{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:58:09Z","timestamp":1792821489515,"version":"4.5.0"},"reference-count":69,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Background: Acute poisonings (AP) are a significant public health problem, accounting for a high number of emergency department visits and thousands of deaths worldwide. This study aimed to assess the epidemiology of AP in an adult population admitted to Cayenne Hospital (French Guiana) and to investigate the clinical and sociodemographic characteristics. Methods: We conducted a monocentric retrospective study from January 2010 to December 2022, including patients over eighteen years of age who had been admitted to the emergency department of Cayenne Hospital for acute poisoning. Results: We included 425 patients. The median age was 34 years (IQR: 25\u201347). The sex ratio (M\/F) was 0.52. A psychiatric disorder was found in 41.9% of patients. The Poisoning Severity Score (PSS) on admission was 1 or 2 for 84% of patients, and the mortality rate was 3.9%. The main involved toxicants were psychotropic drugs (43.1%), benzodiazepines (34.8%), and paracetamol (25.6%). The most lethal toxic was paraquat (5.2%). Intoxication was due to intentional self-poisoning in 84.2% of cases. Independent factors associated with severe poisoning (PSS 3 or 4) were chloroquine, neuroleptics, or paraquat poisoning; metabolic acidosis; and hyperglycemia (&gt;5.5 mmol\/L). The mortality rate was 3.9%, and the most involved toxic in death was paraquat. Conclusion: This study shows the frequent and deadly use of paraquat in APs in French Guiana. Urgent attention should be given to establishing a toxicovigilance monitoring framework and an antipoison center in the region.<\/jats:p>","DOI":"10.3390\/toxics12030200","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T03:03:20Z","timestamp":1709607800000},"page":"200","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and Epidemiological Characteristics of Severe Acute Adult Poisonings in French Amazonia: Urgent Need for a Toxicovigilance Monitoring Framework"],"prefix":"10.3390","volume":"12","author":[{"given":"Jean Marc","family":"Pujo","sequence":"first","affiliation":[{"name":"Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana"},{"name":"Tropical Biome and Immunopathology CNRS UMR-9017, Inserm U 1019, Universit\u00e9 de Guyane, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Simon","sequence":"additional","affiliation":[{"name":"Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy Roger","family":"Lontsi Ngoulla","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubacar","family":"Signat\u00e9","sequence":"additional","affiliation":[{"name":"Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-0119","authenticated-orcid":false,"given":"R\u00e9mi","family":"Mutricy","sequence":"additional","affiliation":[{"name":"Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5365-6191","authenticated-orcid":false,"given":"Alexis","family":"Fr\u00e9mery","sequence":"additional","affiliation":[{"name":"Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Burin","sequence":"additional","affiliation":[{"name":"Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand de","family":"Toffol","sequence":"additional","affiliation":[{"name":"Tropical Biome and Immunopathology CNRS UMR-9017, Inserm U 1019, Universit\u00e9 de Guyane, Cayenne 97300, French Guiana"},{"name":"Neurology Department, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-2747","authenticated-orcid":false,"given":"Ibtissem","family":"Ben Amara","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Houcke","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-6431","authenticated-orcid":false,"given":"Amina","family":"Nasri","sequence":"additional","affiliation":[{"name":"Tropical Biome and Immunopathology CNRS UMR-9017, Inserm U 1019, Universit\u00e9 de Guyane, Cayenne 97300, French Guiana"},{"name":"Neurology Department, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7273-2521","authenticated-orcid":false,"given":"Dabor","family":"Resiere","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Martinique University Hospital, Fort de France 97261, Martinique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Kallel","sequence":"additional","affiliation":[{"name":"Tropical Biome and Immunopathology CNRS UMR-9017, Inserm U 1019, Universit\u00e9 de Guyane, Cayenne 97300, French Guiana"},{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e021881","DOI":"10.1136\/bmjopen-2018-021881","article-title":"Acute Poisoning in Shenyang, China: A Retrospective and Descriptive Study from 2012 to 2016","volume":"8","author":"Zhang","year":"2018","journal-title":"BMJ Open"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Resiere, D., Kallel, H., Oxybel, O., Chabartier, C., Florentin, J., Brouste, Y., Gueye, P., Megarbane, B., and Mehdaoui, H. (2020). Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes. Toxics, 8.","DOI":"10.3390\/toxics8020028"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/DHPS.S241413","article-title":"A Retrospective Study of Acute Poisoning Cases and Their Management at Emergency Department of Dessie Referral Hospital, Northeast Ethiopia","volume":"12","author":"Getie","year":"2020","journal-title":"Drug Healthc. Patient Saf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jflm.2012.04.034","article-title":"Study of Poisoning Trends in North India\u2014A Perspective in Relation to World Statistics","volume":"20","author":"Singh","year":"2013","journal-title":"J. Forensic Leg. Med."},{"key":"ref_5","unstructured":"Baud, F., and Garnier, R. (2017). Toxicologie Clinique, Lavoisier M\u00e9decine-sciences. [6th ed.]."},{"key":"ref_6","unstructured":"WHO (2024, January 14). Poison Control and Unintentional Poisoning. Available online: https:\/\/www.who.int\/data\/gho\/data\/themes\/topics\/indicator-groups\/poison-control-and-unintentional-poisoning."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0960327108099679","article-title":"Acute Adult Poisoning Cases Admitted to a University Hospital in Tabriz, Iran","volume":"28","author":"Islambulchilar","year":"2009","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Albano, G.D., Malta, G., La Spina, C., Rifiorito, A., Provenzano, V., Triolo, V., Vaiano, F., Bertol, E., Zerbo, S., and Argo, A. (2022). Toxicological Findings of Self-Poisoning Suicidal Deaths: A Systematic Review by Countries. Toxics, 10.","DOI":"10.3390\/toxics10110654"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.4103\/0250-474X.78525","article-title":"Assessment of Prevalence and Mortality Incidences Due to Poisoning in a South Indian Tertiary Care Teaching Hospital","volume":"72","author":"Jesslin","year":"2010","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.5847\/wjem.j.1920-8642.2016.04.009","article-title":"Pattern of Acute Poisoning in Jimma University Specialized Hospital, South West Ethiopia","volume":"7","author":"Teklemariam","year":"2016","journal-title":"World J. Emerg. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/BF02849959","article-title":"Retrospective Evaluation of Emergency Service Patients with Poisoning: A 3-Year Study","volume":"22","author":"Baydin","year":"2005","journal-title":"Adv. Ther."},{"key":"ref_12","first-page":"825","article-title":"Poison episodes reported to French poison control centers in 2006","volume":"58","author":"Villa","year":"2008","journal-title":"Rev. Prat."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Boedeker, W., Watts, M., Clausing, P., and Marquez, E. (2020). The Global Distribution of Acute Unintentional Pesticide Poisoning: Estimations Based on a Systematic Review. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-09939-0"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.jsps.2022.06.025","article-title":"Hospital Admission Profile Related to Poisoning by, Adverse Effect of and Underdosing of Psychotropic Drugs in England and Wales: An Ecological Study","volume":"30","author":"Naser","year":"2022","journal-title":"Saudi Pharm. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"108843","DOI":"10.1016\/j.drugalcdep.2021.108843","article-title":"Trends in Psychotropic-Drug-Implicated Mortality: Psychotropic Drugs as a Contributing but Non-Underlying Cause of Death","volume":"226","author":"Vuolo","year":"2021","journal-title":"Drug Alcohol Depend."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.amepre.2010.01.022","article-title":"Hospitalizations for Poisoning by Prescription Opioids, Sedatives, and Tranquilizers","volume":"38","author":"Coben","year":"2010","journal-title":"Am. J. Prev. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1742-7843.2012.00894.x","article-title":"Comparative Drug Dose and Drug Combinations in Patients That Present to Hospital Due to Self-Poisoning","volume":"111","author":"Armstrong","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1542\/peds.2007-2008","article-title":"Epidemiologic Features of Antipsychotic Prescribing to Children and Adolescents in Primary Care in the United Kingdom","volume":"121","author":"Rani","year":"2008","journal-title":"Pediatrics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e27664","DOI":"10.1097\/MD.0000000000027664","article-title":"Psychotropic Medication Prescribing during the COVID-19 Pandemic","volume":"100","author":"Hirschtritt","year":"2021","journal-title":"Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jclinepi.2003.05.001","article-title":"Prescription Psychotropic Medication Use among the U.S. Adult Population: Results from the Third National Health and Nutrition Examination Survey, 1988\u20131994","volume":"57","author":"Jonas","year":"2004","journal-title":"J. Clin. Epidemiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"220","DOI":"10.14740\/jnr640","article-title":"Gender and Psychotropic Poisoning in the USA","volume":"10","author":"Vargas","year":"2020","journal-title":"J. Neurol. Res."},{"key":"ref_22","unstructured":"(2020, November 18). CIM-10 Version: 2008. Available online: https:\/\/icd.who.int\/browse10\/2008\/fr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s13181-017-0614-8","article-title":"The Poisoning Severity Score: If It Did Not Exist, We Would Have to Invent It","volume":"13","author":"Cairns","year":"2017","journal-title":"J. Med. Toxicol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO Clinical Practice Guidelines for Acute Kidney Injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1080\/15563650.2019.1677022","article-title":"2018 Annual Report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 36th Annual Report","volume":"57","author":"Gummin","year":"2019","journal-title":"Clin. Toxicol."},{"key":"ref_26","unstructured":"(2023, September 22). Tooplate NPIS. Available online: https:\/\/www.npis.org\/index.html."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s00101-015-0030-x","article-title":"Self-Poisoning in the Acute Care Medicine 2005\u20132012","volume":"64","author":"Sorge","year":"2015","journal-title":"Anaesthesist"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/aas.13005","article-title":"Intensive Care Admissions Due to Poisoning","volume":"61","author":"Lindqvist","year":"2017","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/bcpt.12132","article-title":"Deliberate Drug Poisoning with Slight Symptoms on Admission: Are There Predictive Factors for Intensive Care Unit Referral? A Three-Year Retrospective Study","volume":"114","author":"Maignan","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5694\/j.1326-5377.1993.tb121644.x","article-title":"Experience with 732 Acute Overdose Patients Admitted to an Intensive Care Unit over Six Years","volume":"158","author":"Henderson","year":"1993","journal-title":"Med. J. Aust."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1136\/bmj.316.7134.831","article-title":"Management of Deliberate Self Poisoning in Adults in Four Teaching Hospitals: Descriptive Study","volume":"316","author":"Kapur","year":"1998","journal-title":"BMJ"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jcrc.2010.08.009","article-title":"Risk Factors for Prolonged Intensive Care Unit Stay and Hospital Mortality in Acute Drug-Poisoned Patients: An Evaluation of the Physiologic and Laboratory Parameters on Admission","volume":"26","author":"Liisanantti","year":"2011","journal-title":"J. Crit. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.4103\/jfmpc.jfmpc_237_19","article-title":"Mortality and Morbidity Associated with Acute Poisoning Cases in North-East India: A Retrospective Study","volume":"8","author":"Sharma","year":"2019","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/tmi.13156","article-title":"Assessment of Pattern and Outcomes of Pesticides Poisoning in a Tertiary Care Hospital","volume":"23","author":"Prashar","year":"2018","journal-title":"Trop. Med. Int. Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1235304","DOI":"10.3389\/fpubh.2023.1235304","article-title":"Trends and Profiles of Acute Poisoning Cases: A Retrospective Analysis","volume":"11","author":"Liu","year":"2023","journal-title":"Front. Public Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/0960327110361501","article-title":"Pattern of Acute Food, Drug, and Chemical Poisoning in Sari City, Northern Iran","volume":"29","author":"Ahmadi","year":"2010","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/ip-2023-044940","article-title":"Suicide Poisoning Mortality: A Comparison of the National Poison Data System and Centers for Disease Control National Dataset","volume":"30","author":"Apata","year":"2023","journal-title":"Inj. Prev."},{"key":"ref_38","first-page":"9926682","article-title":"The Individualized Management Approach for Acute Poisoning","volume":"2021","author":"AlHomidah","year":"2021","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.7196\/SAMJ.6648","article-title":"Toxicovigilance. II: A Survey of the Spectrum of Acute Poisoning and Current Practices in the Initial Management of Poisoning Cases Admitted to South African Hospitals","volume":"103","author":"Veale","year":"2013","journal-title":"S. Afr. Med. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00063110-200306000-00006","article-title":"National Multicentre Study of Acute Intoxication in Emergency Departments of Spain","volume":"10","author":"Munne","year":"2003","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1097\/CCM.0000000000000245","article-title":"In-Hospital Mortality and Long-Term Survival of Patients with Acute Intoxication Admitted to the ICU*","volume":"42","author":"Brandenburg","year":"2014","journal-title":"Crit. Care Med."},{"key":"ref_42","unstructured":"(2022, October 25). [Multisource observatory of acute intoxications in \u00cele-de-France: An exploratory study]. Available online: https:\/\/www.santepubliquefrance.fr\/notices\/observatoire-multisources-des-intoxications-aigues-en-ile-de-france-une-etude-exploratoire."},{"key":"ref_43","unstructured":"WHO (2023, December 04). Suicide (2023). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/suicide."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1027\/0227-5910.27.2.77","article-title":"High Rates of Suicide and Attempted Suicide Using Pesticides in Nickerie, Suriname, South America","volume":"27","author":"Graafsma","year":"2006","journal-title":"Crisis"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e9621","DOI":"10.1097\/MD.0000000000009621","article-title":"Clinical Features and Prognosis of Paraquat Poisoning in French Guiana: A Review of 62 Cases","volume":"97","author":"Elenga","year":"2018","journal-title":"Medicine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s10646-023-02714-y","article-title":"Ecotoxicology of the Herbicide Paraquat: Effects on Wildlife and Knowledge Gaps","volume":"32","author":"Donaher","year":"2023","journal-title":"Ecotoxicology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.2174\/0929867329666220817125800","article-title":"Curcumin Combats against Organophosphate Pesticides Toxicity: A Review of the Current Evidence and Molecular Pathways","volume":"30","author":"Jafari","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"ref_48","unstructured":"(2020, November 19). [Senate bans use of the herbicide Paraquat in France]. Available online: https:\/\/www.senat.fr\/questions\/base\/2004\/qSEQ040712949.html."},{"key":"ref_49","first-page":"7034","article-title":"Paraquat Poisoning in Western French Guyana: A Public Health Problem Persisting Ten Years after Its Withdrawal from the French Market","volume":"22","author":"Flechel","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1051\/ata\/2013037","article-title":"Intoxications Au Paraquat En Guyane Fran\u00e7aise: Utilisation Persistante Lors de Comportements Suicidaires En Outre-Mer","volume":"25","author":"Schmitt","year":"2013","journal-title":"Ann. Toxicol. Anal."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.etap.2019.03.017","article-title":"Human Exposure to Banned Pesticides Reported to the French Poison Control Centers: 2012\u20132016","volume":"69","author":"Rambourg","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1002\/ece3.6459","article-title":"A Real-World Implementation of a Nationwide, Long-Term Monitoring Program to Assess the Impact of Agrochemicals and Agricultural Practices on Biodiversity","volume":"11","author":"Andrade","year":"2021","journal-title":"Ecol. Evol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2165\/00002018-199005040-00002","article-title":"Paraquat Poisoning: An Overview of the Current Status","volume":"5","author":"Bismuth","year":"1990","journal-title":"Drug Saf."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Wilks, M.F., Fernando, R., Ariyananda, P.L., Eddleston, M., Berry, D.J., Tomenson, J.A., Buckley, N.A., Jayamanne, S., Gunnell, D., and Dawson, A. (2008). Improvement in Survival after Paraquat Ingestion Following Introduction of a New Formulation in Sri Lanka. PLoS Med., 5.","DOI":"10.1371\/journal.pmed.0050049"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1080\/15563650.2022.2105709","article-title":"Evidence for the Efficacy of the Emetic PP796 in Paraquat SL20 Formulations\u2013a Narrative Review of Published and Unpublished Evidence","volume":"60","author":"Eddleston","year":"2022","journal-title":"Clin. Toxicol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Myung, W., Lee, G.-H., Won, H.-H., Fava, M., Mischoulon, D., Nyer, M., Kim, D.K., Heo, J.-Y., and Jeon, H.J. (2015). Paraquat Prohibition and Change in the Suicide Rate and Methods in South Korea. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128980"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1017\/wsc.2020.14","article-title":"Current Situation Regarding Herbicide Regulation and Public Perception in South America","volume":"68","author":"Camargo","year":"2020","journal-title":"Weed Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Pathak, V.M., Verma, V.K., Rawat, B.S., Kaur, B., Babu, N., Sharma, A., Dewali, S., Yadav, M., Kumari, R., and Singh, S. (2022). Current Status of Pesticide Effects on Environment, Human Health and It\u2019s Eco-Friendly Management as Bioremediation: A Comprehensive Review. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.962619"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Hoffmann, V., Paul, B., Falade, T., Moodley, A., Ramankutty, N., Olawoye, J., Djouaka, R., Lekei, E., de Haan, N., and Ballantyne, P. (2022). A One Health Approach to Plant Health. CABI Agric. Biosci., 3.","DOI":"10.1186\/s43170-022-00118-2"},{"key":"ref_60","first-page":"43","article-title":"Epidemiology of Acute Poisoning by Substances of Abuse in the Emergency Department. Descriptive Study in District IV of Asturias","volume":"33","year":"2021","journal-title":"Adicciones"},{"key":"ref_61","first-page":"38","article-title":"Sant\u00e9 Publique France Health Barometer 2017: Suicidal Attempts and Suicidal Ideation among the 18\u201375 Years-Old","volume":"3\u20134","year":"2019","journal-title":"Bull. \u00c9pid\u00e9miologique Hebd."},{"key":"ref_62","unstructured":"(2023, August 16). Suicide Acts in 8 States: Incidence and Case Fatality Rates by Demographics and Method\u2013PMC, Available online: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1446422\/."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1017\/S0033291705005404","article-title":"Suicide Attempts, Plans, and Ideation in Culturally Diverse Sites: The WHO SUPRE-MISS Community Survey","volume":"35","author":"Bertolote","year":"2005","journal-title":"Psychol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00127-018-1570-6","article-title":"Descriptive Epidemiology of Suicide Attempts and Suicide in the Remote Villages of French Guiana","volume":"53","author":"Guarmit","year":"2018","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Collados-Ros, A., Torres-S\u00e1nchez, C., P\u00e9rez-C\u00e1rceles, M.D., Luna, A., and Legaz, I. (2022). Suicidal Behavior and Its Relationship with Postmortem Forensic Toxicological Findings. Toxics, 10.","DOI":"10.3390\/toxics10060319"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Pacot, R., Garmit, B., Pradem, M., Nacher, M., and Brousse, P. (2018). The Problem of Suicide among Amerindians in Camopi-Trois Sauts, French Guiana 2008\u20132015. BMC Psychiatry, 18.","DOI":"10.1186\/s12888-018-1670-6"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"16513","DOI":"10.1038\/s41598-022-21054-1","article-title":"Investigation of Acute Organophosphate Poisoning in Humans Based on Sociodemographic and Role of Neurotransmitters with Survival Study in South India","volume":"12","author":"Sinha","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"990262","DOI":"10.3389\/fpubh.2022.990262","article-title":"Clinical and Sociodemographic Profile of Acute Intoxications in an Emergency Department: A Retrospective Cross-Sectional Study","volume":"10","author":"Czapla","year":"2022","journal-title":"Front. Public Health"},{"key":"ref_69","first-page":"e13313","article-title":"Sociodemographic Characteristics and Risk Factors for Childhood Poisoning Reported by Parents at a Tertiary Care Teaching Hospital","volume":"13","author":"Alhaboob","year":"2021","journal-title":"Cureus"}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/12\/3\/200\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:09:20Z","timestamp":1760105360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/12\/3\/200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,5]]},"references-count":69,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["toxics12030200"],"URL":"https:\/\/doi.org\/10.3390\/toxics12030200","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,5]]}}}