{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:16:09Z","timestamp":1790342169247,"version":"4.1.0"},"reference-count":206,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"External Research Board, OVCRI, University of Illinois at Urbana-Champaign","award":["R01ES034112-01A1"],"award-info":[{"award-number":["R01ES034112-01A1"]}]},{"name":"NIEHS","award":["R01ES034112-01A1"],"award-info":[{"award-number":["R01ES034112-01A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.<\/jats:p>","DOI":"10.3390\/toxics11010032","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:19:46Z","timestamp":1672370386000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease"],"prefix":"10.3390","volume":"11","author":[{"given":"Xing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5579-9268","authenticated-orcid":false,"given":"Jodi A.","family":"Flaws","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Carl Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Spinella","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Carl Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-1520","authenticated-orcid":false,"given":"Joseph","family":"Irudayaraj","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Carl Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Beckman Institute of Technology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/elsc.200700017","article-title":"Elimination of Endocrine Disrupting Chemicals using White Rot Fungi and their Lignin Modifying Enzymes: A Review","volume":"7","author":"Cabana","year":"2007","journal-title":"Eng. 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