{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:50:48Z","timestamp":1791323448076,"version":"4.3.1"},"reference-count":137,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["FORDECYT-PRONACES, FOINS 2016-01 3203"],"award-info":[{"award-number":["FORDECYT-PRONACES, FOINS 2016-01 3203"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>In agricultural activities, pest control is essential, and the most effective method is the use of chemical agents that also represent an important source of exposure to potentially toxic compounds. Pesticides constitute a heterogeneous group of compounds designed specifically to control different pests. Besides measuring their levels or that of their metabolites in air, plasma, serum, blood, urine, etc., some studies reported increased DNA damage levels after occupational or environmental pesticides exposure, evidenced by several cytogenetic biomarkers such as chromosomal aberrations (CA), sister chromatid exchanges (SCE), micronuclei frequency (MN) together with other nuclear abnormalities (NA), alkaline comet assay, but also changes in oxidative stress parameters and miRNA levels. Single or combined, these techniques have also been used in genotoxic biomonitoring studies of workers occupationally exposed to pesticides in Mexico. Despite being a country with great agricultural activity and reported excessive pesticide use, genotoxic studies have been relatively few and, in some cases, contradictory. A review was made of the studies available (published until the end of 2020 on PubMed, Web of Science, Redalyc and Scielo, both in English and Spanish) in the scientific literature that evaluated occupational exposure of human samples to pesticides assessed with DNA damage and related biomarkers in Mexico.<\/jats:p>","DOI":"10.3390\/toxics9110272","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T23:27:39Z","timestamp":1634858859000},"page":"272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-0251","authenticated-orcid":false,"given":"Juana","family":"S\u00e1nchez-Alarc\u00f3n","sequence":"first","affiliation":[{"name":"Laboratorio \u201cRafael Villalobos-Pietrini\u201d de Toxicolog\u00eda Gen\u00f3mica y Qu\u00edmica Ambiental, Facultad de Agrobiolog\u00eda, Universidad Aut\u00f3noma de Tlaxcala, CA Gen\u00e9tica y Ambiente UATLX-CA 223, Red Tem\u00e1tica de Toxicolog\u00eda de Plaguicidas, Tlaxcala 90120, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-7185","authenticated-orcid":false,"given":"Mirta","family":"Mili\u0107","sequence":"additional","affiliation":[{"name":"Mutagenesis Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilena","family":"Ka\u0161uba","sequence":"additional","affiliation":[{"name":"Mutagenesis Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6125-4782","authenticated-orcid":false,"given":"Mar\u00eda","family":"Tenorio-Arvide","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n en Ciencias Agr\u00edcolas, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla 72570, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Montiel-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio \u201cRafael Villalobos-Pietrini\u201d de Toxicolog\u00eda Gen\u00f3mica y Qu\u00edmica Ambiental, Facultad de Agrobiolog\u00eda, Universidad Aut\u00f3noma de Tlaxcala, CA Gen\u00e9tica y Ambiente UATLX-CA 223, Red Tem\u00e1tica de Toxicolog\u00eda de Plaguicidas, Tlaxcala 90120, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-6717","authenticated-orcid":false,"given":"Stefano","family":"Bonassi","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy"},{"name":"Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-7694","authenticated-orcid":false,"given":"Rafael","family":"Valencia-Quintana","sequence":"additional","affiliation":[{"name":"Laboratorio \u201cRafael Villalobos-Pietrini\u201d de Toxicolog\u00eda Gen\u00f3mica y Qu\u00edmica Ambiental, Facultad de Agrobiolog\u00eda, Universidad Aut\u00f3noma de Tlaxcala, CA Gen\u00e9tica y Ambiente UATLX-CA 223, Red Tem\u00e1tica de Toxicolog\u00eda de Plaguicidas, Tlaxcala 90120, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1383-5742(03)00015-2","article-title":"Genotoxicity of pesticides: A review of human biomonitoring studies","volume":"543","author":"Bolognesi","year":"2003","journal-title":"Mutat. 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