{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:03:37Z","timestamp":1791241417378,"version":"4.1.0"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health, Czech Republic","award":["00098892"],"award-info":[{"award-number":["00098892"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The most common pesticide agents are organophosphates and phosphides, aluminum phosphide (ALP) in particular. ALP is a major cause of suicidal poisoning in many countries. In other countries, the problem of accidental, mainly occupational-related, poisoning is also real and actual. Almost two thirds of individuals in poisoning cases have died. This case report describes a case of a patient with accidental ALP intoxication. The origin of the poisoning was the fumigation of stored grain in an agricultural building adjacent to the building in which patient was temporarily housed, while both buildings were connected by an underground corridor, through which the released poison gas penetrated. The case was originally presented by the rescuers as well as healthcare professionals of the local hospital as carbon monoxide intoxication, which has a similar symptomatology as ALP intoxication. The patient was treated comprehensively, including using the HBOT method, which is very unique in the case of phosphine intoxication in human medicine, with an excellent final clinical outcome. This was the first described case of HBOT for ALP intoxication in clinical medicine, although the HBOT indication itself became a coincidence in this case. Further studies must be undertaken to demonstrate the effectiveness of HBOT in treating patients with ALP poisoning.<\/jats:p>","DOI":"10.3390\/toxics12040272","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T08:27:52Z","timestamp":1712305672000},"page":"272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Accidental Aluminum Phosphide Intoxication Successfully Treated with Hyperbaric Oxygen Therapy: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-8470","authenticated-orcid":false,"given":"Michal","family":"H\u00e1jek","sequence":"first","affiliation":[{"name":"Centre of Hyperbaric Medicine, Ostrava City Hospital, 72880 Ostrava, Czech Republic"},{"name":"Institute of Laboratory Medicine, Institute of Microbiology, Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic"},{"name":"Centre for Hyperbaric Medicine of Faculty of Medicine University of Ostrava and Ostrava City Hospital, 70300 Ostrava, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-3373","authenticated-orcid":false,"given":"Dittmar","family":"Chmela\u0159","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Institute of Microbiology, Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic"},{"name":"Centre for Hyperbaric Medicine of Faculty of Medicine University of Ostrava and Ostrava City Hospital, 70300 Ostrava, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Tlap\u00e1k","sequence":"additional","affiliation":[{"name":"The Institute of Aviation Medicine, 16000 Prague, Czech Republic"},{"name":"Faculty of Biomedical Engineering, Czech Technical University in Prague, 16000 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Ryb\u00e1rov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Medicolegal Expertises, Jessenius Faculty of Medicine, Comenius University, University Hospital, 036 01 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ondra","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Medical Law, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, 77900 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edr","family":"Halouzka","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Medical Law, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, 77900 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2478\/10004-1254-63-2012-2182","article-title":"A systematic review of aluminium phosphide poisoning","volume":"63","author":"Mehrpour","year":"2012","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1353-1131(03)00073-7","article-title":"Spectrum of unnatural fatalities in the Chandigarh zone of north-west India\u2014A 25 year autopsy study from a tertiary care hospital","volume":"10","author":"Singh","year":"2003","journal-title":"J. Clin. Forensic Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/15563659509020211","article-title":"Aluminum phosphide poisoning\u2014A review","volume":"33","author":"Gupta","year":"1995","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2147\/OAEM.S385420","article-title":"Trends and Outcomes of Acute Poisoning in Felege Hiwot Comprehensive Specialized Hospital Medical Intensive Care Units: Retrospective Study","volume":"14","author":"Shumet","year":"2022","journal-title":"Open Access Emerg. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1080\/19338244.2021.1990829","article-title":"Acute occupational phosphine intoxications in the maritime shipping sector: A scoping review","volume":"77","author":"Canals","year":"2022","journal-title":"Arch. Environ. Occup. Health."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00420-022-01870-8","article-title":"Neuropsychological symptoms in workers handling cargo from shipping containers and export logs","volume":"95","author":"Hinz","year":"2022","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5603\/IMH.2021.0039","article-title":"Fumigation on bulk cargo ships: A chemical threat to seafarers","volume":"72","author":"Djurhuus","year":"2021","journal-title":"Int. Marit. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/2008-2231-20-25","article-title":"An update on toxicology of aluminum phosphide","volume":"20","author":"Moghadamnia","year":"2012","journal-title":"DARU J. Pharm. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/0960327108096382","article-title":"Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor","volume":"27","author":"Mehrpour","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/0972-5229.151019","article-title":"Aluminum phosphide poisoning: Possible role of supportive measures in the absence of specific antidote","volume":"19","author":"Agrawal","year":"2015","journal-title":"Indian. J. Crit. Care Med."},{"key":"ref_11","first-page":"e69","article-title":"Inhalational Toxicity of Aluminum Phosphide as an Ongoing Concern; a Report of Two Cases","volume":"7","author":"Shafahi","year":"2019","journal-title":"Arch. Acad. Emerg. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/PEC.0b013e3182348e40","article-title":"Unintentional fatal phosphine gas poisoning of a family","volume":"27","author":"Lemoine","year":"2011","journal-title":"Pediatr. Emerg. Care."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(02)00246-9","article-title":"Phosphine-induced oxidative damage in rats: Role of glutathione","volume":"179","author":"Hsu","year":"2002","journal-title":"Toxicology."},{"key":"ref_14","first-page":"225","article-title":"A critical evaluation of anti-peroxidant effect of intravenous magnesium in acute aluminium phosphide poisoning","volume":"10","author":"Chugh","year":"1997","journal-title":"Magnes. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.mehy.2011.01.009","article-title":"Could hydroxyethyl starch be a therapeutic option in management of acute aluminum phosphide toxicity?","volume":"76","author":"Marashi","year":"2011","journal-title":"Med Hypotheses."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.18295\/squmj.2016.16.03.015","article-title":"Treatment of Aluminium Phosphide Poisoning with a Combination of Intravenous Glucagon, Digoxin and Antioxidant Agents","volume":"16","author":"Oghabian","year":"2016","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_17","first-page":"1306","article-title":"Effects of hyperbaric oxygenation on survival time of aluminum phosphide intoxicated rats","volume":"16","author":"Saidi","year":"2011","journal-title":"J. Res. Med. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.28920\/dhm47.2.131-132","article-title":"Tenth European Consensus Conference on Hyperbaric Medicine: Recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment","volume":"47","author":"Mathieu","year":"2017","journal-title":"Diving Hyperb. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chmela\u0159, D., Rozlo\u017en\u00edk, M., H\u00e1jek, M., Posp\u00ed\u0161ilov\u00e1, N., and Kuzma, J. (Folia Microbiol., 2023). Effect of hyperbaric oxygen on the growth and susceptibility of facultatively anaerobic bacteria and bacteria with oxidative metabolism to selected antibiotics, Folia Microbiol., ahead of print.","DOI":"10.1007\/s12223-023-01120-5"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.7453\/gahmj.2013.008","article-title":"The CARE Guidelines: Consensus-based Clinical Case Reporting Guideline Development","volume":"2","author":"Gagnier","year":"2013","journal-title":"Glob. Adv. Health Med."},{"key":"ref_21","unstructured":"(2023, March 15). Material Safety Data Sheet. Available online: https:\/\/www.siad.com\/en\/safety\/material-safety-data-sheet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/0972-5229.53111","article-title":"Aluminum phosphide poisoning: Effect of correction of severe metabolic acidosis on patient outcome","volume":"13","author":"Jaiswal","year":"2009","journal-title":"Indian. J. Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.toxrep.2018.10.009","article-title":"Antidotes for aluminum phosphide poisoning\u2014An update","volume":"5","author":"Karimani","year":"2018","journal-title":"Toxicol. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00805004","article-title":"An analysis of the mechanism of the therapeutic effect of oxygen under pressure in poisoning with phosphoorganic compounds","volume":"75","author":"Savateev","year":"1973","journal-title":"Biull Eksp. Biol. Med."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/12\/4\/272\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:23:53Z","timestamp":1760106233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/12\/4\/272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["toxics12040272"],"URL":"https:\/\/doi.org\/10.3390\/toxics12040272","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]}}}