{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:18:17Z","timestamp":1787890697228,"version":"build-2784847793"},"reference-count":46,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of the Environment"},{"id":[{"id":"https:\/\/ror.org\/03rybxa06","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Cadmium (Cd), a widespread pollutant, is primarily absorbed via diet and smoking. Chronic Cd exposure has been associated with various adverse health effects, including renal tubular and skeletal damage. Urinary Cd concentration accurately reflects cumulative Cd exposure owing to its strong correlation with renal cortical Cd levels. This study evaluated the accuracy of estimated lifetime Cd intake by examining its correlation with urinary Cd levels after soil remediation, an aspect unreported even in the Kakehashi River Basin. A total of 565 men and 450 women were included. Lifetime Cd intake (g) was estimated using an established exposure assessment model that incorporated individual residential history, rice Cd concentrations, and dietary assumptions. Urinary Cd concentrations were determined using inductively coupled plasma mass spectrometry. Linear regression analyses were conducted between lifetime cadmium intake and urinary cadmium concentration. The obtained standardized regression coefficients were 0.49 for men and 0.54 for women (both p &lt; 0.001), indicating strong associations. Despite possible exposure misclassification, these findings support the utility of lifetime cadmium intake as a useful surrogate indicator of cumulative cadmium exposure and provide further evidence for its application in risk assessment and the derivation of tolerable cadmium intake values.<\/jats:p>","DOI":"10.3390\/toxics14090762","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:04:32Z","timestamp":1787756672000},"page":"762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Lifetime Cadmium Intake and Urinary Cadmium Concentration Among Residents of the Jinzu River Basin Following Soil Remediation"],"prefix":"10.3390","volume":"14","author":[{"given":"Yu","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-2243","authenticated-orcid":false,"given":"Kazuhiro","family":"Nogawa","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-3225","authenticated-orcid":false,"given":"Masaru","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Social and Environmental Medicine, Kanazawa Medical University, Kahoku 920-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuka","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Department of Social and Environmental Medicine, Kanazawa Medical University, Kahoku 920-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-1828","authenticated-orcid":false,"given":"Yasumitsu","family":"Ogra","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-7408","authenticated-orcid":false,"given":"Yu-ki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaro","family":"Iwase","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Kido","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-0942, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Social and Environmental Medicine, Kanazawa Medical University, Kahoku 920-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Suwazono","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1515\/pac-2016-0910","article-title":"Risk assessment of effects of cadmium on human health (IUPAC Technical Report)","volume":"90","author":"Nordberg","year":"2018","journal-title":"Pure Appl. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Nordberg, G.F., Fowler, B.A., and Nordberg, M. (2015). Chapter 32\u2014Cadmium. Handbook on the Toxicology of Metals, Academic Press. [4th ed.].","DOI":"10.1016\/B978-0-444-59453-2.00001-9"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"114961","DOI":"10.1016\/j.envpol.2020.114961","article-title":"Current status, spatial features, health risks, and potential driving factors of soil heavy metal pollution in China at province level","volume":"266","author":"Hu","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9011","DOI":"10.1038\/s41598-018-27411-3","article-title":"The references level of cadmium intake for renal dysfunction in a Chinese population","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_5","first-page":"143","article-title":"Cadmium-exposed population in Mae Sot District, Tak Province: 1. Prevalence of high urinary cadmium levels in the adults","volume":"90","author":"Swaddiwudhipong","year":"2007","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_6","first-page":"133","article-title":"Human Health Effects from Cadmium Exposure: Comparison between Persons Living in Cadmium-Contaminated and Non-Contaminated Areas in Northwestern Thailand","volume":"46","author":"Swaddiwudhipong","year":"2015","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00420-012-0734-z","article-title":"Variation in benchmark dose (BMD) and the 95% lower confidence limit of benchmark dose (BMDL) among general Japanese populations with no anthropogenic exposure to cadmium","volume":"85","author":"Sakuragi","year":"2012","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref_8","unstructured":"(2026, August 20). National Report on Human Exposure to Environmental Chemicals [Online Database March 2022], Available online: https:\/\/www.cdc.gov\/biomonitoring\/resources\/national-exposure-report.html."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yang, J., Lo, K., and Yang, A. (2022). Trends in Urinary and Blood Cadmium Levels in U.S. Adults with or without Comorbidities, 1999-2018. Nutrients, 14.","DOI":"10.3390\/nu14040802"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of cadmium as an environmental health problem","volume":"238","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"109778","DOI":"10.1016\/j.cbpc.2023.109778","article-title":"Exploring the molecular and toxicological mechanism associated with interactions between heavy metals and the reproductive system of Mytilus galloprovincialis","volume":"275","author":"Marinaro","year":"2024","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Lettieri, G., Marinaro, C., Notariale, R., Perrone, P., Lombardi, M., Trotta, A., Troisi, J., and Piscopo, M. (2023). Impact of Heavy Metal Exposure on Mytilus galloprovincialis Spermatozoa: A Metabolomic Investigation. Metabolites, 13.","DOI":"10.3390\/metabo13080943"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"109104","DOI":"10.1016\/j.reprotox.2025.109104","article-title":"Heavy metals and human reproductive toxicity: Mechanisms, pregnancy outcomes, and mitigation strategies","volume":"139","author":"Marconi","year":"2026","journal-title":"Reprod. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1265\/ehpm.23-00218","article-title":"A population-based urinary and plasma metabolomics study of environmental exposure to cadmium","volume":"29","author":"Ishibashi","year":"2024","journal-title":"Environ. Health Prev. Med."},{"key":"ref_15","unstructured":"Nriagu, J. (2019). Itai-Itai Disease. Encyclopedia of Environmental Health, Elsevier. [2nd ed.]."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/00380768.2016.1159116","article-title":"Itai-itai disease: Renal tubular osteomalacia induced by environmental exposure to cadmium\u2014Historical review and perspectives","volume":"62","author":"Aoshima","year":"2016","journal-title":"Soil Sci. Plant Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Himeno, S., and Aoshima, K. (2019). Historical Lessons on Cadmium Environmental Pollution Problems in Japan and Current Cadmium Exposure Situation. Cadmium Toxicity: New Aspects in Human Disease, Rice Contamination, and Cytotoxicity, Springer.","DOI":"10.1007\/978-981-13-3630-0"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0013-9351(75)90090-0","article-title":"Studies on the women with acquired Fanconi syndrome observed in the Ichi river basin polluted by cadmium. Is this Itai-itai disease?","volume":"10","author":"Nogawa","year":"1975","journal-title":"Environ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/enrs.2000.4086","article-title":"Renal effects of cadmium exposure in cadmium nonpolluted areas in Japan","volume":"84","author":"Suwazono","year":"2000","journal-title":"Environ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1080\/00039896.1993.10545965","article-title":"Urinary beta 2-microglobulin concentration and mortality in a cadmium-polluted area","volume":"48","author":"Nakagawa","year":"1993","journal-title":"Arch. Environ. Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s004200000225","article-title":"Mortality and cancer incidence among a population previously exposed to environmental cadmium","volume":"74","author":"Arisawa","year":"2001","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.toxlet.2007.07.007","article-title":"Cause-specific mortality and cancer incidence rates in relation to urinary beta2-microglobulin: 23-year follow-up study in a cadmium-polluted area","volume":"173","author":"Arisawa","year":"2007","journal-title":"Toxicol. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/jes.2014.44","article-title":"Renal tubular dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas","volume":"25","author":"Suwazono","year":"2015","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/jat.4304","article-title":"Renal tubular dysfunction and cancer mortality in the Japanese general population living in cadmium-non-contaminated areas","volume":"42","author":"Nogawa","year":"2022","journal-title":"J. Appl. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/jam.1994.7.33","article-title":"Drug delivery to the respiratory tract and drug dosimetry","volume":"7","author":"Atkins","year":"1994","journal-title":"J. Aerosol Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Smereczanski, N.M., and Brzoska, M.M. (2023). Current Levels of Environmental Exposure to Cadmium in Industrialized Countries as a Risk Factor for Kidney Damage in the General Population: A Comprehensive Review of Available Data. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098413"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Satarug, S., Vesey, D.A., Gobe, G.C., and \u0110or\u0111evi\u0107, A.B. (2022). The Validity of Benchmark Dose Limit Analysis for Estimating Permissible Accumulation of Cadmium. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192315697"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.toxlet.2010.04.015","article-title":"Recent applications of benchmark dose method for estimation of reference cadmium exposure for renal effects in man","volume":"198","author":"Suwazono","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_29","unstructured":"EFSA (2009). Scientific Opinion of the Panel on Contaminants in the Food Chain on a request from the European Commission on cadmium in food. EFSA J., 980, 1048."},{"key":"ref_30","unstructured":"FAO, and WHO (2011). Evaluation of Certain Food Additives and Contaminants: Seventy-Third [73rd] Report of the Joint FAO\/WHO Expert Committee on Food Additives, World Health Organization."},{"key":"ref_31","unstructured":"FAO, and WHO (2023). Safety Evaluation of Certain Contaminants in Food: Prepared by the Ninety-First Meeting of the Joint FAO\/WHO Expert Committee on Food Additives (JECFA), World Health Organization and Food and Agriculture Organization of the United Nations."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0013-9351(89)80080-5","article-title":"A dose-response analysis of cadmium in the general environment with special reference to total cadmium intake limit","volume":"48","author":"Nogawa","year":"1989","journal-title":"Environ. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0378-4274(93)90096-G","article-title":"Dose-response relationship between total cadmium intake and beta 2-microglobulinuria using logistic regression analysis","volume":"69","author":"Kido","year":"1993","journal-title":"Toxicol. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/risa.12750","article-title":"Estimation of Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants of an Environmentally Exposed River Basin in Japan","volume":"37","author":"Kubo","year":"2017","journal-title":"Risk Anal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/tox.20444","article-title":"Association of lifetime cadmium intake or drinking Jinzu River water with the occurrence of renal tubular dysfunction","volume":"24","author":"Kobayashi","year":"2009","journal-title":"Environ. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.envres.2018.03.019","article-title":"Increase of lifetime cadmium intake dose-dependently increased all cause of mortality in female inhabitants of the cadmium-polluted Jinzu River basin, Toyama, Japan","volume":"164","author":"Nogawa","year":"2018","journal-title":"Environ. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jat.882","article-title":"Dose-response relationship between total cadmium intake calculated from the cadmium concentration in rice collected from each household of farmers and renal dysfunction in inhabitants of the Jinzu River basin, Japan","volume":"22","author":"Kobayashi","year":"2002","journal-title":"J. Appl. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.toxlet.2004.04.001","article-title":"The relation of individual cadmium concentration in urine with total cadmium intake in Kakehashi River basin, Japan","volume":"152","author":"Kido","year":"2004","journal-title":"Toxicol. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00128-005-0654-7","article-title":"Association between lifetime cadmium intake and cadmium concentration in individual urine","volume":"74","author":"Kobayashi","year":"2005","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_40","unstructured":"(2022). Medical Laboratories\u2014Requirements for Quality and Competence (Standard No. ISO 15189:2022)."},{"key":"ref_41","unstructured":"Toyama Prefectural Department of Health and Welfare (1976). Current Status of Polution of Soil and Its Countermeasure: An Interpretation of White Paper on Environmental Pollution, (In Japanese)."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/jat.3444","article-title":"Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark dose analysis","volume":"37","author":"Nogawa","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Himeno, S., and Aoshima, K. (2019). Regulations for Cadmium in Rice and Soil in Japan and Countermeasures to Reduce the Concentrations. Cadmium Toxicity: New Aspects in Human Disease, Rice Contamination, and Cytotoxicity, Springer.","DOI":"10.1007\/978-981-13-3630-0"},{"key":"ref_44","unstructured":"Ishikawa Prefecture, Department of Health (1976). Report on the Health Survey of the Inhabitants of the Kakehashi River Basin, (In Japanese)."},{"key":"ref_45","first-page":"19","article-title":"Cadmium in the environment and in humans","volume":"Volume 33","author":"Yamagata","year":"1978","journal-title":"Cadmium Study in Japan. A Review"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s40572-019-00242-8","article-title":"Urinary Concentration Correction Methods for Arsenic, Cadmium, and Mercury: A Systematic Review of Practice-Based Evidence","volume":"6","author":"Hsieh","year":"2019","journal-title":"Curr. Environ. Health Rep."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/9\/762\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:14:16Z","timestamp":1787890456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/9\/762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":46,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["toxics14090762"],"URL":"https:\/\/doi.org\/10.3390\/toxics14090762","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}