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Microcystin-LR (MC-LR), the most prevalent microcystin congener, is well known for its hepatotoxicity, yet accumulating evidence indicates that it also exerts reproductive and developmental toxicity in mammals. This review summarizes recent experimental and epidemiological studies indicating that MC-LR disrupts reproductive function through direct cellular injury to germ and somatic cells, dysregulation of gonadal steroidogenesis, and impairment of the hypothalamic-pituitary-gonadal (HPG) axis. In males, MC-LR disrupts spermatogenesis and sperm quality, while in females it impairs oocyte competence, uterine receptivity, and placental function, leading to adverse pregnancy outcomes. Importantly, exposure during critical developmental windows can influence developmental trajectories and contribute to long-term, multi-organ dysfunction in offspring via endocrine imbalance and epigenetic reprogramming. Mechanistically, MC-LR toxicity involves convergent oxidative stress, mitochondrial dysfunction, inflammatory signaling, DNA damage, and chromatin remodeling. Collectively, these findings indicate that reproductive and developmental toxicity should be considered in assessments of the health risks associated with MC-LR and support the incorporation of reproductive endpoints into human health and ecological risk assessment frameworks.<\/jats:p>","DOI":"10.3390\/toxics14080734","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:37:34Z","timestamp":1787312254000},"page":"734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reproductive and Developmental Toxicity of Microcystin-LR in Mammals"],"prefix":"10.3390","volume":"14","author":[{"given":"Youngran","family":"Ku","sequence":"first","affiliation":[{"name":"Department of Science Education, Ewha Womans University, Seoul 03760, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3022-8735","authenticated-orcid":false,"given":"Sooyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Science Education, Ewha Womans University, Seoul 03760, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5326-9124","authenticated-orcid":false,"given":"Changwon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Science Education, Ewha Womans University, Seoul 03760, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5334\/aogh.2831","article-title":"Human Health and Ocean Pollution","volume":"86","author":"Landrigan","year":"2020","journal-title":"Ann. Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.taap.2004.02.016","article-title":"Cyanobacterial toxins: Risk management for health protection","volume":"203","author":"Codd","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1111\/gcb.16077","article-title":"Global divergent trends of algal blooms detected by satellite during 1982\u20132018","volume":"28","author":"Fang","year":"2022","journal-title":"Glob. Chang. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s43247-026-03446-7","article-title":"Anthropogenic and climatic factors regulate algal bloom intensity and timing in global lakes under climate change","volume":"7","author":"Xue","year":"2026","journal-title":"Commun. Earth Environ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1289\/ehp.01109663","article-title":"Human fatalities from cyanobacteria: Chemical and biological evidence for cyanotoxins","volume":"109","author":"Carmichael","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2478\/10004-1254-64-2013-2320","article-title":"Human exposure to cyanotoxins and their effects on health","volume":"64","author":"Drobac","year":"2013","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"179260","DOI":"10.1016\/j.scitotenv.2025.179260","article-title":"Management of cyanobacteria and cyanotoxins in drinking water: A comprehensive review on occurrence, toxicity, challenges and treatment approaches","volume":"976","author":"Sahu","year":"2025","journal-title":"Sci. Total Environ."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Meriluoto, J., Spoof, L., and Codd, G.A. (2017). Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis, Wiley.","DOI":"10.1002\/9781119068761"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1016\/j.watres.2006.08.010","article-title":"Methods for determining microcystins (peptide hepatotoxins) and microcystin-producing cyanobacteria","volume":"40","author":"Sangolkar","year":"2006","journal-title":"Water Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bouaicha, N., Miles, C.O., Beach, D.G., Labidi, Z., Djabri, A., Benayache, N.Y., and Nguyen-Quang, T. (2019). Structural Diversity, Characterization and Toxicology of Microcystins. Toxins, 11.","DOI":"10.20944\/preprints201910.0034.v1"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.toxicon.2018.07.010","article-title":"Exposure routes and health effects of microcystins on animals and humans: A mini-review","volume":"151","author":"Massey","year":"2018","journal-title":"Toxicon"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.envint.2016.02.026","article-title":"Acute animal and human poisonings from cyanotoxin exposure\u2014A review of the literature","volume":"91","author":"Wood","year":"2016","journal-title":"Environ. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00204-016-1921-6","article-title":"Toxicology of microcystins with reference to cases of human intoxications and epidemiological investigations of exposures to cyanobacteria and cyanotoxins","volume":"91","author":"Svircev","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"925","DOI":"10.15585\/mmwr.mm6535a1","article-title":"Community Needs Assessment After Microcystin Toxin Contamination of a Municipal Water Supply\u2014Lucas County, Ohio, September 2014","volume":"65","author":"McCarty","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.toxicon.2009.07.006","article-title":"Recreational exposure to microcystins during algal blooms in two California lakes","volume":"55","author":"Backer","year":"2010","journal-title":"Toxicon"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.watres.2007.02.013","article-title":"Distribution and bioaccumulation of microcystins in water columns: A systematic investigation into the environmental fate and the risks associated with microcystins in Meiliang Bay, Lake Taihu","volume":"41","author":"Song","year":"2007","journal-title":"Water Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10661-007-0016-5","article-title":"Seasonal variations in microcystin concentrations in Lake Taihu, China","volume":"145","author":"Xu","year":"2008","journal-title":"Environ. Monit. Assess."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10661-017-6058-4","article-title":"Management of toxic cyanobacteria for drinking water production of Ain Zada Dam","volume":"189","author":"Saoudi","year":"2017","journal-title":"Environ. Monit. Assess."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41579-018-0040-1","article-title":"Cyanobacterial blooms","volume":"16","author":"Huisman","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"119807","DOI":"10.1016\/j.watres.2023.119807","article-title":"Harmful cyanobacteria-diatom\/dinoflagellate blooms and their cyanotoxins in freshwaters: A nonnegligible chronic health and ecological hazard","volume":"233","author":"Zhang","year":"2023","journal-title":"Water Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.toxicon.2005.01.003","article-title":"Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in two freshwater shrimps, Palaemon modestus and Macrobrachium nipponensis, from a large shallow, eutrophic lake of the subtropical China","volume":"45","author":"Chen","year":"2005","journal-title":"Toxicon"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0300-483X(03)00112-4","article-title":"Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice","volume":"188","author":"Gupta","year":"2003","journal-title":"Toxicology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1021\/acs.est.5b03369","article-title":"First Identification of the Toxicity of Microcystins on Pancreatic Islet Function in Humans and the Involved Potential Biomarkers","volume":"50","author":"Zhao","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"127702","DOI":"10.1289\/EHP9736","article-title":"Association between Semen Microcystin Levels and Reproductive Quality: A Cross-Sectional Study in Jiangsu and Anhui Provinces, China","volume":"129","author":"Xu","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"119451","DOI":"10.1016\/j.ecoenv.2025.119451","article-title":"MC-LR triggers trophoblast ferroptosis at the maternal-fetal interface by directly targeting PKM2 to reprogram metabolism","volume":"307","author":"Guo","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.taap.2004.08.012","article-title":"Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin","volume":"203","author":"Fischer","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/S0041-0101(98)00128-7","article-title":"The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types","volume":"36","author":"McDermott","year":"1998","journal-title":"Toxicon"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1039\/C7TX00043J","article-title":"Toxic mechanisms of microcystins in mammals","volume":"6","author":"McLellan","year":"2017","journal-title":"Toxicol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Arman, T., and Clarke, J.D. (2021). Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. Toxins, 13.","DOI":"10.3390\/toxins13080537"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jhazmat.2015.08.041","article-title":"A review of reproductive toxicity of microcystins","volume":"301","author":"Chen","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.toxicon.2022.02.007","article-title":"Male reproductive toxicity induced by Microcystin-leucine-arginine (MC-LR)","volume":"210","author":"Xu","year":"2022","journal-title":"Toxicon"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.toxrep.2015.01.008","article-title":"An overview of the toxic effect of potential human carcinogen Microcystin-LR on testis","volume":"2","author":"Lone","year":"2015","journal-title":"Toxicol. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s10646-013-1141-2","article-title":"Distribution of microcystin-LR to testis of male Sprague-Dawley rats","volume":"22","author":"Wang","year":"2013","journal-title":"Ecotoxicology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"112919","DOI":"10.1016\/j.ecoenv.2021.112919","article-title":"The activated ATM\/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells","volume":"227","author":"Tian","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"113454","DOI":"10.1016\/j.ecoenv.2022.113454","article-title":"Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA\/ROCK pathway","volume":"236","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"127868","DOI":"10.1016\/j.chemosphere.2020.127868","article-title":"MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells","volume":"263","author":"Zhao","year":"2021","journal-title":"Chemosphere"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"116191","DOI":"10.1016\/j.ecoenv.2024.116191","article-title":"Pubertal exposure to Microcystin-LR arrests spermatogonia proliferation by inducing DSB and inhibiting SIRT6 dependent DNA repair in vivo and in vitro","volume":"274","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"126969","DOI":"10.1016\/j.envpol.2025.126969","article-title":"UCHL3-mediated proteasomal degradation of GOPC drives microcystin-LR-induced acrosomal dysgenesis","volume":"384","author":"Gan","year":"2025","journal-title":"Environ. Pollut."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"146730","DOI":"10.1016\/j.scitotenv.2021.146730","article-title":"Microcystin-LR inhibits testosterone synthesis via reactive oxygen species-mediated GCN2\/eIF2alpha pathway in mouse testes","volume":"781","author":"Gao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"111748","DOI":"10.1016\/j.ecoenv.2020.111748","article-title":"Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice","volume":"208","author":"Jin","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"128295","DOI":"10.1016\/j.chemosphere.2020.128295","article-title":"Chronic exposure to microcystin-LR increases the risk of prostate cancer and induces malignant transformation of human prostate epithelial cells","volume":"263","author":"Pan","year":"2021","journal-title":"Chemosphere"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.toxicon.2022.02.023","article-title":"Microcystin-LR induced microfilament rearrangement and cell invasion by activating ERK\/VASP\/ezrin pathway in DU145 cells","volume":"210","author":"Zhang","year":"2022","journal-title":"Toxicon"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"120843","DOI":"10.1016\/j.envpol.2022.120843","article-title":"Acute exposure to microcystins affects hypothalamic-pituitary axes of male rats","volume":"318","author":"Shi","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"166839","DOI":"10.1016\/j.scitotenv.2023.166839","article-title":"Effects of sub-chronic exposure to microcystin-LR on the endocrine system of male rats","volume":"906","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/tox.20467","article-title":"Microcystin extracts induce ultrastructural damage and biochemical disturbance in male rabbit testis","volume":"25","author":"Liu","year":"2010","journal-title":"Environ. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.fct.2013.07.039","article-title":"Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo","volume":"60","author":"Wang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.fct.2017.04.014","article-title":"Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring","volume":"105","author":"Zhang","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2131\/jts.38.661","article-title":"In vivo study on the effects of microcystin-LR on the apoptosis, proliferation and differentiation of rat testicular spermatogenic cells of male rats injected i.p. with toxins","volume":"38","author":"Zhou","year":"2013","journal-title":"J. Toxicol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.reprotox.2008.09.004","article-title":"The toxic effects of microcystin-LR on the reproductive system of male rats in vivo and in vitro","volume":"26","author":"Li","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"39238","DOI":"10.1038\/srep39238","article-title":"Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.fct.2018.01.004","article-title":"Essential roles of Akt\/Snail pathway in microcystin-LR-induced tight junction toxicity in Sertoli cell","volume":"112","author":"Zhou","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chen, L., Zhang, X., Zhou, W., Qiao, Q., Liang, H., Li, G., Wang, J., and Cai, F. (2013). The interactive effects of cytoskeleton disruption and mitochondria dysfunction lead to reproductive toxicity induced by microcystin-LR. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053949"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.reprotox.2011.02.006","article-title":"Decline of sperm quality and testicular function in male mice during chronic low-dose exposure to microcystin-LR","volume":"31","author":"Chen","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1095\/biolreprod.108.068619","article-title":"Toll-like receptor 3 activation induces antiviral immune responses in mouse sertoli cells","volume":"79","author":"Starace","year":"2008","journal-title":"Biol. Reprod."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1620\/tjem.224.235","article-title":"A cyanobacterial toxin, microcystin-LR, induces apoptosis of sertoli cells by changing the expression levels of apoptosis-related proteins","volume":"224","author":"Zhang","year":"2011","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Huang, H., Liu, C., Fu, X., Zhang, S., Xin, Y., Li, Y., Xue, L., Cheng, X., and Zhang, H. (2016). Microcystin-LR Induced Apoptosis in Rat Sertoli Cells via the Mitochondrial Caspase-Dependent Pathway: Role of Reactive Oxygen Species. Front. Physiol., 7.","DOI":"10.3389\/fphys.2016.00397"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2015.05.008","article-title":"Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity","volume":"287","author":"Zhou","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxicon.2013.09.005","article-title":"Microcystin-LR induces autophagy and apoptosis in rat Sertoli cells in vitro","volume":"76","author":"Chen","year":"2013","journal-title":"Toxicon"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.etap.2018.09.001","article-title":"Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4\/NF-kB signaling pathway","volume":"63","author":"Adegoke","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1155\/2008\/905025","article-title":"Androgen-forming stem Leydig cells: Identification, function and therapeutic potential","volume":"24","author":"Zhang","year":"2008","journal-title":"Dis. Markers"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.aquatox.2018.03.018","article-title":"Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels","volume":"199","author":"Chen","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"ref_62","first-page":"463","article-title":"Seminal Plasma Biochemical Components Mediate the Inverse Association of Microcystin Exposure with Sperm Motility: A Mediation Analysis in Chinese Men","volume":"36","author":"Xu","year":"2023","journal-title":"BioMed. Environ. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2009.01.035","article-title":"Involvement of Fas\/FasL system in apoptotic signaling in testicular germ cells of male Wistar rats injected i.v. with microcystins","volume":"54","author":"Xiong","year":"2009","journal-title":"Toxicon"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.scitotenv.2019.02.393","article-title":"A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity","volume":"667","author":"Meng","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxlet.2012.05.001","article-title":"The toxic effects of microcystin-LR on rat spermatogonia in vitro","volume":"212","author":"Zhou","year":"2012","journal-title":"Toxicol. Lett."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1021\/es500152m","article-title":"Regulation of microcystin-LR-induced toxicity in mouse spermatogonia by miR-96","volume":"48","author":"Zhou","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.toxicon.2006.07.039","article-title":"Toxic effects of Microcystis cell extracts on the reproductive system of male mice","volume":"48","author":"Ding","year":"2006","journal-title":"Toxicon"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"077007","DOI":"10.1289\/EHP1050","article-title":"Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis","volume":"125","author":"Prins","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jes.2022.05.051","article-title":"Environmental microcystin exposure triggers the poor prognosis of prostate cancer: Evidence from case-control, animal, and in vitro studies","volume":"127","author":"Pan","year":"2023","journal-title":"J. Environ. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.envpol.2018.08.024","article-title":"Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia","volume":"242","author":"Pan","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Casas-Rodriguez, A., Camean, A.M., and Jos, A. (2022). Potential Endocrine Disruption of Cyanobacterial Toxins, Microcystins and Cylindrospermopsin: A Review. Toxins, 14.","DOI":"10.3390\/toxins14120882"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Liu, S., He, B., and Li, H. (2022). Water Blooms-A Potential Threat to Male Reproduction: Clues From Aquatics and Rodents. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.877292"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ecoenv.2018.07.094","article-title":"Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus","volume":"163","author":"Wang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.scitotenv.2018.06.123","article-title":"Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice","volume":"643","author":"Ding","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.toxicon.2011.12.001","article-title":"Microcystin (-LR) affects hormones level of male mice by damaging hypothalamic-pituitary system","volume":"59","author":"Wang","year":"2012","journal-title":"Toxicon"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"108441","DOI":"10.1016\/j.reprotox.2023.108441","article-title":"Effects of microcystin-LR on mammalian ovaries","volume":"120","author":"Graceli","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"112066","DOI":"10.1016\/j.ecoenv.2021.112066","article-title":"Microcystin-LR induces ovarian injury and apoptosis in mice via activating apoptosis signal-regulating kinase 1-mediated P38\/JNK pathway","volume":"213","author":"Du","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.etap.2013.10.012","article-title":"Reproductive toxicity on female mice induced by microcystin-LR","volume":"37","author":"Wu","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"144070","DOI":"10.1016\/j.scitotenv.2020.144070","article-title":"Microcystin-leucine arginine exposure contributes to apoptosis and follicular atresia in mice ovaries by endoplasmic reticulum stress-upregulated Ddit3","volume":"756","author":"Liu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"109028","DOI":"10.1016\/j.reprotox.2025.109028","article-title":"Microcystin-LR disrupts ovarian granulosa cell glycolysis via GSK3beta-Mediated HK2 mitochondrial dissociation: Evidence from integrated In Vivo and In Vitro models","volume":"137","author":"Yuan","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.3390\/toxins7124872","article-title":"MC-LR Exposure Leads to Subfertility of Female Mice and Induces Oxidative Stress in Granulosa Cells","volume":"7","author":"Wu","year":"2015","journal-title":"Toxins"},{"key":"ref_82","unstructured":"World Health Organization (2020). Background document for development of WHO Guidelines for drinking-water quality and Guidelines for safe recreational water environments. Cyanobacterial Toxins: Microcystins, World Health Organization. WHO\/HEP\/ECH\/WSH\/2020.6."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1530\/REP-19-0313","article-title":"MC-LR induced overproduction of progesterone via inhibiting miR-3473g: In vitro and in vivo evidence","volume":"159","author":"Li","year":"2020","journal-title":"Reproduction"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"111931","DOI":"10.1016\/j.ecoenv.2021.111931","article-title":"The mechanisms of mitochondrial dysfunction and glucose intake decrease induced by Microcystin-LR in ovarian granulosa cells","volume":"212","author":"Zhu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"67010","DOI":"10.1289\/EHP12034","article-title":"Effects of Cyanobacterial Harmful Algal Bloom Toxin Microcystin-LR on Gonadotropin-Dependent Ovarian Follicle Maturation and Ovulation in Mice","volume":"131","author":"Wang","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"143466","DOI":"10.1016\/j.chemosphere.2024.143466","article-title":"Early pregnancy exposure to Microcystin-LR compromises endometrial decidualization in mice via the PI3K\/AKT\/FOXO1 signaling pathway","volume":"366","author":"Yan","year":"2024","journal-title":"Chemosphere"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"113454","DOI":"10.1016\/j.fct.2022.113454","article-title":"Microcystin-LR inhibits early pregnancy by impairing the vascular network of luteum: Involvement of the MEK\/ERK\/SP1\/VEGFR2 axis","volume":"170","author":"Guo","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"174979","DOI":"10.1016\/j.scitotenv.2024.174979","article-title":"Microcystin-LR prenatal exposure induces coronary heart disease through macrophage polarization imbalance mediated by trophoblast-derived extracellular vesicles","volume":"948","author":"Guo","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"114189","DOI":"10.1016\/j.fct.2023.114189","article-title":"Microcystin-LR prenatal exposure drives preeclampsia-like changes in mice by inhibiting the expression of TGF-beta and VEGFA","volume":"182","author":"Guo","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"112203","DOI":"10.1016\/j.mce.2024.112203","article-title":"Single microcystin exposure impairs the hypothalamic-pituitary-gonadal axis at different levels in female rats","volume":"586","author":"Lima","year":"2024","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.1171396","article-title":"MAPK3\/1 (ERK1\/2) in ovarian granulosa cells are essential for female fertility","volume":"324","author":"Fan","year":"2009","journal-title":"Science"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Zhang, X., Zhou, C., Li, W., Li, J., Wu, W., Tao, J., and Liu, H. (2020). Vitamin C Protects Porcine Oocytes From Microcystin-LR Toxicity During Maturation. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.582715"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.theriogenology.2020.09.031","article-title":"Microcystin-LR exposure results in aberrant spindles and induces apoptosis in porcine oocytes","volume":"158","author":"Shi","year":"2020","journal-title":"Theriogenology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.toxicon.2006.07.038","article-title":"Microcystins cause embryonic toxicity in mice","volume":"48","author":"Bu","year":"2006","journal-title":"Toxicon"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"113362","DOI":"10.1016\/j.envpol.2019.113362","article-title":"Microcystin-LR exposure decreased the fetal weight of mice by disturbance of placental development and ROS-mediated endoplasmic reticulum stress in the placenta","volume":"256","author":"Zhao","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"107.e1","DOI":"10.1016\/j.ajog.2018.04.002","article-title":"Long-term mortality risk and life expectancy following recurrent hypertensive disease of pregnancy","volume":"219","author":"Theilen","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/tox.22056","article-title":"Effect of microcystin-LR on human placental villous trophoblast differentiation in vitro","volume":"31","author":"Douglas","year":"2016","journal-title":"Environ. Toxicol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/09513599409072451","article-title":"Low luteal phase serum progesterone levels in regularly cycling women are predictive of subtle ovulation disorders","volume":"8","author":"Koppeschaar","year":"1994","journal-title":"Gynecol. Endocrinol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tox.2017.02.004","article-title":"Toxic effects of microcystin-LR on the development of prostate in mice","volume":"380","author":"Zhang","year":"2017","journal-title":"Toxicology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/pros.23786","article-title":"PiRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine","volume":"79","author":"Han","year":"2019","journal-title":"Prostate"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jprot.2014.11.015","article-title":"A proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in rat offspring","volume":"114","author":"Zhao","year":"2015","journal-title":"J. Proteom."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.envpol.2015.12.055","article-title":"A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure","volume":"212","author":"Zhao","year":"2016","journal-title":"Environ. Pollut."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.toxlet.2025.06.009","article-title":"Prenatal microcystin-LR exposure alters pancreatic proteome and impairs insulin secretion in offspring mice","volume":"410","author":"Chen","year":"2025","journal-title":"Toxicol. Lett."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"139678","DOI":"10.1016\/j.scitotenv.2020.139678","article-title":"The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)-paternal-exposed offspring mice","volume":"736","author":"Meng","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1210\/en.2016-1003","article-title":"Developmental Programming, a Pathway to Disease","volume":"157","author":"Padmanabhan","year":"2016","journal-title":"Endocrinology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.2174\/1389557516666160219130553","article-title":"New Insights on the Mode of Action of Microcystins in Animal Cells\u2014A Review","volume":"16","author":"Valerio","year":"2016","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxicon.2005.03.021","article-title":"Altered expression of p53, Bcl-2 and Bax induced by microcystin-LR in vivo and in vitro","volume":"46","author":"Fu","year":"2005","journal-title":"Toxicon"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Liu, H., Zhang, S., Liu, C., Wu, J., Wang, Y., Yuan, L., Du, X., Wang, R., Marwa, P.W., and Zhuang, D. (2018). Resveratrol Ameliorates Microcystin-LR-Induced Testis Germ Cell Apoptosis in Rats via SIRT1 Signaling Pathway Activation. Toxins, 10.","DOI":"10.3390\/toxins10060235"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jbt.20347","article-title":"Acute effects of microcystins exposure on the transcription of antioxidant enzyme genes in three organs (liver, kidney, and testis) of male Wistar rats","volume":"24","author":"Xiong","year":"2010","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.etap.2011.12.015","article-title":"Microcystin-LR causes cytotoxicity effects in rat testicular Sertoli cells","volume":"33","author":"Li","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1097(03)00100-9","article-title":"Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity","volume":"220","author":"Ding","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/tox.22808","article-title":"P53-Dependent pathway and the opening of mPTP mediate the apoptosis of co-cultured Sertoli-germ cells induced by microcystin-LR","volume":"34","author":"Wu","year":"2019","journal-title":"Environ. Toxicol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"111911","DOI":"10.1016\/j.fct.2020.111911","article-title":"IRE1 and CaMKKbeta pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells","volume":"147","author":"Ma","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.envpol.2017.07.081","article-title":"Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis","volume":"229","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/jat.3771","article-title":"Pharmacological inhibition of TLR4\/NF-kappaB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells","volume":"39","author":"Adegoke","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.toxlet.2022.01.003","article-title":"Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling","volume":"358","author":"Liu","year":"2022","journal-title":"Toxicol. Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1007\/s10646-011-0693-2","article-title":"Toxicity of cyanobacterial bloom extracts from Taihu Lake on mouse, Mus musculus","volume":"20","author":"Li","year":"2011","journal-title":"Ecotoxicology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1021\/es5059132","article-title":"Effects of chronic exposure to microcystin-LR on hepatocyte mitochondrial DNA replication in mice","volume":"49","author":"Li","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/tox.20532","article-title":"Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis","volume":"26","author":"Li","year":"2011","journal-title":"Environ. Toxicol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00204-016-1913-6","article-title":"Cyanotoxins: Producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation","volume":"91","author":"Buratti","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1115035","article-title":"Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis","volume":"311","author":"Lakhani","year":"2006","journal-title":"Science"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Ho, Y.C., Ku, C.S., Tsai, S.S., Shiu, J.L., Jiang, Y.Z., Miriam, H.E., Zhang, H.W., Chen, Y.T., Chiu, W.T., and Chang, S.B. (2022). PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair. PLoS Genet., 18.","DOI":"10.1371\/journal.pgen.1010545"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1098\/rstb.2009.0323","article-title":"Evolution and spermatogenesis","volume":"365","author":"Bausek","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"116636","DOI":"10.1016\/j.ecoenv.2024.116636","article-title":"Bta-miR-149-3p suppresses inflammatory response in bovine Sertoli cells exposed to microcystin-leucine arginine (MC-LR) through TLR4\/NF-kB signaling pathway","volume":"281","author":"Xue","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Meng, X., Zhang, L., Chen, X., Xiang, Z., Li, D., and Han, X. (2016). MiR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice. Toxins, 8.","DOI":"10.3390\/toxins8090260"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxicon.2017.01.022","article-title":"Expression analysis of microRNAs and mRNAs in ovarian granulosa cells after microcystin-LR exposure","volume":"129","author":"Li","year":"2017","journal-title":"Toxicon"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"125073","DOI":"10.1016\/j.chemosphere.2019.125073","article-title":"Histone acetylation plays an important role in MC-LR-induced apoptosis and cycle disorder in SD rat testicular cells","volume":"241","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/tox.22865","article-title":"Epigenetic modification of H3K4 and oxidative stress are involved in MC-LR-induced apoptosis in testicular cells of SD rats","volume":"35","author":"Yuan","year":"2020","journal-title":"Environ. Toxicol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"115288","DOI":"10.1016\/j.ecoenv.2023.115288","article-title":"Microcystin-LR induces lactate production disruption via altering the m(6)A modification in Sertoli cells","volume":"263","author":"Meng","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"158262","DOI":"10.1016\/j.scitotenv.2022.158262","article-title":"A new identity of microcystins: Environmental endocrine disruptors? An evidence-based review","volume":"851","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxicon.2016.10.011","article-title":"Microcystin-LR causes sexual hormone disturbance in male rat by targeting gonadotropin-releasing hormone neurons","volume":"123","author":"Wang","year":"2016","journal-title":"Toxicon"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"118780","DOI":"10.1016\/j.ecoenv.2025.118780","article-title":"Evaluation of potential androgenic and antiandrogenic activities of pure cyanotoxins (microcystin-LR and cylindrospermopsin) using the hershberger bioassay (OECD TG 441)","volume":"302","author":"Camean","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Mallia, V., Ivanova, L., Eriksen, G.S., Harper, E., Connolly, L., and Uhlig, S. (2020). Investigation of In Vitro Endocrine Activities of Microcystis and Planktothrix Cyanobacterial Strains. Toxins, 12.","DOI":"10.3390\/toxins12040228"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"108529","DOI":"10.1016\/j.reprotox.2023.108529","article-title":"Mediation of association between semen microcystin exposure and semen quality by sex hormones in Chinese men","volume":"124","author":"Luo","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"110254","DOI":"10.1016\/j.envres.2020.110254","article-title":"The latest advances in the reproductive toxicity of microcystin-LR","volume":"192","author":"Zhang","year":"2021","journal-title":"Environ. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"106661","DOI":"10.1016\/j.envint.2021.106661","article-title":"Advances in the toxicology research of microcystins based on Omics approaches","volume":"154","author":"Ma","year":"2021","journal-title":"Environ. Int."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1080\/15287394.2014.919838","article-title":"The course of toxicity in the pregnant mouse after exposure to the cyanobacterial toxin cylindrospermopsin: Clinical effects, serum chemistries, hematology, and histopathology","volume":"77","author":"Chernoff","year":"2014","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.toxicon.2015.09.022","article-title":"Undifferentiated murine embryonic stem cells used to model the effects of the blue-green algal toxin cylindrospermopsin on preimplantation embryonic cell proliferation","volume":"106","author":"Reid","year":"2015","journal-title":"Toxicon"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/toxsci\/kfp196","article-title":"Long-term cognitive impairments in adult rats treated neonatally with beta-N-Methylamino-L-Alanine","volume":"112","author":"Karlsson","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12640-017-9802-1","article-title":"Perinatal Exposure to the Cyanotoxin beta-N-Methylamino-L-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring-Potential Involvement of DNA Damage and Oxidative Stress","volume":"33","author":"Laugeray","year":"2018","journal-title":"Neurotox. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.toxicon.2020.10.015","article-title":"Effects of saxitoxins exposure on oligodendrocyte development in mouse neonates","volume":"188","author":"Nogaroli","year":"2020","journal-title":"Toxicon"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1007\/s43032-022-00907-0","article-title":"Cylindrospermopsin Disrupts Estrous Cycle and Increases Spermatogenesis in Mice","volume":"29","author":"Caires","year":"2022","journal-title":"Reprod. Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"119239","DOI":"10.1016\/j.ecoenv.2025.119239","article-title":"Nitrite and microcystins co-exposure triggers PINK1-mediated mitophagy in spermatogonia","volume":"305","author":"Wang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"123929","DOI":"10.1016\/j.envpol.2024.123929","article-title":"Environmentally related microcystin-LR-induced ovarian dysfunction via the CCL2-CCR10 axis in mice ameliorated by dietary mulberry","volume":"349","author":"Du","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.envpol.2019.04.114","article-title":"Icariin attenuate microcystin-LR-induced gap junction injury in Sertoli cells through suppression of Akt pathways","volume":"251","author":"Zhou","year":"2019","journal-title":"Environ. 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