{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:21:15Z","timestamp":1788258075463,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42107292"],"award-info":[{"award-number":["42107292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["42107292"],"award-info":[{"award-number":["42107292"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Guangzhou Basic and Applied Basic Research Foundation","award":["2023A1515010804"],"award-info":[{"award-number":["2023A1515010804"]}]},{"name":"Open Project of Key Laboratory, Guangxi Zhuang Autonomous Region Fisheries Research Institute","award":["GXKEYLA-2023-01-5"],"award-info":[{"award-number":["GXKEYLA-2023-01-5"]}]},{"award":["GXKEYLA-2023-01-5"],"award-info":[{"award-number":["GXKEYLA-2023-01-5"]}],"id":[{"id":"https:\/\/ror.org\/05dk86115","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Talent Program of Shanghai Institute of Technology to Dan Li"},{"name":"Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Bisphenol analogues, including bisphenol F (BPF) and bisphenol S (BPS), are increasingly used as alternatives to bisphenol A (BPA), yet their potential olfactory effects remain poorly understood. In this study, adult zebrafish (Danio rerio) were exposed to environmentally relevant concentrations (5 \u03bcg\/L) of BPF and BPS for 28 days to investigate their impacts on the olfactory system. Histopathological assessment revealed changes in olfactory epithelial morphology, particularly in the BPF-exposed group. Transcriptomic analysis identified 3260 and 1602 differentially expressed genes in BPF and BPS exposure groups, respectively, involving pathways related to signal transduction, immune response, endocrine regulation, cell apoptosis, and olfactory signaling. Further molecular docking and 200 ns molecular dynamics simulations demonstrated stable interactions between with BPF exhibiting stronger binding affinities and more hydrophobic contacts with the targeted proteins (OR, GNB2 and p53) among the targeted proteins. Binding free energy calculations confirmed BPF\u2019s greater binding potential. These findings suggest that BPF may exert more potent olfactory toxicity than BPS, disrupting signal transmission and sensory function in aquatic species. This study provides new mechanistic insights into the molecular basis of bisphenol-induced olfactory disruption and emphasizes the ecological risks of BPF and BPS in aquatic environments.<\/jats:p>","DOI":"10.3390\/toxics14090776","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:48:36Z","timestamp":1788256116000},"page":"776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Molecular Mechanisms of Bisphenol-Induced Olfactory Toxicity in Zebrafish"],"prefix":"10.3390","volume":"14","author":[{"given":"Yaxuan","family":"Li","sequence":"first","affiliation":[{"name":"The Research Institution of Beautiful China and Ecological Civilization (A University Think Tank of Shanghai Municipality), Shanghai Institute of Technology, Shanghai 201418, China"},{"name":"Guangxi Academy of Fishery Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Jing","family":"Cao","sequence":"additional","affiliation":[{"name":"The Research Institution of Beautiful China and Ecological Civilization (A University Think Tank of Shanghai Municipality), Shanghai Institute of Technology, Shanghai 201418, China"},{"name":"Guangxi Academy of Fishery Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Haoliang","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Research Institution of Beautiful China and Ecological Civilization (A University Think Tank of Shanghai Municipality), Shanghai Institute of Technology, Shanghai 201418, China"},{"name":"Guangxi Academy of Fishery Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Hou","sequence":"additional","affiliation":[{"name":"The Research Institution of Beautiful China and Ecological Civilization (A University Think Tank of Shanghai Municipality), Shanghai Institute of Technology, Shanghai 201418, China"},{"name":"Guangxi Academy of Fishery Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Xuefeng","family":"Hu","sequence":"additional","affiliation":[{"name":"The Research Institution of Beautiful China and Ecological Civilization (A University Think Tank of Shanghai Municipality), Shanghai Institute of Technology, Shanghai 201418, China"},{"name":"Guangxi Academy of Fishery Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Chen","sequence":"additional","affiliation":[{"name":"Faculty of Urban Construction and Ecological Technology, Shanghai Institute of Technology, Shanghai 201418, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-3483","authenticated-orcid":false,"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"The Research Institution of Beautiful China and Ecological Civilization (A University Think Tank of Shanghai Municipality), Shanghai Institute of Technology, Shanghai 201418, China"},{"name":"Guangxi Academy of Fishery Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Yongju","family":"Luo","sequence":"additional","affiliation":[{"name":"Faculty of Urban Construction and Ecological Technology, Shanghai Institute of Technology, Shanghai 201418, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"168509","DOI":"10.1016\/j.scitotenv.2023.168509","article-title":"Bisphenol analogues in infant foods in south China and implications for infant exposure","volume":"910","author":"Zheng","year":"2024","journal-title":"Sci. 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