{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:24:11Z","timestamp":1792463051119,"version":"4.5.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The rapid development of the global chemical industry has led to widespread groundwater contamination, with frequent pollution incidents posing severe threats to water safety. However, there has been insufficient assessment of the health risks posed by chlorinated hydrocarbon contamination in groundwater around chemical industrial parks. This study evaluates the chlorinated hydrocarbon contamination in groundwater at a chemical park and conducts a multi-pathway health risk assessment, identifying the key risk pollutants. In addition, sensitivity analysis of the primary exposure pathways was performed using the Monte Carlo method. The results indicate severe exceedance of pollutant concentrations with widespread diffusion. Carcinogenic risks were mainly driven by vinyl chloride, whose oral cancer slope factor was significantly higher than that of other substances, while non-carcinogenic risks were dominated by trichloro-ethylene, which had the lowest reference dose. Both carcinogenic and non-carcinogenic risks through the drinking water pathway accounted for approximately 90% of the total risk, whereas the risk contribution from dermal contact was negligible. Although boiling water can partially reduce the risks, its effect on high-concentration pollutants is limited. Additionally, sensitivity analysis showed that pollutant concentration was the primary influencing factor for risk values, followed by exposure duration. The findings of this study provide a scientific basis for effectively formulating pollution control measures and ensuring the drinking water safety of nearby residents.<\/jats:p>","DOI":"10.3390\/toxics12120894","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T11:16:48Z","timestamp":1733743008000},"page":"894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Human Health Risk Assessment of Chlorinated Hydrocarbons in Groundwater Based on Multi-Pathway Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Yidi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Resource and Environmental Engineering, Inner Mongolia University of Technology, Hohhot 010051, China"},{"name":"Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang 050061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Resource and Environmental Engineering, Inner Mongolia University of Technology, Hohhot 010051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang 050061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Resource and Environmental Engineering, Inner Mongolia University of Technology, Hohhot 010051, China"},{"name":"Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang 050061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifang","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilu","family":"Xing","sequence":"additional","affiliation":[{"name":"School of Resource and Environmental Engineering, Inner Mongolia University of Technology, Hohhot 010051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang 050061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Resource and Environmental Engineering, Inner Mongolia University of Technology, Hohhot 010051, China"},{"name":"Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang 050061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119185","DOI":"10.1016\/j.envres.2024.119185","article-title":"Quantitative tracing the sources and human risk assessment of complex soil pollution in an industrial park","volume":"257","author":"Xu","year":"2024","journal-title":"Environ. 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