{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:10:14Z","timestamp":1789449014119,"version":"build-2803163510"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Silesia","award":["PCN-1-103\/N\/1\/F"],"award-info":[{"award-number":["PCN-1-103\/N\/1\/F"]}]},{"name":"Medical University of Silesia","award":["PCN-2-119\/N\/0\/O"],"award-info":[{"award-number":["PCN-2-119\/N\/0\/O"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Methanol poisonings caused by drinking industrial alcohol remain a severe problem worldwide. Education on types of alcohol and their harmfulness and legal regulations limiting the industrial alcohol trade seem to be the keys to reducing the number of poisonings. Methanol distribution in different tissues after absorption is not well understood. This research aimed to quantify the methanol and formic acid distribution in body fluids and tissue material in post-mortem samples collected from 19 fatal victims of massive intoxication with industrial alcohol in the Silesia Region (Poland) who died between April and June 2022. The samples were analyzed using a gas chromatography\u2013flame ionization detector (GC-FID), and correlation coefficients for methanol and formic acid were determined. The results show a wide distribution of methanol and formic acid in human post-mortem biological fluids (blood, urine, vitreous humor, bile, and cerebrospinal fluid) and tissues (muscle, kidney, liver, spleen, lung, and brain). The strongest correlation for methanol concentration in blood and body fluids\/tissues was obtained in the cerebrospinal fluid (r = 0.997) and for formic acid in muscle tissue (r = 0.931). The obtained results may be a valuable tool in toxicological analysis and improve medical standards of early diagnosis and targeted treatment.<\/jats:p>","DOI":"10.3390\/toxics10120800","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T09:05:09Z","timestamp":1671440709000},"page":"800","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fatal Methanol Poisoning Caused by Drinking Industrial Alcohol: Silesia Region, Poland, April\u2013June 2022"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-4685","authenticated-orcid":false,"given":"Marcin","family":"Tomsia","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine and Forensic Toxicology, Medical University of Silesia, 18 Medyk\u00f3w Street, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"G\u0142az","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Forensic Toxicology, Medical University of Silesia, 18 Medyk\u00f3w Street, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Nowicka","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Forensic Toxicology, Medical University of Silesia, 18 Medyk\u00f3w Street, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Cie\u015bla","sequence":"additional","affiliation":[{"name":"Students Scientific Society, Medical University of Silesia, 18 Medyk\u00f3w Street, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Sosnowski","sequence":"additional","affiliation":[{"name":"Students Scientific Society, Medical University of Silesia, 18 Medyk\u00f3w Street, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0111-438X","authenticated-orcid":false,"given":"El\u017cbieta","family":"Che\u0142mecka","sequence":"additional","affiliation":[{"name":"Department of Statistics, Department of Instrumental Analysis, Faculty of Pharmaceutical Sciences, Medical University of Silesia, Ostrog\u00f3rska 30, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101995","DOI":"10.1016\/j.legalmed.2021.101995","article-title":"Fatal methanol poisoning with different clinical and autopsy findings: Case report and literature review","volume":"54","author":"Tian","year":"2022","journal-title":"Leg. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/biot.201400158","article-title":"Effects of methanol on lipases: Molecular, kinetic and process issues in the production of biodiesel","volume":"10","author":"Lotti","year":"2015","journal-title":"Biotechnol. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chung, J.Y., Ho, C.H., Chen, Y.C., Chen, J.H., Lin, H.J., Wang, J.J., Hsu, C.C., and Huang, C.C. (2018). Association between acute methanol poisoning and subsequent mortality: A nationwide study in Taiwan. BMC Public Health, 18.","DOI":"10.1186\/s12889-018-5918-3"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-0773.1991.tb01290.x","article-title":"Methanol and formic acid toxicity: Biochemical mechanisms","volume":"69","author":"Liesivuori","year":"1991","journal-title":"Pharmacol. Toxicol."},{"key":"ref_5","unstructured":"International Programme on Chemical Safety (IPCS) (1997). Methanol, World Health Organization. Environmental Health Criteria 196."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1081\/CLT-120006745","article-title":"American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning","volume":"40","author":"Barceloux","year":"2002","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5816162","DOI":"10.1155\/2020\/5816162","article-title":"Fatal methanol poisoning caused by drinking adulterated locally distilled alcohol: Wakiso District, Uganda, June 2017","volume":"2020","author":"Doreen","year":"2020","journal-title":"J. Environ. Public Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.15585\/mmwr.mm6932e1","article-title":"Serious adverse health events, including death, associated with ingesting alcohol-based hand sanitizers containing methanol\u2014Arizona and New Mexico, May\u2013June 2020","volume":"69","author":"Yip","year":"2020","journal-title":"Morb. Mortal Wkly Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.3109\/15563650.2014.974106","article-title":"Czech mass methanol outbreak 2012: Epidemiology, challenges and clinical features","volume":"52","author":"Zakharov","year":"2014","journal-title":"Clin. Toxicol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00204-021-03202-0","article-title":"Methanol-induced optic neuropathy: A still-present problem","volume":"96","author":"Liberski","year":"2022","journal-title":"Arch. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ajim.23315","article-title":"Severe visual loss caused by inhalational methanol poisoning in fireworks production: A report on 3 cases","volume":"65","author":"Luo","year":"2022","journal-title":"Am. J. Ind. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Erfanifar, A., Mahjani, M., Salimpour, S., Zamani, N., and Hassanian-Moghaddam, H. (2022). Diabetic ketoacidosis as a complication of methanol poisoning; A case report. BMC Endocr. Disord., 22.","DOI":"10.1186\/s12902-022-01037-z"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mohammed, W.B., Tarabzouni, S., and Bohlega, S. (2022). Methanol-induced parkinsonism and cerebral vasculopathy due to perfume inhalation. BMJ Neurol. Open., 4.","DOI":"10.1136\/bmjno-2021-000221"},{"key":"ref_14","first-page":"3","article-title":"A retrospective study on methyl alcohol poisoning in Turkey: Treatment strategy","volume":"24","author":"Kaya","year":"2022","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kuusela, E., J\u00e4rvisalo, M.J., Hellman, T., and Uusalo, P. (2022). Mortality and associated risk factors in patients with severe methanol or ethylene glycol poisoning treated with dialysis: A retrospective cohort study. J. Int. Med. Res., 50.","DOI":"10.1177\/03000605221081427"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/bcp.12824","article-title":"Antidotes for poisoning by alcohols that form toxic metabolites","volume":"81","author":"McMartin","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1080\/01480545.2020.1845192","article-title":"The outbreak of methanol intoxication during COVID-19 pandemic: Prevalence of brain lesions and its predisposing factors","volume":"45","author":"Simani","year":"2022","journal-title":"Drug Chem. Toxicol."},{"key":"ref_18","first-page":"57","article-title":"Predictors of poor outcomes in acute methanol poisoning","volume":"22","author":"Elbastawesy","year":"2022","journal-title":"Egypt. J. Forensic Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0006-2944(80)90073-3","article-title":"Gas chromatographic head-space assay of formic acid as methyl formate in biologic fluids: Potential application to methanol poisoning","volume":"23","author":"Abolin","year":"1980","journal-title":"Biochem. Med."},{"key":"ref_20","first-page":"669","article-title":"The effects of ethanol on methanol intoxication. I. A simple headspace gas chromatography for the determination of blood formic acid","volume":"36","author":"Kuo","year":"1982","journal-title":"Jpn. J. Legal Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.forsciint.2008.05.014","article-title":"Fatal methanol intoxication with different survival times\u2014Morphological findings and postmortem methanol distribution","volume":"179","author":"Andresen","year":"2008","journal-title":"Forensic Sci. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3109\/15563650.2015.1086488","article-title":"Long-term visual damage after acute methanol poisonings: Longitudinal cross-sectional study in 50 patients","volume":"53","author":"Zakharov","year":"2015","journal-title":"Clin. Toxicol."},{"key":"ref_23","first-page":"291","article-title":"Analyse statistique de 597 dosages d\u2019alcool \u00e9thylique pratiqu\u00e9s dans le sang, les humeurs et les organes d\u2019un total de 93 cadavres; Signification physiologique et int\u00e9r\u00eat m\u00e9dico-l\u00e9gal [Statistical analysis of 597 determinations of ethyl alcohol in the blood, fluids and organs of a total of 93 cadavers; physiological significance and medico-legal value]","volume":"31","author":"Handovsky","year":"1951","journal-title":"Ann. Med. Leg. Criminol. Police Sci. Toxicol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/15563650.2019.1637525","article-title":"The impact of co-morbidities on a 6-year survival after methanol mass poisoning outbreak: Possible role of metabolic formaldehyde","volume":"58","author":"Zakharov","year":"2020","journal-title":"Clin. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"36171","DOI":"10.32598\/ijmtfm.v12i1.36171","article-title":"Demographic and clinical characteristics of patients who died of methanol toxicity during COVID 19 outbreak in Loghman-e-Hakim Hospital, Tehran","volume":"12","author":"Shadnia","year":"2022","journal-title":"Int. J. Med. Toxicol. Forensic Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/s13256-022-03600-7","article-title":"Methanol poisoning outbreak in Saudi Arabia: A case series","volume":"16","author":"Eskandrani","year":"2022","journal-title":"J. Med. Case Rep."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Vaibhav, V., Shukla, P.K., Meshram, R., Bhute, A.R., Varun, A., and Durgapal, P. (2022). Methanol poisoning: An autopsy-based study at the tertiary care center of Uttarakhand, India. Cureus, 14.","DOI":"10.7759\/cureus.25434"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ajem.2021.11.026","article-title":"Methanol poisoning during COVID-19 pandemic; A systematic scoping review","volume":"52","author":"Arzhangzadeh","year":"2022","journal-title":"Am. J. Emerg. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.37506\/ijfmt.v16i1.17902","article-title":"Methanol toxicity in Eastern Province: An emergency department and toxicologist dilemma-case series with a review of the literature","volume":"16","author":"Issa","year":"2022","journal-title":"Indian J. Forensic Med. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Abdelwahab, H.M., Nafea, O.E., Elsherif, R., Gharib, A.F., Alrehaili, A.A., and Abdelhamid, W.G. (2022). Neutrophil-to-lymphocyte ratio versus platelet-to-lymphocyte ratio in predicting clinical outcomes in acute methanol poisoning. Hum. Exp. Toxicol., 41.","DOI":"10.1177\/09603271221102504"},{"key":"ref_31","unstructured":"Ashurst, J.V., and Nappe, T.M. (2022). Methanol Toxicity, StatPearls Publishing."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.5740\/jaoacint.17-0006","article-title":"Simultaneous determination of volatile organic compounds in commercial alcoholic beverages by gas chromatography with flame ionization detection","volume":"100","author":"Kim","year":"2017","journal-title":"J. AOAC Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"128924","DOI":"10.1016\/j.foodchem.2020.128924","article-title":"The application of headspace gas chromatographic method for the determination of ethyl alcohol in craft beers, wines and soft drinks","volume":"346","author":"Szpot","year":"2021","journal-title":"Food Chem."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/10\/12\/800\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:44:12Z","timestamp":1760147052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/10\/12\/800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["toxics10120800"],"URL":"https:\/\/doi.org\/10.3390\/toxics10120800","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,19]]}}}