{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:53:45Z","timestamp":1788274425823,"version":"build-2803163510"},"reference-count":202,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Arsenic (As) is a poisonous metalloid that is toxic to both humans and animals. Drinking water contamination has been linked to the development of cancer (skin, lung, urinary bladder, and liver), as well as other disorders such as diabetes and cardiovascular, gastrointestinal, neurological, and developmental damage. According to epidemiological studies, As contributes to male infertility, sexual dysfunction, poor sperm quality, and developmental consequences such as low birth weight, spontaneous abortion, and small for gestational age (SGA). Arsenic exposure negatively affected male reproductive systems by lowering testicular and accessory organ weights, and sperm counts, increasing sperm abnormalities and causing apoptotic cell death in Leydig and Sertoli cells, which resulted in decreased testosterone synthesis. Furthermore, during male reproductive toxicity, several molecular signalling pathways, such as apoptosis, inflammation, and autophagy are involved. Phytonutrient intervention in arsenic-induced male reproductive toxicity in various species has received a lot of attention over the years. The current review provides an in-depth summary of the available literature on arsenic-induced male toxicity, as well as therapeutic approaches and future directions.<\/jats:p>","DOI":"10.3390\/toxics10120744","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T02:24:46Z","timestamp":1669861486000},"page":"744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention"],"prefix":"10.3390","volume":"10","author":[{"given":"Mahesh","family":"Rachamalla","sequence":"first","affiliation":[{"name":"Department of Biology, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshi","family":"Chinthada","sequence":"additional","affiliation":[{"name":"Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S Nagar 160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-3034","authenticated-orcid":false,"given":"Sapana","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Transit Campus, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow 226002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravan Kumar","family":"Putnala","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittaranjan","family":"Sahu","sequence":"additional","affiliation":[{"name":"Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S Nagar 160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopabandhu","family":"Jena","sequence":"additional","affiliation":[{"name":"Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S Nagar 160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Som","family":"Niyogi","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada"},{"name":"Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/0378-6323.16612","article-title":"Cryptic Exposure to Arsenic","volume":"71","author":"Rossy","year":"2005","journal-title":"Indian J. 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