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Currently, more and more studies show that some pollutants in the environment can affect the metabolism of Trp and consequently affect human health. The present paper offers a comprehensive overview of prior research investigating the impact of environmental pollutants, including inorganic and organic contaminants, microplastics, and nanoplastics on the nervous system, immune system, digestive system, and maternal\u2013fetal pregnancy, revealing their detrimental effects on Trp metabolism and human well-being.<\/jats:p>","DOI":"10.3390\/toxics13040311","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T20:05:56Z","timestamp":1744920356000},"page":"311","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Environmental Pollutants on Tryptophan Metabolism"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9991-5834","authenticated-orcid":false,"given":"Hongyang","family":"Hu","sequence":"first","affiliation":[{"name":"School of Public Health, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxun","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Public Health, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoliang","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Public Health, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5291-642X","authenticated-orcid":false,"given":"Xiaoshan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"ref_1","first-page":"58","article-title":"Physiological and biochemical effects of tryptophan and its application","volume":"3","author":"Li","year":"2005","journal-title":"Amino Acids Biol. 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