{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:28:47Z","timestamp":1791419327880,"version":"4.3.3"},"reference-count":135,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The mitochondrial dysfunction has a critical role in several disorders including chemotherapy-induced peripheral neuropathies (CIPN). This is due to a related dysregulation of pathways involving calcium signalling, reactive oxygen species and apoptosis. Vincristine is able to affect calcium movement through the Dorsal Root Ganglia (DRG) neuronal mitochondrial membrane, altering its homeostasis and leading to abnormal neuronal excitability. Paclitaxel induces the opening of the mitochondrial permeability transition pore in axons followed by mitochondrial membrane potential loss, increased reactive oxygen species generation, ATP level reduction, calcium release and mitochondrial swelling. Cisplatin and oxaliplatin form adducts with mitochondrial DNA producing inhibition of replication, disruption of transcription and morphological abnormalities within mitochondria in DRG neurons, leading to a gradual energy failure. Bortezomib is able to modify mitochondrial calcium homeostasis and mitochondrial respiratory chain. Moreover, the expression of a certain number of genes, including those controlling mitochondrial functions, was altered in patients with bortezomib-induced peripheral neuropathy.<\/jats:p>","DOI":"10.3390\/toxics3020198","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T10:23:07Z","timestamp":1433499787000},"page":"198-223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":199,"title":["Mitochondrial Dysfunction in Chemotherapy-Induced Peripheral Neuropathy (CIPN)"],"prefix":"10.3390","volume":"3","author":[{"given":"Annalisa","family":"Canta","sequence":"first","affiliation":[{"name":"Experimental Neurology Unit, Department of Surgery and Translational Medicine, University of Milan-Bicocca, Via Cadore 48, 20900 Monza (MB), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, Department of Surgery and Translational Medicine, University of Milan-Bicocca, Via Cadore 48, 20900 Monza (MB), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0963-7107","authenticated-orcid":false,"given":"Valentina","family":"Carozzi","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, Department of Surgery and Translational Medicine, University of Milan-Bicocca, Via Cadore 48, 20900 Monza (MB), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.2174\/092986708786848569","article-title":"Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies","volume":"15","author":"Park","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2011.10.019","article-title":"Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy","volume":"291","author":"Jaggi","year":"2012","journal-title":"Toxicology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/annonc\/mdf058","article-title":"Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer","volume":"13","author":"Strumberg","year":"2002","journal-title":"Ann Oncol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.2042-7158.1997.tb06759.x","article-title":"Reversible blockade of retrograde axonal transport in the rat sciatic nerve by vincristine","volume":"49","author":"Macfarlane","year":"1997","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s004410050019","article-title":"Taxol impairs anterograde axonal transport of microinjected horseradish peroxidase in dorsal root ganglia neurons in vitro","volume":"299","author":"Theiss","year":"2000","journal-title":"Cell Tissue Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"940","DOI":"10.4161\/cc.7.7.5625","article-title":"Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: A possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition","volume":"7","author":"Poruchynsky","year":"2008","journal-title":"Cell Cycle"},{"key":"ref_7","first-page":"389","article-title":"Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration","volume":"21","author":"Cavaletti","year":"2003","journal-title":"Neurotoxic"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1034\/j.1600-0404.2003.00203.x","article-title":"Thalidomide neuropathy: Clinical, electrophysiological and neuroradiological features","volume":"109","author":"Isoardo","year":"2004","journal-title":"Acta Neurol. Scand."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.expneurol.2006.11.010","article-title":"Bortezomib-induced peripheral neurotoxicity: A neurophysiological and pathological study in the rat","volume":"204","author":"Cavaletti","year":"2007","journal-title":"Exp. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1213\/01.ane.0000204318.35194.ed","article-title":"Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy","volume":"102","author":"Siau","year":"2006","journal-title":"Anesth. Analg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.pain.2006.09.016","article-title":"Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat","volume":"128","author":"Ling","year":"2007","journal-title":"Pain"},{"key":"ref_12","first-page":"520","article-title":"Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice","volume":"137","author":"Nieto","year":"2008","journal-title":"Brain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.neuroscience.2010.05.019","article-title":"Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models","volume":"169","author":"Ghelardini","year":"2010","journal-title":"Neuroscience"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuro.2006.04.010","article-title":"Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding","volume":"27","author":"Ta","year":"2006","journal-title":"Neurotoxicology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1161\/CIRCULATIONAHA.104.470849","article-title":"Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: Attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth","volume":"111","author":"Kirchmair","year":"2002","journal-title":"Circulation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/sj.mt.6300019","article-title":"Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: Taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF","volume":"15","author":"Kirchmair","year":"2007","journal-title":"Mol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1744-8069-6-15","article-title":"Transient receptor potential vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice","volume":"6","author":"Ta","year":"2010","journal-title":"Mol. Pain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1744-8069-6-82","article-title":"Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons","volume":"6","author":"Anand","year":"2010","journal-title":"Mol. Pain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pbb.2010.02.009","article-title":"Antinociceptive effect of three common analgesic drugs on peripheral neuropathy induced by paclitaxel in rats","volume":"95","author":"Pascual","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s12640-009-9114-1","article-title":"Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat","volume":"17","author":"Carozzi","year":"2010","journal-title":"Neurotox. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jpain.2008.01.335","article-title":"Oxaliplatin acts on IB4-positive nociceptors to induce an oxidative stress-dependent acute painful peripheral neuropathy","volume":"9","author":"Joseph","year":"2008","journal-title":"J. Pain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejphar.2008.03.042","article-title":"Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats","volume":"587","author":"Muthuraman","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/ALN.0b013e3181ca31bd","article-title":"Phenyl N-tert-butylnitrone, a free radical scavenger, reduces mechanical allodynia in chemotherapy-induced neuropathic pain in rats","volume":"112","author":"Kim","year":"2010","journal-title":"Anesthesiology"},{"key":"ref_24","first-page":"107","article-title":"Study on mechanism of bortezomib inducing peripheral neuropathy and the reversing effect of reduced glutathione","volume":"32","author":"Wang","year":"2011","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pain.2006.01.037","article-title":"Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction","volume":"122","author":"Flatters","year":"2006","journal-title":"Pain"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.expneurol.2008.08.013","article-title":"Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy","volume":"214","author":"Melli","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1470-2045(10)70206-0","article-title":"Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: A prospective analysis of data from the HOVON-65\/GMMG-HD4 trial","volume":"11","author":"Broyl","year":"2010","journal-title":"Lancet Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.cb.07.110191.002321","article-title":"Replication and transcription of vertebrate mitochondrial DNA","volume":"7","author":"Clayton","year":"1991","journal-title":"Annu. Rev. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1111\/j.1460-9568.2004.03750.x","article-title":"Caspase signalling in neuropathic and inflammatory pain in the rat","volume":"20","author":"Joseph","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0143-4160(02)00095-7","article-title":"Role of mitochondria in intracellular calcium signaling in primary and secondary sensory neurones of rats","volume":"32","author":"Shishkin","year":"2002","journal-title":"Cell Calcium"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1124\/mi.4.5.3","article-title":"The role of reactive oxygen species (ROS) in persistent pain","volume":"4","author":"Chung","year":"2004","journal-title":"Mol. Interv."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ncb1101-e255","article-title":"Organelle-specific initiation of cell death pathways","volume":"3","author":"Ferri","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/35048073","article-title":"The mitochondrion in apoptosis: How Pandora\u2019s box opens","volume":"2","author":"Zamzami","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.yjmcc.2009.02.007","article-title":"The molecular composition of the mitochondrial permeability transition pore","volume":"46","author":"Baines","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/j.1742-4658.2006.05213.x","article-title":"The mitochondrial permeability transition from in vitro artifact to disease target","volume":"273","author":"Bernardi","year":"2006","journal-title":"FEBS J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.pain.2011.12.011","article-title":"Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin","volume":"153","author":"Xiao","year":"2012","journal-title":"Pain"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2011.08.016","article-title":"Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy","volume":"232","author":"Zheng","year":"2011","journal-title":"Exp. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.expneurol.2012.08.023","article-title":"Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy","volume":"238","author":"Zheng","year":"2012","journal-title":"Exp. Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/cne.1403","article-title":"Three-dimensional reconstruction of scleral cold thermoreceptors of the cat eye","volume":"441","author":"Heppelmann","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.pain.2007.06.001","article-title":"Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-L-carnitine","volume":"135","author":"Xiao","year":"2008","journal-title":"Pain"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nrneurol.2014.77","article-title":"Mitotoxicity in distal symmetrical sensory peripheral neuropathies","volume":"10","author":"Bennett","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuroscience.2011.10.010","article-title":"Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat","volume":"29","author":"Xiao","year":"2011","journal-title":"Neuroscience"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.redox.2014.01.006","article-title":"Oxidative stress and nerve damage: Role in chemotherapy induced peripheral neuropathy","volume":"18","author":"Areti","year":"2014","journal-title":"Redox. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.expneurol.2009.02.015","article-title":"The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice","volume":"218","author":"Martin","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2","volume":"36","author":"Mersiyanova","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1021\/ja00738a045","article-title":"Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia","volume":"93","author":"Wani","year":"1971","journal-title":"J. Am. Chem. Soc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"10435","DOI":"10.1016\/S0021-9258(19)68639-4","article-title":"Taxol-induced polymerization of purified tubulin. Mechanism of action","volume":"256","author":"Kumar","year":"1981","journal-title":"Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1021\/bi00007a014","article-title":"Substoichiometric binding of taxol suppresses microtubule dynamics","volume":"34","author":"Derry","year":"1985","journal-title":"Biochemistry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3253","article-title":"Microtubule-binding agents: A dynamic field of cancer therapeutics","volume":"9","author":"Dumontet","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_52","first-page":"816","article-title":"Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death","volume":"56","author":"Jordan","year":"1996","journal-title":"Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pain.2004.01.021","article-title":"Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients","volume":"109","author":"Dougherty","year":"2004","journal-title":"Pain"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.critrevonc.2008.01.008","article-title":"Peripheral nerve damage associated with administration of taxanes in patients with cancer","volume":"66","author":"Argyriou","year":"2008","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1001\/archneur.1994.00540190110024","article-title":"Taxol neuropathy, Electrodiagnostic and sural nerve biopsy findings","volume":"51","author":"Sahenk","year":"1994","journal-title":"Arch. Neurol."},{"key":"ref_56","first-page":"1065","article-title":"Paclitaxel toxicity in post-mitotic dorsal root ganglion (DRG) cells","volume":"26","author":"Scuteri","year":"2006","journal-title":"Anticancer Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.expneurol.2009.04.017","article-title":"Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degeneration","volume":"128","author":"Yang","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/oxfordjournals.annonc.a059220","article-title":"Paclitaxel-induced neuropathy","volume":"6","author":"Postma","year":"1995","journal-title":"Ann. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0014-5793(96)00875-7","article-title":"Microtubule-active drugs suppress the closure of the permeability transition pore in tumour mitochondria","volume":"393","author":"Evtodienko","year":"1996","journal-title":"FEBS Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.1074\/jbc.M106802200","article-title":"Paclitaxel affects cytosolic Ca2+ signals by opening the mitochondrial permeability transition pore","volume":"277","author":"Kidd","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1074\/jbc.M409819200","article-title":"[Ca2+]i signaling between mitochondria and endoplasmic reticulum in neurons is regulated by microtubules. From mitochondrial permeability transition pore to Ca2+-induced Ca2+ release","volume":"280","author":"Mironov","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0092-8674(95)90430-1","article-title":"Decoding of cytosolic calcium oscillations in the mitochondria","volume":"82","author":"Seitz","year":"1995","journal-title":"Cell"},{"key":"ref_63","first-page":"5349","article-title":"Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells","volume":"60","author":"Braguer","year":"2000","journal-title":"Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"33664","DOI":"10.1074\/jbc.M203834200","article-title":"Tubulin is an inherent component of mitochondrial membranes that interacts with the voltage-dependent anion channel","volume":"277","author":"Carles","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0891-5849(01)00616-5","article-title":"Direct effect of Taxol on free radical formation and mitochondrial permeability transition","volume":"31","author":"Varbiro","year":"2001","journal-title":"Radic. Biol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/jmbi.1998.2303","article-title":"Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein","volume":"285","author":"Rodi","year":"1999","journal-title":"J. Mol. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.expneurol.2007.11.001","article-title":"Prevention of paclitaxel evoked painful peripheral neuropathy by acetyl-L-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells","volume":"210","author":"Jin","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/B:NEON.0000021787.70029.ce","article-title":"Neurotoxicity of Platinum Compounds: Comparison of the Effects of Cisplatin and Oxaliplatin on the Human Neuroblastoma Cell Line SH-SY5Y","volume":"67","author":"Donzelli","year":"2004","journal-title":"J. Neurooncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1158\/1535-7163.MCT-08-0840","article-title":"Platinum neurotoxicity pharmacogenetics","volume":"8","author":"McWhinney","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1006\/nbdi.2001.0426","article-title":"Alterations in cell cycle regulation underlie cisplatin induced apoptosis of dorsal root ganglion neurons in vivo","volume":"8","author":"Fischer","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2014.10.014","article-title":"Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?","volume":"596","author":"Carozzi","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF00227662","article-title":"Morphometric study of the sensory neuron and peripheral nerve changes induced by chronic cisplatin (DDP) administration in rats","volume":"84","author":"Cavaletti","year":"1992","journal-title":"Acta Neuropathol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1054\/bjoc.2001.2024","article-title":"Nucleolar damage correlates with neurotoxicity induced by different platinum drugs","volume":"85","author":"McKeage","year":"2001","journal-title":"Br. J. Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1152\/jn.2001.85.5.2293","article-title":"A Possible Explanation for a Neurotoxic Effect of the Anticancer Agent Oxaliplatin on Neuronal Voltage-Gated Sodium Channels","volume":"85","author":"Grolleau","year":"2001","journal-title":"J. Neurophysiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.ctrv.2014.04.004","article-title":"Chemotherapy-induced neuropathy: A comprehensive survey","volume":"40","author":"Miltenburg","year":"2014","journal-title":"Cancer Treat. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"iv45","DOI":"10.1093\/neuonc\/nos203","article-title":"Peripheral neuropathies from chemotherapeutics and targeted agents: Diagnosis, treatment, and prevention","volume":"14","author":"Grisold","year":"2012","journal-title":"Neuro Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"201593","DOI":"10.1155\/2011\/201593","article-title":"Oxaliplatin-induced neuropathy in colorectal cancer","volume":"2011","author":"Weickhardt","year":"2011","journal-title":"J. Oncol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S1470-2045(11)70131-0","article-title":"Chemotherapy-induced peripheral neurotoxicity in the era of pharmacogenomics","volume":"12","author":"Cavaletti","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/tx800481j","article-title":"Development of an ultraperformance liquid chromatography\/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts","volume":"22","author":"Boysen","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.nbd.2010.11.017","article-title":"Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons","volume":"41","author":"Podratz","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0162-0134(99)00135-X","article-title":"Platinum neurotoxicity: Clinical profiles, experimental models and neuroprotective approaches","volume":"77","author":"Screnci","year":"1999","journal-title":"J. Inorg. Biochem."},{"key":"ref_82","first-page":"18","article-title":"Chemotherapy-induced neurotoxicity: The value of neuroprotective strategies","volume":"70","author":"Beijers","year":"2012","journal-title":"Neth. J. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nbd.2004.09.013","article-title":"Cisplatin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: A potential mechanism for neurotoxicity","volume":"18","author":"McDonald","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/BJ20071615","article-title":"Cisplatin-mediated impairment of mitochondrial DNA metabolism inversely correlates with glutathione levels","volume":"414","author":"Garrido","year":"2008","journal-title":"Biochem. J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"F991","DOI":"10.1152\/ajprenal.1986.250.6.F991","article-title":"2nd Mitochondrial alterations in cisplatin-induced acute renal failure","volume":"250","author":"Gordon","year":"1986","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1124\/jpet.108.147181","article-title":"Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative\/nitrosative stress, inflammation, and cell death","volume":"328","author":"Pan","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1158\/0008-5472.CAN-08-1173","article-title":"Implications of apurinic\/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons","volume":"68","author":"Jiang","year":"2008","journal-title":"Cancer Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e81162","DOI":"10.1371\/journal.pone.0081162","article-title":"Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions","volume":"8","author":"Marullo","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1172\/JCI1130","article-title":"Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle","volume":"101","author":"Gill","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1681\/ASN.V134858","article-title":"Cisplatin Induces Apoptosis in LLC-PK1 Cells via Activation of Mitochondrial Pathways","volume":"13","author":"Park","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/nbdi.2001.0468","article-title":"Cisplatin-induced apoptosis of DRG neurons involves bax redistribution and cytochrome c release but not fas receptor signaling","volume":"9","author":"McDonald","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10863-006-9059-5","article-title":"Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer","volume":"39","author":"Cullen","year":"2007","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1113\/jphysiol.2007.144709","article-title":"Aerobic metabolism underlies complexity and capacity","volume":"86","author":"Koch","year":"2008","journal-title":"J. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1040-8428(01)00219-0","article-title":"Particular aspects of platinum compounds used at present in cancer treatment","volume":"42","author":"Desoize","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jpain.2008.12.003","article-title":"Comparison of oxaliplatin- and cisplatin-induced painful peripheral neuropathy in the rat","volume":"10","author":"Joseph","year":"2009","journal-title":"J. Pain"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1477-5751-8-2","article-title":"Oxaliplatin neurotoxicity\u2014No general ion channel surface-charge effect","volume":"8","author":"Broomand","year":"2009","journal-title":"J. Negat. Results Biomed."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuroscience.2011.12.023","article-title":"Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel","volume":"203","author":"Xiao","year":"2012","journal-title":"Neuroscience"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e106485","DOI":"10.1371\/journal.pone.0106485","article-title":"Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy","volume":"9","author":"Kelley","year":"2014","journal-title":"PLoS ONE"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1038\/sj.bjc.6602215","article-title":"Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells","volume":"91","author":"Arango","year":"2004","journal-title":"Br. J. Cancer"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1038\/sj.onc.1208047","article-title":"Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA","volume":"23","author":"Gourdier","year":"2004","journal-title":"Oncogene"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1021\/bi953037i","article-title":"Interaction of Vinca Alkaloids with Tubulin: A Comparison of Vinblastine, Vincristine, and Vinorelbine","volume":"35","author":"Lobert","year":"1996","journal-title":"Biochemistry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1021\/bi00056a013","article-title":"Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine","volume":"32","author":"Toso","year":"1993","journal-title":"Biochemistry"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1021\/bi00463a016","article-title":"Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations","volume":"29","author":"Jordan","year":"1990","journal-title":"Biochemistry"},{"key":"ref_104","first-page":"2212","article-title":"Mechanism of inhibition of cell proliferation by Vinca alkaloids","volume":"51","author":"Jordan","year":"1991","journal-title":"Cancer Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF01050259","article-title":"Long-term effects of vincristine on the peripheral nervous system","volume":"15","author":"Postma","year":"1993","journal-title":"Neurooncology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1517\/14740338.2011.543417","article-title":"Chemotherapy-induced peripheral neuropathies: From clinical relevance to preclinical evidence","volume":"10","author":"Balayssac","year":"2011","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/(SICI)1096-9861(19980615)395:4<481::AID-CNE5>3.0.CO;2-Y","article-title":"Microtubule disorientation and axonal swelling in unmyelinated sensory axons during vincristine- induced painful neuropathy in rat","volume":"395","author":"Tanner","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1523\/JNEUROSCI.18-16-06480.1998","article-title":"Nociceptor hyper- responsiveness during vincristine-induced painful peripheral neuropathy in the rat","volume":"18","author":"Tanner","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10048-012-0313-1","article-title":"Vincristine exacerbates asymptomatic Charcot\u2013Marie\u2013tooth disease with a novel EGR2 mutation","volume":"13","author":"Nakamura","year":"2012","journal-title":"Neurogenetics"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1212\/01.WNL.0000154642.45474.28","article-title":"Dose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worsening","volume":"64","author":"Verstappen","year":"2005","journal-title":"Neurology"},{"key":"ref_111","first-page":"323","article-title":"Clinical and electrophysiological studies in vincristine induced neuropathy","volume":"39","author":"Pal","year":"1999","journal-title":"Electromyogr. Clin. Neurophysiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0031-6989(86)90147-5","article-title":"Action of vinca alkaloides on calcium movements through mitochondrial membrane","volume":"18","author":"Tari","year":"1986","journal-title":"Pharmacol. Res. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.145.4.795","article-title":"Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes","volume":"145","author":"Boitier","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/35000001","article-title":"Chromaffin-cell stimulation triggers fast millimolar mitochondrial Ca2+ transients that modulate secretion","volume":"2","author":"Montero","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pain.2005.12.010","article-title":"Mitochondrial electron transport in models of neuropathic and inflammatory pain","volume":"121","author":"Joseph","year":"2006","journal-title":"Pain"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1081\/CNV-120030218","article-title":"Development of the Proteasome Inhibitor Velcade (Bortezomib)","volume":"22","author":"Adams","year":"2004","journal-title":"Cancer Investig."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.clon.2013.11.022","article-title":"Bortezomib in multiple myeloma: A practice guideline","volume":"26","author":"Kouroukis","year":"2014","journal-title":"Clin. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2165\/00003495-200969070-00006","article-title":"Bortezomib: A review of its use in patients with multiple myeloma","volume":"69","author":"Curran","year":"2009","journal-title":"Drugs"},{"key":"ref_119","first-page":"913","article-title":"Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastatic melanoma: Basic and clinical aspects","volume":"1","author":"Mohammad","year":"2001","journal-title":"Am. J. Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1002\/j.1460-2075.1994.tb06878.x","article-title":"A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B","volume":"13","author":"Traenckner","year":"1994","journal-title":"EMBO J."},{"key":"ref_121","first-page":"151","article-title":"CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats","volume":"5","author":"Meregalli","year":"2012","journal-title":"J. Pain Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3324\/haematol.11752","article-title":"Bortezomib-induced peripheral neurotoxicity: Still far from a painless gain","volume":"92","author":"Cavaletti","year":"2007","journal-title":"Haematologica"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1182\/blood-2008-04-149385","article-title":"Bortezomib-induced peripheral neuropathy in multiple myeloma: A comprehensive review of the literature","volume":"112","author":"Argyriou","year":"2008","journal-title":"Blood"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10072-010-0475-2","article-title":"Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: An immunofluorescence study","volume":"32","author":"Giannoccaro","year":"2011","journal-title":"Neurol. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jpain.2006.09.014","article-title":"Quantitative sensory findings in patients with bortezomib-induced pain","volume":"8","author":"Cata","year":"2007","journal-title":"J. Pain"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1200\/JCO.2005.04.7779","article-title":"Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib","volume":"24","author":"Richardson","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuro.2013.09.001","article-title":"Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons","volume":"39","author":"Staff","year":"2013","journal-title":"Neurotoxicolohy"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuro.2013.05.008","article-title":"Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: Implications for chemotherapy-induced peripheral neuropathy","volume":"37","author":"LaPointe","year":"2013","journal-title":"Neurotoxicology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.bbrc.2004.07.049","article-title":"The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta","volume":"321","author":"Durrant","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1158\/1078-0432.CCR-03-0561","article-title":"Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors","volume":"10","author":"Pei","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1158\/0008-5472.CAN-05-0676","article-title":"Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells","volume":"65","author":"Qin","year":"2005","journal-title":"Cancer Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1158\/0008-5472.CAN-04-3684","article-title":"Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341\/bortezomib) cytotoxicity in myeloma cell lines","volume":"65","author":"Landowski","year":"2005","journal-title":"Cancer Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.clinph.2013.07.014","article-title":"Bortezomib-induced neuropathy: Axonal membrane depolarization precedes development of neuropathy","volume":"125","author":"Nasu","year":"2014","journal-title":"Clin. Neurophysiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/brain\/123.12.2542","article-title":"Effects of membrane polarization and ischaemia on the excitability properties of human motor axons","volume":"123","author":"Kiernan","year":"2000","journal-title":"Brain"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.clinph.2008.04.295","article-title":"Changes in human sensory axonal excitability induced by an ischaemic insult","volume":"119","author":"Han","year":"2008","journal-title":"Clin. Neurophysiol."}],"container-title":["Toxics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6304\/3\/2\/198\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:47:30Z","timestamp":1760215650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6304\/3\/2\/198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,5]]},"references-count":135,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,6]]}},"alternative-id":["toxics3020198"],"URL":"https:\/\/doi.org\/10.3390\/toxics3020198","relation":{},"ISSN":["2305-6304"],"issn-type":[{"value":"2305-6304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,5]]}}}