{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:56:09Z","timestamp":1780696569456,"version":"3.54.1"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Environmental Health Sciences","award":["R01 ES016932"],"award-info":[{"award-number":["R01 ES016932"]}]},{"name":"National Institute of Environmental Health Sciences","award":["R01 ES017022"],"award-info":[{"award-number":["R01 ES017022"]}]},{"name":"National Institute of Environmental Health Sciences","award":["T32 ES007062"],"award-info":[{"award-number":["T32 ES007062"]}]},{"name":"National Institute of Environmental Health Sciences","award":["P30 ES017885"],"award-info":[{"award-number":["P30 ES017885"]}]},{"name":"National Institute of Environmental Health Sciences","award":["T42 OH008455-09"],"award-info":[{"award-number":["T42 OH008455-09"]}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["R01 ES016932"],"award-info":[{"award-number":["R01 ES016932"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["R01 ES017022"],"award-info":[{"award-number":["R01 ES017022"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["T32 ES007062"],"award-info":[{"award-number":["T32 ES007062"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["P30 ES017885"],"award-info":[{"award-number":["P30 ES017885"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["T42 OH008455-09"],"award-info":[{"award-number":["T42 OH008455-09"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Michigan MCubed Program","award":["R01 ES016932"],"award-info":[{"award-number":["R01 ES016932"]}]},{"name":"University of Michigan MCubed Program","award":["R01 ES017022"],"award-info":[{"award-number":["R01 ES017022"]}]},{"name":"University of Michigan MCubed Program","award":["T32 ES007062"],"award-info":[{"award-number":["T32 ES007062"]}]},{"name":"University of Michigan MCubed Program","award":["P30 ES017885"],"award-info":[{"award-number":["P30 ES017885"]}]},{"name":"University of Michigan MCubed Program","award":["T42 OH008455-09"],"award-info":[{"award-number":["T42 OH008455-09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>High blood pressure (BP) is a risk factor for hypertensive disease during pregnancy. Exposure to multiple toxic air pollutants can affect BP in pregnancy but has been rarely studied. We evaluated trimester-specific associations between air pollution exposure and systolic (SBP) and diastolic BP (DBP). Ozone (O3), sulfur dioxide (SO2), carbon monoxide (CO), nitrogen dioxide (NO2), and particulate matter less than 10 and 2.5 \u03bcm in aerodynamic diameter (PM10, PM2.5) in the Pregnancy Research on Inflammation, Nutrition, &amp; City Environment: Systematic Analyses (PRINCESA) study. Multipollutant generalized linear regression models with each pollutant and O3 were fit. Due to nonlinear pollution\/BP associations, results are presented for \u201cbelow the median\u201d or \u201cabove the median\u201d, where the beta estimate is the change in BP at a pollutant\u2019s median versus BP at the pollutant\u2019s minimum or maximum, respectively. Associations varied across trimesters and pollutants, and deleterious associations (higher blood pressure with higher pollution) were found only at pollutant values below the median: for SBP with NO2 in the second and third trimesters, and PM2.5 during the third trimester, and for DBP, PM2.5, and NO2 in the second and third trimesters. Findings suggest that minimizing prenatal exposure to air pollution may reduce the risks of changes in BP.<\/jats:p>","DOI":"10.3390\/toxics11050424","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T02:03:18Z","timestamp":1683165798000},"page":"424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations between Air Pollution Exposure and Blood Pressure during Pregnancy among PRINCESA Cohort Participants"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-2566","authenticated-orcid":false,"given":"Miatta A.","family":"Buxton","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Heydarzadeh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0533-745X","authenticated-orcid":false,"given":"Carina J.","family":"Gronlund","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"},{"name":"Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Castillo-Castrejon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stephenson Cancer Center, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-7591","authenticated-orcid":false,"given":"Myrna Souraye","family":"Godines-Enriquez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie S.","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"},{"name":"Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-4200","authenticated-orcid":false,"given":"Felipe","family":"Vadillo-Ortega","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"},{"name":"Unidad de Vinculaci\u00f3n Cient\u00edfica de la Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico en el Instituto Nacional de Medicina Gen\u00f3mica, Mexico City 14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2018741","DOI":"10.1001\/jamanetworkopen.2020.18741","article-title":"Evaluation of US State\u2013Level Variation in Hypertensive Disorders of Pregnancy","volume":"3","author":"Butwick","year":"2020","journal-title":"JAMA Netw. 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