{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:53:45Z","timestamp":1790812425870,"version":"4.1.0"},"reference-count":99,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["111-2314-B-002-095"],"award-info":[{"award-number":["111-2314-B-002-095"]}]},{"name":"National Science and Technology Council","award":["105-2628-B-002-034-MY2"],"award-info":[{"award-number":["105-2628-B-002-034-MY2"]}]},{"name":"National Science and Technology Council","award":["NTU-113L9004"],"award-info":[{"award-number":["NTU-113L9004"]}]},{"name":"National Science and Technology Council","award":["NTU-112L9004"],"award-info":[{"award-number":["NTU-112L9004"]}]},{"name":"National Science and Technology Council","award":["NTU-111L881004"],"award-info":[{"award-number":["NTU-111L881004"]}]},{"name":"National Science and Technology Council","award":["NTU-110L8810"],"award-info":[{"award-number":["NTU-110L8810"]}]},{"name":"Population Health and Welfare Research Center from Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE)","award":["111-2314-B-002-095"],"award-info":[{"award-number":["111-2314-B-002-095"]}]},{"name":"Population Health and Welfare Research Center from Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE)","award":["105-2628-B-002-034-MY2"],"award-info":[{"award-number":["105-2628-B-002-034-MY2"]}]},{"name":"Population Health and Welfare Research Center from Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE)","award":["NTU-113L9004"],"award-info":[{"award-number":["NTU-113L9004"]}]},{"name":"Population Health and Welfare Research Center from Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE)","award":["NTU-112L9004"],"award-info":[{"award-number":["NTU-112L9004"]}]},{"name":"Population Health and Welfare Research Center from Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE)","award":["NTU-111L881004"],"award-info":[{"award-number":["NTU-111L881004"]}]},{"name":"Population Health and Welfare Research Center from Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE)","award":["NTU-110L8810"],"award-info":[{"award-number":["NTU-110L8810"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Perfluoroalkyl substances (PFASs) have elimination half-lives in years in humans and are persistent in the environment. PFASs can cross the placenta and impact fetal development. Exposure to PFASs may lead to adverse effects through epigenetic mechanisms. This study aimed to investigate whether prenatal exposure to perfluorooctyl sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA) was associated with global histone methylation level changes among the 130 2-year-old children followed-up in a birth cohort study in Taiwan. PFOS, PFOA, PFNA, and PFUA were measured by UHPLC\/MS\/MS in cord blood. Global histone methylation levels were measured from the blood leukocytes of 2-year-old children by Western blotting. Multivariable regression analyses were applied to adjust for potential confounding effects. Among the 2-year-old children, an IQR increase in the natural log-transformed PFUA exposure was associated with an increased H3K4me3 level by 2.76-fold (95%CI = (0.79, 4.73), p = 0.007). PFOA and PFNA exposures was associated with a decreased H3K27me3 level by 2.35-fold (95%CI = (\u22124.29, \u22120.41), p = 0.01) and 2.01-fold (95%CI = (\u22124.00, \u22120.03), p = 0.04), respectively. Our findings suggest that prenatal PFAS exposure affected histone post-translational modifications.<\/jats:p>","DOI":"10.3390\/toxics12120876","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T10:07:10Z","timestamp":1733306830000},"page":"876","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prenatal Perfluoroalkyl Substance Exposure in Association with Global Histone Post-Translational Methylation in 2-Year-Old Children"],"prefix":"10.3390","volume":"12","author":[{"given":"Wan-Ju","family":"Tsai","sequence":"first","affiliation":[{"name":"Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Shiun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cathay General Hospital, Taipei 106, Taiwan"},{"name":"Department of Pediatrics, National Taiwan University College of Medicine, Taipei 100, Taiwan"},{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-5974","authenticated-orcid":false,"given":"Pau-Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei 100, Taiwan"},{"name":"Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan"},{"name":"National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli 350, Taiwan"},{"name":"Department of Public Health, College of Public Health, National Taiwan University, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei 100, Taiwan"},{"name":"Department of Public Health, College of Public Health, National Taiwan University, Taipei 100, Taiwan"},{"name":"Global Health Program, College of Public Health, National Taiwan University, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1021\/es2011622","article-title":"Polyfluorinated compounds: Past, Present, and Future","volume":"45","author":"Lindstrom","year":"2011","journal-title":"Environ. 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