{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T04:35:53Z","timestamp":1777178153751,"version":"3.51.4"},"reference-count":93,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016928","name":"National Institute of Pediatrics","doi-asserted-by":"crossref","award":["060\/2018"],"award-info":[{"award-number":["060\/2018"]}],"id":[{"id":"10.13039\/100016928","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Serotoninomics, a nascent emerging discipline within the field of omics, provides a transdisciplinary framework for understanding reproductive toxicology via serotonergic signalling. This research investigates the neuroendocrine effects of permethrin, a commonly used pyrethroid insecticide often considered to pose a low risk to humans, and positions it as a model compound for evaluating reproductive susceptibility beyond conventional endocrine endpoints. It is hypothesized that serotonin, traditionally examined in neuropsychiatric contexts, plays an essential role in gonadal function, hormonal regulation, and emotional resilience. Although permethrins are generally regarded as safe, acute exposure may subtly interfere with serotonergic pathways, potentially resulting in molecular, biochemical, behavioural, and reproductive alterations. These effects could extend beyond immediate exposure, including during gestation, considering permethrins\u2019 ability to cross the placental barrier and influence foetal development. By synthesizing evidence across molecular, organismal, and environmental domains, we advocate for a serotonergic approach to facilitate a more comprehensive assessment of risk and resilience. We emphasize the importance of fostering a transdisciplinary dialogue to redefine reproductive health through the perspectives of serotonergic vulnerability and systemic resilience.<\/jats:p>","DOI":"10.3390\/toxics14050365","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:28:23Z","timestamp":1777040903000},"page":"365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Serotoninomic Framework for Reproductive and Integrative Toxicology: Molecular, Neurochemical, and Behavioural Perspectives on Permethrin Exposure"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-2119","authenticated-orcid":false,"given":"Francisco","family":"Jim\u00e9nez-Trejo","sequence":"first","affiliation":[{"name":"Laboratorio de Morfolog\u00eda Celular y Tisular, Instituto Nacional de Pediatr\u00eda, Mexico City 04530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Carmona-Aparicio","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Instituto Nacional de Pediatr\u00eda, Mexico City 04530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-0784","authenticated-orcid":false,"given":"Elvia","family":"Coballase-Urrutia","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Instituto Nacional de Pediatr\u00eda, Mexico City 04530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia L.","family":"Jim\u00e9nez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento Psiquiatria, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Arriaga-Canon","sequence":"additional","affiliation":[{"name":"Laboratorio de Innovaci\u00f3n y Medicina de Precisi\u00f3n, Instituto Nacional de Medicina Gen\u00f3mica, Mexico City 14610, Mexico"},{"name":"Escuela de Ciencias M\u00e9dicas y de la Salud, Tecnol\u00f3gico de Monterrey, Mexico City 14380, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-9306","authenticated-orcid":false,"given":"Luis A.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias M\u00e9dicas y de la Salud, Tecnol\u00f3gico de Monterrey, Mexico City 14380, Mexico"},{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sheikh, I.A., and Beg, M.A. (2021). 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