{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:30:52Z","timestamp":1791325852058,"version":"4.3.1"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["2021R1A2C2093275"],"award-info":[{"award-number":["2021R1A2C2093275"]}]},{"DOI":"10.13039\/501100003725","name":"Korean government (MSIT)","doi-asserted-by":"publisher","award":["2021R1A2C2093275"],"award-info":[{"award-number":["2021R1A2C2093275"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The female reproductive system becomes fertile through the action of hormones involved in the hypothalamic-pituitary-ovarian axis. On the other hand, estrogen-like endocrine disruptors released into the environment come into contact with humans by various routes and affect the reproductive system. Exposure to these chemicals can cause problems with the reproductive process, from egg ovulation to implantation, or cause female reproductive diseases. These reproductive problems cause infertility. Decamethylcyclopentasiloxane (D5) is used for lubrication in silicone polymers, households, and personal care products. In the case of D5, it is discharged through factory wastewater and can bioaccumulate. Therefore, it accumulates in the human body. In this study, D5 was administered orally for four weeks to determine the effects of D5 on the reproductive process. As a result, D5 increases the number of follicles in the ovary and suppresses the expression of genes related to the growth of follicles. In addition, it increases the gonadotropin hormone, inducing estradiol enhancement and progesterone reduction. Because of these changes in the reproductive system when exposed to D5, the industry should reconsider using D5.<\/jats:p>","DOI":"10.3390\/toxics11040302","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T03:01:14Z","timestamp":1679886074000},"page":"302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Decamethylcyclopentasiloxane on Reproductive Systems in Female Rats"],"prefix":"10.3390","volume":"11","author":[{"given":"Jimin","family":"Lee","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Chungbuk National University, Chengju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8109-7793","authenticated-orcid":false,"given":"Kangmin","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chungbuk National University, Chengju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Mi","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chungbuk National University, Chengju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Sook","family":"Kwon","sequence":"additional","affiliation":[{"name":"AevisBio, Inc., Deajeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8936-916X","authenticated-orcid":false,"given":"Eui-Bae","family":"Jeung","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chungbuk National University, Chengju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00018-020-03576-x","article-title":"New insights into anti-M\u00fcllerian hormone role in the hypothalamic-pituitary-gonadal axis and neuroendocrine development","volume":"78","author":"Silva","year":"2021","journal-title":"Cell Mol. 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