{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:10:42Z","timestamp":1790845842737,"version":"4.1.0"},"reference-count":91,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Beside partial coverage in three reviews so far (1994, 2009, 2019), there is no review on genotoxic studies dealing with mercury (Hg) and human exposure using the most usual genotoxic assays: sister chromatid exchanges (SCE), chromosomal aberrations (CA), cytochalasin B blocked micronucleus assay (CBMN), and single-cell gel electrophoresis (SCGE or alkaline comet assay). Fifty years from the first Hg genotoxicity study and with the Minamata Convention in force, the genotoxic potential of Hg and its derivatives is still controversial. Considering these antecedents, we present this first systematic literature overview of genotoxic studies dealing with Hg and human exposure that used the standard genotoxic assays. To date, there is not sufficient evidence for Hg human carcinogen classification, so the new data collections can be of great help. A review was made of the studies available (those published before the end of October 2021 on PubMed or Web of Science in English or Spanish language) in the scientific literature dealing with genotoxic assays and human sample exposure ex vivo, in vivo, and in vitro. Results from a total of 66 articles selected are presented. Organic (o)Hg compounds were more toxic than inorganic and\/or elemental ones, without ruling out that all represent a risk. The most studied inorganic (i)Hg compounds in populations exposed accidentally, occupationally, or iatrogenically, and\/or in human cells, were Hg chloride and Hg nitrate and of the organic compounds, were methylmercury, thimerosal, methylmercury chloride, phenylmercuric acetate, and methylmercury hydroxide.<\/jats:p>","DOI":"10.3390\/toxics9120326","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T02:56:14Z","timestamp":1638413774000},"page":"326","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Genotoxicity of Mercury and Its Derivatives Demonstrated In Vitro and In Vivo in Human Populations Studies. Systematic Review"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-0251","authenticated-orcid":false,"given":"Juana","family":"S\u00e1nchez-Alarc\u00f3n","sequence":"first","affiliation":[{"name":"Doctorado en Ciencias de la Salud, Facultad de Ciencias de la Conducta, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50180, Estado de M\u00e9xico, Mexico"},{"name":"Cuerpo Acad\u00e9mico Ambiente y Gen\u00e9tica UATLX-CA-223, Laboratorio \u201cRafael Villalobos-Pietrini\u201d de Toxicolog\u00eda Gen\u00f3mica y Qu\u00edmica Ambiental, Facultad de Agrobiolog\u00eda, Universidad Aut\u00f3noma de Tlaxcala, Santa Mar\u00eda Acuitlapilco 90120, Tlaxcala, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-7185","authenticated-orcid":false,"given":"Mirta","family":"Mili\u0107","sequence":"additional","affiliation":[{"name":"Mutagenesis Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-9982","authenticated-orcid":false,"given":"Lilia Patricia","family":"Bustamante-Montes","sequence":"additional","affiliation":[{"name":"Decanato de Ciencias de la Salud, Universidad Aut\u00f3noma de Guadalajara, Guadalajara 451293, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keila","family":"Isaac-Oliv\u00e9","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50180, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-7694","authenticated-orcid":false,"given":"Rafael","family":"Valencia-Quintana","sequence":"additional","affiliation":[{"name":"Cuerpo Acad\u00e9mico Ambiente y Gen\u00e9tica UATLX-CA-223, Laboratorio \u201cRafael Villalobos-Pietrini\u201d de Toxicolog\u00eda Gen\u00f3mica y Qu\u00edmica Ambiental, Facultad de Agrobiolog\u00eda, Universidad Aut\u00f3noma de Tlaxcala, Santa Mar\u00eda Acuitlapilco 90120, Tlaxcala, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninfa","family":"Ram\u00edrez-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50180, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0165-1110(94)90012-4","article-title":"Genotoxicity of mercury compounds. 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