{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:49:34Z","timestamp":1790754574772,"version":"4.1.0"},"reference-count":106,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>This review highlights the nature, characteristics, properties, pharmacological differences between different types of benzodiazepines, the mechanism of action in the central nervous system, and the degradation of benzodiazepines. In the end, the efforts to reduce the benzodiazepines\u2019 adverse effects are shown and a reflection is made on the responsible uses of these medications.<\/jats:p>","DOI":"10.3390\/toxics9020025","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T11:40:48Z","timestamp":1612179648000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Benzodiazepines: Their Use either as Essential Medicines or as Toxics Substances"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-8696","authenticated-orcid":false,"given":"Edilma","family":"Sanabria","sequence":"first","affiliation":[{"name":"Grupo GICRIM, Programa de Investigaci\u00f3n Criminal, Universidad Manuela Beltr\u00e1n, Avenida Circunvalar No. 60-00, 111321 Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Edgardo","family":"Cuenca","sequence":"additional","affiliation":[{"name":"Grupo GICRIM, Programa de Investigaci\u00f3n Criminal, Universidad Manuela Beltr\u00e1n, Avenida Circunvalar No. 60-00, 111321 Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Esteso","sequence":"additional","affiliation":[{"name":"Universidad Cat\u00f3lica Santa Teresa de Jes\u00fas de \u00c1vila, Calle los Canteros s\/n, 05005 \u00c1vila, Spain"},{"name":"U.D. Qu\u00edmica F\u00edsica, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogot\u00e1, Cr. 30 No. 45-03, 111321 Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.tetlet.2005.01.113","article-title":"Scandium (III) triflate as an efficient and reusable catalyst for synthesis of 1,5-benzodiazepinevderivatives","volume":"46","author":"De","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/S0040-4039(03)00096-0","article-title":"Roomtemperature ionic liquid promoted synthesis of 1,5-benzodiazepine derivatives under ambient conditions","volume":"44","author":"Jarikote","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1080\/00397919908086183","article-title":"Synthesis of 1,5-benzodiazepine derivatives","volume":"29","author":"Jung","year":"1999","journal-title":"Synth. 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