{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:31:28Z","timestamp":1786699888576,"version":"build-2736575974"},"reference-count":66,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Areas Research and Development Programs of Guangdong","award":["2023B0303040001"],"award-info":[{"award-number":["2023B0303040001"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2024A151501522"],"award-info":[{"award-number":["2024A151501522"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Center of Technology Innovation for Dairy","award":["2023-JSCG-8"],"award-info":[{"award-number":["2023-JSCG-8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The metabolic mechanisms linking prenatal particulate matter (PM) to fetal growth remain unclear. A prospective cohort of 616 mother\u2013fetus pairs in Guangzhou had ultrasound-based fetal growth parameters repeatedly measured from mid to late pregnancy. Fetal head circumference (HC), abdominal circumference (AC), femur length (FL), and biparietal diameter (BPD) were standardized as z-scores. Estimated fetal weight (EFW) trajectories were classified as average, slow, and rapid growth. Residential PM1, PM2.5, and PM10 were assessed with 1 km spatiotemporal models. Multinomial logistic regression analyzed PM-EFW trajectory associations. Generalized estimating equations evaluated PM\u2013fetal growth z-score relationships. Maternal plasma glucose and insulin levels at mid-pregnancy were examined as intermediate factors. Each 5 \u03bcg\/m3 increase in PM was associated with higher odds of rapid EFW growth versus average growth (OR PM1 = 1.56, 95% CI: 1.03, 2.37; OR PM2.5 = 1.44, 95% CI: 1.10, 1.88; OR PM10 = 1.28, 95% CI: 1.05, 1.56). Positive associations were also observed for BPD, HC, and AC z-scores, with PM1 showing the numerically larger effect estimates. Maternal fasting plasma glucose and insulin resistance may partly explain the observed associations of PM exposure with rapid EFW growth and fetal growth parameters, with estimated proportions of 5.0\u201329.4%. This study highlights the potential risk of accelerated fetal growth associated with maternal PM exposures, and maternal glucose metabolism may represent a plausible pathway.<\/jats:p>","DOI":"10.3390\/toxics14080709","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:57:26Z","timestamp":1786521446000},"page":"709","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Exposure to Size-Fractionated Particulate Matter and Fetal Growth Trajectories: Mediation by Maternal Glucose Metabolism in a Birth Cohort"],"prefix":"10.3390","volume":"14","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Child Healthcare, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China"},{"name":"Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Child Healthcare, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China"},{"name":"Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou 510631, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-5986","authenticated-orcid":false,"given":"Li","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiliang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Child Healthcare, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China"},{"name":"Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Child Healthcare, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China"},{"name":"Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-0531","authenticated-orcid":false,"given":"Yujing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","unstructured":"Health Effects Institute (2024, November 20). State of Global Air 2024. Available online: https:\/\/www.healthdata.org\/research-analysis\/library\/state-global-air-2024."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jmwh.2007.03.020","article-title":"Air Pollution: Impact on Maternal and Perinatal Health","volume":"52","author":"Hackley","year":"2007","journal-title":"J. Midwifery Women\u2019s Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e804","DOI":"10.1016\/S2542-5196(22)00200-5","article-title":"Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: An analysis of two independent population-based observational studies","volume":"6","author":"Bongaerts","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1289\/ehp.9081","article-title":"Exposures to Airborne Particulate Matter and Adverse Perinatal Outcomes: A Biologically Plausible Mechanistic Framework for Exploring Potential Effect Modification by Nutrition","volume":"114","author":"Kannan","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1289\/ehp.11074","article-title":"Meeting Report: Atmospheric Pollution and Human Reproduction","volume":"116","author":"Slama","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1095\/biolreprod.108.069591","article-title":"Particulate Urban Air Pollution Affects the Functional Morphology of Mouse Placenta","volume":"79","author":"Veras","year":"2008","journal-title":"Biol. Reprod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/uog.11204","article-title":"Fetal growth: A review of terms, concepts and issues relevant to obstetrics","volume":"41","author":"Mayer","year":"2013","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/uog.20279","article-title":"Maternal and neonatal complications of fetal macrosomia: Systematic review and meta-analysis","volume":"54","author":"Beta","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"MacDonald, T.M., Robinson, A.J., Hiscock, R.J., Hui, L., Dane, K.M., Middleton, A.L., Kennedy, L.M., Tong, S., and Walker, S.P. (2021). Accelerated fetal growth velocity across the third trimester is associated with increased shoulder dystocia risk among fetuses who are not large-for-gestational-age: A prospective observational cohort study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0258634"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1467-789X.2011.00867.x","article-title":"Birth weight and subsequent risk of obesity: A systematic review and meta-analysis","volume":"12","author":"Yu","year":"2011","journal-title":"Obes. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/oby.23701","article-title":"Association of large for gestational age with cardiovascular metabolic risks: A systematic review and meta-analysis","volume":"31","author":"Zhang","year":"2023","journal-title":"Obesity"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"150744","DOI":"10.1016\/j.scitotenv.2021.150744","article-title":"Maternal exposure to ambient PM2.5 and term birth weight: A systematic review and meta-analysis of effect estimates","volume":"807","author":"Gong","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"116526","DOI":"10.1016\/j.ecoenv.2024.116526","article-title":"Prenatal exposure to ambient air pollution and risk of fetal overgrowth: Systematic review of cohort studies","volume":"280","author":"Rahnemaei","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3109\/08958378.2013.850127","article-title":"Particulate matter beyond mass: Recent health evidence on the role of fractions, chemical constituents and sources of emission","volume":"25","author":"Cassee","year":"2013","journal-title":"Inhal. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110726","DOI":"10.1016\/j.ecoenv.2020.110726","article-title":"Prenatal exposure to ambient air multi-pollutants significantly impairs intrauterine fetal development trajectory","volume":"201","author":"Shao","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.envres.2019.03.056","article-title":"Prenatal exposure to fine particulate matter, maternal hemoglobin concentration, and fetal growth during early pregnancy: Associations and mediation effects analysis","volume":"173","author":"Liao","year":"2019","journal-title":"Environ. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"017004","DOI":"10.1289\/EHP9824","article-title":"Exposure to PM2.5 during Pregnancy and Fetal Growth in Eastern Massachusetts, USA","volume":"130","author":"Leung","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1289\/ehp.1003316","article-title":"Air Pollution Exposure During Pregnancy, Ultrasound Measures of Fetal Growth, and Adverse Birth Outcomes: A Prospective Cohort Study","volume":"120","author":"Pierik","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"114628","DOI":"10.1016\/j.envres.2022.114628","article-title":"Susceptible windows of exposure to fine particulate matter and fetal growth trajectories in the Spanish INMA (INfancia y Medio Ambiente) birth cohort","volume":"216","author":"Chen","year":"2023","journal-title":"Environ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ji, N., Johnson, M., Eckel, S.P., Gauderman, W.J., Chavez, T.A., Berhane, K., Faham, D., Lurmann, F., Pavlovic, N.R., and Grubbs, B.H. (2023). Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: A cohort study. BMC Med., 21.","DOI":"10.1186\/s12916-023-03050-y"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"110627","DOI":"10.1016\/j.envres.2020.110627","article-title":"Prenatal exposure to air pollutants and early childhood growth trajectories: A population-based prospective birth cohort study","volume":"194","author":"Tan","year":"2021","journal-title":"Environ. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/ije\/dyy019","article-title":"Effects of prenatal exposure to ambient air pollutant PM10 on ultrasound-measured fetal growth","volume":"47","author":"Zhao","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e2236003","DOI":"10.1001\/jamanetworkopen.2022.36003","article-title":"Associations of Early-Life Exposure to Submicron Particulate Matter With Childhood Asthma and Wheeze in China","volume":"5","author":"Wu","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"125314","DOI":"10.1016\/j.envpol.2024.125314","article-title":"Characterization of soot and crystalline atmospheric ultrafine particles","volume":"364","author":"Schiavo","year":"2025","journal-title":"Environ. Pollut."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s41598-025-30407-5","article-title":"The role of fine and submicron aerosol particles in urban air pollution in the context of meeting new air quality standards","volume":"16","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"110729","DOI":"10.1016\/j.envres.2021.110729","article-title":"Prenatal exposure to airborne particulate matter of 1 \u03bcm or less and fetal growth: A birth cohort study in Beijing, China","volume":"194","author":"Lin","year":"2021","journal-title":"Environ. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ije\/dyad021","article-title":"Individual and joint effect of indoor air pollution index and ambient particulate matter on fetal growth: A prospective cohort study","volume":"52","author":"Zhou","year":"2023","journal-title":"Int. J. Epidemiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"106313","DOI":"10.1016\/j.envint.2020.106313","article-title":"Prenatal fine particulate matter exposure, placental DNA methylation changes, and fetal growth","volume":"147","author":"Zhao","year":"2021","journal-title":"Environ. Int."},{"key":"ref_29","unstructured":"Kovacs, C.S., and Deal, C.L. (2020). Chapter 34\u2014Developmental Physiology of Carbohydrate Metabolism and the Pancreas. Maternal-Fetal and Neonatal Endocrinology, Academic Press."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"HAPO Study Cooperative Research Group, Metzger, B.E., Lowe, L.P., Dyer, A.R., Trimble, E.R., Chaovarindr, U., Coustan, D.R., Hadden, D.R., McCance, D.R., and Hod, M. (2008). Hyperglycemia and adverse pregnancy outcomes. N. Engl. J. Med., 358, 1991\u20132002.","DOI":"10.1056\/NEJMoa0707943"},{"key":"ref_31","first-page":"292","article-title":"Placental regulation of fetal nutrient supply","volume":"16","author":"Koletzko","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1021\/acs.est.4c03087","article-title":"Gestational and Postpartum Exposure to PM 2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study","volume":"58","author":"Chen","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"128404","DOI":"10.1016\/j.chemosphere.2020.128404","article-title":"Prenatal exposure to fine particulate matter and fetal growth: A cohort study from a velocity perspective","volume":"262","author":"Cao","year":"2021","journal-title":"Chemosphere"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"115128","DOI":"10.1016\/j.envpol.2020.115128","article-title":"The mediation effect of maternal glucose on the association between ambient air pollution and birth weight in Foshan, China","volume":"266","author":"Yang","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9378(85)90298-4","article-title":"Estimation of fetal weight with the use of head, body, and femur measurements\u2014A prospective study","volume":"151","author":"Hadlock","year":"1985","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105793","DOI":"10.1016\/j.envint.2020.105793","article-title":"The associations of residential greenness with fetal growth in utero and birth weight: A birth cohort study in Beijing, China","volume":"141","author":"Lin","year":"2020","journal-title":"Environ. Int."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Dai, L., Deng, C., Li, Y., Zhu, J., Mu, Y., Deng, Y., Mao, M., Wang, Y., Li, Q., and Ma, S. (2014). Birth Weight Reference Percentiles for Chinese. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104779"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.5194\/acp-20-3273-2020","article-title":"Improved 1 km resolution PM2.5 estimates across China using enhanced space\u2013time extremely randomized trees","volume":"20","author":"Wei","year":"2020","journal-title":"Atmos. Chem. Phys."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13265","DOI":"10.1021\/acs.est.9b03258","article-title":"Satellite-Derived 1-km-Resolution PM1 Concentrations from 2014 to 2018 across China","volume":"53","author":"Wei","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"106290","DOI":"10.1016\/j.envint.2020.106290","article-title":"The ChinaHighPM10 dataset: Generation, validation, and spatiotemporal variations from 2015 to 2019 across China","volume":"146","author":"Wei","year":"2021","journal-title":"Environ. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"112136","DOI":"10.1016\/j.rse.2020.112136","article-title":"Reconstructing 1-km-resolution high-quality PM2.5 data records from 2000 to 2018 in China: Spatiotemporal variations and policy implications","volume":"252","author":"Wei","year":"2021","journal-title":"Remote Sens. Environ."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger, B.E., Gabbe, S.G., Persson, B., Buchanan, T.A., Catalano, P.A., Damm, P., Dyer, A.R., de Leiva, A., and Hod, M. (2010). Panel International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy. Diabetes Care, 33, 676\u2013682.","DOI":"10.2337\/dc09-1848"},{"key":"ref_43","first-page":"1","article-title":"Estimation of Extended Mixed Models Using Latent Classes and Latent Processes: The R Package lcmm","volume":"78","author":"Philipps","year":"2017","journal-title":"J. Stat. Softw."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12940-022-00925-0","article-title":"Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort","volume":"21","author":"Peterson","year":"2022","journal-title":"Environ. Health"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-publhealth-032315-021402","article-title":"Mediation Analysis: A Practitioner\u2019s Guide","volume":"37","author":"VanderWeele","year":"2016","journal-title":"Annu. Rev. Public Health"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1207\/s15327906mbr3901_4","article-title":"Confidence Limits for the Indirect Effect: Distribution of the Product and Resampling Methods","volume":"39","author":"Mackinnon","year":"2004","journal-title":"Multivar. Behav. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1007\/s10461-015-1042-x","article-title":"Mediation of an Efficacious HIV Risk Reduction Intervention for South African Men","volume":"19","author":"Jemmott","year":"2015","journal-title":"AIDS Behav."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","article-title":"Bias reduction of maximum likelihood estimates","volume":"80","author":"Firth","year":"1993","journal-title":"Biometrika"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.envint.2017.07.018","article-title":"Maternal exposure to ambient air pollution and fetal growth in North-East Scotland: A population-based study using routine ultrasound scans","volume":"107","author":"Clemens","year":"2017","journal-title":"Environ. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.scitotenv.2017.11.058","article-title":"Air pollution exposure during pregnancy and ultrasound and birth measures of fetal growth: A prospective cohort study in Korea","volume":"619\u2013620","author":"Lamichhane","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12940-019-0485-3","article-title":"Maternal exposure to ambient fine particulate matter and fetal growth in Shanghai, China","volume":"18","author":"Cao","year":"2019","journal-title":"Environ. Health"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"136246","DOI":"10.1016\/j.scitotenv.2019.136246","article-title":"The associations of particulate matters with fetal growth in utero and birth weight: A birth cohort study in Beijing, China","volume":"709","author":"Lin","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11465","DOI":"10.1021\/acs.est.3c03280","article-title":"Association of Fine Particulate Matter and Its Components with Macrosomia: A Nationwide Birth Cohort Study of 336 Chinese Cities","volume":"57","author":"Huang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"116792","DOI":"10.1016\/j.envpol.2021.116792","article-title":"The association of prenatal exposure to particulate matter with infant growth: A birth cohort study in Beijing, China","volume":"277","author":"Zhou","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Modzelewski, J., Kajdy, A., Muzyka-Placzy\u0144ska, K., Sys, D., and Rabijewski, M. (2021). Fetal Growth Acceleration\u2014Current Approach to the Big Baby Issue. Medicina, 57.","DOI":"10.20944\/preprints202101.0374.v1"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S2213-8587(20)30024-3","article-title":"Glycaemic status during pregnancy and longitudinal measures of fetal growth in a multi-racial US population: A prospective cohort study","volume":"8","author":"Li","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S2213-8587(20)30189-3","article-title":"Gestational diabetes and fetal overgrowth: Time to rethink screening guidelines","volume":"8","author":"Chiefari","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"215.e1","DOI":"10.1016\/j.ajog.2020.07.050","article-title":"Early pregnancy metabolites predict gestational diabetes mellitus: Implications for fetal programming","volume":"224","author":"Koos","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.metabol.2011.09.009","article-title":"The association between triglyceride to high-density-lipoprotein cholesterol ratio and insulin resistance in a multiethnic primary prevention cohort","volume":"61","author":"Gasevic","year":"2012","journal-title":"Metabolism"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/cen.12742","article-title":"The associations between triglyceride to high-density lipoprotein cholesterol ratios and the risks of gestational diabetes mellitus and large-for-gestational-age infant","volume":"83","author":"Wang","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Stefaniak, M., Dmoch-Gajzlerska, E., Mazurkiewicz, B., and Gajzlerska-Majewska, W. (2019). Maternal serum and cord blood leptin concentrations at delivery. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0224863"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/ijpo.12248","article-title":"Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight","volume":"13","author":"Alderete","year":"2018","journal-title":"Pediatr. Obes."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/ppe.12074","article-title":"Maternal Weight Status, Cord Blood Leptin and Fetal Growth: A Prospective Mother\u2013Child Cohort Study (Rhea Study)","volume":"27","author":"Karakosta","year":"2013","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s00018-020-03674-w","article-title":"Regulation of maternal-fetal metabolic communication","volume":"78","author":"Bowman","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/1471-0528.17727","article-title":"Ambient air pollution and adverse birth outcomes: A review of underlying mechanisms","volume":"131","author":"Fussell","year":"2024","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_66","unstructured":"Obstetrics Subgroup, Chinese Society of Obstetrics and Gynecology, Chinese Medical Association (2018). Guideline of preconception and prenatal care(2018). Zhonghua Fu Chan Ke Za Zhi, 53, 7\u201313."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/8\/709\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:46:38Z","timestamp":1786697198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/8\/709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":66,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["toxics14080709"],"URL":"https:\/\/doi.org\/10.3390\/toxics14080709","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}