{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:34:04Z","timestamp":1763566444287,"version":"3.45.0"},"reference-count":30,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Health Institutes of T\u00fcrkiye","award":["21345"],"award-info":[{"award-number":["21345"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>This study aimed to assess oxidative DNA damage products in healthcare workers who are directly exposed to or use ionizing radiation in their work. In the study, three groups were defined based on the probability of radiation exposure, ranging from the highest-risk group to the lowest, with the fourth group designated as the control group. First, a questionnaire was administered to the participants, and then their first morning urine samples were taken to detect oxidative DNA damage markers. According to the Kruskal-Wallis test results among the four groups in our study, statistically significant differences were found only in terms of age, height, and weight (p values = 0.011, 0.038, and 0.003, respectively). However, it was observed that there was no significant relationship between the oxidative DNA damage parameters 8-hydroxy-2\u2032-deoxyguanosine (8-OH-dG), and 8,5\u2032-cyclo-2\u2032-deoxyadenosines (S- and R-cdA) in relation to radiation exposure, with p-values of 0.132, 0.179, and 0.611, respectively. The study\u2019s results revealed that exposure to ionizing radiation did not cause a significant increase in urinary oxidative DNA damage markers. This outcome may be associated with the effective use of personal protective equipment and strict adherence to radiation safety protocols among healthcare workers.<\/jats:p>","DOI":"10.3390\/toxics13110990","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:03:15Z","timestamp":1763564595000},"page":"990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of Oxidative DNA Damage Levels in Urine of Healthcare Workers Exposed to Ionizing Radiation"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-4950","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"Yurt","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Department of Medical Physics, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"},{"name":"Vocational School of Health Science, Medical Imaging Techniques, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3731-2978","authenticated-orcid":false,"given":"Ay\u015fe Co\u015fkun","family":"Beyan","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-4020","authenticated-orcid":false,"given":"Gamze","family":"Tuna","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Department of Molecular Medicine, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"},{"name":"Medical Laboratory Techniques Program, Vocational School of Health Services, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"},{"name":"BioIzmir-Izmir Health Technologies Development and Accelerator Research and Application Center, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7960-5317","authenticated-orcid":false,"given":"Ya\u015far Aysun","family":"Manisal\u0131gil","sequence":"additional","affiliation":[{"name":"Vocational School of Health Science, Medical Imaging Techniques, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1857-1863","authenticated-orcid":false,"given":"Sabriye","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-5616","authenticated-orcid":false,"given":"Hande","family":"O\u011fuzhan","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Department of Molecular Medicine, Dokuz Eylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40557-018-0220-5","article-title":"Probability of causation for occupational cancer after exposure to ionizing radiation","volume":"30","author":"Kim","year":"2018","journal-title":"Ann. 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