{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:36:10Z","timestamp":1783420570017,"version":"3.54.6"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2021-12M-1-001"],"award-info":[{"award-number":["2021-12M-1-001"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2022YFC3703000"],"award-info":[{"award-number":["2022YFC3703000"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["200909016"],"award-info":[{"award-number":["200909016"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021-12M-1-001"],"award-info":[{"award-number":["2021-12M-1-001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3703000"],"award-info":[{"award-number":["2022YFC3703000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["200909016"],"award-info":[{"award-number":["200909016"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Scientific Research Fund for Public Welfare of Environmental Protection from the Ministry of Environmental Protection of China","award":["2021-12M-1-001"],"award-info":[{"award-number":["2021-12M-1-001"]}]},{"name":"Special Scientific Research Fund for Public Welfare of Environmental Protection from the Ministry of Environmental Protection of China","award":["2022YFC3703000"],"award-info":[{"award-number":["2022YFC3703000"]}]},{"name":"Special Scientific Research Fund for Public Welfare of Environmental Protection from the Ministry of Environmental Protection of China","award":["200909016"],"award-info":[{"award-number":["200909016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Ischemic stroke (IS), chronic obstructive pulmonary disease (COPD) and diabetes mellitus (DM) account for a large burden of premature deaths. However, few studies have investigated the associations between fine particular matter (PM2.5) components and mortality of IS, COPD and DM. We aimed to examine these associations in Beijing, China. Data on daily mortality, air pollutants and meteorological factors from 2008 to 2011 in Beijing were collected. Daily concentrations of five PM2.5 components, namely, sulfate ion (SO42\u2212), ammonium ion (NH4+), nitrate ion (NO3\u2212), organic matter (OM) and black carbon (BC), were obtained from the Tracking Air Pollution (TAP) database in China. The association between PM2.5 components and daily deaths was explored using a quasi-Poisson regression with the distributed lag nonlinear model (DLNM). The average daily concentrations of SO42\u2212, NH4+, NO3\u2212, OM and BC were 11.24, 8.37, 12.00, 17.34 and 3.32 \u03bcg\/m3, respectively. After adjusting for temperature, relative humidity, pressure, particulate matter less than 10 \u03bcm in aerodynamic diameter (PM10), nitrogen dioxide (NO2) and sulfur dioxide (SO2), an IQR increase in OM at lag day 2 and lag day 6 was associated with an increased DM mortality risk (RR 1.038; 95% CI: 1.005\u20131.071) and COPD mortality risk (RR 1.013; 95% CI: 1.001\u20131.026). An IQR increase in BC at lag day 0 and lag day 6 was associated with increased COPD mortality risk (RR 1.228; 95% CI: 1.017\u20131.48, RR 1.059; 95% CI: 1.001\u20131.121). Cumulative exposure to SO42\u2212 and NH4+ was associated with an increased mortality risk for IS, with the highest effect found for lag of 0\u20137 days (RR 1.085; 95% CI: 1.010\u20131.167, RR 1.083; 95% CI: 1.003\u20131.169). These effects varied by sex and age group. This study demonstrated associations of short-term exposure to PM2.5 components with increased risk of IS, COPD and DM mortality in the general population. Our study also highlighted susceptible subgroups.<\/jats:p>","DOI":"10.3390\/toxics12060381","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T09:58:47Z","timestamp":1716458327000},"page":"381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Associations between PM2.5 Components and Mortality of Ischemic Stroke, Chronic Obstructive Pulmonary Disease and Diabetes in Beijing, China"],"prefix":"10.3390","volume":"12","author":[{"given":"Hao","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China"},{"name":"Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China"},{"name":"Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China"},{"name":"Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiduo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China"},{"name":"Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Jin","sequence":"additional","affiliation":[{"name":"Center for Digital Medicine and Artificial Intelligence, Institute of Clinical Medicine, Peking Union Medical College Hospital, Beijing 100730, China"},{"name":"Department of Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"},{"name":"Department of Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2023, December 12). Noncommunicable Diseases. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/noncommunicable-diseases."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.46234\/ccdcw2023.211","article-title":"Transitions in Chronic Disease Mortality in China: Evidence and Implications","volume":"5","author":"Su","year":"2023","journal-title":"China CDC Wkly"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1161\/STROKEAHA.111.635755","article-title":"Stroke and stroke care in China: Huge burden, significant workload, and a national priority","volume":"42","author":"Liu","year":"2011","journal-title":"Stroke"},{"key":"ref_4","unstructured":"World Health Organization (2024, January 12). Advancing COPD care in China through a comprehensive approach. Available online: https:\/\/www.who.int\/news-room\/feature-stories\/detail\/advancing-copd-care-in-china-through-a-comprehensive-approach."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1001\/jama.2021.22208","article-title":"Prevalence and Treatment of Diabetes in China, 2013\u20132018","volume":"326","author":"Wang","year":"2021","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1609267","DOI":"10.1155\/2022\/1609267","article-title":"Mortality and Years of Life Lost in Diabetes Mellitus and Its Subcategories in China and Its Provinces, 2005\u20132020","volume":"2022","author":"Wang","year":"2022","journal-title":"J Diabetes Res"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1016\/S2542-5196(22)00090-0","article-title":"Pollution and health: A progress update","volume":"6","author":"Fuller","year":"2022","journal-title":"Lancet Planet Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"15965","DOI":"10.1038\/s41598-023-43119-5","article-title":"Research progress of different components of PM2.5 and ischemic stroke","volume":"13","author":"Li","year":"2023","journal-title":"Sci Rep"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1915834","DOI":"10.1001\/jamanetworkopen.2019.15834","article-title":"Burden of Cause-Specific Mortality Associated With PM2.5 Air Pollution in the United States","volume":"2","author":"Bowe","year":"2019","journal-title":"JAMA Netw Open"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1090443","DOI":"10.3389\/fpubh.2022.1090443","article-title":"Association between air pollution exposure and coronary heart disease hospitalization in a humid sub-tropical region of China: A time-series study","volume":"10","author":"Feng","year":"2022","journal-title":"Front Public Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"38328","DOI":"10.1038\/srep38328","article-title":"Acute Effects of Nitrogen Dioxide on Cardiovascular Mortality in Beijing: An Exploration of Spatial Heterogeneity and the District-specific Predictors","volume":"6","author":"Luo","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"27779","DOI":"10.1007\/s11356-021-17892-7","article-title":"Associations of air pollutants with pneumonia hospital admissions in Qingdao, China: A prospective cohort study","volume":"29","author":"Wang","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12940-020-00575-0","article-title":"The impact of long-term PM2.5 exposure on specific causes of death: Exposure-response curves and effect modification among 53 million U.S. Medicare beneficiaries","volume":"19","author":"Wang","year":"2020","journal-title":"Environ. Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.envint.2017.09.010","article-title":"Acute effects of fine particulate matter constituents on mortality: A systematic review and meta-regression analysis","volume":"109","author":"Achilleos","year":"2017","journal-title":"Environ. Int."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Feng, Q., Chen, Y., Su, S., Zhang, X., and Lin, X. (2022). Acute effect of fine particulate matter and respiratory mortality in Changsha, China: A time-series analysis. BMC Pulm. Med., 22.","DOI":"10.1186\/s12890-022-02216-3"},{"key":"ref_16","first-page":"1","article-title":"Global Burden of Disease from Major Air Pollution Sources (GBD MAPS): A Global Approach","volume":"210","author":"McDuffie","year":"2021","journal-title":"Res.Rep. Health Eff. Inst."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4209\/aaqr.2016.07.0307","article-title":"Trends of PM2.5 and Chemical Composition in Beijing, 2000\u20132015","volume":"17","author":"Lang","year":"2017","journal-title":"Aerosol Air Qual. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.envpol.2018.12.060","article-title":"Short-term and long-term exposures to fine particulate matter constituents and health: A systematic review and meta-analysis","volume":"247","author":"Yang","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2337\/dc22-1585","article-title":"Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China","volume":"46","author":"Li","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2147\/COPD.S402122","article-title":"The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease","volume":"18","author":"Wang","year":"2023","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/10962247.2015.1020396","article-title":"Long-term particulate matter exposure: Attributing health effects to individual PM components","volume":"65","author":"Wyzga","year":"2015","journal-title":"J. Air Waste Manag. Assoc."},{"key":"ref_22","unstructured":"Sacks, J., Buckley, B., Deflorio-Barker, S., Jenkins, S., Kirrane, E., Krajewski, A., Luben, T., McDow, S., Stewart, M., and Dubois, J.J. (2022). Supplement to the 2019 Integrated Science Assessment for Particulate Matter, U.S. Environmental Protection Agency."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16517","DOI":"10.1021\/acs.est.2c06510","article-title":"Tracking Daily Concentrations of PM2.5 Chemical Composition in China since 2000","volume":"56","author":"Liu","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9187","DOI":"10.5194\/acp-17-9187-2017","article-title":"Chemical composition of ambient PM2.\u20095 over China and relationship to precursor emissions during 2005\u20132012","volume":"17","author":"Geng","year":"2017","journal-title":"Atmos Chem. Phys."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gou, A., Tan, G., Ding, X., Wang, J., Lv, X., Gou, C., and Tan, Q. (2023). Urban-rural difference in the lagged effects of PM2.5 and PM10 on COPD mortality in Chongqing, China. BMC Public Health, 23.","DOI":"10.1186\/s12889-023-16113-9"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"117886","DOI":"10.1016\/j.envpol.2021.117886","article-title":"Short-term exposure to ambient air pollution and type 2 diabetes mortality: A population-based time series study","volume":"289","author":"Wu","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1001\/jama.2017.17923","article-title":"Association of Short-term Exposure to Air Pollution With Mortality in Older Adults","volume":"318","author":"Di","year":"2017","journal-title":"JAMA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12931-019-1117-8","article-title":"Ambient air pollution and respiratory mortality in Xi\u2019an, China: A time-series analysis","volume":"20","author":"Mokoena","year":"2019","journal-title":"Respir. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(14)62114-0","article-title":"Mortality risk attributable to high and low ambient temperature: A multicountry observational study","volume":"386","author":"Gasparrini","year":"2015","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1002\/sim.3940","article-title":"Distributed lag non-linear models","volume":"29","author":"Gasparrini","year":"2010","journal-title":"Stat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Gasparrini, A., and Leone, M. (2014). Attributable risk from distributed lag models. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-55"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"107156","DOI":"10.1016\/j.envint.2022.107156","article-title":"Associations of long-term exposure to fine particulate matter and its constituents with cardiovascular mortality: A prospective cohort study in China","volume":"162","author":"Liang","year":"2022","journal-title":"Environ. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105854","DOI":"10.1016\/j.envint.2020.105854","article-title":"Long-term exposure to ambient source-specific particulate matter and its components and incidence of cardiovascular events-The Heinz Nixdorf Recall study","volume":"142","author":"Rodins","year":"2020","journal-title":"Environ. Int."},{"key":"ref_34","first-page":"100679","article-title":"Long-term exposure to ambient fine particulate matter chemical composition and in-hospital case fatality among patients with stroke in China","volume":"32","author":"Cai","year":"2023","journal-title":"Lancet Reg. Health West. Pac."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1066804","DOI":"10.3389\/fmed.2023.1066804","article-title":"Global, regional, and national burden of chronic respiratory diseases and associated risk factors, 1990-2019: Results from the Global Burden of Disease Study 2019","volume":"10","author":"Chen","year":"2023","journal-title":"Front. Med."},{"key":"ref_36","first-page":"e69679","article-title":"Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990\u20132019: Results from the Global Burden of Disease Study 2019","volume":"378","author":"Safiri","year":"2022","journal-title":"BMJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/EDE.0b013e3181debc88","article-title":"Urban ambient particle metrics and health: A time-series analysis","volume":"21","author":"Atkinson","year":"2010","journal-title":"Epidemiology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.2337\/dc12-2189","article-title":"Long-term fine particulate matter exposure and mortality from diabetes in Canada","volume":"36","author":"Brook","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"n1904","DOI":"10.1136\/bmj.n1904","article-title":"Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project: Pooled analysis","volume":"374","author":"Strak","year":"2021","journal-title":"BMJ"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.atmosenv.2012.07.036","article-title":"Attributing health effects to individual particulate matter constituents","volume":"62","author":"Rohr","year":"2012","journal-title":"Atmos. Environ."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1183\/09031936.05.00099204","article-title":"Standardised mortality rates in females and males with COPD and asthma","volume":"25","author":"Ringbaek","year":"2005","journal-title":"Eur. Respir J."},{"key":"ref_42","first-page":"100064","article-title":"Changes in Life Expectancy of Respiratory Diseases from Attaining Daily PM2.5 Standard in China: A Nationwide Observational Study","volume":"1","author":"Yang","year":"2020","journal-title":"Innovation"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"105876","DOI":"10.1016\/j.envint.2020.105876","article-title":"Short-term exposure to particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), and ozone (O3) and all-cause and cause-specific mortality: Systematic review and meta-analysis","volume":"142","author":"Orellano","year":"2020","journal-title":"Environ. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1289\/ehp.7387","article-title":"Estimating the exposure-response relationships between particulate matter and mortality within the APHEA multicity project","volume":"113","author":"Samoli","year":"2005","journal-title":"Environ. Health Perspect."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/12\/6\/381\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:47:25Z","timestamp":1760107645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/12\/6\/381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["toxics12060381"],"URL":"https:\/\/doi.org\/10.3390\/toxics12060381","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]}}}