{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:47:01Z","timestamp":1792802821833,"version":"4.5.0"},"reference-count":87,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Glyphosate, a widely used non-selective herbicide, has been a subject of intense scientific debate due to its environmental persistence and potential health risks. This review examines glyphosate\u2019s mechanisms of action, its effects on crop production, and its broader environmental impact, including soil degradation, water contamination, and biodiversity loss. Furthermore, it examines the expanding body of research linking glyphosate exposure to various human health concerns, including metabolic, neurological, reproductive, and oncological disorders. The review also assesses glyphosate\u2019s role in hindering the achievement of the Sustainable Development Goals (SDGs), particularly those related to food security, health, access to clean water, and the protection of marine ecosystems. Finally, potential alternatives to glyphosate-based weed control, including organic and non-chemical methods, are discussed to promote sustainable agricultural practices that balance productivity with ecological and public health considerations. The evidence reviewed highlights glyphosate\u2019s pervasive presence across ecosystems and its potential to disrupt both environmental and human health. The findings underscore the urgent need to regulate glyphosate use, prioritize soil and water protection, and accelerate the transition toward sustainable, low-toxicity weed management strategies that align with global sustainability objectives.<\/jats:p>","DOI":"10.3390\/toxics13110971","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T10:56:47Z","timestamp":1762945007000},"page":"971","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Glyphosate Use in Crop Systems: Risks to Health and Sustainable Alternatives"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-9585","authenticated-orcid":false,"given":"Pamela G.","family":"Aoun","sequence":"first","affiliation":[{"name":"Doctoral School of Sciences and Technology, Lebanese University, Rafic Hariri Campus, Hadath 1533, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Khairallah","sequence":"additional","affiliation":[{"name":"Endocrinology Bellevue Medical Center, Medical Director Green Clinics, Mansourieh 22411, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-5377","authenticated-orcid":false,"given":"Abderahman","family":"Rejeb","sequence":"additional","affiliation":[{"name":"Kautz Faculty of Business and Economics, Sz\u00e9chenyi Istv\u00e1n University, 9026 Gy\u0151r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8932-4313","authenticated-orcid":false,"given":"Amira","family":"Haddarah","sequence":"additional","affiliation":[{"name":"Doctoral School of Sciences and Technology, Lebanese University, Rafic Hariri Campus, Hadath 1533, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","unstructured":"Seneff, S. 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