ncomms2668","article-title":"Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice","volume":"4","author":"Okada","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Sasaki, H., Miyakawa, H., Watanabe, A., Nakayama, Y., Lyu, Y., Hama, K., and Shibata, S. (2019). Mice Microbiota Composition Changes by Inulin Feeding with a Long Fasting Period under a Two-Meals-Per-Day Schedule. Nutrients, 11.","DOI":"10.3390\/nu11112802"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Liu, Y., and Sam, A.G. (2020). The Organic Premium of Baby Food Estimated with National Level Scanner Data, Social Science Research Network.","DOI":"10.2139\/ssrn.3757104"},{"key":"ref_114","first-page":"187","article-title":"Focus on Babies: A Note on Parental Attitudes and Preferences for Organic Babyfood","volume":"24","author":"Maguire","year":"2006","journal-title":"J. Agribus."},{"key":"ref_115","unstructured":"Maguire, K.B., Owens, N., and Simon, N.B. (2004). Focus on Babies: Evidence on Parental Attitudes towards Pesticide Risks, AgEcon Search."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.envres.2014.03.034","article-title":"Development of an analytical strategy based on LC\u2013MS\/MS for the measurement of different classes of pesticides and theirs metabolites in meconium: Application and characterisation of foetal exposure in France","volume":"132","author":"Berton","year":"2014","journal-title":"Environ. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.envint.2018.06.002","article-title":"Isolated hypospadias: The impact of prenatal exposure to pesticides, as determined by meconium analysis","volume":"119","author":"Haraux","year":"2018","journal-title":"Environ. Int."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijheh.2019.10.010","article-title":"Multiple pesticides in mothers\u2019 hair samples and children\u2019s measurements at birth: Results from the French national birth cohort (ELFE)","volume":"223","author":"Hardy","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/10\/3\/138\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:35:40Z","timestamp":1760135740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/10\/3\/138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,12]]},"references-count":118,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["toxics10030138"],"URL":"https:\/\/doi.org\/10.3390\/toxics10030138","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,12]]}}}