{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:00:56Z","timestamp":1779897656739,"version":"3.53.1"},"reference-count":22,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Research on adolescent substance use is of utmost importance. Using local toxicological data, both prevalence and pattern of substance use (SU) and substance-related death (SRD) can be assessed to design effective prevention programs. A retrospective study of toxicology investigations of all adolescents referred to the medico-legal section of the Toxicology Unit of the University Hospital of Lille, France, for a 2-year period from 2017 to 2018. In the total sample of 1961 cases, adolescents accounted for 3.3% of the cases (n = 65). Among the adolescents, 16.9% were aged 10\u201314 years and 83.1% were aged &gt;14\u201319 years. About 69.2% were males. Less than 70% of all presented adolescents used substances. More than two-thirds (74%) of positive detections were male. Illicit substances (43%) were the most detected substance followed by alcohol (20%) and prescription substances (20%). Tetrahydrocannabinol (THC) was extremely common as it was found in 29% of all adolescents. Cocaine and amphetamines were detected in 13.8% of total tested adolescents. Polysubstance use was common between alcohol and THC and among males. About one-third of deaths were due to substance use. About 54% of SRD was associated with polysubstance detection. It is recommended that illicit substances, ethanol, and prescription substances are targeted for testing among adolescents in order to provide appropriate prevention.<\/jats:p>","DOI":"10.3390\/toxics10100594","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T06:13:27Z","timestamp":1665468807000},"page":"594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Substance Use among Adolescents: A Retrospective Study (2017\u20132018) in the Toxicology Unit, University Hospital of Lille, France"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1049-3211","authenticated-orcid":false,"given":"Sanaa M.","family":"Aly","sequence":"first","affiliation":[{"name":"Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt"},{"name":"CHU Lille, Unit\u00e9 Fonctionnelle de Toxicologie, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-5581","authenticated-orcid":false,"given":"Ahmed","family":"Omran","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-4671","authenticated-orcid":false,"given":"Jean-Michel","family":"Gaulier","sequence":"additional","affiliation":[{"name":"CHU Lille, Unit\u00e9 Fonctionnelle de Toxicologie, F-59000 Lille, France"},{"name":"Universit\u00e9 de Lille, URL 4483\u2014IMPECS\u2014IMPact de l\u2019Environnement Chimique sur la Sant\u00e9 Humaine, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-3319","authenticated-orcid":false,"given":"Delphine","family":"Allorge","sequence":"additional","affiliation":[{"name":"CHU Lille, Unit\u00e9 Fonctionnelle de Toxicologie, F-59000 Lille, France"},{"name":"Universit\u00e9 de Lille, URL 4483\u2014IMPECS\u2014IMPact de l\u2019Environnement Chimique sur la Sant\u00e9 Humaine, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jflm.2018.04.002","article-title":"Teens, Drugs, & Vegas: Toxicological surveillance of illicit prescription and illegal drug abuse in adolescents (12\u201317 years) using post-mortem data in Clark County, Nevada from 2005 to 2015","volume":"58","author":"Paul","year":"2018","journal-title":"J. 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