{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:47:48Z","timestamp":1793299668337,"version":"4.5.0"},"reference-count":87,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Science and Technology of Liaoning Province","award":["2022-BS-248"],"award-info":[{"award-number":["2022-BS-248"]}]},{"name":"Department of Science and Technology of Liaoning Province","award":["2022LCJSGC15"],"award-info":[{"award-number":["2022LCJSGC15"]}]},{"name":"Second Affiliated Hospital of Dalian Medical University","award":["2022-BS-248"],"award-info":[{"award-number":["2022-BS-248"]}]},{"name":"Second Affiliated Hospital of Dalian Medical University","award":["2022LCJSGC15"],"award-info":[{"award-number":["2022LCJSGC15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Per- and polyfluoroalkyl substances (PFASs) are a class of anthropogenic organic compounds widely present in the natural and human living environments. These emerging persistent pollutants can enter the human body through multiple channels, posing risks to human health. In particular, exposure to PFASs in women may cause a series of reproductive health hazards and infertility. Based on a review of the existing literature, this study preliminarily summarizes the effects of PFAS exposure on the occurrence and development of female reproductive endocrine diseases, such as polycystic ovary syndrome (PCOS), endometriosis, primary ovarian insufficiency (POI), and diminished ovarian reserve (DOR). Furthermore, we outline the relevant mechanisms through which PFASs interfere with the physiological function of the female ovary and finally highlight the role played by nutrients in reducing the reproductive health hazards caused by PFASs. It is worth noting that the physiological mechanisms of PFASs in the above diseases are still unclear. Therefore, it is necessary to further study the molecular mechanisms of PFASs in female reproductive diseases and the role of nutrients in this process.<\/jats:p>","DOI":"10.3390\/toxics12080539","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T06:17:44Z","timestamp":1721974664000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Per- and Polyfluoroalkyl Substances (PFASs) and Their Potential Effects on Female Reproductive Diseases"],"prefix":"10.3390","volume":"12","author":[{"given":"Yuqing","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1039\/D1EM00296A","article-title":"The Case for a More Precise Definition of Regulated PFAS","volume":"23","author":"Wallington","year":"2021","journal-title":"Environ. 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