{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:27:59Z","timestamp":1790702879259,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The analysis of drugs of abuse in hair and other biological matrices of forensic interest requires great selectivity and sensitivity. This has been traditionally achieved through target analysis, using one or more analytical methods that include different preanalytical stages, and more complex procedures followed by toxicological laboratories. There is no exception with 2C-series drugs, such as 2C-B, a new psychoactive substance (NPS), which use has emerged and significantly increased, year by year, in the last decades. Continuously new analytical methods are required to selectively detect and identify these new marketed substances at very low concentrations. In this case report, one former case of a polydrug consumer (charged of a crime against public health in Spain) was reanalyzed in hair matrix. In this reanalysis, 2C-B has been positively detected and identified using liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS\/MS). The most selective analytical UHPLC-HRMS\/MS method alongside a universal and simpler pretreatment methodology has opened up more possibilities for the detection of substances of different chemical structure and optimization of different HRMS\/MS detection approaches allowing the identification of 2-CB in the hair of a real forensic case.<\/jats:p>","DOI":"10.3390\/toxics9070170","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T02:52:34Z","timestamp":1626317554000},"page":"170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of 2C-B in Hair by UHPLC-HRMS\/MS. A Real Forensic Case"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-9941","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Matey","sequence":"first","affiliation":[{"name":"Department of Chemistry and Drugs, National Institute of Toxicology and Forensic Sciences, Calle Jos\u00e9 Echegaray 4, Las Rozas de Madrid, 28232 Madrid, Spain"},{"name":"Instituto Universitario de Investigaci\u00f3n en Ciencias Policiales (IUICP), Universidad de Alcal\u00e1, Calle Libreros 27, Alcal\u00e1 de Henares, 28801 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0753-1598","authenticated-orcid":false,"given":"Adri\u00e1n","family":"L\u00f3pez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Anal\u00edtica, Universidad de Alcal\u00e1, Qu\u00edmica F\u00edsica e Ingenier\u00eda Qu\u00edmica Ctra, Madrid\u2013Barcelona km 33,600, Alcal\u00e1 de Henares, 28871 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda-Ruiz","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Investigaci\u00f3n en Ciencias Policiales (IUICP), Universidad de Alcal\u00e1, Calle Libreros 27, Alcal\u00e1 de Henares, 28801 Madrid, Spain"},{"name":"Departamento de Qu\u00edmica Anal\u00edtica, Universidad de Alcal\u00e1, Qu\u00edmica F\u00edsica e Ingenier\u00eda Qu\u00edmica Ctra, Madrid\u2013Barcelona km 33,600, Alcal\u00e1 de Henares, 28871 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5640-8908","authenticated-orcid":false,"given":"Gemma","family":"Montalvo","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Investigaci\u00f3n en Ciencias Policiales (IUICP), Universidad de Alcal\u00e1, Calle Libreros 27, Alcal\u00e1 de Henares, 28801 Madrid, Spain"},{"name":"Departamento de Qu\u00edmica Anal\u00edtica, Universidad de Alcal\u00e1, Qu\u00edmica F\u00edsica e Ingenier\u00eda Qu\u00edmica Ctra, Madrid\u2013Barcelona km 33,600, Alcal\u00e1 de Henares, 28871 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-4632","authenticated-orcid":false,"given":"F\u00e9lix","family":"Zapata","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Drugs, National Institute of Toxicology and Forensic Sciences, Calle Jos\u00e9 Echegaray 4, Las Rozas de Madrid, 28232 Madrid, Spain"},{"name":"Instituto Universitario de Investigaci\u00f3n en Ciencias Policiales (IUICP), Universidad de Alcal\u00e1, Calle Libreros 27, Alcal\u00e1 de Henares, 28801 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s13181-013-0295-x","article-title":"2C or Not 2C: Phenethylamine Designer Drug Review","volume":"9","author":"Dean","year":"2013","journal-title":"J. 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