{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:31:11Z","timestamp":1789835471193,"version":"4.0.1"},"reference-count":75,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Human exposure to arsenic and other toxic elements such as cadmium, lead and mercury may lead to a wide range of adverse health effects. In relation to this, it is well established that the diet is the main route of exposure to both essential and toxic trace elements. In recent years, the levels of toxic elements in foodstuffs have been measured in numerous studies conducted all over the world. Scientific databases show that, in the current century, China and Spain have been the countries where the most surveys on this topic have been carried out. Regarding Spain, Catalonia is the region where most studies aimed at determining the concentrations of trace elements in food have been performed. The objective of this paper was to review the studies carried out in Catalonia on the concentrations of As and toxic metals (including Cd, Hg and Pb) in food, as well as their estimated dietary intakes (EDIs). The results of total diet studies (TDSs) and duplicate diet (DD) studies have been included. For most toxic elements, a continued reduction in the EDI has been observed. This reduction is associated with a decrease in their concentrations in food, and with certain changes in dietary habits. Fish and seafood is the food group showing the highest content of toxic elements. However, none of the adult groups exceeded\u2014in general\u2014the safety thresholds for As, Cd, Hg and Pb established by the European Food Safety Agency (EFSA).<\/jats:p>","DOI":"10.3390\/toxics12100749","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T10:11:04Z","timestamp":1729073464000},"page":"749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human Exposure through the Diet to Arsenic and Other Toxic Elements: A Literature Review of Scientific Studies Conducted in Catalonia, Spain, in the Current Century"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-9470","authenticated-orcid":false,"given":"Jose L.","family":"Domingo","sequence":"first","affiliation":[{"name":"Laboratory of Toxicology and Environmental Health, School of Medicine, Universitat Rovira i Virgili, San Llorens 21, 43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"ref_1","first-page":"133","article-title":"Heavy metal toxicity and the environment","volume":"101","author":"Tchounwou","year":"2012","journal-title":"Exp. Suppl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e04691","DOI":"10.1016\/j.heliyon.2020.e04691","article-title":"Heavy metal pollution in the environment and their toxicological effects on humans","volume":"6","author":"Briffa","year":"2020","journal-title":"Heliyon"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"158734","DOI":"10.1016\/j.scitotenv.2022.158734","article-title":"Metals in urban soils of Europe: A systematic review","volume":"854","author":"Binner","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"109631","DOI":"10.1016\/j.envres.2020.109631","article-title":"Adverse health effects for populations living near waste incinerators with special attention to hazardous waste incinerators. A review of the scientific literature","volume":"187","author":"Domingo","year":"2020","journal-title":"Environ. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"128656","DOI":"10.1016\/j.jhazmat.2022.128656","article-title":"Fate and emission behavior of heavy metals during hazardous chemical waste incineration","volume":"431","author":"Chuai","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"137595","DOI":"10.1016\/j.chemosphere.2022.137595","article-title":"Distribution, sources and health risks of heavy metals in indoor dust across China","volume":"313","author":"Wang","year":"2023","journal-title":"Chemosphere"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"174467","DOI":"10.1016\/j.scitotenv.2024.174467","article-title":"Atmospheric emissions of particulate matter-bound heavy metals from industrial sources","volume":"947","author":"Yang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jinorgbio.2019.03.013","article-title":"The essential metals for humans: A brief overview","volume":"195","author":"Zoroddu","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3355733","DOI":"10.1155\/2023\/3355733","article-title":"Understanding how minerals contribute to optimal immune function","volume":"2023","author":"Stefanache","year":"2023","journal-title":"J. Immunol. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41392-023-01679-y","article-title":"Cellular zinc metabolism and zinc signaling: From biological functions to diseases and therapeutic targets","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.mrgentox.2008.09.015","article-title":"The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress","volume":"674","author":"Gonsebatt","year":"2009","journal-title":"Mutat. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cannas, D., Loi, E., Serra, M., Firinu, D., Valera, P., and Zavattari, P. (2020). Relevance of essential trace elements in nutrition and drinking water for human health and autoimmune disease isk. Nutrients, 12.","DOI":"10.3390\/nu12072074"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/15376516.2019.1701594","article-title":"The effects of heavy metals on human metabolism","volume":"30","author":"Fu","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Balali-Mood, M., Naseri, K., Tahergorabi, Z., Khazdair, M.R., and Sadeghi, M. (2021). Toxic mechanisms of five heavy metals: Mercury, lead, chromium, cadmium, and arsenic. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.643972"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"129735","DOI":"10.1016\/j.chemosphere.2021.129735","article-title":"Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium)\u2014Induced hepatotoxicity\u2014A review","volume":"271","author":"Renu","year":"2021","journal-title":"Chemosphere"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.chemosphere.2018.11.165","article-title":"Toxic metals (Al, Cd, Pb and Hg) in the most consumed edible seaweeds in Europe","volume":"218","author":"Paz","year":"2019","journal-title":"Chemosphere"},{"key":"ref_17","unstructured":"ATSDR Agency for Toxic Substances and Disease Registry (2024, July 15). ATSDR\u2019s Substance Priority List, Available online: https:\/\/www.atsdr.cdc.gov\/index.html."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449509089885","article-title":"Minamata disease: Methylmercury poisoning in Japan caused by environmental pollution","volume":"25","author":"Harada","year":"1995","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Genchi, G., Sinicropi, M.S., Lauria, G., Carocci, A., and Catalano, A. (2020). The Effects of Cadmium Toxicity. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17113782"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"173577","DOI":"10.1016\/j.scitotenv.2024.173577","article-title":"Mercury-induced toxicity: Mechanisms, molecular pathways, and gene regulation","volume":"943","author":"Kang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_21","unstructured":"IARC, International Agency for Research on Cancer (2024, July 15). Arsenic, Metals, Fibres, and Dusts, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 100C. Available online: https:\/\/publications.iarc.fr\/."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.3892\/mmr.2017.6381","article-title":"Immunological effects of occupational exposure to lead","volume":"15","author":"Fenga","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/bmb\/ldg032","article-title":"Hazards of heavy metal contamination","volume":"68","year":"2003","journal-title":"Br. Med. Bull."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/15287399409531868","article-title":"Metal-induced developmental toxicity in mammals: A review","volume":"42","author":"Domingo","year":"1994","journal-title":"J. Toxicol. Environ. Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"62067","DOI":"10.1007\/s11356-021-16581-9","article-title":"Environmental and occupational exposure of metals and female reproductive health","volume":"29","author":"Dutta","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10534-019-00193-5","article-title":"Exposure routes and health effects of heavy metals on children","volume":"32","author":"Yang","year":"2019","journal-title":"Biometals"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Witkowska, D., S\u0142owik, J., and Chilicka, K. (2021). Heavy metals and human health: Possible exposure pathways and the competition for protein binding sites. Molecules, 26.","DOI":"10.3390\/molecules26196060"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Koch, W., Czop, M., I\u0142owiecka, K., Nawrocka, A., and Wi\u0105cek, D. (2022). Dietary intake of toxic heavy metals with major groups of food products\u2014Results of analytical determinations. Nutrients, 14.","DOI":"10.3390\/nu14081626"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1016\/j.sjbs.2021.04.047","article-title":"Food packaging\u2019s materials: A food safety perspective","volume":"28","author":"Alamri","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109414","DOI":"10.1016\/j.foodres.2020.109414","article-title":"Relationships between food and diseases: What to know to ensure food safety","volume":"137","author":"Gallo","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1021\/jf020734q","article-title":"Concentrations of arsenic, cadmium, mercury, and lead in common foods and estimated daily intake by children, adolescents, adults, and seniors of Catalonia, Spain","volume":"51","author":"Llobet","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1021\/jf0610110","article-title":"Daily intake of arsenic, cadmium, mercury, and lead by consumption of edible marine species","volume":"54","author":"Llobet","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12011-008-8162-3","article-title":"Dietary intake of arsenic, cadmium, mercury, and lead by the population of Catalonia, Spain","volume":"125","author":"Llobet","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12011-010-8787-x","article-title":"Human exposure to arsenic, cadmium, mercury, and lead from foods in Catalonia, Spain: Temporal trend","volume":"142","author":"Martorell","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_35","first-page":"748","article-title":"Dietary intake of trace elements by the population of Catalonia (Spain): Results from a total diet study","volume":"32","author":"Vicente","year":"2015","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"110721","DOI":"10.1016\/j.fct.2019.110721","article-title":"Dietary intake of arsenic, cadmium, mercury and lead by the population of Catalonia, Spain: Analysis of the temporal trend","volume":"132","author":"Timoner","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1385\/BTER:104:3:193","article-title":"Human exposure to metals through the diet in Tarragona, Spain: Temporal trend","volume":"104","author":"Bocio","year":"2005","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1016\/S0045-6535(98)00581-5","article-title":"PCDDs and PCDFs in food samples from Catalonia, Spain. An assessment of dietary intake","volume":"38","author":"Domingo","year":"1999","journal-title":"Chemosphere"},{"key":"ref_39","first-page":"136","article-title":"Biological monitoring of environmental pollution and human exposure to metals in Tarragona, Spain","volume":"15","author":"Llobet","year":"1998","journal-title":"IV. Estimation of the dietary intake. Trace Elem. Electrolytes"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12011-009-8368-z","article-title":"Dietary exposure to metals by individuals living near a hazardous waste incinerator in Catalonia, Spain: Temporal trend","volume":"131","author":"Domingo","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5414\/TEX01380","article-title":"Dietary exposure to metals by adults living near a hazardous waste incinerator in Catalonia, Spain: Temporal trend","volume":"32","author":"Nadal","year":"2015","journal-title":"Trace Elem. Electrolytes"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"110469","DOI":"10.1016\/j.foodres.2021.110469","article-title":"Temporal trend of the dietary exposure to metals\/metalloids: A case study in Tarragona County, Spain","volume":"147","author":"Nadal","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Contaminants in the Food Chain (CONTAM), Schrenk, D., Bignami, M., Bodin, L., Chipman, J.K., Del Mazo, J., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L.R., and Leblanc, J.C. (2020). Update of the risk assessment of nickel in food and drinking water. EFSA J., 18, e06268.","DOI":"10.2903\/j.efsa.2020.6268"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s12011-011-9269-5","article-title":"Dietary intake of metals by the population of Tarragona County (Catalonia, Spain): Results from a duplicate diet study","volume":"146","author":"Domingo","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-012-9587-2","article-title":"Human dietary exposure to uranium in catalonia, Spain","volume":"152","author":"Linares","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12011-008-8113-z","article-title":"Risk assessment of metals from consuming vegetables, fruits and rice grown on soils irrigated with waters of the Ebro River in Catalonia, Spain","volume":"123","author":"Schuhmacher","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1080\/10807030802235235","article-title":"Exposure to metals through the consumption of fish and seafood by the population living near the Ebro River in Catalonia, Spain: Health risks","volume":"14","author":"Nadal","year":"2008","journal-title":"Hum. Ecol. Risk Assess."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1080\/10807030902892604","article-title":"Human health risk assessment for environmental exposure to metals in the Catalan stretch of the Ebro River, Spain","volume":"15","author":"Nadal","year":"2009","journal-title":"Hum. Ecol. Risk Assess."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/02652030903150559","article-title":"Mercury and methylmercury intake estimation due to seafood products for the Catalonian population (Spain)","volume":"27","author":"Fontcuberta","year":"2010","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fct.2015.09.012","article-title":"Oral bioaccessibility of arsenic, mercury and methylmercury in marine species commercialized in Catalonia (Spain) and health risks for the consumers","volume":"86","author":"Maulvault","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"120274","DOI":"10.1016\/j.envpol.2022.120274","article-title":"Wild fish and seafood species in the western Mediterranean Sea with low safe mercury concentrations","volume":"314","author":"Capodiferro","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6543","DOI":"10.1021\/jf058027v","article-title":"Lead dietary intake in a Spanish population (Canary Islands)","volume":"53","author":"Rubio","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.envres.2005.01.008","article-title":"Cadmium dietary intake in the Canary Islands, Spain","volume":"100","author":"Rubio","year":"2006","journal-title":"Environ. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/02652030801993597","article-title":"Total dietary intake of mercury in the Canary Islands, Spain","volume":"25","author":"Rubio","year":"2008","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.chemosphere.2017.01.064","article-title":"Metals in edible seaweed","volume":"173","author":"Rubio","year":"2017","journal-title":"Chemosphere"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10661-018-6614-6","article-title":"Trace element and toxic metal intake from the consumption of canned mushrooms marketed in Spain","volume":"190","author":"Rubio","year":"2018","journal-title":"Environ. Monit. Assess."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4315\/0362-028X.JFP-17-181","article-title":"A limited survey of metal content in blue jack mackerel (Trachurus picturatus) obtained from markets in the Canary Islands","volume":"81","author":"Rubio","year":"2018","journal-title":"J. Food Prot."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"932","DOI":"10.4315\/JFP-19-565","article-title":"Human Exposure to potentially toxic elements from the consumption of soybean beverages commercialized in Spain","volume":"84","author":"Rubio","year":"2021","journal-title":"J. Food Prot."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Rubio-Armendariz, C., Paz, S., Guti\u00e9rrez, \u00c1.J., Gonz\u00e1lez-Weller, D., Revert, C., and Hardisson, A. (2021). Human exposure to toxic metals (Al, Cd, Cr, Ni, Pb, Sr) from the consumption of cereals in Canary Islands. Foods, 10.","DOI":"10.3390\/foods10061158"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"28787","DOI":"10.1007\/s11356-019-06090-1","article-title":"Toxic (Al, Cd, and Pb) and trace metal (B, Ba, Cu, Fe, Mn, Sr, and Zn) levels in tissues of slaughtered steers: Risk assessment for the consumers","volume":"26","author":"Hardisson","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12011-018-1538-0","article-title":"Toxic metals and trace elements in artisanal honeys from the Canary Islands","volume":"190","author":"Paz","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.scitotenv.2016.03.035","article-title":"Assessment of human health hazards associated with the dietary exposure to organic and inorganic contaminants through the consumption of fishery products in Spain","volume":"557-558","author":"Camacho","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.scitotenv.2016.09.142","article-title":"Comparative study of the intake of toxic persistent and semi persistent pollutants through the consumption of fish and seafood from two modes of production (wild-caught and farmed)","volume":"575","author":"Camacho","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Hern\u00e1ndez, \u00c1., Zumbado, M., Henr\u00edquez-Hern\u00e1ndez, L.A., Boada, L.D., and Luzardo, O.P. (2019). Dietary intake of essential, toxic, and potentially toxic elements from mussels (Mytilus spp.) in the Spanish population: A nutritional assessment. Nutrients, 11.","DOI":"10.3390\/nu11040864"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Henr\u00edquez-Hern\u00e1ndez, L.A., Acosta-Dacal, A.C., Boada, L.D., Zumbado, M., Serra-Majem, L., and Luzardo, O.P. (2023). Concentration of essential, toxic, and rare earth elements in ready-to-eat baby purees from the Spanish market. Nutrients, 15.","DOI":"10.3390\/nu15143251"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1021\/jf030453y","article-title":"Survey of persistent organochlorine contaminants (PCBs, PCDD\/Fs, and PAHs), heavy metals (Cu, Cd, Zn, Pb, and Hg), and arsenic in food samples from Huelva (Spain): Levels and health implications","volume":"52","author":"Bordajandi","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0048-9697(02)00611-3","article-title":"Mineral content in legumes and nuts: Contribution to the Spanish dietary intake","volume":"308","author":"Cabrera","year":"2003","journal-title":"Sci. Total Environ."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.envres.2017.04.030","article-title":"Integrated assessment of infant exposure to persistent organic pollutants and mercury via dietary intake in a central western Mediterranean site (Menorca Island)","volume":"156","author":"Arce","year":"2017","journal-title":"Environ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"113862","DOI":"10.1016\/j.envres.2022.113862","article-title":"Environmental and dietary determinants of metal exposure in four-year-old children from a cohort located in an industrial area (Asturias, Northern Spain)","volume":"214","author":"Grimalt","year":"2022","journal-title":"Environ. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.envres.2017.05.033","article-title":"Mercury concentrations in lean fish from the Western Mediterranean Sea: Dietary exposure and risk assessment in the population of the Balearic Islands","volume":"158","author":"Llull","year":"2017","journal-title":"Environ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1080\/02652030110113744","article-title":"Contribution of cattle products to dietary intake of trace and toxic elements in Galicia, Spain","volume":"19","author":"Benedito","year":"2002","journal-title":"Food Addit. Contam."},{"key":"ref_72","first-page":"128","article-title":"Cadmium and lead accumulation in cattle in NW Spain","volume":"45","author":"Miranda","year":"2003","journal-title":"Vet. Hum. Toxicol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1080\/19393210.2015.1131753","article-title":"Aluminium, nickel, cadmium and lead in candy products and assessment of daily intake by children in Spain","volume":"9","author":"Barber","year":"2016","journal-title":"Food Addit. Contam. Part B Surveill."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/19393210802236935","article-title":"Monitoring programme on cadmium, lead and mercury in fish and seafood from Valencia, Spain: Levels and estimated weekly intake","volume":"1","author":"Suelves","year":"2008","journal-title":"Food Addit. Contam. Part B Surveill."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1080\/10408398.2012.742985","article-title":"Nutrients and chemical pollutants in fish and shellfish. Balancing Health benefits and risks of regular fish consumption","volume":"56","author":"Domingo","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/12\/10\/749\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:13:57Z","timestamp":1760112837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/12\/10\/749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":75,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["toxics12100749"],"URL":"https:\/\/doi.org\/10.3390\/toxics12100749","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]}}}