{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:42:05Z","timestamp":1787067725088,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Industrial air emissions are major contributors to human exposure to toxic pollutants, posing significant health risks. Life cycle assessment (LCA) is increasingly used to quantify human toxicity impacts from industrial processes. Conventional LCA often overlooks spatial and temporal variability, limiting its ability to capture actual inhaled doses and exposure-driven impacts. To address this, we developed a site-dependent dynamic LCA (SdDLCA) framework that integrates conventional LCA with Enhanced Structural Path Analysis (ESPA) and atmospheric dispersion modeling. Applied to the production of double-glazed PVC windows for a residential project, the framework generates high-resolution, site-specific emission inventories for three key pollutants: nitrogen oxides (NOx), sulfur dioxide (SO2), and fine particulate matter (PM2.5). Local concentration fields are compared with World Health Organization (WHO) air quality thresholds to identify hotspots and periods of elevated exposure. By coupling these fields with the ReCiPe 2016 endpoint methodology and localized demographic and meteorological data, SdDLCA quantifies human health impacts in Disability-Adjusted Life Years (DALYs), providing a direct measure of inhalation toxicity. This approach enhances LCA\u2019s ability to capture exposure-driven effects, identifies populations at greatest risk, and offers a robust, evidence-based tool to guide industrial planning and operations that minimize health hazards from air emissions.<\/jats:p>","DOI":"10.3390\/toxics14010023","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:50:21Z","timestamp":1766710221000},"page":"23","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Site-Dependent Dynamic Life Cycle Assessment of Human Health Impacts from Industrial Air Pollutants: Inhalation Exposure to NOx, SO2, and PM2.5 in PVC Window Manufacturing"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8363-7393","authenticated-orcid":false,"given":"Patrice","family":"Megange","sequence":"first","affiliation":[{"name":"Le Laboratoire de M\u00e9canique et d\u2019Energ\u00e9tique d\u2019Evry (LMEE), Universit\u00e9 \u00c9vry Paris-Saclay, 91020 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir-Ali","family":"Feiz","sequence":"additional","affiliation":[{"name":"Le Laboratoire de M\u00e9canique et d\u2019Energ\u00e9tique d\u2019Evry (LMEE), Universit\u00e9 \u00c9vry Paris-Saclay, 91020 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ngae","sequence":"additional","affiliation":[{"name":"Le Laboratoire de M\u00e9canique et d\u2019Energ\u00e9tique d\u2019Evry (LMEE), Universit\u00e9 \u00c9vry Paris-Saclay, 91020 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thien Phu","family":"Le","sequence":"additional","affiliation":[{"name":"Le Laboratoire de M\u00e9canique et d\u2019Energ\u00e9tique d\u2019Evry (LMEE), Universit\u00e9 \u00c9vry Paris-Saclay, 91020 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rousseaux","sequence":"additional","affiliation":[{"name":"Institut Pprime, Universit\u00e9 de Poitiers, CNRS UPR 3346, IRIAF, 11 rue Archim\u00e8de, 79000 Niort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, December 13). 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