{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T18:48:03Z","timestamp":1770576483037,"version":"3.49.0"},"reference-count":51,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ZhiShan Scholar Program of Southeast University","award":["2242022R40061"],"award-info":[{"award-number":["2242022R40061"]}]},{"name":"ZhiShan Scholar Program of Southeast University","award":["NHXX-WJW-2023022"],"award-info":[{"award-number":["NHXX-WJW-2023022"]}]},{"name":"ZhiShan Scholar Program of Southeast University","award":["YKK21088"],"award-info":[{"award-number":["YKK21088"]}]},{"name":"Hainan Province Clinical Medical Center","award":["2242022R40061"],"award-info":[{"award-number":["2242022R40061"]}]},{"name":"Hainan Province Clinical Medical Center","award":["NHXX-WJW-2023022"],"award-info":[{"award-number":["NHXX-WJW-2023022"]}]},{"name":"Hainan Province Clinical Medical Center","award":["YKK21088"],"award-info":[{"award-number":["YKK21088"]}]},{"name":"Nanhai Xinxing Medical and Health Talent Platform Project of Hainan Province","award":["2242022R40061"],"award-info":[{"award-number":["2242022R40061"]}]},{"name":"Nanhai Xinxing Medical and Health Talent Platform Project of Hainan Province","award":["NHXX-WJW-2023022"],"award-info":[{"award-number":["NHXX-WJW-2023022"]}]},{"name":"Nanhai Xinxing Medical and Health Talent Platform Project of Hainan Province","award":["YKK21088"],"award-info":[{"award-number":["YKK21088"]}]},{"name":"Nanjing Health Science and Technology Development Special Fund Project","award":["2242022R40061"],"award-info":[{"award-number":["2242022R40061"]}]},{"name":"Nanjing Health Science and Technology Development Special Fund Project","award":["NHXX-WJW-2023022"],"award-info":[{"award-number":["NHXX-WJW-2023022"]}]},{"name":"Nanjing Health Science and Technology Development Special Fund Project","award":["YKK21088"],"award-info":[{"award-number":["YKK21088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Widespread glyphosate contamination in the environment and its endocrine-disrupting potential are concerning. However, evidence of glyphosate\u2019s effects on glycemic health is limited. To examine the association between glyphosate and glucose homeostasis in the general US population, a total of 3038 individuals were enrolled from the 2013-2016 cycles of the National Health and Nutrition Examination Survey (NHANES). Survey-weighted linear regression and restricted cubic spline curves were used to detect the associations between glyphosate and glycemic disorders. The effects of interactions between sex hormones and glyphosate on glycemic outcomes were evaluated. The results showed that glyphosate was significantly linked to increased glycated hemoglobin A1c (HbA1c) levels (\u03b2 = 0.01; 95%CI, 0.01 to 0.02; p = 0.001) and the compromised homeostatic model assessment of beta-cell function (HOMA-beta) scores (\u03b2 = \u22120.09; 95%CI, \u22120.17 to \u22120.01; p = 0.024). More importantly, these \u201cglyphosate\u2013glycemic disorder\u201d associations were significantly modified by sex hormone-binding globulin (SHBG; P for interaction &lt; 0.05), with more pronounced relationships being identified in individuals with low SHBG levels. Our findings indicate that glyphosate is correlated with glucose dyshomeostasis. Individuals with low SHBG levels exhibited susceptibility to glyphosate-related glycemic toxicity; therefore, it might be prudent to determine glycemic health in those subjects with glyphosate exposure.<\/jats:p>","DOI":"10.3390\/toxics12080600","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T06:41:31Z","timestamp":1724049691000},"page":"600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations between Glyphosate Exposure and Glycemic Disorders: A Focus on the Modifying Effect of Sex Hormones"],"prefix":"10.3390","volume":"12","author":[{"given":"Yu","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Dermatology, The Fifth People\u2019s Hospital of Hainan Province, Haikou 570000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuge","family":"Shu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhou","family":"Duan","sequence":"additional","affiliation":[{"name":"Preventive Health Service, Jiangxi Provincial People\u2019s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongquan","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116678","DOI":"10.1016\/j.envres.2023.116678","article-title":"Glyphosate and environmental toxicity with \u201cOne Health\u201d approach, a review","volume":"235","author":"Ferrante","year":"2023","journal-title":"Environ. 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