{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:21:35Z","timestamp":1785410495993,"version":"3.56.0"},"reference-count":83,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Nacional del Centro del Per\u00fa","award":["N\u00b0072025293158"],"award-info":[{"award-number":["N\u00b0072025293158"]}]},{"award":["N\u00b0072025293158"],"award-info":[{"award-number":["N\u00b0072025293158"]}],"id":[{"id":"https:\/\/ror.org\/008d6q968","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Bovine milk is a primary dietary source of nutrients and bioactive compounds. However, its safety is increasingly under threat due to contamination from mining and intensive agriculture. In the Peruvian Andes, where small-scale dairy farming coexists with historical environmental liabilities, identifying the transfer of metals into the food chain is essential for public health. This study quantifies the concentrations of lead (Pb) and cadmium (Cd) in raw milk from small-scale producers in rural districts in the province of Huancayo. Non-carcinogenic risks for populations aged 2\u201385 years were assessed under three consumption scenarios. Forty-five samples were analyzed using microwave plasma atomic emission spectrometry (MP-AES). The mean concentrations of Pb and Cd were 11.30 \u00b1 18.94 \u00b5g\/kg and 7.85 \u00b1 18.11 \u00b5g\/kg, respectively, which are below the maximum permissible limits (MPL). However, spatial analysis identified critical hotspots near smelters, where Pb levels reached 103 \u00b5g\/kg, which is a significant exceedance of the MPL of 20 \u00b5g\/kg. Toxicological modelling showed that the Hazard Index (HI) remained below the unity threshold (HI &lt; 1) for all scenarios, ruling out immediate systemic risks. Nevertheless, the highest HI (0.78) was observed in two-year-old children in the high-consumption scenario, highlighting a localized neurodevelopmental concern. These findings emphasize the importance of georeferenced environmental monitoring and differentiated public health policies to mitigate the chronic low-level exposure to metals in vulnerable, high-altitude populations.<\/jats:p>","DOI":"10.3390\/toxics14050385","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:47:28Z","timestamp":1777546048000},"page":"385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Assessment of Lead and Cadmium Exposure Through Raw Milk Consumption from Small-Scale Dairy Systems in the Central Peruvian Andes"],"prefix":"10.3390","volume":"14","author":[{"given":"Doris","family":"Chirinos-Peinado","sequence":"first","affiliation":[{"name":"Food and Nutritional Security Research Group, Universidad Nacional del Centro del Per\u00fa, Huancayo 12000, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-6917","authenticated-orcid":false,"given":"Jorge","family":"Castro-Bedri\u00f1ana","sequence":"additional","affiliation":[{"name":"Food and Nutritional Security Research Group, Universidad Nacional del Centro del Per\u00fa, Huancayo 12000, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elva","family":"R\u00edos-R\u00edos","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Universidad Nacional Agraria La Molina, Lima 15012, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Castro-Chirinos","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Universidad Peruana de Ciencias Aplicadas, Lima 15086, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mery","family":"Baquerizo-Canchumanya","sequence":"additional","affiliation":[{"name":"Faculty of Applied Sciences of Tarma, Universidad Nacional del Centro del Per\u00fa, Tarma 12651, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.geoderma.2017.09.016","article-title":"Origin and spatial distribution of heavy metals and carcinogenic risk assessment in mining areas at You\u2019xi County southeast China","volume":"310","author":"Jiao","year":"2018","journal-title":"Geoderma"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"110984","DOI":"10.1016\/j.foodres.2022.110984","article-title":"Critical review: Metabolomics in dairy science\u2014Evaluation of milk and milk product quality","volume":"154","author":"Suh","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Souto, M.R., Pimenta, A.M., Catarino, R.I., Leal, M.F., and Sim\u00f5es, E.T.R. (2025). Heavy Metals in Milk and Dairy Products: Safety and Analysis. Pollutants, 5.","DOI":"10.3390\/pollutants5030029"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.envpol.2017.12.005","article-title":"Association between human exposure to heavy metals\/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana","volume":"235","author":"Ikenaka","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105401","DOI":"10.1016\/j.jfca.2023.105401","article-title":"Evaluation of biological (feed, water), seasonal, and geological factors affecting the heavy metal content of raw milk","volume":"121","author":"Dikici","year":"2023","journal-title":"J. Food Compos. Anal."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"109298","DOI":"10.1016\/j.envres.2020.109298","article-title":"Macroelements and toxic trace elements in muscle and liver of fish species from the largest three reservoirs in Turkey and human risk assessment based on the worst-case scenarios","volume":"184","author":"Varol","year":"2020","journal-title":"Environ. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zaw, Y.H., and Taneepanichskul, N. (2019). Blood heavy metals and brain-derived neurotrophic factor in the first trimester of pregnancy among migrant workers. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0218409"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1016\/j.scitotenv.2018.09.094","article-title":"Large scale study of the within and between spatial variability of lead, arsenic, and cadmium contamination of cow milk in China","volume":"650","author":"Zhou","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"141830","DOI":"10.1016\/j.scitotenv.2020.141830","article-title":"Heavy metals levels in raw cow milk and health risk assessment across the globe: A systematic review","volume":"751","author":"Boudebbouz","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez, D., Gonz\u00e1lez, D.F., Blanco, T., Pineda, B., G\u00f3mez, S., Marcial, J., Carrillo, P., and P\u00e9rez de la Cruz, V. (2021). Cognitive impairment induced by lead exposure during lifespan: Mechanisms of lead neurotoxicity. Toxics, 9.","DOI":"10.3390\/toxics9020023"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106468","DOI":"10.1016\/j.envint.2021.106468","article-title":"Metal and essential element concentrations during pregnancy and associations with autism spectrum disorder and attention-deficit\/hyperactivity disorder in children","volume":"152","author":"Skogheim","year":"2021","journal-title":"Environ. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113855","DOI":"10.1016\/j.ijheh.2021.113855","article-title":"Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility","volume":"238","author":"Gundacker","year":"2021","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_13","first-page":"100094","article-title":"Bioaccumulation of lead (Pb) and its effects on human: A review","volume":"7","author":"Collin","year":"2022","journal-title":"J. Hazard. Mater. Adv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"115714","DOI":"10.1016\/j.ecoenv.2023.115714","article-title":"Urinary heavy metals and attention-deficit\/hyperactivity symptoms of preschool children: A mixed-exposure analysis","volume":"268","author":"Huang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"175011","DOI":"10.1016\/j.scitotenv.2024.175011","article-title":"Is the milk we drink safe from elevated concentrations of prioritised heavy metals\/metalloids?\u2014A global systematic review and meta-analysis followed by a cursory risk assessment reporting","volume":"948","author":"Hasanvand","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_16","first-page":"797","article-title":"Molecular signature of cadmium-mediated neurodevelopmental disorders in prenatal to postnatal stages","volume":"24","author":"Preety","year":"2025","journal-title":"EXCLI J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jogn.2025.08.005","article-title":"Prevention of Lead Exposure in the Perinatal Period","volume":"55","author":"Wessel","year":"2025","journal-title":"J. Obstet. Gynecol. Neonatal Nurs."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1089\/ars.2017.7272","article-title":"Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: Redox signaling and oxidative stress","volume":"28","author":"Posadas","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/bs.ant.2020.11.002","article-title":"Chapter Five-Molecular mechanisms of lead neurotoxicity","volume":"5","author":"Virgolini","year":"2021","journal-title":"Adv. Neurotoxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"89874","DOI":"10.1007\/s11356-022-23620-6","article-title":"Metabolic effects of long-term cadmium exposure: An overview","volume":"29","author":"Chen","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00204-024-03903-2","article-title":"Heavy metals: Toxicity and human health effects","volume":"99","author":"Jomova","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.14334\/wartazoa.v27i3.1597","article-title":"Quality of Milk from Organic Farms","volume":"27","author":"Wanniatie","year":"2017","journal-title":"Wartazoa"},{"key":"ref_23","first-page":"23","article-title":"Level of lead contamination in the blood of Bali cattle associated with their age and geographical location","volume":"22","author":"Berata","year":"2021","journal-title":"Biodiversitas"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102485","DOI":"10.1016\/j.foodpol.2023.102485","article-title":"Growth in milk consumption and reductions in child stunting: Historical evidence from cross-country panel data","volume":"118","author":"Haile","year":"2023","journal-title":"Food Policy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102567","DOI":"10.1016\/j.foodpol.2023.102567","article-title":"Household dairy production, dairy intake, and anthropometric outcomes in rural Bangladesh","volume":"121","author":"Bakhtiar","year":"2023","journal-title":"Food Policy"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104864","DOI":"10.1016\/j.jfca.2022.104864","article-title":"Non-carcinogenic risk assessment of cadmium and lead in raw milk from dairy production farms in Iran, using Monte Carlo simulation approach","volume":"115","author":"Jaafarzadeh","year":"2023","journal-title":"J. Food Compos. Anal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"012005","DOI":"10.1088\/1755-1315\/1314\/1\/012005","article-title":"Analysis of Lead (Pb) and Cadmium (Cd) heavy metals in cow\u2019s milk in Central Java, Indonesia","volume":"1314","author":"Rachmawati","year":"2024","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"ref_28","first-page":"101558","article-title":"Health risk assessment of lead and cadmium in milk-based products of Iran","volume":"19","author":"Farahmandkia","year":"2025","journal-title":"J. Agric. Food Res."},{"key":"ref_29","unstructured":"USDA (2025, February 22). An Overview of Peru\u2019s Dairy Sector. Foreign Agricultural Service. Global Agricultural Information Network, Available online: https:\/\/apps.fas.usda.gov\/newgainapi\/api\/report\/downloadreportbyfilename?filename=Dairy%20Update_Lima_Peru_4-15-2019.pdf."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e03579","DOI":"10.1016\/j.heliyon.2020.e03579","article-title":"Lead and cadmium blood levels and transfer to milk in cattle reared in a mining area","volume":"6","year":"2020","journal-title":"Heliyon"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.25046\/aj050216","article-title":"Lead Bioaccumulation in Root and Aerial Part of Natural and Cultivated Pastures in Highly Contaminated Soils in Central Andes of Peru","volume":"5","year":"2020","journal-title":"Adv. Sci. Technol. Eng. Syst. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"112382","DOI":"10.1016\/j.ecoenv.2021.112382","article-title":"Dietary risk of milk contaminated with lead and cadmium in areas near mining-metallurgical industries in the Central Andes of Peru","volume":"220","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Chirinos-Peinado, D., Castro-Bedri\u00f1ana, J., R\u00edos-R\u00edos, E., Mamani-Gamarra, G., Quijada-Caro, E., Huacho-Jurado, A., and Nu\u00f1ez-Rojas, W. (2022). Lead and Cadmium Bioaccumulation in Fresh Cow\u2019s Milk in an Intermediate Area of the Central Andes of Peru and Risk to Human Health. Toxics, 10.","DOI":"10.3390\/toxics10060317"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Chirinos-Peinado, D., Castro-Bedri\u00f1ana, J., Barnes, E.P., R\u00edos-R\u00edos, E., Garc\u00eda-Olarte, E., and Castro-Chirinos, G. (2024). Assessing the Health Risk and Trophic Transfer of Lead and Cadmium in Dairy Farming Systems in the Mantaro Catchment, Central Andes of Peru. Toxics, 12.","DOI":"10.3390\/toxics12050308"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e04691","DOI":"10.1016\/j.heliyon.2020.e04691","article-title":"Heavy metal pollution in the environment and their toxicological effects on humans","volume":"6","author":"Briffa","year":"2020","journal-title":"Heliyon"},{"key":"ref_36","first-page":"e02737","article-title":"Determination of lead, cadmium, and arsenic concentrations in breast milk of women living in Misrata, Libya","volume":"28","author":"Serrar","year":"2025","journal-title":"Sci. Afr."},{"key":"ref_37","unstructured":"(2016). General Requirements for the Competence of Reference Material Producers (Standard No. ISO 17034 (2016))."},{"key":"ref_38","unstructured":"CENAN-INEI (2011). Estado Nutricional en el Per\u00fa. Componente Nutricional ENAHO-CENAN-INS, Ministerio de Salud. Available online: https:\/\/cdn.www.gob.pe\/uploads\/document\/file\/4527657\/Estado_Nutricional_en_el_Per%C3%BA_2009-2010.pdf?v=1683569874."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"103238","DOI":"10.1016\/j.jfca.2019.103238","article-title":"Determination of heavy metals and health risk assessment of cheese products consumed in Greece","volume":"82","author":"Christophoridis","year":"2010","journal-title":"J. Food Compos. Anal."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Singh, G.M., Micha, R., Khatibzadeh, S., Shi, P., Lim, S., Andrews, K.G., Engell, R.E., Ezzati, M., and Mozaffarian, D. (2015). Global, regional, and national consumption of sugar-sweetened beverages, fruit juices, and milk: A systematic assessment of beverage intake in 187 countries. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124845"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/19393210.2018.1520742","article-title":"Health risk due to chronic heavy metal consumption via cow\u2019s milk produced in Puebla, Mexico, in irrigated wastewater areas","volume":"12","author":"Guillermo","year":"2019","journal-title":"Food Addit. Contam. Part B"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"EFSA (2012). Lead dietary exposure in the European population. EFSA J., 10, 2831\u20132890.","DOI":"10.2903\/j.efsa.2012.2831"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"EFSA (2012). Cadmium dietary exposure in the European population. EFSA J., 10, 2551.","DOI":"10.2903\/j.efsa.2012.2551"},{"key":"ref_44","unstructured":"Joint FAO\/WHO Expert Committee on Food Additives (JECFA) (2011). Evaluation of Certain Food Additives and Contaminants, WHO. Available online: http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/44515\/WHO_TRS_960_eng.pdf."},{"key":"ref_45","unstructured":"Joint FAO\/WHO Expert Committee on Food Additives (JECFA) (2012). Safety Evaluation of Certain Food Additives and Contaminants: Prepared by the Seventy Fourth Meetings of the Joint FAO\/WHO Expert Committee on Food Additives (JECFA), World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241660655."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/MPG.0b013e318235b23e","article-title":"Is cows\u2019 milk harmful for a child\u02bcs health?","volume":"53","author":"Agostoni","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/nure.12078","article-title":"Dairy product intake in children and adolescents in developed countries: Trends, nutritional contribution, and a review of association with health outcomes","volume":"72","author":"Dror","year":"2013","journal-title":"Nutr. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000503357","article-title":"Role of milk and dairy products in growth of the child","volume":"93","author":"Grenov","year":"2020","journal-title":"Nestl\u00e9 Nutr. Inst. Workshop Ser."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.scitotenv.2018.04.138","article-title":"Lead and cadmium levels in raw bovine milk and dietary risk assessment in areas near petroleum extraction industries","volume":"635","author":"Norouzirad","year":"2018","journal-title":"Sci. Total. Environ."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Su, C., Gao, Y., Qu, X., Zhou, X., Yang, X., Huang, S., Han, L., Zheng, N., and Wang, J. (2021). The occurrence, pathways, and risk assessment of heavy metals in raw milk from industrial areas in China. Toxics, 9.","DOI":"10.3390\/toxics9120320"},{"key":"ref_51","unstructured":"World Health Organization (WHO) (2011). Safety Evaluation of Certain Food Additives and Contaminants, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/44521\/9789241660648_eng.pdf."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ecoenv.2014.09.008","article-title":"Human health risks from metals and metalloid via consumption of food animals near gold mines in Tarkwa, Ghana: Estimation of the daily intakes and target hazard quotients (THQs)","volume":"111","author":"Nakayama","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/19393210.2017.1316320","article-title":"Assessment risk to children\u2019s health due to consumption of cow\u2019s milk in polluted areas in Puebla and Tlaxcala, Mexico","volume":"10","author":"Moreno","year":"2017","journal-title":"Food Addit. Contam. Part B Surveill."},{"key":"ref_54","unstructured":"European Union (2021). Commission Regulation (EC) 2021\/1323 of 10 August 2021 amending regulation (EC) N\u00b01881\/2006 as regards maximum limit of cadmium in certain foodstuffs (Text with EEA relevance). Off. J. Eur. Union, 288, 13\u201318."},{"key":"ref_55","unstructured":"Codex Alimentarius Commission (2017). Working Document for Information and Use in Discussions Related to Contaminants and Toxins in the GSCTFF, Joint FAO-WHO, Food Standards Program Codex Committee on Contaminants in Foods. Available online: https:\/\/www.fao.org\/fao-who-codexalimentarius\/sh-proxy\/zh\/?lnk=1&url=https%253A%252F%252Fworkspace.fao.org%252Fsites%252Fcodex%252FMeetings%252FCX-735-11%252FWD%252Fcf11_INF01x.pdf."},{"key":"ref_56","unstructured":"FAO\/WHO-Food and Agriculture Organization, and World Health Organization (2011, January 21\u201325). Food Standards Program Codex Committee on Contaminants in Foods. Proceedings of the Foods Fifth Session, Hague, The Netherlands. Available online: http:\/\/www.fao.org\/tempref\/codex\/Meetings\/CCCF\/CCCF5\/cf05_INF.pdf."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Carrera-Beltr\u00e1n, L., Gavilanes-Ter\u00e1n, I., Valverde-Orozco, V.H., Ramos-Romero, S., Paredes, C., Carbonell-Barrachina, \u00c1.A., and Signes-Pastor, A.J. (2025). Assessment of Heavy Metal Transfer from Soil to Forage and Milk in the Tungurahua Volcano Area, Ecuador. Agriculture, 15.","DOI":"10.3390\/agriculture15192072"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"88","DOI":"10.15406\/ijh.2022.06.00306","article-title":"Heavy metals and their impact on surface waters of the Mantaro river basin, Junin, Peru","volume":"6","author":"Chira","year":"2022","journal-title":"Int. J. Hydrol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1016\/j.scitotenv.2018.10.047","article-title":"Trace elements in soil-vegetables interface: Translocation, bioaccumulation, toxicity and amelioration\u2014A review","volume":"651","author":"Gupta","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"418","DOI":"10.25046\/aj050153","article-title":"Biofortification of the Ryegrass (Lolium multiflorum L.) with Chicken Manure Compost in the Central Sierra of Peru","volume":"5","year":"2020","journal-title":"Adv. Sci. Technol. Eng. Syst. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"117138","DOI":"10.1016\/j.geoderma.2024.117138","article-title":"Comprehensive spatial mapping of metals and metalloids in the Peruvian Mantaro Valley using advanced geospatial data Integration","volume":"453","author":"Pizarro","year":"2025","journal-title":"Geoderma"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.gca.2018.02.021","article-title":"More than ten million years of hyper-aridity recorded in the Atacama Gravels","volume":"227","author":"Sun","year":"2018","journal-title":"Geochim. Cosmochim. Acta"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"878","DOI":"10.2471\/BLT.12.106419","article-title":"Lead exposure from soil in Peruvian mining towns: A national assessment supported by two contrasting examples","volume":"90","author":"Bravo","year":"2012","journal-title":"Bull. World Health Organ."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ecoenv.2014.12.025","article-title":"Contamination and health risks of soil heavy metals around a lead\/zinc smelter in southwestern China","volume":"113","author":"Li","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00128-012-0550-x","article-title":"Contamination of Cow\u2019s milk by heavy metal in Egypt","volume":"88","author":"Malhat","year":"2012","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jtemb.2018.06.022","article-title":"Analysis of lead and cadmium in cereal products and duplicate diets of a small group of selected Brisbane children for estimation of daily metal exposure","volume":"50","author":"Tinggi","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.scitotenv.2019.04.337","article-title":"Geographical variation in arsenic, cadmium, and lead of soils and rice in the major rice producing regions of China","volume":"677","author":"Mu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"104152","DOI":"10.1016\/j.jfca.2021.104152","article-title":"Essential and potentially toxic elements in raw milk from different geographical regions of Croatia and their health risk assessment in the adult population","volume":"104","author":"Sedak","year":"2021","journal-title":"J. Food Compos. Anal."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/1471-0307.12764","article-title":"Concentrations of toxic elements (As, Cd, Hg and Pb) in cow milk: A review of the recent scientific literature","volume":"74","author":"Domingo","year":"2021","journal-title":"Int. J. Dairy Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s10661-020-8088-6","article-title":"Determination of some element levels in various kinds of cow\u2019s milk processed in different ways","volume":"192","author":"Totan","year":"2020","journal-title":"Environ. Monit. Assess."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"101481","DOI":"10.1016\/j.nexres.2026.101481","article-title":"Lead and cadmium in raw milk from family-based dairy systems in the central highlands of Peru: Implications for physicochemical composition and potential health risk","volume":"7","author":"Barnes","year":"2026","journal-title":"Next Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"113973","DOI":"10.1016\/j.jece.2024.113973","article-title":"Understanding the silent threat: Lead exposure in children and its detection using colorimetric and fluorimetric methods","volume":"12","author":"Alissa","year":"2024","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.2174\/0929867330666230409135310","article-title":"Early-Life Lead Exposure: Risks and Neurotoxic Consequences","volume":"31","author":"Tippairote","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"106587","DOI":"10.1016\/j.envint.2021.106587","article-title":"Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation","volume":"155","author":"Childebayeva","year":"2021","journal-title":"Environ. Int."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Wang, T., Zhang, J., and Xu, Y. (2020). Epigenetic basis of lead-induced neurological disorders. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17134878"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural effects of developmental toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/toxsci\/kfs090","article-title":"Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): Implications for an environmental basis of neurodevelopmental disorders","volume":"127","author":"Stansfield","year":"2012","journal-title":"Toxicol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1289\/ehp.0901234","article-title":"Cadmium, environmental exposure, and health outcomes","volume":"118","author":"Satarug","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Generalova, A., Davidova, S., and Satchanska, G. (2025). The Mechanisms of Lead Toxicity in Living Organisms. J. Xenobiot., 15.","DOI":"10.20944\/preprints202507.1462.v1"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Qu, F., and Zheng, W. (2024). Cadmium Exposure: Mechanisms and Pathways of Toxicity and Implications for Human Health. Toxics, 12.","DOI":"10.3390\/toxics12060388"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kwon, Y., Lee, S.W., Cho, Y.S., Jeong, S.J., and Han, M.Y. (2021). Is High Milk Intake Good for Children\u2019s Health? A National Population-Based Observational Cohort Study. Nutrients, 13.","DOI":"10.3390\/nu13103494"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Basaran, B. (2025). Occurrence of Potentially Toxic Metals Detected in Milk and Dairy Products in T\u00fcrkiye: An Assessment in Terms of Human Exposure and Health Risks. Foods, 14.","DOI":"10.3390\/foods14152561"},{"key":"ref_83","unstructured":"(2010). EFSA Panel on Contaminants (CONTAM). Scientific Opinion on Lead in Food. EFSA J., 8, 1570."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/5\/385\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:27:49Z","timestamp":1777548469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/5\/385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":83,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["toxics14050385"],"URL":"https:\/\/doi.org\/10.3390\/toxics14050385","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}