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University","award":["18ykpy14"],"award-info":[{"award-number":["18ykpy14"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Benzene, toluene, and xylene (BTX) co-exist in human environments, yet their individual and combined effects on genetic damage at low exposure levels are not fully understood. Additionally, single nucleotide polymorphisms in microRNAs (mirSNPs) might be involved in cancer etiology by affecting the related early health damage. To investigate the influence of BTX exposure, mirSNPs, and their interactions on genetic damage, we conducted a cross-sectional study in 1083 Chinese petrochemical workers, quantifying the BTX cumulative exposure levels and multiple genetic damage biomarkers. Additionally, we genotyped multiple common mirSNPs. Benzene and a BTX mixture were positive associated with the olive tail moment (OTM) and tail DNA% (p &lt; 0.05). Higher levels of toluene and xylene enhanced the association of benzene with genetic damage levels. Genotypes and\/or mutant allele counts of miR-4482-related rs11191980, miR-4433-related rs136547, miR-27a-related rs2594716, miR-3130-related rs725980, and miR-3928-related rs878718 might significantly influence genetic damage levels. Stronger effect estimates of benzene\/BTX exposure were found in carriers of miR-196a-2-related rs11614913 heterozygotes and of wild homozygotes of miR-1269b-related rs12451747, miR-612-related rs12803915, and miR-4804-related rs266437. Our findings provide further support of the involvement of BTX co-exposure, mirSNPs, and their gene\u2013environment interactions in determining the severity of DNA strand break in a complex manner.<\/jats:p>","DOI":"10.3390\/toxics12110821","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T11:58:07Z","timestamp":1732017487000},"page":"821","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1972-7743","authenticated-orcid":false,"given":"Shuangqi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China"},{"name":"Huadu Center for Disease Control and Prevention, Guangzhou 510801, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaorui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifei","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"ref_1","unstructured":"(2024). 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