{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:25:29Z","timestamp":1792427129706,"version":"4.5.0"},"reference-count":153,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The antioxidant properties of resveratrol (RES) against oxidative toxicity induced by testicular toxicants are well documented. The current study aimed to investigate the probable beneficial role of RES on male reproduction in adult rats following prepubertal exposure to perfluorooctanoic acid (PFOA). Healthy rats of the Wistar strain (23 days old) were allocated into four groups. Rats in group I did not receive any treatment, while rats in groups II, III, and IV received RES, PFOA, and RES + PFOA, respectively, between days 23 and 56 and were monitored for up to 90 days. Exposure to PFOA resulted in a significant reduction in spermiogram parameters, testicular 3\u03b2- and 17\u03b2-HSD activity levels, and circulatory levels of testosterone. A significant elevation in LPx, PCs, H2O2, and O2\u2212, associated with a concomitant reduction in SOD, CAT, GPx, GR, and GSH, was noticed in the testes, as well as region-specific changes in pro- and antioxidants in the epididymides of exposed rats compared to controls. A significant increase in serum FSH and LH, testicular cholesterol levels, and caspase-3 activity was observed in PFOA-exposed rats compared to controls. Histological analysis revealed that the integrity of the testes was deteriorated in PFOA-exposed rats. Transcriptomic profiling of the testes and epididymides revealed 98 and 611 altered genes, respectively. In the testes, apoptosis and glutathione pathways were disrupted, while in the epididymides, glutathione and bile secretion pathways were altered in PFOA-exposed rats. PFOA exposure resulted in the down-regulation in the testes of 17\u03b2-HSD, StAR, nfe2l2, ar, Lhcgr, and mRNA levels, associated with the up-regulation of casp3 mRNA, and down-regulation of alpha 1 adrenoceptor, muscarinic choline receptor 3, and androgen receptor in the epididymides of exposed rats compared to the controls. These events might lead to male infertility in PFOA-exposed rats. In contrast, restoration of selected reproductive variables was observed in RES plus PFOA-exposed rats compared to rats exposed to PFOA alone. Taken together, we postulate that prepubertal exposure to PFOA triggered oxidative damage and altered genes in the testes and epididymides, leading to suppressed male reproductive health in adult rats, while RES, with its steroidogenic, antiapoptotic, and antioxidant effects, restored PFOA-induced fertility potential in rats.<\/jats:p>","DOI":"10.3390\/toxics13020111","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T04:01:39Z","timestamp":1738209699000},"page":"111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protective Effects of Resveratrol Against Perfluorooctanoic Acid-Induced Testicular and Epididymal Toxicity in Adult Rats Exposed During Their Prepubertal Period"],"prefix":"10.3390","volume":"13","author":[{"given":"R.","family":"Pavani","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Vikrama Simhapuri University, Nellore 524324, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Venkaiah","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Vikrama Simhapuri University, Nellore 524324, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Gnana","family":"Prakasam","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Vikrama Simhapuri University, Nellore 524324, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya R.","family":"Dirisala","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Vignan\u2019s Foundation for Science, Technology and Research, Vadlamudi, Guntur 522213, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-4973","authenticated-orcid":false,"given":"P. Gopi","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Zoology, Vikrama Simhapuri University PG Centre, Kavali 524201, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kishori","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Sri Padmavathi Mahila Viswavidyalayam, Tirupati 517502, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. B.","family":"Sainath","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Vikrama Simhapuri University, Nellore 524324, India"},{"name":"Department of Food Technology, Vikrama Simhapuri University, Nellore 524324, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref_1","first-page":"e13646","article-title":"Environmental contaminants and male infertility: Effects and mechanisms","volume":"53","author":"Selvaraju","year":"2020","journal-title":"Andrologia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr. Env. Assess. 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