{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:40:35Z","timestamp":1774489235505,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research (AFOSR) Laboratory Research Initiation Request (LRIR)","doi-asserted-by":"publisher","award":["14RH09COR"],"award-info":[{"award-number":["14RH09COR"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research (AFOSR) Laboratory Research Initiation Request (LRIR)","doi-asserted-by":"publisher","award":["711HPW\/RHBAF"],"award-info":[{"award-number":["711HPW\/RHBAF"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Program Committee 5 (JPC-5)","award":["14RH09COR"],"award-info":[{"award-number":["14RH09COR"]}]},{"name":"Joint Program Committee 5 (JPC-5)","award":["711HPW\/RHBAF"],"award-info":[{"award-number":["711HPW\/RHBAF"]}]},{"name":"Air Force Research Laboratory","award":["14RH09COR"],"award-info":[{"award-number":["14RH09COR"]}]},{"name":"Air Force Research Laboratory","award":["711HPW\/RHBAF"],"award-info":[{"award-number":["711HPW\/RHBAF"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded to simulate inhalation exposures to one or more selected compounds: toluene, ethylbenzene, xylenes, n-nonane, n-decane, and naphthalene. The model structure accounts for metabolism of compounds in the lung and liver, as well as kinetics of each compound in multiple tissues, including the cochlea and brain regions associated with auditory signaling (brainstem and temporal lobe). The model can accommodate either diffusion-limited or flow-limited kinetics (or a combination), allowing the same structure to be utilized for compounds with different characteristics. The resulting model satisfactorily simulated blood concentration and tissue dosimetry data from multiple published single chemical rat studies. The model was then utilized to predict tissue kinetics for the jet fuel hearing loss study (JTEH A, 25:1-14). The model was also used to predict rat kinetic comparisons between hypothetical exposures to JP-8 or a Virent Synthesized Aromatic Kerosene (SAK):JP-8 50:50 blend at the occupational exposure limit (200 mg\/m3). The array model has proven useful for comparing potential tissue burdens resulting from complex mixture exposures.<\/jats:p>","DOI":"10.3390\/toxics11020187","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T03:53:49Z","timestamp":1676606029000},"page":"187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Complex Mixtures: Array PBPK Modeling of Jet Fuel Components"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-6947","authenticated-orcid":false,"given":"Teresa R.","family":"Sterner","sequence":"first","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Wright-Patterson Air Force Base, Dayton, OH 45433, USA"},{"name":"Air Force Research Laboratory, 711HPW\/RHBAF, Wright-Patterson Air Force Base, Dayton, OH 45433, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammie R.","family":"Covington","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Wright-Patterson Air Force Base, Dayton, OH 45433, USA"},{"name":"Air Force Research Laboratory, 711HPW\/RHBAF, Wright-Patterson Air Force Base, Dayton, OH 45433, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Mattie","sequence":"additional","affiliation":[{"name":"Air Force Research Laboratory, 711HPW\/RHBAF, Wright-Patterson Air Force Base, Dayton, OH 45433, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"ref_1","unstructured":"Stucker, J.P., Schank, J.F., and Dombey-Moore, B. (1994). Assessment of DoD Fuel Standardization Policies, RAND National Defense Research Institute."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/20464177.2011.11020246","article-title":"Development of multi-fuel, power dense engines for maritime combat craft","volume":"10","author":"Work","year":"2011","journal-title":"J. Mar. Eng. Technol."},{"key":"ref_3","unstructured":"National Research Council (2003). Toxicologic Assessment of Jet-Propulsion Fuel 8, The National Academies Press."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4103\/1463-1741.85509","article-title":"Hearing status among aircraft maintenance personnel in a commercial airline company","volume":"13","author":"Smedje","year":"2011","journal-title":"Noise Health"},{"key":"ref_5","first-page":"57","article-title":"Hearing in military pilots: One-time audiometry in pilots of fighters, transports, and helicopters","volume":"77","author":"Raynal","year":"2006","journal-title":"Aviat. Space Environ. Med."},{"key":"ref_6","first-page":"S232","article-title":"Prevalence and an analysis of noise--induced hearing loss in army helicopter pilots and aircraft mechanics","volume":"88","author":"Jaruchinda","year":"2005","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/01.jom.0000155710.28289.0e","article-title":"Effects of concurrent noise and jet fuel exposure on hearing loss","volume":"47","author":"Kaufman","year":"2005","journal-title":"J. Occup. Environ. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/1463-1741.31876","article-title":"Effect of exposure to a mixture of solvents and noise on hearing and balance in aircraft maintenance workers","volume":"7","author":"Prasher","year":"2005","journal-title":"Noise Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/ajim.20867","article-title":"Hearing impairment in F-111 maintenance workers: The study of health outcomes in aircraft maintenance personnel (SHOAMP) general health and medical study","volume":"53","author":"Guest","year":"2010","journal-title":"Am. J. Ind. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"950","DOI":"10.7205\/MILMED-D-14-00733","article-title":"Jet Fuel, Noise, and the Central Auditory Nervous System: A Literature Review","volume":"180","author":"Warner","year":"2015","journal-title":"Mil. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/toxsci\/kfm101","article-title":"JP-8 jet fuel can promote auditory impairment resulting from subsequent noise exposure in rats","volume":"98","author":"Fechter","year":"2007","journal-title":"Toxicol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/toxsci\/kfq110","article-title":"Ototoxic potential of JP-8 and a Fischer-Tropsch synthetic jet fuel following subacute inhalation exposure in rats","volume":"116","author":"Fechter","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/15287394.2012.652060","article-title":"Subchronic JP-8 jet fuel exposure enhances vulnerability to noise-induced hearing loss in rats","volume":"75","author":"Fechter","year":"2012","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/15287394.2013.862892","article-title":"Exposure to low levels of jet-propulsion fuel impairs brainstem encoding of stimulus intensity","volume":"77","author":"Guthrie","year":"2014","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1080\/15287394.2015.1070389","article-title":"Inhalation of Hydrocarbon Jet Fuel Suppress Central Auditory Nervous System Function","volume":"78","author":"Guthrie","year":"2015","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/15287394.2022.2069064","article-title":"Abnormal neural adaptation consequent to combined exposure to jet fuel and noise","volume":"85","author":"Guthrie","year":"2022","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/15287394.2021.1980166","article-title":"Degenerate brainstem circuitry after combined physiochemical exposure to jet fuel and noise","volume":"85","author":"Guthrie","year":"2022","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_18","unstructured":"Shafer, L.M., Striebich, R.C., Gomach, J., and Edwards, T. (2006). 14th AIAA\/AHI Space Planes and Hypersonic Systems and Technologies Conference, AIAA 2006-7972, American Institute of Aeronautics and Astronautics."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/toxsci\/kfm109","article-title":"Promotion of noise-induced cochlear injury by toluene and ethylbenzene in the rat","volume":"98","author":"Fechter","year":"2007","journal-title":"Toxicol. Sci."},{"key":"ref_20","unstructured":"Johnson, A.-C., and Morata, T.C. (2010). The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 142. Occupational Exposure to Chemicals and Hearing Impairment, Arbete och Halsa."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0892-0362(95)02014-4","article-title":"Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats","volume":"18","author":"Lund","year":"1996","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_22","unstructured":"SCOEL (2007). Recommendation from the Scientific Committee on Occupational Exposure Limits for \u201cWhite Spirit\u201d, Scientific Committee on Occupational Exposure Limits, European Commission. SCOEL\/SUM\/87."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/oem.60.12.969","article-title":"Benzene and naphthalene in air and breath as indicators of exposure to jet fuel","volume":"60","author":"Egeghy","year":"2003","journal-title":"Occup. Environ. Med."},{"key":"ref_24","unstructured":"IRIS (1998). Chemical Assessment Summary: Naphthalene, Integrated Risk Information System, U.S. Environmental Protection Agency. CASRN 91-20-3."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1289\/ehp.8288","article-title":"Dermal exposure to jet fuel JP-8 significantly contributes to the production of urinary naphthols in fuel-cell maintenance workers","volume":"114","author":"Chao","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/ajim.20049","article-title":"Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8)","volume":"46","author":"Serdar","year":"2004","journal-title":"Am. J. Ind. Med."},{"key":"ref_27","unstructured":"Fisher, J.W., and Gearhart, J.M. (2020). Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment, Academic Press."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08958378.2011.631297","article-title":"Development of a physiologically based pharmacokinetic model for inhalation of jet fuels in the rat","volume":"24","author":"Martin","year":"2012","journal-title":"Inhal. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/toxsci\/kfz243","article-title":"Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology","volume":"174","author":"Ruiz","year":"2020","journal-title":"Toxicol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/toxsci\/63.2.160","article-title":"Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone","volume":"63","author":"Clewell","year":"2001","journal-title":"Toxicol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1080\/08958370801949159","article-title":"Improved predictive model for n-decane kinetics across species, as a component of hydrocarbon mixtures","volume":"20","author":"Merrill","year":"2008","journal-title":"Inhal. Toxicol."},{"key":"ref_32","unstructured":"IPCS (2010). Characterization and Application of Physiologically Based Pharmacokinetic Models in Risk Assessment, International Programme on Chemical Safety, World Health Organization."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1021\/bp990057t","article-title":"Use of in vitro data for construction of a physiologically based pharmacokinetic model for naphthalene in rats and mice to probe species differences","volume":"15","author":"Quick","year":"1999","journal-title":"Biotechnol. Prog."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/taap.2001.9269","article-title":"A physiologically based pharmacokinetic model for inhalation and intravenous administration of naphthalene in rats and mice","volume":"176","author":"Willems","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/08958378.2014.896059","article-title":"A hybrid CFD-PBPK model for naphthalene in rat and human with IVIVE for nasal tissue metabolism and cross-species dosimetry","volume":"26","author":"Campbell","year":"2014","journal-title":"Inhal. Toxicol."},{"key":"ref_36","unstructured":"Merrill, E.A., Sterner, T.R., Robinson, P.J., Hulla, J.E., and Proctor, S.P. (2019). Modeling Real-Time Occupational Naphthalene Exposures to Predict Urinary Biomarkers, Air Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate. AFRL-RH-WP-TR-2019-0091."},{"key":"ref_37","unstructured":"Sterner, T.R., Robinson, P.J., Hack, C.E., Qi, L., Narayanan, L., Law, S.T., Covington, T.R., Merrill, E.A., Grobe, N., and Brown, D.N. (2017). Jet Fuel Exacerbated Noise-Induced Hearing Loss: Focus on Prediction of Central Auditory Processing Dysfunction, Air Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate. AFRL-RH-WP-TR-2017-0079."},{"key":"ref_38","unstructured":"Arms, A.D., and Travis, C.C. (1988). Reference Physiological Parameters in Phannacokinetic Modeling, U.S. Environmental Protection Agency. EPA\/600\/6-88\/004."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/074823379701300401","article-title":"Physiological parameter values for physiologically based pharmacokinetic models","volume":"13","author":"Brown","year":"1997","journal-title":"Toxicol. Ind. Health"},{"key":"ref_40","unstructured":"Robinson, P.J., Sterner, T.R., Merrill, E.A., Gearhart, J.M., and Mattie, D.R. (2013). Preliminary Mathematical Model for Jet Fuel Exacerbated Noise-Induced Hearing Loss, Air Force Research Laboratory, 711th Human Performance Wing, Human Effectiveness Directorate. AFRL-RH-WP-TR-2013-0044."},{"key":"ref_41","first-page":"H1487","article-title":"Distribution of cardiac output during diurnal changes of activity in rats","volume":"261","author":"Delp","year":"1991","journal-title":"Am. J. Physiol."},{"key":"ref_42","first-page":"82","article-title":"Cochlear blood volume in the guinea pig measured with Cr51 labelled red blood cells","volume":"14","author":"Morizono","year":"1968","journal-title":"Otol. Fukuoka"},{"key":"ref_43","unstructured":"Sterner, T.R., Robinson, P.J., Reddy, G., Mattie, D.R., and Merrill, E.A. (2022). Expanded Development and Application of an Array-Based Mathematical Model for Fuels Exposure and Dosimetry, Air Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate. AFRL-RH-WP-TR-2022-0051."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/jps.24011","article-title":"Predicting passive and active tissue:plasma partition coefficients: Interindividual and interspecies variability","volume":"103","author":"Ruark","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/15376516.2018.1508263","article-title":"Lipid, water, and protein composition to facilitate kinetic modeling of the auditory pathway","volume":"29","author":"Grobe","year":"2019","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-0773.1999.tb00072.x","article-title":"Distribution of dearomatised white spirit in brain, blood, and fat tissue after repeated exposure of rats","volume":"85","author":"Lof","year":"1999","journal-title":"Pharmacol. Toxicol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/taap.1999.8803","article-title":"Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons","volume":"161","author":"Haddad","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_48","unstructured":"ACGIH (2022). TLVs and BEIs, ACGIH."},{"key":"ref_49","unstructured":"Virent (2023, February 14). Sustainable Aviation Fuel (SAF). Available online: https:\/\/www.virent.com\/products\/sustainable-aviation-fuel\/."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0041-008X(90)90287-5","article-title":"Mechanism of transport and distribution of organic solvents in blood","volume":"104","author":"Lam","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s002040050292","article-title":"Comparison of the influence of binary mixtures versus a ternary mixture of inhaled aromatic hydrocarbons on their blood kinetics in the rat","volume":"70","author":"Tardif","year":"1996","journal-title":"Arch. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/08958370490490473","article-title":"Development of a physiologically based pharmacokinetic model for decane, a constituent of jet propellent-8","volume":"16","author":"Perleberg","year":"2004","journal-title":"Inhal. Toxicol."},{"key":"ref_53","unstructured":"NTP (2000). NTP Technical Report on the Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in F344\/N Rats (Inhalation Studies), National Toxicology Program."},{"key":"ref_54","unstructured":"Robinson, P.J., and Merrill, E.A. (2008). A Harmonized Physiologically-Based Pharmacokinetic Model for Nonane as a Component of Jet Fuel, Air Force Research Laboratory, Human Effectiveness Directorate. AFRL-RH-WP-TR-2008-0067."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF03160026","article-title":"Regional lipid composition in the rat brain","volume":"18","author":"Chavko","year":"1993","journal-title":"Mol. Chem. Neuropathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","article-title":"Structure and function of the blood-brain barrier","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Banks, W.A. (2009). Characteristics of compounds that cross the blood-brain barrier. BMC Neurol., 9.","DOI":"10.1186\/1471-2377-9-S1-S3"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/BF01607852","article-title":"Rise of inhaled toluene, ethyl benzene, m-xylene, or mesitylene in rat blood after treatment with ethanol","volume":"37","author":"Romer","year":"1986","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_59","unstructured":"RTI (1996). The Toxicokinetics of Naphthalene: Protocol RTI-518: The Toxicokinetics of Intravenously Administered Naphthalene (NAP) in Male and Female B6C3F1 Mice and F344 Rats, Research Triangle Institute."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/toxsci\/kfv009","article-title":"Human inhalation exposures to toluene, ethylbenzene, and m-xylene and physiologically based pharmacokinetic modeling of exposure biomarkers in exhaled air, blood, and urine","volume":"144","author":"Marchand","year":"2015","journal-title":"Toxicol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3109\/08958378.2016.1162232","article-title":"Evaluation and modeling of the impact of coexposures to VOC mixtures on urinary biomarkers","volume":"28","author":"Marchand","year":"2016","journal-title":"Inhal. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1080\/08958370390215749","article-title":"Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach","volume":"15","author":"Dennison","year":"2003","journal-title":"Inhal. Toxicol."},{"key":"ref_63","unstructured":"Gustafson, J.B., Griffith Tell, J., and Orem, D. (1997). Total Petroleum Hydrocarbon Criteria Working Group Series: Volume 3: Selection of Representative TPH Fractions Based on Fate and Transport Considerations, Amherst Scientific Publications."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/11\/2\/187\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:39:15Z","timestamp":1760121555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/11\/2\/187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":63,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["toxics11020187"],"URL":"https:\/\/doi.org\/10.3390\/toxics11020187","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]}}}