{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:58:49Z","timestamp":1792807129423,"version":"4.5.0"},"reference-count":57,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas (CONAHCYT)","award":["00290312"],"award-info":[{"award-number":["00290312"]}],"id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas (CONAHCYT)","award":["0087121"],"award-info":[{"award-number":["0087121"]}],"id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Exposure to arsenic (As) is a public health problem associated with cancer (skin and colon) and it has been reported that epigenetic changes may be a potential mechanism of As carcinogenesis. It is pertinent to evaluate this process in genes that have been associated with cancer, such as ADAMTS9 and C18ORF8. Gestation and delivery data were obtained from the POSGRAD study. Exposure to As was measured in urine during pregnancy. Gene methylation was performed by sodium bisulfite sequencing; 26 CpG sites for the C18ORF8 gene and 21 for ADAMTS9 were analyzed. These sites are located on the CpG islands near the start of transcription. Sociodemographic characteristics were obtained by a questionnaire. The statistical analysis was performed using multiple linear regression models adjusted for potential confounders. Newborns with an As exposure above 49.4 \u03bcg g\u22121 showed a decrease of 0.21% on the methylation rate in the sites CpG15, CpG19, and CpG21 of the C18ORF8 gene (adjusted \u00df = \u22120.21, p-value = 0.02). No statistically significant association was found between prenatal exposure to As and methylation of the ADAMTS9 gene. Prenatal exposure to As was associated with decreased DNA methylation at the CpG15, CpG19, and CpG21 sites of the C18ORF8 gene. These sites can provide information to elucidate epigenetic mechanisms associated with prenatal exposure to As and cancer.<\/jats:p>","DOI":"10.3390\/toxics12070476","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T10:14:46Z","timestamp":1719828886000},"page":"476","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prenatal Arsenic Exposure on DNA Methylation of C18ORF8 and ADAMTS9 Genes of Newborns from the POSGRAD Birth Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-8395","authenticated-orcid":false,"given":"Carolina","family":"Lerma-Trevi\u00f1o","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Nutrici\u00f3n y Salud, Instituto Nacional de Salud P\u00fablica, Cuernavaca 62100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-2758","authenticated-orcid":false,"given":"Leticia","family":"Hern\u00e1ndez-Cadena","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Salud Ambiental, Instituto Nacional de Salud P\u00fablica, Cuernavaca 62100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5146-0689","authenticated-orcid":false,"given":"Jorge Octavio","family":"Acosta-Montes","sequence":"additional","affiliation":[{"name":"Facultad de Enfermer\u00eda y Nutriolog\u00eda, Universidad Aut\u00f3noma de Chihuahua, Chihuahua 31000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Hern\u00e1ndez-Montes","sequence":"additional","affiliation":[{"name":"CIC-UNAM-Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Alvarado-Cruz","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-5273","authenticated-orcid":false,"given":"Isabelle","family":"Romieu","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Salud Ambiental, Instituto Nacional de Salud P\u00fablica, Cuernavaca 62100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-4175","authenticated-orcid":false,"given":"Albino","family":"Barraza-Villarreal","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Salud Ambiental, Instituto Nacional de Salud P\u00fablica, Cuernavaca 62100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1126\/science.aba1510","article-title":"Global Threat of Arsenic in Groundwater","volume":"368","author":"Podgorski","year":"2020","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jhazmat.2012.08.005","article-title":"Co-Occurrence of Arsenic and Fluoride in Groundwater of Semi-Arid Regions in Latin America: Genesis, Mobility and Remediation","volume":"262","author":"Bundschuh","year":"2013","journal-title":"J. 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