{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:19:34Z","timestamp":1788254374493,"version":"build-2803163510"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Occupational Research Agenda","award":["9390HTP"],"award-info":[{"award-number":["9390HTP"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants associated with adverse health effects, yet dermal exposure remains poorly characterized. This study evaluated the influence of vehicle and chemical structure on dermal absorption and skin barrier integrity using a reconstructed human epidermis model (EpiDermFT). Two C6 PFAS, perfluorohexane sulfonate (PFHxS) and perfluorohexanoic acid (PFHxA), were applied in three vehicles (acetone, water, and diethylene glycol monobutyl ether [DEGME]) at concentrations of 0\u20130.015% for 4 or 24 h. PFAS concentrations were quantified in tissue and receptor media, and skin barrier integrity was assessed using histological and immunological endpoints. Increasing exposure resulted in higher concentrations of PFHxS and PFHxA in both tissue and media across all vehicles, indicating dermal penetration and absorption. PFHxS exhibited greater tissue retention but only a few small, isolated changes in cytokine and gene expression and no significant effect on barrier integrity. In contrast, PFHxA induced increased expression of inflammatory mediators and alterations in skin barrier function. These findings indicate a divergence between dermal retention and biological activity. Overall, while the vehicle influenced PFAS transport, biological responses were more strongly associated with functional group. These results suggest that functional group-dependent toxicity is an important determinant of dermal PFAS effects and should be considered when characterizing PFAS dermal hazard and grouping structurally related compounds for assessment.<\/jats:p>","DOI":"10.3390\/toxics14090756","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:59:23Z","timestamp":1787741963000},"page":"756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dermal Permeability of Perfluorohexane Sulfonic Acid (PFHxS) and Perfluorohexanoic Acid (PFHxA) in Varying Vehicles and the Effects on Skin Integrity in a Reconstructed Human Epidermis Model"],"prefix":"10.3390","volume":"14","author":[{"given":"Lisa","family":"Weatherly","sequence":"first","affiliation":[{"name":"Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Notashia","family":"Baughman","sequence":"additional","affiliation":[{"name":"Chemical and Biomonitoring Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3368-9209","authenticated-orcid":false,"given":"Callee","family":"Walsh","sequence":"additional","affiliation":[{"name":"Chemical and Biomonitoring Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Jackson","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Lukomska","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Madison","family":"Cooper","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7707-1550","authenticated-orcid":false,"given":"Jason","family":"Ham","sequence":"additional","affiliation":[{"name":"Chemical and Biomonitoring Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Anderson","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/10408444.2025.2501420","article-title":"Per- and polyfluoroalkyl substances (PFAS): Immunotoxicity at the primary sites of exposure","volume":"55","author":"Arnesdotter","year":"2025","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: A review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"key":"ref_3","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR) (2021). Toxicological Profile for Perfluoroalkyls."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1021\/acs.est.6b04806","article-title":"A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"14546","DOI":"10.1007\/s11356-015-4202-7","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in consumer products","volume":"22","author":"Kotthoff","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13845","DOI":"10.1021\/acs.est.2c02111","article-title":"Per- and Polyfluoroalkyl Substances in North American School Uniforms","volume":"56","author":"Xia","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Yang, Y., Wang, J., Tang, S., Qiu, J., Luo, Y., Yang, C., Lai, X., Wang, Q., and Cao, H. (2025). Per- and Polyfluoroalkyl Substances (PFAS) in Consumer Products: An Overview of the Occurrence, Migration, and Exposure Assessment. Molecules, 30.","DOI":"10.3390\/molecules30050994"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105766","DOI":"10.1016\/j.yrtph.2024.105766","article-title":"Evaluating dermal absorption of perfluorooctanoic acid (PFOA) and implications for other per- and polyfluoroalkyl substances (PFAS)","volume":"156","author":"Yeh","year":"2025","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/15287394.2011.615108","article-title":"Dermal Penetration Potential of Perfluorooctanoic Acid (PFOA) in Human and Mouse Skin","volume":"75","author":"Franko","year":"2012","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108772","DOI":"10.1016\/j.envint.2024.108772","article-title":"Dermal bioavailability of perfluoroalkyl substances using in vitro 3D human skin equivalent models","volume":"188","author":"Harrad","year":"2024","journal-title":"Environ. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"119478","DOI":"10.1016\/j.envpol.2022.119478","article-title":"Dermal uptake: An important pathway of human exposure to perfluoroalkyl substances?","volume":"307","author":"Abdallah","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"138846","DOI":"10.1016\/j.jhazmat.2025.138846","article-title":"Decorative cosmetics and skin care products contribute significantly to short-chain perfluoroalkyl carboxylates exposure","volume":"495","author":"Wang","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7723","DOI":"10.1021\/es102033k","article-title":"Occupational exposure to airborne perfluorinated compounds during professional ski waxing","volume":"44","author":"Freberg","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.chemosphere.2013.01.066","article-title":"Perfluoroalkyl carboxylic acids with up to 22 carbon atoms in snow and soil samples from a ski area","volume":"91","author":"Plassmann","year":"2013","journal-title":"Chemosphere"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1021\/acs.est.9b05490","article-title":"Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco","volume":"54","author":"Trowbridge","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"ref_16","unstructured":"U.S. Environmental Protection Agency (2026, June 18). Risk Management for Per- and Polyfluoroalkyl Substances (PFAS) Under TSCA, Available online: https:\/\/www.epa.gov\/assessing-and-managing-chemicals-under-tsca\/risk-management-and-polyfluoroalkyl-substances-pfas."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.toxlet.2014.09.007","article-title":"Firefighters\u2019 exposure to perfluoroalkyl acids and 2-butoxyethanol present in firefighting foams","volume":"231","author":"Laitinen","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Maizel, A., Thompson, A., Tighe, M., Escobar, S., Rodowa, A., Falkenstein-Smith, R., Benner, B., Hoffman, K., Donnelly, M., and Hernandez, O. (2023). Per- and Polyfluroalkyl Substances in New Firefighter Turnout Gear Textiles, Technical Note (NIST TN)-2248.","DOI":"10.6028\/NIST.TN.2248"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"115164","DOI":"10.1016\/j.envres.2022.115164","article-title":"Perfluoroalkyl substances exposure in firefighters: Sources and implications","volume":"220","author":"Rosenfeld","year":"2023","journal-title":"Environ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mazumder, N.U., Hossain, M.T., Jahura, F.T., Girase, A., Hall, A.S., Lu, J., and Ormond, R.B. (2023). Firefighters\u2019 exposure to per-and polyfluoroalkyl substances (PFAS) as an occupational hazard: A review. Front. Mater., 10.","DOI":"10.3389\/fmats.2023.1143411"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1097\/JOM.0000000000002062","article-title":"Per- and Polyfluoroalkyl Substance and Cardio Metabolic Markers in Firefighters","volume":"62","author":"Khalil","year":"2020","journal-title":"J. Occup. Environ. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/ajim.23413","article-title":"Serum per- and polyfluoroalkyl substance concentrations in four municipal US fire departments","volume":"66","author":"Burgess","year":"2023","journal-title":"Am. J. Ind. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1016\/j.chemosphere.2013.08.060","article-title":"Elimination kinetics of perfluorohexanoic acid in humans and comparison with mouse, rat and monkey","volume":"93","author":"Russell","year":"2013","journal-title":"Chemosphere"},{"key":"ref_24","first-page":"e85995","article-title":"Evaluation of Per- and Polyfluoroalkyl Substance (PFAS) Levels in Drinking Water: A Study of Riverside Municipal Wells","volume":"17","author":"Bachhu","year":"2025","journal-title":"Cureus"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1021\/acs.est.3c06499","article-title":"Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs","volume":"58","author":"Nielsen","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"120916","DOI":"10.1016\/j.envres.2025.120916","article-title":"Per- and polyfluoroalkyl substances (PFAS) exposure in the U.S. population: NHANES 1999\u2013March 2020","volume":"270","author":"Botelho","year":"2025","journal-title":"Environ. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.chemosphere.2017.06.023","article-title":"Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes","volume":"184","author":"Siebenaler","year":"2017","journal-title":"Chemosphere"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12940-025-01165-8","article-title":"Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: Their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS","volume":"24","author":"Schlezinger","year":"2025","journal-title":"Environ. Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41370-024-00742-2","article-title":"Associations between per-and polyfluoroalkyl substances (PFAS) and county-level cancer incidence between 2016 and 2021 and incident cancer burden attributable to PFAS in drinking water in the United States","volume":"35","author":"Li","year":"2025","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"127007","DOI":"10.1289\/EHP13174","article-title":"Case-Cohort Study of the Association between PFAS and Selected Cancers among Participants in the American Cancer Society\u2019s Cancer Prevention Study II LifeLink Cohort","volume":"131","author":"Winquist","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"ref_31","unstructured":"U.S. Environmental Protection Agency (2025). IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS, CASRN 335-46-4) and Related Salts."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"117047","DOI":"10.1016\/j.taap.2024.117047","article-title":"The long-chain polyfluorinated alkyl substance perfluorohexane sulfonate (PFHxS) promotes bone marrow adipogenesis","volume":"491","author":"Garmo","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117484","DOI":"10.1016\/j.taap.2025.117484","article-title":"PFAS-exposed zebrafish embryos show impaired innate immune response after infection with mycobacteria","volume":"503","author":"Carlier","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e2409383","DOI":"10.1002\/advs.202409383","article-title":"Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood-Testis Barrier in Mice","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Jiao, X., Zhao, L., Xu, Y., Gao, J., Tang, W., Wu, Y., Yang, L., Huang, J., Guo, Y., and Sun, K. (2025). Environmental exposure to per- and polyfluoroalkyl substances and childhood congenital heart disease: A mixed analysis. Front. Public Health, 13.","DOI":"10.3389\/fpubh.2025.1657168"},{"key":"ref_36","unstructured":"U.S. Environmental Protection Agency (2023). IRIS Toxicological Review of Perfluorohexanoic Acid [PFHxA, CASRN 307-24-4] and Related Salts."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"113515","DOI":"10.1016\/j.fct.2022.113515","article-title":"Systemic toxicity induced by topical application of perfluoroheptanoic acid (PFHpA), perfluorohexanoic acid (PFHxA), and perfluoropentanoic acid (PFPeA) in a murine model","volume":"171","author":"Weatherly","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"114578","DOI":"10.1016\/j.fct.2024.114578","article-title":"Systemic and immunotoxicity induced by topical application of perfluorohexane sulfonic acid (PFHxS) in a murine model","volume":"186","author":"Weatherly","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2148781","DOI":"10.1080\/1547691X.2022.2148781","article-title":"Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis","volume":"20","author":"Baur","year":"2023","journal-title":"J. Immunotoxicol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/ics.12742","article-title":"Olive leaf-derived PPAR agonist complex induces collagen IV synthesis in human skin models","volume":"43","author":"Majewski","year":"2021","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/exd.13531","article-title":"3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function","volume":"27","author":"Niehues","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/026119290403201s12","article-title":"Full Thickness EpiDerm: A dermal-epidermal skin model to study epithelial-mesenchymal interactions","volume":"32","author":"Kubilus","year":"2004","journal-title":"Altern. Lab. Anim."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/pharmaceutics4010026","article-title":"Tissue engineered human skin equivalents","volume":"4","author":"Zhang","year":"2012","journal-title":"Pharmaceutics"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"123660","DOI":"10.1016\/j.colsurfa.2019.123660","article-title":"Modulation of fluorocarbon surfactant diffusion with diethylene glycol butyl ether for improved foam characteristics and fire suppression","volume":"579","author":"Giles","year":"2019","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"340","DOI":"10.18433\/jpps32921","article-title":"Review of Pharmaceutical Applications of Diethylene Glycol Monoethyl Ether","volume":"25","author":"Hashemzadeh","year":"2022","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_46","unstructured":"National Institute of Environmental Health Sciences (2023). Rapid Scoping Review of East Palestine, Ohio Chemicals of Interest."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"123138","DOI":"10.1016\/j.jchromb.2022.123138","article-title":"Simultaneous determination of perfluorooctanoic acid and perfluorooctanesulfonic acid in Korean sera using LC-MS\/MS","volume":"1192","author":"Heo","year":"2022","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/srt.13165","article-title":"Characterization and ex vivo evaluation of excised skin samples as substitutes for human dermal barrier in pharmaceutical and dermatological studies","volume":"28","author":"Kocsis","year":"2022","journal-title":"Skin. Res. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1600-0625.2006.00437.x","article-title":"Transepidermal water loss reflects permeability barrier status: Validation in human and rodent in vivo and ex vivo models","volume":"15","author":"Fluhr","year":"2006","journal-title":"Exp. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1039\/D0EM00291G","article-title":"An overview of the uses of per- and polyfluoroalkyl substances (PFAS)","volume":"22","author":"Scheringer","year":"2020","journal-title":"Environ. Sci. Process Impacts"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"117093","DOI":"10.1016\/j.envres.2023.117093","article-title":"Dermal bioaccessibility of perfluoroalkyl substances from household dust; influence of topically applied cosmetics","volume":"238","author":"Abdallah","year":"2023","journal-title":"Environ. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"117487","DOI":"10.1016\/j.taap.2025.117487","article-title":"Systemic toxicity induced by topical application of the sulfonic acids, perfluorobutane sulfonic acid (PFBS) and perfluoropentane sulfonic acid (PFPeS), in a murine model","volume":"503","author":"Cooper","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2371868","DOI":"10.1080\/1547691X.2024.2371868","article-title":"Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model","volume":"21","author":"Weatherly","year":"2024","journal-title":"J. Immunotoxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"112528","DOI":"10.1016\/j.fct.2021.112528","article-title":"Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model","volume":"156","author":"Weatherly","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Langenbach, B., and Wilson, M. (2021). Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182111142"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"108601","DOI":"10.1016\/j.envint.2024.108601","article-title":"Exposure to per- and polyfluoroalkyl substances and high-throughput proteomics in Hispanic youth","volume":"186","author":"Chen","year":"2024","journal-title":"Environ. Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1021\/acs.estlett.1c00240","article-title":"Fluorinated Compounds in North American Cosmetics","volume":"8","author":"Whitehead","year":"2021","journal-title":"Environ. Sci. Technol. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"8187","DOI":"10.1021\/es4018877","article-title":"Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil","volume":"47","author":"Houtz","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Hall, A.S., Baynes, R., Neumann, L.M., Maibach, H.I., and Ormond, R.B. (2024). Skin Permeability of Perfluorocarboxylic Acids Using Flow-Through Diffusion on Porcine Skin. Toxics, 12.","DOI":"10.3390\/toxics12100703"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"144408","DOI":"10.1016\/j.chemosphere.2025.144408","article-title":"Dermal permeation of perfluoroalkyl substances in human skin\u2014An in-vitro study","volume":"378","author":"Espartero","year":"2025","journal-title":"Chemosphere"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e70245","DOI":"10.1111\/risa.70245","article-title":"A Critical Review of Scientific Data Pertaining to Dermal Exposures to Per- and Polyfluoroalkyl Substances (PFAS)","volume":"46","author":"Heywood","year":"2026","journal-title":"Risk Anal."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1021\/es061000n","article-title":"Sorption of perfluorinated surfactants on sediments","volume":"40","author":"Higgins","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.chemosphere.2011.06.046","article-title":"Partitioning of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS) and perfluorooctane sulfonamide (PFOSA) between water and sediment","volume":"85","author":"Ahrens","year":"2011","journal-title":"Chemosphere"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1021\/acs.est.8b05052","article-title":"Membrane-Water Partition Coefficients to Aid Risk Assessment of Perfluoroalkyl Anions and Alkyl Sulfates","volume":"53","author":"Droge","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"109874","DOI":"10.1016\/j.cbpc.2024.109874","article-title":"A comparative review of the toxicity mechanisms of perfluorohexanoic acid (PFHxA) and perfluorohexanesulphonic acid (PFHxS) in fish","volume":"279","author":"Kreychman","year":"2024","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_66","unstructured":"ITRC (2023). PFAS Technical and Regulatory Guidance Document and Fact Sheets PFAS-1, Interstate Technology & Regulatory Council, PFAS Team. Available online: https:\/\/pfas-1.itrcweb.org."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/9\/756\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:56:53Z","timestamp":1788253013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/9\/756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":66,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["toxics14090756"],"URL":"https:\/\/doi.org\/10.3390\/toxics14090756","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}