{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:54:31Z","timestamp":1790823271767,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T00:00:00Z","timestamp":1661644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural National Scientific Foundation of China","award":["81973006"],"award-info":[{"award-number":["81973006"]}]},{"name":"Natural National Scientific Foundation of China","award":["81973076"],"award-info":[{"award-number":["81973076"]}]},{"name":"Natural National Scientific Foundation of China","award":["81402658"],"award-info":[{"award-number":["81402658"]}]},{"name":"Natural National Scientific Foundation of China","award":["2020A1515010753"],"award-info":[{"award-number":["2020A1515010753"]}]},{"name":"Natural National Scientific Foundation of China","award":["202002030281"],"award-info":[{"award-number":["202002030281"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["81973006"],"award-info":[{"award-number":["81973006"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["81973076"],"award-info":[{"award-number":["81973076"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["81402658"],"award-info":[{"award-number":["81402658"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2020A1515010753"],"award-info":[{"award-number":["2020A1515010753"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["202002030281"],"award-info":[{"award-number":["202002030281"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["81973006"],"award-info":[{"award-number":["81973006"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["81973076"],"award-info":[{"award-number":["81973076"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["81402658"],"award-info":[{"award-number":["81402658"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["2020A1515010753"],"award-info":[{"award-number":["2020A1515010753"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["202002030281"],"award-info":[{"award-number":["202002030281"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Benzene, toluene, and xylenes (BTX) commonly co-exist. Exposure to individual components and BTX-rich mixtures can induce hematological effects. However, the hematological effects of long-term exposure to BTX are still unclear, and respective reference levels based on empirical evidence should be developed. We conducted a follow-up study in BTX-exposed petrochemical workers. Long-term exposure levels were quantified by measuring cumulative exposure (CE). Generalized weighted quantile sum (WQS) regression models and Benchmark Dose (BMD) Software were used to evaluate their combined effects and calculate their BMDs, respectively. Many hematologic parameters were significantly decreased at the four-year follow-up (p &lt; 0.05). We found positive associations of CE levels of benzene, toluene, and xylene with the decline in monocyte counts, lymphocyte counts, and hematocrit, respectively (\u03b2 &gt; 0.010, Ptrend &lt; 0.05). These associations were stronger in subjects with higher baseline parameters, males, drinkers, or overweight subjects (Pinteraction &lt; 0.05). BTX had positive combined effects on the decline in monocyte counts, red-blood-cell counts, and hemoglobin concentrations (Ptrend for WQS indices &lt; 0.05). The estimated BMDs for CE levels of benzene, toluene, and xylene were 2.138, 1.449, and 2.937 mg\/m3 \u00d7 year, respectively. Our study demonstrated the hematological effects of long-term BTX co-exposure and developed 8h-RELs of about 0.01 ppm based on their hematological effects.<\/jats:p>","DOI":"10.3390\/toxics10090502","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T02:09:36Z","timestamp":1661911776000},"page":"502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hematological Effects and Benchmark Doses of Long-Term Co-Exposure to Benzene, Toluene, and Xylenes in a Follow-Up Study on Petrochemical Workers"],"prefix":"10.3390","volume":"10","author":[{"given":"Zhaorui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanchao","family":"Lai","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aichu","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshun","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanfeng","family":"Dang","sequence":"additional","affiliation":[{"name":"Occupational Disease Prevention and Treatment Institute of Sinopec Maoming Petrochemical Company, Maoming 525000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Occupational Disease Prevention and Treatment Institute of Sinopec Maoming Petrochemical Company, Maoming 525000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-0402","authenticated-orcid":false,"given":"Qifei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"},{"name":"School of Public Health, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1021\/es505316f","article-title":"New look at BTEX: Are ambient levels a problem?","volume":"49","author":"Bolden","year":"2015","journal-title":"Environ. 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