{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:25:45Z","timestamp":1767205545315,"version":"build-2238731810"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Scientific Project of China","award":["No. 2011CB933501"],"award-info":[{"award-number":["No. 2011CB933501"]}]},{"name":"National Key Scientific Project of China","award":["No. 81570132"],"award-info":[{"award-number":["No. 81570132"]}]},{"name":"National Key Scientific Project of China","award":["No. 81873437"],"award-info":[{"award-number":["No. 81873437"]}]},{"name":"National Key Scientific Project of China","award":["No. BK20181130"],"award-info":[{"award-number":["No. BK20181130"]}]},{"name":"NSFC Project","award":["No. 2011CB933501"],"award-info":[{"award-number":["No. 2011CB933501"]}]},{"name":"NSFC Project","award":["No. 81570132"],"award-info":[{"award-number":["No. 81570132"]}]},{"name":"NSFC Project","award":["No. 81873437"],"award-info":[{"award-number":["No. 81873437"]}]},{"name":"NSFC Project","award":["No. BK20181130"],"award-info":[{"award-number":["No. BK20181130"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["No. 2011CB933501"],"award-info":[{"award-number":["No. 2011CB933501"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["No. 81570132"],"award-info":[{"award-number":["No. 81570132"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["No. 81873437"],"award-info":[{"award-number":["No. 81873437"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["No. BK20181130"],"award-info":[{"award-number":["No. BK20181130"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taihu Top-tier Medical Team Project","award":["No. 2011CB933501"],"award-info":[{"award-number":["No. 2011CB933501"]}]},{"name":"Taihu Top-tier Medical Team Project","award":["No. 81570132"],"award-info":[{"award-number":["No. 81570132"]}]},{"name":"Taihu Top-tier Medical Team Project","award":["No. 81873437"],"award-info":[{"award-number":["No. 81873437"]}]},{"name":"Taihu Top-tier Medical Team Project","award":["No. BK20181130"],"award-info":[{"award-number":["No. BK20181130"]}]},{"name":"National Institute of Health Research (NIHR) Biomedical Research Centre funding scheme","award":["No. 2011CB933501"],"award-info":[{"award-number":["No. 2011CB933501"]}]},{"name":"National Institute of Health Research (NIHR) Biomedical Research Centre funding scheme","award":["No. 81570132"],"award-info":[{"award-number":["No. 81570132"]}]},{"name":"National Institute of Health Research (NIHR) Biomedical Research Centre funding scheme","award":["No. 81873437"],"award-info":[{"award-number":["No. 81873437"]}]},{"name":"National Institute of Health Research (NIHR) Biomedical Research Centre funding scheme","award":["No. BK20181130"],"award-info":[{"award-number":["No. BK20181130"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Toxics"],"abstract":"<jats:p>Inflammation is associated with an increased risk of developing various cancers in both animals and humans, primarily solid tumors but also myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Multi-walled carbon nanotubes (MWCNTs), a type of carbon nanotubes (CNTs) increasingly used in medical research and other fields, are leading to a rising human exposure. Our study demonstrated that exposing mice to MWCNTs accelerated the progression of spontaneous MOL4070LTR virus-induced leukemia. Additionally, similar exposures elevated pro-inflammatory cytokines such as interleukin (IL)-1\u03b2, IL-6, and tumor necrosis factor (TNF)-\u03b1 and induced reactive oxygen species (ROS) in a murine macrophage cell line. These effects were significantly reduced in immunodeficient mice and when mice were treated with methoxypolyethylene glycol amine (PEG)-modified MWCNTs. These findings underscore the necessity of evaluating the safety of MWCNTs, particularly for those with hematologic cancers.<\/jats:p>","DOI":"10.3390\/toxics12090646","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T12:54:42Z","timestamp":1725281682000},"page":"646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model"],"prefix":"10.3390","volume":"12","author":[{"given":"Qingqing","family":"Wang","sequence":"first","affiliation":[{"name":"Clinical Medical Research Center, The Affiliated Wuxi No.2 People\u2019s Hospital of Nanjing Medical University, Wuxi 214002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingdan","family":"Han","sequence":"additional","affiliation":[{"name":"Clinical Medical Research Center, The Affiliated Wuxi No.2 People\u2019s Hospital of Nanjing Medical University, Wuxi 214002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujia","family":"Wei","sequence":"additional","affiliation":[{"name":"Clinical Medical Research Center, The Affiliated Wuxi No.2 People\u2019s Hospital of Nanjing Medical University, Wuxi 214002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huikai","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gale","sequence":"additional","affiliation":[{"name":"Haematology Research Centre, Department of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yin","sequence":"additional","affiliation":[{"name":"Clinical Medical Research Center, The Affiliated Wuxi No.2 People\u2019s Hospital of Nanjing Medical University, Wuxi 214002, China"},{"name":"Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China"},{"name":"Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/d41586-019-01767-6","article-title":"Sunlight harvested by nanotubes","volume":"570","author":"Yang","year":"2019","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.aan2438","article-title":"Enhanced water permeability and tunable ion selectivity in subnanometer carbon nanotube 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