{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:17:57Z","timestamp":1789575477112,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Occupational exposure as a firefighter was recently classified as carcinogenic to humans by the IARC. Fire instructors\u2019 exposure to carcinogenic PAHs is a major concern, and studies that have tried to assess the determinants of their exposure are scarce. An air and biomonitoring study was conducted in fire instructors performing simulated training exercises in enclosed containers. Air samples were collected, as well as urine samples from 22 firefighting instructors, and skin wipes were collected from FFs\u2019 skin at the end of the exercises. PAH metabolites (1-hydroxypyrene, 3-hydroxybenzo(a)pyrene, 2\/3-hydroxyfluorene, and 2\/3-hydroxyphenanthrene) were measured in urine samples at three sampling times (beginning of shift, end of shift, and next morning). Airborne PAHs were dominated by low molecular weight compounds (naphthalene), and levels were as high as 67 \u00b5g\u00b7m\u22123 close to the containers, decreasing at higher distances. Skin contamination was observed both on the neck\/face and hands\/wrists of fire instructors and pilots. Ten times lower skin contamination was observed when nitrile undergloves were worn. High internal exposure was measured, with 1-hydroxypyrene and 3-hydroxybenzo(a)pyrene levels frequently exceeding maximum recommended values in occupational settings (up to 2.8 \u00b5mol\/mol creatinine for 1-OHP, 14 \u00b5mol\/mol creatinine for \u03a3OH-PAH, and 1.0 nmol\/mol creatinine for 3-OHBaP), whereas benzene exposure was revealed to be very low. These types of exposure were found to derive both from dermal absorption (combustion products deposited on the skin) and inhalation (when removing SCBA outside the containers). Several recommendations are proposed in order to reduce both exposure routes (nitrile undergloves and half-masks in the vicinity of containers), harmonise decontamination (PPEs) and cleaning procedures, and prevent the dermal absorption of PAH from turnout gear. This study emphasises the complex PAH exposure profiles of fire instructors and characterises the main drivers of exposure, highlighting the need for better mitigation strategies.<\/jats:p>","DOI":"10.3390\/toxics13020106","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T03:26:10Z","timestamp":1738121170000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Air, Skin, and Biological Monitoring of French Fire Instructors\u2019 Exposure to Particles\/PAHs During Controlled Fire and Mitigation Strategies"],"prefix":"10.3390","volume":"13","author":[{"given":"Pauline","family":"Zangl","sequence":"first","affiliation":[{"name":"Service D\u00e9partemental d\u2019Incendie et de Secours (SDIS) Is\u00e8re, 38000 Grenoble, France"},{"name":"Grenoble Teaching Hospital, EPSP-TIMC Laboratory, Universit\u00e9 Grenoble Alpes, 38400 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Collart","sequence":"additional","affiliation":[{"name":"Service D\u00e9partemental d\u2019Incendie et de Secours (SDIS) Is\u00e8re, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-2917","authenticated-orcid":false,"given":"Renaud","family":"Persoons","sequence":"additional","affiliation":[{"name":"Grenoble Teaching Hospital, EPSP-TIMC Laboratory, Universit\u00e9 Grenoble Alpes, 38400 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"ref_1","unstructured":"IARC (International Agency Research on Cancer) (2022). 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