{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:03:58Z","timestamp":1789535038440,"version":"build-2803163510"},"reference-count":138,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health","award":["PRR.AP015.165"],"award-info":[{"award-number":["PRR.AP015.165"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The escalating global burden of neurodegenerative and neuropsychiatric disorders is deeply intertwined with cumulative environmental toxicant exposure. To accurately capture the prodromal and subclinical impacts of this multi-chemical \u201cpollutome\u201d, research is shifting from symptom-based assessments toward the use of objective, quantifiable biological indicators. Guided by the PRISMA-ScR framework, this scoping review systematically analyzed literature across PubMed, Scopus, Web of Science, and Embase databases without temporal restrictions. The final selection included 52 human observational studies that evaluated the relationship between environmental stressors and objective neurobiological markers across diverse geographical populations and life stages. The synthesized evidence reveals that varied environmental insults\u2014including ambient air pollution (e.g., fine particulate matter, PM2.5), heavy metals, agrochemicals, and persistent organic contaminants\u2014frequently correlate with measurable alterations in fluid biomarkers. These exposures are primarily associated with variations in markers of axonal damage (neurofilament light chain), astrocytic reactivity (glial fibrillary acidic protein), potential microglial dysfunction (soluble triggering receptor expressed on myeloid cells 2), and cytostructural alterations (Tau proteins and amyloid-beta). The literature highlights distinct windows of vulnerability, spanning from early-life epigenetic modifications (DNA methylation) to adult neurovascular injury. Mechanistically, despite their chemical heterogeneity, the available evidence suggests that these pollutants may converge on shared pathophysiological pathways defined by blood\u2013brain barrier disruption and chronic, self-perpetuating neuroinflammation. Understanding environmental neurotoxicity may benefit from moving beyond traditional single-pollutant approaches toward a broader exposome framework. Future epidemiological research should integrate high-dimensional human biomonitoring with artificial intelligence and machine learning architectures. This computational integration would be essential to decode non-linear multi-pollutant interactions and accelerate the deployment of targeted, early-stage public health interventions.<\/jats:p>","DOI":"10.3390\/toxics14090817","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:09:51Z","timestamp":1789387791000},"page":"817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Exposome\u2013Brain Axis: A Scoping Review of Biological Biomarkers in Environmental Neurotoxicity, Neuroinflammation, and Neurodegeneration"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-302X","authenticated-orcid":false,"given":"Olivia","family":"Curzio","sequence":"first","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3365-3732","authenticated-orcid":false,"given":"Gabriele","family":"Donzelli","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-6217","authenticated-orcid":false,"given":"Said","family":"Daoudagh","sequence":"additional","affiliation":[{"name":"Institute of Information Science and Technologies \u201cAlessandro Faedo\u201d, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Baldacci","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bustaffa","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2643-2121","authenticated-orcid":false,"given":"Chiara","family":"Cavigli","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0785-1492","authenticated-orcid":false,"given":"Maria","family":"Morales-Su\u00e1rez-Varela","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de Val\u00e8ncia, Av. Vicent Andr\u00e9s Estelles s\/n, Burjassot, 46100 Valencia, Spain"},{"name":"Biomedical Research Center in Epidemiology and Public Health Network (CIBERESP), Carlos III Health Institute, Av. Monforte de Lemos 3-5 Pabell\u00f3n 11 Planta 0, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-4583","authenticated-orcid":false,"given":"Paolo","family":"Paradisi","sequence":"additional","affiliation":[{"name":"Institute of Information Science and Technologies \u201cAlessandro Faedo\u201d, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-5126","authenticated-orcid":false,"given":"Davide","family":"Moroni","sequence":"additional","affiliation":[{"name":"Institute of Information Science and Technologies \u201cAlessandro Faedo\u201d, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-4731","authenticated-orcid":false,"given":"Fabrizio","family":"Minichilli","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1474-4422(19)30411-9","article-title":"The global burden of neurological disorders: Translating evidence into policy","volume":"19","author":"Feigin","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_2","unstructured":"GBD 2021 Nervous System Disorders Collaborators (2024). Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol., 23, 344\u2013381."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.bpobgyn.2013.07.007","article-title":"Neurological disorders","volume":"27","author":"Haider","year":"2013","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00415-015-7893-2","article-title":"Functional neurological disorders: Mechanisms and treatment","volume":"263","author":"Lehn","year":"2016","journal-title":"J. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Murphy, S.L., Kochanek, K.D., Xu, J., and Arias, E. (2024). Mortality in the United States, 2023, NCHS Data Briefs [Internet].","DOI":"10.15620\/cdc\/170564"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106247","DOI":"10.1016\/j.neubiorev.2025.106247","article-title":"The exposome from neurodevelopment to neurodegeneration: A narrative review","volume":"176","author":"Dallere","year":"2025","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Di Renzo, L., Gualtieri, P., Frank, G., Cianci, R., Caldarelli, M., Leggeri, G., Raffaelli, G., Pizzocaro, E., Cirillo, M., and De Lorenzo, A. (2024). Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases. Diseases, 12.","DOI":"10.3390\/diseases12080176"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"118441","DOI":"10.1016\/j.envres.2024.118441","article-title":"Exploring environmental exposomes and the gut-brain nexus: Unveiling the impact of pesticide exposure","volume":"250","author":"Khoo","year":"2024","journal-title":"Environ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1007\/s11357-023-00913-3","article-title":"Exposome and unhealthy aging: Environmental drivers from air pollution to occupational exposures","volume":"45","author":"Pandics","year":"2023","journal-title":"Geroscience"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100922","DOI":"10.1016\/j.bbih.2024.100922","article-title":"What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways","volume":"43","author":"Catapano","year":"2025","journal-title":"Brain Behav. Immun.-Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/wps.21068","article-title":"Impact of mental disorders on clinical outcomes of physical diseases: An umbrella review assessing population attributable fraction and generalized impact fraction","volume":"22","author":"Dragioti","year":"2023","journal-title":"World Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1192\/j.eurpsy.2022.2349","article-title":"The biopsychosocial model of schizophrenia and cancer: Unraveling the etiopathogenesis of complex diseases","volume":"65","author":"Fiorillo","year":"2022","journal-title":"Eur. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Roberts, M., Colley, K., Currie, M., Eastwood, A., Li, K.-H., Avery, L.M., Beevers, L.C., Braithwaite, I., Dallimer, M., and Davies, Z.G. (2023). The Contribution of Environmental Science to Mental Health Research: A Scoping Review. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20075278"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/wps.20998","article-title":"Psychiatric diagnosis and treatment in the 21st century: Paradigm shifts versus incremental integration","volume":"21","author":"Stein","year":"2022","journal-title":"World Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1007\/s12011-023-03965-w","article-title":"An Update Overview on Mechanistic Data and Biomarker Levels in Cobalt and Chromium-Induced Neurodegenerative Diseases","volume":"202","author":"Ajibo","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"dvae027","DOI":"10.1093\/eep\/dvae027","article-title":"A systematic review of associations between the environment, DNA methylation, and cognition","volume":"11","author":"Glover","year":"2025","journal-title":"Environ. Epigenet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"37963","DOI":"10.1007\/s11356-024-33735-7","article-title":"Heavy metal exposure and metabolomics analysis: An emerging frontier in environmental health","volume":"31","author":"Ilyas","year":"2024","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s43188-023-00184-2","article-title":"Recent insights into autophagy and metals\/nanoparticles exposure","volume":"39","author":"Li","year":"2023","journal-title":"Toxicol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Monaco, M., Torazza, C., Fedele, E., and Grilli, M. (2025). The Impact of the Exposome on Alzheimer\u2019s Disease: The Influence of Nutrition. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26073015"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Newell, M.E., Aravindan, A., Babbrah, A., and Halden, R.U. (2025). Epigenetic Biomarkers Driven by Environmental Toxins Associated with Alzheimer\u2019s Disease, Parkinson\u2019s Disease, and Amyotrophic Lateral Sclerosis in the United States: A Systematic Review. Toxics, 13.","DOI":"10.3390\/toxics13020114"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"25001","DOI":"10.1289\/EHP9889","article-title":"The Interplay of Environmental Exposures and Mental Health: Setting an Agenda","volume":"130","author":"Reuben","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tota, M., Karska, J., Kowalski, S., Pi\u0105tek, N., Pszczo\u0142owska, M., Mazur, K., and Piotrowski, P. (2024). Environmental pollution and extreme weather conditions: Insights into the effect on mental health. Front. Psychiatry, 15.","DOI":"10.3389\/fpsyt.2024.1389051"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"176941","DOI":"10.1016\/j.scitotenv.2024.176941","article-title":"Neurotoxicity of per- and polyfluoroalkyl substances: Evidence and future directions","volume":"955","author":"Bharal","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"121646","DOI":"10.1016\/j.envres.2025.121646","article-title":"Gestational exposures to mixtures of multiple chemical classes and autism spectrum disorder in the MARBLES study","volume":"278","author":"Choi","year":"2025","journal-title":"Environ. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mi\u0161\u013eanov\u00e1, C., and Valachovi\u010dov\u00e1, M. (2025). Health Impacts of Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review. Life, 15.","DOI":"10.3390\/life15040573"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"154030","DOI":"10.1016\/j.tox.2024.154030","article-title":"Microplastics\/nanoplastics and neurological health: An overview of neurological defects and mechanisms","volume":"511","author":"Sun","year":"2025","journal-title":"Toxicology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s40572-024-00451-w","article-title":"Metabolic Perturbations Associated with both PFAS Exposure and Perinatal\/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Scoping Review","volume":"11","author":"Suthar","year":"2024","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5334\/aogh.4459","article-title":"An Umbrella Review of Meta-Analyses Evaluating Associations between Human Health and Exposure to Major Classes of Plastic-Associated Chemicals","volume":"90","author":"Symeonides","year":"2024","journal-title":"Ann. Glob. Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1289\/ehp.1307175","article-title":"The Navigation Guide systematic review methodology: A rigorous and transparent method for translating environmental health science into better health outcomes","volume":"122","author":"Woodruff","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/10937404.2019.1661588","article-title":"An overview of the current progress, challenges, and prospects of human biomonitoring and exposome studies","volume":"22","author":"Bocato","year":"2019","journal-title":"J. Toxicol. Environ. Health Part B"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.fct.2015.03.025","article-title":"Toxicological importance of human biomonitoring of metallic and metalloid elements in different biological samples","volume":"80","author":"Gil","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kon\u00ed\u010dkov\u00e1, D., Men\u0161\u00edkov\u00e1, K., Tu\u010dkov\u00e1, L., H\u00e9nykov\u00e1, E., Strnad, M., Friedeck\u00fd, D., Stejskal, D., Mat\u011bj, R., and Ka\u0148ovsk\u00fd, P. (2022). Biomarkers of Neurodegenerative Diseases: Biology, Taxonomy, Clinical Relevance, and Current Research Status. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071760"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"fcab086","DOI":"10.1093\/braincomms\/fcab086","article-title":"Biomarkers in neurological disorders: A fast-growing market","volume":"3","year":"2021","journal-title":"Brain Commun."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Reddy, D.S., and Abeygunaratne, H.N. (2022). Experimental and Clinical Biomarkers for Progressive Evaluation of Neuropathology and Therapeutic Interventions for Acute and Chronic Neurological Disorders. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911734"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1007\/s11064-023-03873-4","article-title":"Biomarkers: Role and Scope in Neurological Disorders","volume":"48","author":"Sharma","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Chang, X., Wang, Y., Zheng, B., Chen, Y., Xie, J., Song, Y., Ding, X., Hu, X., Hu, X., and Yu, Q. (2022). The Role of Acrolein in Neurodegenerative Diseases and Its Protective Strategy. Foods, 11.","DOI":"10.3390\/foods11203203"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10565-024-09926-w","article-title":"Exogenous and endogenous formaldehyde-induced DNA damage in the aging brain: Mechanisms and implications for brain diseases","volume":"40","author":"Tian","year":"2024","journal-title":"Cell Biol. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15333175221143274","DOI":"10.1177\/15333175221143274","article-title":"Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases","volume":"37","author":"Xu","year":"2022","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Contaminants in the Food Chain (CONTAM) (2010). Chain (CONTAM) EP on C in the F. Scientific Opinion on Lead in Food. EFSA J., 8, 1570.","DOI":"10.2903\/j.efsa.2010.1570"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"113855","DOI":"10.1016\/j.ijheh.2021.113855","article-title":"Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility","volume":"238","author":"Gundacker","year":"2021","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00702-018-1910-4","article-title":"Diagnostic biomarkers for Parkinson\u2019s disease at a glance: Where are we?","volume":"125","author":"Cova","year":"2018","journal-title":"J. Neural Transm."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"He, R., Yan, X., Guo, J., Xu, Q., Tang, B., and Sun, Q. (2018). Recent Advances in Biomarkers for Parkinson\u2019s Disease. Front. Aging Neurosci., 10.","DOI":"10.3389\/fnagi.2018.00305"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1007\/s11356-020-11620-3","article-title":"A mechanistic view on the neurotoxic effects of air pollution on central nervous system: Risk for autism and neurodegenerative diseases","volume":"28","author":"Shabani","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1177\/10783903221139831","article-title":"Climate Change is an Emerging Threat to Perinatal Mental Health","volume":"30","author":"Barkin","year":"2024","journal-title":"J. Am. Psychiatr. Nurses Assoc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"104729","DOI":"10.1016\/j.neuint.2020.104729","article-title":"Olfactory cell cultures to investigate health effects of air pollution exposure: Implications for neurodegeneration","volume":"136","author":"Kanninen","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1001\/jamapsychiatry.2023.2996","article-title":"Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience: A Review","volume":"80","author":"Schumann","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.3390\/cimb46050256","article-title":"Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences","volume":"46","author":"Sofield","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"109940","DOI":"10.1016\/j.cbpc.2024.109940","article-title":"Review: Progress towards research on the toxicology of pyrimethanil","volume":"283","author":"Chen","year":"2024","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/08958378.2023.2172486","article-title":"Air Pollutant impacts on the brain and neuroendocrine system with implications for peripheral organs: A perspective","volume":"35","author":"Kodavanti","year":"2023","journal-title":"Inhal. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101867","DOI":"10.1016\/j.arr.2023.101867","article-title":"The pollutome-connectome axis: A putative mechanism to explain pollution effects on neurodegeneration","volume":"86","author":"Pini","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Hikisz, P., and Jacenik, D. (2023). The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity. Cells, 12.","DOI":"10.3390\/cells12060879"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/s12276-024-01261-8","article-title":"NLRP3 inflammasome: A key player in the pathogenesis of life-style disorders","volume":"56","author":"Ramachandran","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"113680","DOI":"10.1016\/j.biopha.2022.113680","article-title":"The cGAS-STING-mediated NLRP3 inflammasome is involved in the neurotoxicity induced by manganese exposure","volume":"154","author":"Liu","year":"2022","journal-title":"BioMed Pharmacother."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"110396","DOI":"10.1016\/j.mehy.2020.110396","article-title":"Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality","volume":"146","author":"Lara","year":"2021","journal-title":"Med. Hypotheses"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Heidari, H., and Lawrence, D.A. (2023). Climate Stressors and Physiological Dysregulations: Mechanistic Connections to Pathologies. Int. J. Environ. Res. Public Health, 21.","DOI":"10.3390\/ijerph21010028"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/0748233717733852","article-title":"Neural autoantibodies in patients with neurological symptoms and histories of chemical\/mold exposures","volume":"34","author":"Lieberman","year":"2018","journal-title":"Toxicol. Ind. Health"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/jnnp-2020-322815","article-title":"Environmental exposure to phthalates and dementia with Lewy bodies: Contribution of metabolomics","volume":"91","author":"Agin","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"106864","DOI":"10.1016\/j.envint.2021.106864","article-title":"Associations between air pollution and biomarkers of Alzheimer\u2019s disease in cognitively unimpaired individuals","volume":"157","author":"Alemany","year":"2021","journal-title":"Environ. Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neuro.2018.07.018","article-title":"Assessing mercury intoxication in isolated\/remote populations: Increased S100B mRNA in blood in exposed riverine inhabitants of the Amazon","volume":"68","author":"Paraense","year":"2018","journal-title":"Neurotoxicology"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Balachandar, R., Viramgami, A., Singh, D.P., Kulkarni, N., Chudasama, B., Sivaperumal, P., and Upadhyay, K. (2025). Association between chronic PM2.5 exposure and neurodegenerative biomarkers in adults from critically polluted area. BMC Public Health, 25.","DOI":"10.1186\/s12889-025-22641-3"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"45645","DOI":"10.1038\/s41598-025-30715-w","article-title":"Alterations in neuroinflammatory and neurodegenerative biomarkers among long-term residents of a critically polluted area: A cross-sectional comparative study","volume":"15","author":"Balachandar","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"glaf135","DOI":"10.1093\/gerona\/glaf135","article-title":"Increased A\u03b240 in plasma is associated with severity of exposure to airborne pollutants at the World Trade Center: A cross-sectional study of neurological biomarkers","volume":"80","author":"Barber","year":"2025","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"171893","DOI":"10.1016\/j.scitotenv.2024.171893","article-title":"Association between volatile organic compounds and serum neurofilament light chain in US adults","volume":"926","author":"Bi","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1212\/01.wnl.0000304049.31377.f2","article-title":"A-Synuclein, pesticides, and Parkinson disease","volume":"70","author":"Brighina","year":"2008","journal-title":"Neurology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"132780","DOI":"10.1016\/j.jhazmat.2023.132780","article-title":"Epigenome-wide association study on short-, intermediate- and long-term ozone exposure in Han Chinese, the NSPT study","volume":"463","author":"Cai","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JAD-2012-120610","article-title":"White matter hyperintensities, systemic inflammation, brain growth, and cognitive functions in children exposed to air pollution","volume":"31","author":"Styner","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Calder\u00f3n-Garcidue\u00f1as, L., Stommel, E.W., Lachmann, I., Waniek, K., Chao, C.K., Gonz\u00e1lez-Maciel, A., Garc\u00eda-Rojas, E., Torres-Jard\u00f3n, R., Delgado-Ch\u00e1vez, R., and Mukherjee, P.S. (2022). TDP-43 CSF Concentrations Increase Exponentially with Age in Metropolitan Mexico City Young Urbanites Highly Exposed to PM2.5 and Ultrafine Particles and Historically Showing Alzheimer and Parkinson\u2019s Hallmarks. Brain TDP-43 Pathology in MMC Residents Is Associated with High Cisternal CSF TDP-43 Concentrations. Toxics, 10.","DOI":"10.3390\/toxics10100559"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"47001","DOI":"10.1289\/EHP13503","article-title":"Association between Fine Particulate Matter Exposure and Cerebrospinal Fluid Biomarkers of Alzheimer\u2019s Disease among a Cognitively Healthy Population-Based Cohort","volume":"132","author":"Casey","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1038\/s41598-023-29843-y","article-title":"DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms","volume":"13","author":"Choi","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"glad208","DOI":"10.1093\/gerona\/glad208","article-title":"First Observations of a Potential Association Between Accumulation of Per- and Polyfluoroalkyl Substances in the Central Nervous System and Markers of Alzheimer\u2019s Disease","volume":"79","author":"Delcourt","year":"2024","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"dvaf011","DOI":"10.1093\/eep\/dvaf011","article-title":"Interaction of mercury exposure and DNA methylation with sustained attention in children in a novel analysis of epigenetic susceptibility","volume":"11","author":"Ehlinger","year":"2025","journal-title":"Environ. Epigenet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"122335","DOI":"10.1016\/j.envres.2025.122335","article-title":"Agricultural copper pesticide exposure and DNA methylation in Central Valley of California residents with and without Parkinson\u2019s disease","volume":"285","author":"Gong","year":"2025","journal-title":"Environ. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"107800","DOI":"10.1016\/j.envint.2023.107800","article-title":"Air pollution and plasma amyloid beta in a cohort of older adults: Evidence from the Ginkgo Evaluation of Memory study","volume":"172","author":"Hajat","year":"2023","journal-title":"Environ. Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"144204","DOI":"10.1016\/j.chemosphere.2025.144204","article-title":"Changes in molecular biomarkers of neurotoxicity in newborns following prenatal exposure to organophosphate compounds","volume":"374","year":"2025","journal-title":"Chemosphere"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Honkova, K., Rossnerova, A., Chvojkova, I., Milcova, A., Margaryan, H., Pastorkova, A., Ambroz, A., Rossner, P., Jirik, V., and Rubes, J. (2022). Genome-Wide DNA Methylation in Policemen Working in Cities Differing by Major Sources of Air Pollution. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031666"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/jamaneurol.2020.3962","article-title":"Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults with Cognitive Impairment","volume":"78","author":"Iaccarino","year":"2021","journal-title":"JAMA Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3233\/JAD-200694","article-title":"Long-Term Exposure to PM10 and in vivo Alzheimer\u2019s Disease Pathologies","volume":"78","author":"Lee","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/acn3.51671","article-title":"Association between air pollution and CSF sTREM2 in cognitively normal older adults: The CABLE study","volume":"9","author":"Li","year":"2022","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"121726","DOI":"10.1016\/j.envres.2025.121726","article-title":"Metal exposure is associated with cognitive function and plasma sTrem2 levels in coal miners: A cross-sectional study","volume":"279","author":"Li","year":"2025","journal-title":"Environ. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1289\/ehp.1408577","article-title":"Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood","volume":"124","author":"Li","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"141078","DOI":"10.1016\/j.jhazmat.2026.141078","article-title":"Short-term black carbon exposure impairs mental health and DNA methylation signatures of mitochondrial carrier genes","volume":"503","author":"Liu","year":"2026","journal-title":"J. Hazard. Mater."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"116771","DOI":"10.1016\/j.ecoenv.2024.116771","article-title":"Association between cadmium exposure and serum neurofilament light chain levels: A nationwide population-based survey","volume":"282","author":"Luo","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1038\/s41380-026-03662-9","article-title":"Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer\u2019s disease among a cognitively normal population-based cohort","volume":"31","author":"Ma","year":"2026","journal-title":"Mol. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.biopsych.2022.05.017","article-title":"Association of Long-term Exposure to Ambient Air Pollution with Cognitive Decline and Alzheimer\u2019s Disease-Related Amyloidosis","volume":"93","author":"Ma","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Maggio, A.G., Shu, H.T., Laufer, B.I., Bi, C., Lai, Y., LaSalle, J.M., and Hu, V.W. (2022). Elevated exposures to persistent endocrine disrupting compounds impact the sperm methylome in regions associated with autism spectrum disorder. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.929471"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1080\/15592294.2021.1975917","article-title":"Prenatal exposure to endocrine disrupting chemicals is associated with altered DNA methylation in cord blood","volume":"17","author":"Mattonet","year":"2022","journal-title":"Epigenetics"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1289\/ehp.1104474","article-title":"Prenatal Lead Levels, Plasma Amyloid \u03b2 Levels, and Gene Expression in Young Adulthood","volume":"120","author":"Mazumdar","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"115227","DOI":"10.1016\/j.envres.2023.115227","article-title":"Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment","volume":"220","author":"Mouat","year":"2023","journal-title":"Environ. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.scitotenv.2018.07.143","article-title":"Organophosphate pesticide exposure and differential genome-wide DNA methylation","volume":"645","author":"Paul","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.envint.2018.01.005","article-title":"Shorter telomere length in cord blood associated with prenatal air pollution exposure: Benefits of intervention","volume":"113","author":"Perera","year":"2018","journal-title":"Environ. Int."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"117152","DOI":"10.1016\/j.ecoenv.2024.117152","article-title":"The impact of metals on cognitive impairment in the elderly and the mediating role of oxidative stress: A cross-sectional study in Shanghai, China","volume":"286","author":"Qing","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"167209","DOI":"10.1016\/j.scitotenv.2023.167209","article-title":"Short-term ozone exposure and serum neural damage biomarkers in healthy elderly adults: Evidence from a panel study","volume":"905","author":"Qu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s41983-025-01061-5","article-title":"Novel risk factors and comprehensive assessment of Alzheimer\u2019s disease patients: Case control hospital-based study","volume":"62","author":"Sarhan","year":"2026","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41531-024-00704-3","article-title":"Genetic variation and pesticide exposure influence blood DNA methylation signatures in females with early-stage Parkinson\u2019s disease","volume":"10","author":"SSchaffner","year":"2024","journal-title":"npj Park. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3233\/JAD-190563","article-title":"Fine Particulate Matter Exposure and Cerebrospinal Fluid Markers of Vascular Injury","volume":"71","author":"Shaffer","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.1021\/acs.est.1c03754","article-title":"Associations of Short-Term Exposure to Fine Particulate Matter with Neural Damage Biomarkers: A Panel Study of Healthy Retired Adults","volume":"56","author":"Song","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Urbano, T., Vinceti, M., Carbone, C., Wise, L.A., Malavolti, M., Tondelli, M., Bedin, R., Vinceti, G., Marti, A., and Chiari, A. (2024). Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment. Toxics, 12.","DOI":"10.3390\/toxics12120933"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"115425","DOI":"10.1016\/j.envres.2023.115425","article-title":"Particulate matter exposure from motorized traffic and risk of conversion from mild cognitive impairment to dementia: An Italian prospective cohort study","volume":"222","author":"Urbano","year":"2023","journal-title":"Environ. Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Wang, A.-Y., Hu, H.-Y., Sun, Y., Ou, Y.-N., Ma, Y.-H., Li, M., Li, Q.-Y., and Tan, L. (2024). Association between air pollution and cerebrospinal fluid alpha-synuclein in urban elders: The CABLE study. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1422772"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Wang, X., Bakulski, K.M., Karvonen-Gutierrez, C.A., Park, S.K., Morgan, D., Jackson, B.P., Albin, R.L., and Paulson, H.L. (2025). Blood essential trace elements and Alzheimer\u2019s disease biomarkers in midlife. Front. Aging Neurosci., 17.","DOI":"10.3389\/fnagi.2025.1539749"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/bioinformatics\/btz630","article-title":"A powerful and flexible weighted distance-based method incorporating interactions between DNA methylation and environmental factors on health outcomes","volume":"36","author":"Wang","year":"2020","journal-title":"Bioinformatics"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"117473","DOI":"10.1016\/j.ecoenv.2024.117473","article-title":"Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013-2014","volume":"289","author":"Wang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"161812","DOI":"10.1016\/j.scitotenv.2023.161812","article-title":"Associations between multiple heavy metals exposure and neural damage biomarkers in welders: A cross-sectional study","volume":"869","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Zaw, Y.H., and Taneepanichskul, N. (2019). Blood heavy metals and brain-derived neurotrophic factor in the first trimester of pregnancy among migrant workers. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0218409"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Lu, Z., Sun, Y., Guo, L., Zhang, X., Liao, Y., Kang, Z., Feng, X., Zhao, G., and Sun, J. (2024). Interactive effect of air pollution and genetic risk of depression on processing speed by resting-state functional connectivity of occipitoparietal network. BMC Med., 22.","DOI":"10.1186\/s12916-024-03614-6"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"120665","DOI":"10.1016\/j.jad.2025.120665","article-title":"STREM2 mediates the associations of air pollution with depression and anxiety symptoms: The CABLE study","volume":"395","author":"Zhang","year":"2026","journal-title":"J. Affect. Disord."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"118369","DOI":"10.1016\/j.ecoenv.2025.118369","article-title":"Associations among blood heavy metals, neurofilament light chains and cognition function in US adults: NHANES 2013\u20132014","volume":"299","author":"Zhou","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(17)32345-0","article-title":"The Lancet Commission on pollution and health","volume":"391","author":"Landrigan","year":"2018","journal-title":"Lancet"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1158\/1055-9965.EPI-05-0456","article-title":"Complementing the genome with an \u2018exposome\u2019: The outstanding challenge of environmental exposure measurement in molecular epidemiology","volume":"14","author":"Wild","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"105887","DOI":"10.1016\/j.envint.2020.105887","article-title":"What is new in the exposome?","volume":"143","author":"Vineis","year":"2020","journal-title":"Environ. Int."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"A137","DOI":"10.1289\/EHP412","article-title":"The Exposome: Embracing the Complexity for Discovery in Environmental Health","volume":"124","author":"Cui","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tins.2009.05.009","article-title":"Air pollution: Mechanisms of neuroinflammation and CNS disease","volume":"32","author":"Block","year":"2009","journal-title":"Trends Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0192623307313011","article-title":"Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults","volume":"36","author":"Solt","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1517\/14728222.9.5.887","article-title":"Neuroinflammation: A potential therapeutic target","volume":"9","author":"Craft","year":"2005","journal-title":"Expert. Opin. Ther. Targets"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Gordon, R., and Woodruff, T.M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-Modifying Targets in Neurodegenerative Disorders, Academic Press.","DOI":"10.1016\/B978-0-12-805120-7.00003-8"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(13)70060-7","article-title":"Mechanisms of sporadic cerebral small vessel disease: Insights from neuroimaging","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/08958370490439597","article-title":"Translocation of inhaled ultrafine particles to the brain","volume":"16","author":"Sharp","year":"2004","journal-title":"Inhal. Toxicol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American heart association\/American stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/MOP.0b013e32832925cc","article-title":"Epigenetics and environmental chemicals","volume":"21","author":"Baccarelli","year":"2009","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"dvw017","DOI":"10.1093\/eep\/dvw017","article-title":"Epigenetic alterations induced by environmental stress associated with metabolic and neurodevelopmental disorders","volume":"2","author":"Kubota","year":"2016","journal-title":"Environ. Epigenet."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Bilbo, S.D., and Schwarz, J.M. (2009). Early-life programming of later-life brain and behavior: A critical role for the immune system. Front. Behav. Neurosci., 3.","DOI":"10.3389\/neuro.08.014.2009"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s42003-024-07444-3","article-title":"Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations","volume":"8","author":"King","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Wal, P., Mishra, S., Pradhan, D., Wal, A., Purohit, D., Nainwal, L.M., Dhir, V., and Gasmi, A. (2026). Environmental epigenetic modifiers in neurodegenerative diseases: A systematic review of epigenomic mechanisms and therapeutic targets. Front. Epigenet. Epigenom., 4.","DOI":"10.3389\/freae.2026.1833533"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrg3405","article-title":"From promises to practical strategies in epigenetic epidemiology","volume":"14","author":"Mill","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopsych.2008.09.002","article-title":"Experience-dependent epigenetic modifications in the central nervous system","volume":"65","author":"Sweatt","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s42466-025-00452-6","article-title":"Environmental toxins in neurodegeneration\u2014A narrative review","volume":"7","author":"Piel","year":"2025","journal-title":"Neurol. Res. Pract."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1097\/EDE.0000000000000231","article-title":"Confounding adjustment and exposure prediction in environmental epidemiology: Additional insights","volume":"26","author":"Dominici","year":"2015","journal-title":"Epidemiology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.aay3164","article-title":"The exposome and health: Where chemistry meets biology","volume":"367","author":"Vermeulen","year":"2020","journal-title":"Science"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Joubert, B.R., Kioumourtzoglou, M.-A., Chamberlain, T., Chen, H.Y., Gennings, C., Turyk, M.E., Miranda, M.L., Webster, T.F., Ensor, K.B., and Dunson, D.B. (2022). Powering Research through Innovative Methods for Mixtures in Epidemiology (PRIME) Program: Novel and Expanded Statistical Methods. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031378"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13148-019-0713-2","article-title":"Air pollution and DNA methylation: Effects of exposure in humans","volume":"11","author":"Rider","year":"2019","journal-title":"Clin. Epigenet."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/bph.14888","article-title":"Dietary antioxidants remodel DNA methylation patterns in chronic disease","volume":"177","author":"Beetch","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"\u010c\u00ed\u017e, M., Dvo\u0159\u00e1kov\u00e1, A., Sko\u010dkov\u00e1, V., and Kubala, L. (2020). The Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes. Antioxidants, 9.","DOI":"10.3390\/antiox9080691"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.18632\/aging.202913","article-title":"Potential reversal of epigenetic age using a diet and lifestyle intervention: A pilot randomized clinical trial","volume":"13","author":"Fitzgerald","year":"2021","journal-title":"Aging"}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/9\/817\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:28:38Z","timestamp":1789532918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/14\/9\/817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":138,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["toxics14090817"],"URL":"https:\/\/doi.org\/10.3390\/toxics14090817","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}