{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:31:30Z","timestamp":1788010290570,"version":"build-2784847793"},"reference-count":94,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Bacteria such as Salmonella spp. are primarily transmitted through contaminated eggs and infected poultry; however, other routes, including the movement of personnel, vehicles, and lapses in biosecurity protocols, also play a significant role in their dissemination within poultry systems. Control of a wide range of microorganisms, including bacteria, is often carried out using chemical agents, such as formaldehyde, applied in its solid, liquid, or gaseous forms. Reports on the use of formaldehyde in poultry production date back more than a century. However, it continues to attract research interest due to growing concerns about bacterial resistance, embryotoxicity, occupational exposure, the generation of toxic byproducts, and the search for safer alternatives in poultry production systems. It remains widely used worldwide, but comprehensive and updated evaluations of its efficacy, toxicity, and risks to both poultry and workers are still limited. This review aims to synthesize the current knowledge on the use of formaldehyde in poultry production. Overall, the synthesis shows that formaldehyde remains an effective but high-risk sanitizer whose continued use in poultry systems requires rigorous control and monitoring protocols, and that the development and adoption of efficient and safer alternatives is recommended.<\/jats:p>","DOI":"10.3390\/toxics13111003","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T15:00:17Z","timestamp":1763650817000},"page":"1003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Use of Formaldehyde in Poultry Production for the Treatment of Litter, Hatching Eggs, Hatcheries, and Feed: An Updated Mini Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Pedro Henrique Gomes de S\u00e1","family":"Santos","sequence":"first","affiliation":[{"name":"Faculty of Agronomy and Veterinary Medicine, University of Bras\u00edlia, Bras\u00edlia 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2948-6652","authenticated-orcid":false,"given":"Gabriel da Silva","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Agronomy and Veterinary Medicine, University of Bras\u00edlia, Bras\u00edlia 70910-900, Brazil"},{"name":"Federal Institute of Bras\u00edlia\u2014Campus Planaltina, Bras\u00edlia 73380-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepta","family":"McManus","sequence":"additional","affiliation":[{"name":"Center for Nuclear Energy in Agriculture (CENA), University of S\u00e3o Paulo, S\u00e3o Paulo 13416-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1249-0230","authenticated-orcid":false,"given":"Vin\u00edcius Machado","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Faculty of Agronomy and Veterinary Medicine, University of Bras\u00edlia, Bras\u00edlia 70910-900, Brazil"},{"name":"Federal Institute of Bras\u00edlia\u2014Campus Planaltina, Bras\u00edlia 73380-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1139\/cjm-2019-0280","article-title":"Persistent contamination of Salmonella, Campylobacter, Escherichia coli, and Staphylococcus aureus at a broiler farm in New Zealand","volume":"66","author":"Sattlegger","year":"2020","journal-title":"Can. 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