{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:07:29Z","timestamp":1760144849643,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Project \u201cUnveiling the Top\u201d for Hainan Branch, Shanghai Children\u2019s Medical Center (Sanya Maternal and Children Health Hospital)","award":["SYFY-JBGS-202201","82173534","81872637"],"award-info":[{"award-number":["SYFY-JBGS-202201","82173534","81872637"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["SYFY-JBGS-202201","82173534","81872637"],"award-info":[{"award-number":["SYFY-JBGS-202201","82173534","81872637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Insecticide exposure may affect childhood asthma\/wheezing, but evidence is scarce in low- and middle-income countries. We conducted a population-based cross-sectional study in Sanya, China. Generalized linear models were adopted to assess the associations of insecticide exposure with childhood asthma\/wheezing, reported as odds ratios (ORs) and 95% confidence intervals (CIs). A subgroup analysis was performed to explore the possible effects of sociodemographic and environmental factors on these associations. The median age of the 9754 children was 6.7 years, and 5345 (54.8%) were boys. The prevalences of ever asthma (EA), ever wheezing (EW), and current wheezing (CW) were 7.4%, 5.3%, and 2.9%, respectively. We found a greater prevalence of childhood EA with insecticide exposure (OR = 1.18, 95% CI: 1.00, 1.38). Outdoor insecticide exposure was associated with elevated ORs for EA (1.24, 95% CI: 1.03, 1.50), EW (1.27, 95% CI: 1.03, 1.57), and CW (1.38, 95% CI: 1.04, 1.81). The p for the trend in insecticide exposure frequency was significant for EA (p = 0.001) and CW (p = 0.034). These adverse impacts were pronounced in girls who were exposed to low temperatures. Our findings suggest adverse effects of insecticide use, especially outdoors, on childhood asthma\/wheezing. Further studies are warranted to verify this association and develop tailored prevention measures.<\/jats:p>","DOI":"10.3390\/toxics12060392","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T09:33:31Z","timestamp":1716802411000},"page":"392","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of Insecticide Exposure with Childhood Asthma and Wheezing: A Population-Based Cross-Sectional Study in Sanya, China"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-5554","authenticated-orcid":false,"given":"Yabin","family":"Hu","sequence":"first","affiliation":[{"name":"Hainan Branch, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China"},{"name":"Department of Clinical Epidemiology and Biostatistics, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Hainan Branch, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Branch, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangyang","family":"Gu","sequence":"additional","affiliation":[{"name":"Hainan Branch, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xie","sequence":"additional","affiliation":[{"name":"Hainan Branch, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyue","family":"Huang","sequence":"additional","affiliation":[{"name":"Hainan Branch, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"},{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"},{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wei","sequence":"additional","affiliation":[{"name":"Hainan Branch, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilu","family":"Tong","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health, Chinese Centers for Disease Control and Prevention, Beijing 102206, China"},{"name":"School of Public Health and Social Work, Queensland University of Technology, Brisbane 4001, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-463X","authenticated-orcid":false,"given":"Shijian","family":"Liu","sequence":"additional","affiliation":[{"name":"Hainan Branch, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China"},{"name":"Department of Clinical Epidemiology and Biostatistics, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"},{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref_1","unstructured":"GBD 2019 Chronic Respiratory Diseases Collaborators (GBD2019CRDC) (2023). 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