{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:06:36Z","timestamp":1769112396724,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cPROINVENT\u201d","award":["62487\/03.06.2022-POCU\/993\/6\/13-Code 153299"],"award-info":[{"award-number":["62487\/03.06.2022-POCU\/993\/6\/13-Code 153299"]}]},{"name":"The Human Capital Operational Programme 2014\u20132020 (POCU), Romania","award":["62487\/03.06.2022-POCU\/993\/6\/13-Code 153299"],"award-info":[{"award-number":["62487\/03.06.2022-POCU\/993\/6\/13-Code 153299"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Oxidative stress is induced by tobacco smoking and is also associated with exposure to air pollution, which are two of the most important risk factors for chronic obstructive pulmonary disease (COPD). The aim of this study was to correlate tobacco use and exposure to air pollution with oxidative stress markers useful in clinical practice in patients with COPD. A total of 102 patients were included and the levels of polycyclic aromatic hydrocarbons (PAHs), malondialdehyde, uric acid and number of packs-years (PY) were determined. Also, six different ratios were used to assess the source of exposure. The results obtained in this study show an admission of pollutants according to smoking status (former smokers\/smoker\/non-smokers) quantified in average total concentrations for the group of patients with COPD of 4.12 ng\/mL, 6.76 ng\/mL, 6.04 ng\/mL. The six ratios used show that in COPD, the content of PAHs in the blood could be a result of diesel emissions and fuel combustion. Uric acid levels were lower in the smoker group of COPD patients (mean = 5.21 mg\/dL), which indicates that oxidative stress is intensified with each cigarette smoked. Additionally, high concentrations of malondialdehyde were quantified for smoking patients diagnosed with COPD (mean = 2.72 \u00b5mol\/L) compared to former smokers (mean = 2.43 \u00b5mol\/L) and non-smoking (mean = 2.32 \u00b5mol\/L) patients, which is another indicator of the implication of smoking in oxidative stress in COPD patients.<\/jats:p>","DOI":"10.3390\/toxics10110681","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T01:39:54Z","timestamp":1668130794000},"page":"681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-6218","authenticated-orcid":false,"given":"Ioana","family":"Buculei","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"},{"name":"Doctoral School, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona Elisabeta","family":"Dobrin","sequence":"additional","affiliation":[{"name":"Medical Science Department, University of Medicine and Pharmacy, Iuliu Ha\u021bieganu, 400347 Cluj-Napoca, Romania"},{"name":"Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Matei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-0719","authenticated-orcid":false,"given":"Ilie","family":"Onu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"},{"name":"Doctoral School of the Faculty of Chemical Engineering and Environmental Protection \u201cCristofor Simionescu\u201d, Technical University \u201cGheorghe Asachi\u201d, 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Vicol","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"},{"name":"Doctoral School, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6136-5204","authenticated-orcid":false,"given":"Ionel Bogdan","family":"Cioroiu","sequence":"additional","affiliation":[{"name":"Romanian Academy, Ia\u0219i Branch, Research Center for Oenology, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-277X","authenticated-orcid":false,"given":"Marius","family":"Niculaua","sequence":"additional","affiliation":[{"name":"Romanian Academy, Ia\u0219i Branch, Research Center for Oenology, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-2030","authenticated-orcid":false,"given":"Daniel Andrei","family":"Iordan","sequence":"additional","affiliation":[{"name":"Department of Individual Sports and Kinetotherapy, Faculty of Physical Education and Sport, \u201cDun\u0103rea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"Center of Physical Therapy and Rehabilitation, \u201cDun\u0103rea de Jos\u201d University of Galati, 800008 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5690-8638","authenticated-orcid":false,"given":"Andrei","family":"Cernomaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3252-7715","authenticated-orcid":false,"given":"Antigona Carmen","family":"Trofor","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020). WHO Methods and Data Sources for Country-Level Causes of Death 2000\u20132019, Department of Data and Analytics (DNA) Division of Data, Analytics and Delivery for Impact (DDI)."},{"key":"ref_2","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (2022, September 20). Global Strategy for The Diagnosis, Management, And Prevention Of Chronic Obstructive Pulmonary Disease (2022 Report). Available online: https:\/\/goldcopd.org\/wp-content\/uploads\/2021\/12\/GOLD-REPORT-2022-v1.1-22Nov2021_WMV.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.mcna.2018.12.005","article-title":"Chronic Obstructive Pulmonary Disease: Evaluation and Management","volume":"103","author":"Duffy","year":"2019","journal-title":"Med. Clin. N. Am."},{"key":"ref_4","unstructured":"Paul, W., Colin, P., Alan, T., and Manuel, M. (2019). Polycyclic Aromatic Hydrocarbons Determination. Encyclopedia of Analytical Science, Academic Press. [3rd ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejpe.2015.03.011","article-title":"A review on polycyclic aromatic hydrocarbons: Source, environmental impact, effect on human health and remediation","volume":"25","author":"Mansour","year":"2016","journal-title":"Egypt. J. Pet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/15412555.2016.1214948","article-title":"Role of Inflammation and Oxidative Stress in the Pathology of Ageing in COPD: Potential Therapeutic Interventions","volume":"14","author":"Choudhury","year":"2017","journal-title":"COPD J. Chronic Obstr. Pulm. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envres.2019.108910","article-title":"Indoor PM2.5, tobacco smoking and chronic lung diseases: A narrative review","volume":"181","author":"Ni","year":"2020","journal-title":"Environ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12931-020-1292-7","article-title":"Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: An observational longitudinal study","volume":"21","author":"Stranieri","year":"2020","journal-title":"Respir. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"653e658","DOI":"10.1136\/oem.2010.055020","article-title":"Polycyclic aromatic hydrocarbon-induced oxidative stress and lipid peroxidation in relation to immunological alteration","volume":"68","author":"Jeng","year":"2011","journal-title":"Occup. Environ. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.advms.2017.05.005","article-title":"Endogenous non-enzymatic antioxidants in the human body","volume":"63","author":"Witkowska","year":"2018","journal-title":"Adv. Med. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3892\/etm.2022.11142","article-title":"Benefits and adverse events of melatonin use in the elderly (Review)","volume":"23","author":"Anghel","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.2174\/138161205774913255","article-title":"Uric Acid and Oxidative Stress","volume":"11","author":"Glantzounis","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s12199-010-0198-2","article-title":"Effect of cigarette smoking on plasma uric acid concentrations","volume":"16","author":"Ezzaher","year":"2011","journal-title":"Environ. Health Prev. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2217\/bmm-2017-0420","article-title":"Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis","volume":"12","author":"Paliogiannis","year":"2018","journal-title":"Biomark. Med."},{"key":"ref_15","unstructured":"Mocanu, G.D., and Munteanu, D. (2019). \u202aEtic\u0103 \u0219i Integritate \u00een Domeniile Educa\u021bional \u0219i Sportiv, Galati University Press."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.chemosphere.2013.02.014","article-title":"Polycyclic aromatic hydrocarbons in lung tissue of patients withpulmonary cancer from Romania. Influence according as demographicstatus and ABO phenotypes","volume":"92","author":"Cioroiu","year":"2013","journal-title":"Chemosphere"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jchromb.2016.07.013","article-title":"Development and evaluation of a liquid chromatography-mass spectrometry method for rapid, accurate quantitation of malondialdehyde in human plasma","volume":"1029","author":"Sobsey","year":"2016","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.reprotox.2007.10.012","article-title":"Quantification of benzo[a]pyrene and other PAHs in the serum and follicular fluid of smokers versus non-smokers","volume":"25","author":"Neal","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/15412555.2021.1920902","article-title":"Sociodemographic Characteristics and Physical Activity in Patients with COPD: A 3-Month Cohort Study","volume":"18","author":"Dragnich","year":"2021","journal-title":"COPD"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00508-013-0452-x","article-title":"Changes in physical activity in healthy people and COPD patients","volume":"126","author":"Tudorache","year":"2014","journal-title":"Wien Klin. Wochenschr."},{"key":"ref_21","unstructured":"Mocanu, G.D. (2018). Loisir. Activit\u0103\u021bi Motrice de Timp Liber, Galati University Press."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mocanu, G.D., Murariu, G., and Munteanu, D. (2021). The Influence of Socio-Demographic Factors on the Forms of Leisure for the Students at the Faculty of Physical Education and Sports. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182312577"},{"key":"ref_23","first-page":"14","article-title":"Prediction of the professional orientation of students with vocational profile","volume":"56","author":"Corlaci","year":"2019","journal-title":"Discobolul-Phys. Educ. Sport Kinetother. J."},{"key":"ref_24","first-page":"6","article-title":"study on the human body\u2019s central axis. day-to-day life verticality","volume":"52","year":"2018","journal-title":"Discobolul\u2013Phys. Educ. Sport Kinetother. J."},{"key":"ref_25","unstructured":"Kl\u00e1nov\u00e1, J., Cupr, P., and Holoubek, I. (2006). Application of Passive Sampler for Monitoring of POPs in Ambient Air. Part II: Pilot Study for Development of the Monitoring Network in the Central and Eastern Europe (MONET_CEEC), Masaryk University."},{"key":"ref_26","unstructured":"Verschueren, K. (2001). Handbook of Environmental Data on Organic Chemicals, John Wiley & Sons. [4th ed.]."},{"key":"ref_27","unstructured":"National Center for Biotechnology Information (2022, April 11). PubChem Compound Summary for CID 5889, Dibenz[a,h]anthracene, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Dibenz_a_h_anthracene."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chrysochou, E., Kanellopoulos, P.G., Koukoulakis, K.G., Sakellari, A., Karavoltsos, S., Minaidis, M., and Bakeas, E. (2021). Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution. Molecules, 26.","DOI":"10.3390\/molecules26113207"},{"key":"ref_29","unstructured":"WHO (1998). Environmental Health Criteria 202: Selected Non-Heterocyclic Polycyclic Aromatic Hydrocarburs, TPCS, Internatioanl Programme on Chemical Safety World Health Organization."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3109\/01902149809087376","article-title":"Mechanistic relationships between DNA adducts, oncogene mutations, and lung tumorigenesis in strain A mice","volume":"24","author":"Nesnow","year":"1998","journal-title":"Exp. Lung Res."},{"key":"ref_31","unstructured":"National Center for Biotechnology Information (2022, April 11). PubChem Compound Summary for CID 2336, Benzo[a]pyrene, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Benzo_a_pyrene."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/10590500902885684","article-title":"8-hydroxy-2\u2032-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis","volume":"27","author":"Valavanidis","year":"2009","journal-title":"J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.apr.2020.06.018","article-title":"Leukemia and PAHs levels in human blood serum: Preliminary results from an adult cohort in Greece","volume":"11","author":"Koukoulakis","year":"2020","journal-title":"Atmos. Pollut. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.yrtph.2006.11.007","article-title":"Characterization of EPA\u2019s 16 priority pollutant polycyclic aromatic hydrocarbons (PAHs) in tank bottom solids and associated contaminated soils at oil exploration and production sites in Texas","volume":"47","author":"Bojes","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_35","unstructured":"United States Environmental Protection Agency (2002). Polycyclic aromatic hydrocarbons, 15 listings. Rep. Carcinog., 10, 201\u2013204."},{"key":"ref_36","unstructured":"International Agency for Research on Cancer (IARC) (2010). Some Non-Heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures; IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, International Agency for Research on Cancer (IARC)."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1139\/H08-147","article-title":"Oxidative stress in the brain of nicotine-induced toxicity: Protective role of Andrographis paniculata Nees and vitamin E","volume":"34","author":"Das","year":"2009","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0197-0186(03)00009-3","article-title":"Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells","volume":"43","author":"Guan","year":"2003","journal-title":"Neurochem. Int."},{"key":"ref_39","first-page":"2479","article-title":"A meta-analysis of lipid peroxidation markers in major depression","volume":"11","author":"Mazereeuw","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.31925\/farmacia.2020.1.12","article-title":"Evaluation of oxidative stress in smoking and non-smoking patients diagnosed with anxious-depressive disorder","volume":"68","author":"Trofor","year":"2020","journal-title":"Farmacia"},{"key":"ref_41","first-page":"375","article-title":"Free radicals and cigarette smoke","volume":"56","author":"Zaga","year":"2002","journal-title":"Giorn. Mal. Tor."},{"key":"ref_42","first-page":"283","article-title":"Effect of Cigarette Smoking on Serum Lipid Profile in Male Population of Udaipur","volume":"5","author":"Singh","year":"2016","journal-title":"Biochem. Anal. Biochem."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/10\/11\/681\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:14:18Z","timestamp":1760145258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/10\/11\/681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,11]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["toxics10110681"],"URL":"https:\/\/doi.org\/10.3390\/toxics10110681","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,11]]}}}