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Pesticides, while broadly applied in modern agriculture for pest control and crop protection, have raised concerns due to their unintended effects on non-target organisms. The immune system exerts a key role in the protection against the exposome, which could result in cellular imbalances and tissue damage through the inflammatory response. Pesticides, which encompass a diverse array of chemicals, have been linked to inflammation in experimental models. Therefore, the aim of this review is to discuss the increasing concern over the risks of pesticide exposure focusing on the effects of various chemical classes on inflammation by covering, as broadly as possible, different experimental approaches as well as the multiple or co-exposure of pesticides. Overall, pesticides potentially induce inflammation in different experimental models, manifested through skin irritation, respiratory impairment, or systemic effects. The connection between pesticides and inflammation highlights the importance of proper handling and regulation of these substances and underscores the need for research into safer and sustainable practices to reduce our reliance on synthetic pesticides and fertilizers.<\/jats:p>","DOI":"10.3390\/toxics11110896","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:53:32Z","timestamp":1698756812000},"page":"896","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Pesticide-Induced Inflammation at a Glance"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-7482","authenticated-orcid":false,"given":"Monica","family":"Lopes-Ferreira","sequence":"first","affiliation":[{"name":"Immunoregulation Unit, Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, S\u00e3o Paulo 05503900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-9012","authenticated-orcid":false,"given":"Luiz Rog\u00e9rio Ludwig","family":"Farinha","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit, Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, S\u00e3o Paulo 05503900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3668-5662","authenticated-orcid":false,"given":"Yasmin Stefanie Oliveira","family":"Costa","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit, Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, S\u00e3o Paulo 05503900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-940X","authenticated-orcid":false,"given":"Felipe Justiniano","family":"Pinto","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit, Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, S\u00e3o Paulo 05503900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4561-1361","authenticated-orcid":false,"given":"Geonildo Rodrigo","family":"Disner","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit, Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, S\u00e3o Paulo 05503900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1738-2634","authenticated-orcid":false,"given":"Jo\u00e3o Gabriel dos Santos","family":"da Rosa","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit, Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, S\u00e3o Paulo 05503900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-966X","authenticated-orcid":false,"given":"Carla","family":"Lima","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit, Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, S\u00e3o Paulo 05503900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"ref_1","unstructured":"Food and Agriculture Organization\u2014FAO (2022). 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