{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:25:40Z","timestamp":1780637140178,"version":"3.54.1"},"reference-count":95,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Botulinum toxin (BTX) is a neurotoxin, and its injection in masticatory muscles induces muscle weakness and paralysis. This paralytic effect of BTX induces growth retardation of the maxillofacial bones, changes in dental eruption and occlusion state, and facial asymmetry. Using masticatory muscle paralysis and its effect via BTX, BTX can be used for the correction of malocclusion after orthognathic surgery and mandible fracture. The paralysis of specific masticatory muscles by BTX injection reduces the tensional force to the mandible and prevents relapse and changes in dental occlusion. BTX injection in the anterior belly of digastric and mylohyoid muscle prevents the open-bite and deep bite of dental occlusion and contributes to mandible stability after orthognathic surgery. The effect of BTX injection in masticatory muscles for maxillofacial bone growth and dental occlusion is reviewed in this article. The clinical application of BTX is also discussed for the correction of dental malocclusion and suppression of post-operative relapse after mandibular surgery.<\/jats:p>","DOI":"10.3390\/toxins10010027","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T12:00:06Z","timestamp":1514980806000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Correction of Malocclusion by Botulinum Neurotoxin Injection into Masticatory Muscles"],"prefix":"10.3390","volume":"10","author":[{"given":"Hyun","family":"Seok","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju 28644, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5088-2732","authenticated-orcid":false,"given":"Seong-Gon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ajodo.2015.12.016","article-title":"Posterior tooth angulations in patients with anterior open bite and normal occlusion","volume":"150","author":"Janson","year":"2016","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ortho\/26.2.103","article-title":"The heritability of malocclusion: Part 1\u2014Genetics, principles and terminology","volume":"26","author":"Mossey","year":"1999","journal-title":"Br. J. Orthod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ajodo.2005.04.043","article-title":"Treatment effects of the bionator and high-pull facebow combination followed by fixed appliances in patients with increased vertical dimensions","volume":"131","author":"Freeman","year":"2007","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/ortho\/25.2.109","article-title":"An evaluation of the biomechanical response of the tooth and periodontium to orthodontic forces in adolescent and adult subjects","volume":"25","author":"Tanne","year":"1998","journal-title":"Br. J. Orthod."},{"key":"ref_5","first-page":"243","article-title":"Treatment and posttreatment dentoalveolar changes following intrusion of mandibular molars with application of a skeletal anchorage system (SAS) for open bite correction","volume":"17","author":"Sugawara","year":"2002","journal-title":"Int. J. Adult Orthod. Orthognath. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"396.e1","DOI":"10.1016\/j.ajodo.2010.04.023","article-title":"Long-term stability of anterior open-bite treatment by intrusion of maxillary posterior teeth","volume":"138","author":"Baek","year":"2010","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.12968\/denu.2003.30.5.235","article-title":"The causes, diagnosis and treatment of anterior open bite","volume":"30","author":"Burford","year":"2003","journal-title":"Dent. Update"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ajodo.2015.12.014","article-title":"Evaluation of long-term stability of skeletal anterior open bite correction in adults treated with maxillary posterior segment intrusion using zygomatic miniplates","volume":"150","author":"Marzouk","year":"2016","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/taap.1994.1181","article-title":"Measurement of botulinum toxin activity: Evaluation of the lethality assay","volume":"128","author":"Pearce","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrmicro3295","article-title":"Botulinum neurotoxins: Genetic, structural and mechanistic insights","volume":"12","author":"Rossetto","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40064-016-2680-9","article-title":"Apoptotic action of botulinum toxin on masseter muscle in rats: Early and late changes in the expression of molecular markers","volume":"5","author":"Moon","year":"2016","journal-title":"Springerplus"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40902-016-0051-7","article-title":"A clinical evaluation of botulinum toxin-A injections in the temporomandibular disorder treatment","volume":"38","author":"Kim","year":"2016","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_13","first-page":"649","article-title":"Treatment of masseteric hypertrophy with botulinum toxin: A report of two cases","volume":"15","author":"Ozan","year":"2010","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1054\/jocn.2000.0684","article-title":"The current use of botulinum toxin","volume":"7","author":"Mahant","year":"2000","journal-title":"J. Clin. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.bdj.4808002","article-title":"Mastication and swallowing: An overview","volume":"173","author":"Thexton","year":"1992","journal-title":"Br. Dent. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40902-015-0010-8","article-title":"Effects of a botulinum toxin type A injection on the masseter muscle: An animal model study","volume":"37","author":"Park","year":"2015","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"142.e1","DOI":"10.1016\/j.ajodo.2008.06.020","article-title":"Effects on craniofacial growth and development of unilateral botulinum neurotoxin injection into the masseter muscle","volume":"135","author":"Tsai","year":"2009","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/SAP.0b013e31818d4559","article-title":"The effect of the botulinum toxin-A on craniofacial development: An experimental study","volume":"63","author":"Babuccu","year":"2009","journal-title":"Ann. Plast. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.joms.2009.12.009","article-title":"Morphologic and bony structural changes in the mandible after a unilateral injection of botulinum neurotoxin in adult rats","volume":"68","author":"Tsai","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ajodo.2012.10.023","article-title":"Botulinum neurotoxin type a in the masseter muscle: Effects on incisor eruption in rabbits","volume":"143","author":"Navarrete","year":"2013","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_21","first-page":"44","article-title":"Mechanism of mastication","volume":"24","author":"Ahlgren","year":"1966","journal-title":"Acta Odontol. Scand."},{"key":"ref_22","first-page":"77","article-title":"The masticatory system\u2014An overview","volume":"7","year":"2005","journal-title":"Stomatologija"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1971.sp009454","article-title":"Evidence for central timing of rhythmical mastication","volume":"215","author":"Dellow","year":"1971","journal-title":"J. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/10454411910020010401","article-title":"Mastication and its control by the brain stem","volume":"2","author":"Lund","year":"1991","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/0022-3913(71)90085-0","article-title":"Functional movements of the mandible","volume":"26","author":"Gibbs","year":"1971","journal-title":"J. Prosthet. Dent."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pneurobio.2012.01.011","article-title":"Generation of the masticatory central pattern and its modulation by sensory feedback","volume":"96","author":"Morquette","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.cmet.2016.12.002","article-title":"Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication","volume":"25","author":"Nakamura","year":"2017","journal-title":"Cell Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1152\/jn.1986.55.4.806","article-title":"Localization of central rhythm generator involved in cortically induced rhythmical masticatory jaw-opening movement in the guinea pig","volume":"55","author":"Nozaki","year":"1986","journal-title":"J. Neurophysiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0169-2607(90)90028-8","article-title":"Analysis of jaw movements and masticatory muscle activity","volume":"31","author":"Neeman","year":"1990","journal-title":"Comput. Methods Programs Biomed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0003-9969(86)90056-7","article-title":"The electromyographic activity of the inferior part of the human lateral pterygoid muscle during clenching and chewing","volume":"31","author":"Wood","year":"1986","journal-title":"Arch. Oral Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2842.1989.tb01331.x","article-title":"Effects of texture of food on chewing patterns in the human subject","volume":"16","author":"Horio","year":"1989","journal-title":"J. Oral Rehabilit."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/00016359509005972","article-title":"Masticatory muscle influence on craniofacial growth","volume":"53","author":"Kiliaridis","year":"1995","journal-title":"Acta Odontol. Scand."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40902-016-0083-z","article-title":"The sequential management of recurrent temporomandibular joint ankylosis in a growing child: A case report","volume":"38","author":"Cho","year":"2016","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40902-015-0027-z","article-title":"Three-dimensional functional unit analysis of hemifacial microsomia mandible\u2014A preliminary report","volume":"37","author":"Choi","year":"2015","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_35","first-page":"95","article-title":"The role of the functional matrix in mandibular growth","volume":"38","author":"Moss","year":"1968","journal-title":"Angle Orthod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.joms.2015.03.051","article-title":"An animal model for inducing deviation of the mandible","volume":"73","author":"Chen","year":"2015","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0889-5406(97)70215-4","article-title":"The influence of the masticatory hypofunction on the craniofacial growth and development in rats","volume":"111","author":"Ulgen","year":"1997","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40902-015-0029-x","article-title":"Facial asymmetry: A case report of localized linear scleroderma patient with muscular strain and spasm","volume":"37","author":"Kim","year":"2015","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/aja.1001700109","article-title":"The effect of dietary consistency on gross and histologic morphology in the craniofacial region of young rats","volume":"170","author":"Bouvier","year":"1984","journal-title":"Am. J. Anat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0889-5406(95)70034-X","article-title":"Changes in mandibular rotation after muscular resection. Experimental study in rats","volume":"108","author":"Navarro","year":"1995","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0002-9416(82)90214-7","article-title":"Morphologic alterations in macaca mulatta following destruction of the motor nucleus of the trigeminal nerve","volume":"81","author":"Phillips","year":"1982","journal-title":"Am. J. Orthod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ijom.2010.02.011","article-title":"The influence of masticatory hypofunction on developing rat craniofacial structure","volume":"39","author":"Tsai","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jss.2006.09.003","article-title":"The effects of masseter muscle paralysis on facial bone growth","volume":"139","author":"Matic","year":"2007","journal-title":"J. Surg. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.0909-8836.1999.eos107107.x","article-title":"Effect of masticatory function on the internal bone structure in the mandible of the growing rat","volume":"107","author":"Bresin","year":"1999","journal-title":"Eur. J. Oral Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.bone.2011.11.015","article-title":"Botulinum toxin in masticatory muscles: Short-and long-term effects on muscle, bone, and craniofacial function in adult rabbits","volume":"50","author":"Rafferty","year":"2012","journal-title":"Bone"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/ejo\/cjq029","article-title":"Bone changes in the mandible following botulinum neurotoxin injections","volume":"33","author":"Tsai","year":"2010","journal-title":"Eur. J. Orthod."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0003-9969(95)00136-0","article-title":"Masseter muscle thickness in growing individuals and its relation to facial morphology","volume":"41","author":"Raadsheer","year":"1996","journal-title":"Arch. Oral Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1601-0825.2007.01435.x","article-title":"Growth effects of botulinum toxin type a injected into masseter muscle on a developing rat mandible","volume":"14","author":"Kim","year":"2008","journal-title":"Oral Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1016\/8756-3282(95)00292-L","article-title":"Skeletal adaptations to mechanical usage: Results from tibial loading studies in rats","volume":"17","author":"Forwood","year":"1995","journal-title":"Bone"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bone.2009.10.025","article-title":"Transient muscle paralysis disrupts bone homeostasis by rapid degradation of bone morphology","volume":"46","author":"Poliachik","year":"2010","journal-title":"Bone"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bone.2013.09.009","article-title":"Metaphyseal and diaphyseal bone loss in the tibia following transient muscle paralysis are spatiotemporally distinct resorption events","volume":"57","author":"Ausk","year":"2013","journal-title":"Bone"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40902-016-0079-8","article-title":"S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection","volume":"38","author":"Park","year":"2016","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bone.2015.03.023","article-title":"Botulinum toxin in masticatory muscles of the adult rat induces bone loss at the condyle and alveolar regions of the mandible associated with a bone proliferation at a muscle enthesis","volume":"77","author":"Libouban","year":"2015","journal-title":"Bone"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.micron.2017.03.008","article-title":"Contrast enhancement with uranyl acetate allows quantitative analysis of the articular cartilage by microct: Application to mandibular condyles in the BTX rat model of disuse","volume":"97","author":"Manero","year":"2017","journal-title":"Micron"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Dutra, E.H., O\u2019Brien, M.H., Lima, A., Kalajzic, Z., Tadinada, A., Nanda, R., and Yadav, S. (2016). Cellular and matrix response of the mandibular condylar cartilage to botulinum toxin. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164599"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.ajodo.2015.05.034","article-title":"Bone and cartilage changes in rabbit mandibular condyles after 1 injection of botulinum toxin","volume":"148","author":"Matthys","year":"2015","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1097\/01.prs.0000282309.94147.22","article-title":"The change of maximum bite force after botulinum toxin type A injection for treating masseteric hypertrophy","volume":"120","author":"Ahn","year":"2007","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijom.2005.04.006","article-title":"A comparison of craniofacial morphology in patients with and without facial asymmetry\u2014A three-dimensional analysis with computed tomography","volume":"35","author":"Kwon","year":"2006","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/oxfordjournals.ejo.a035975","article-title":"Muscle function and craniofacial morphology: A clinical study in patients with myotonic dystrophy","volume":"11","author":"Kiliaridis","year":"1989","journal-title":"Eur. J. Orthod."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jcms.2016.01.021","article-title":"Botulinum toxin as a therapeutic agent to prevent relapse in deep bite patients","volume":"44","author":"Kanatas","year":"2016","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0030-4220(89)90181-3","article-title":"Short-term stability and muscle adaptation after mandibular advancement surgery with and without suprahyoid myotomy in juvenile macaca mulatta","volume":"68","author":"Carlson","year":"1989","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0889-5406(87)90368-4","article-title":"Adaptation of the suprahyoid muscle complex to mandibular advancement surgery","volume":"92","author":"Carlson","year":"1987","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_63","unstructured":"Wiliams, J.L., and Rowe, N.L. (1994). Applied surgical anatomy. Rowe and Williams\u2019 Maxillofacial Injuries, Churchill Livingstone. [2nd ed.]."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bjoms.2005.11.018","article-title":"Treatment of post-traumatic open bite by radiofrequency","volume":"45","author":"Choi","year":"2007","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5125\/jkaoms.2013.39.4.188","article-title":"Correction of post-traumatic anterior open bite by injection of botulinum toxin type A into the anterior belly of the digastric muscle: Case report","volume":"39","author":"Seok","year":"2013","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"165","DOI":"10.5125\/jkaoms.2015.41.3.165","article-title":"Screening for variations in anterior digastric musculature prior to correction of post-traumatic anterior open bite by injection of botulinum toxin type A: A technical note","volume":"41","author":"Zdilla","year":"2015","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ajodo.2017.04.004","article-title":"Lateral open bite and crossbite correction in a class III patient with missing maxillary first premolars","volume":"152","author":"Park","year":"2017","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ajodo.2010.10.019","article-title":"Stability of treatment for anterior open-bite malocclusion: A meta-analysis","volume":"139","author":"Greenlee","year":"2011","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0002-9416(84)90138-6","article-title":"Components of adult class III open-bite malocclusion","volume":"86","author":"Ellis","year":"1984","journal-title":"Am. J. Orthod."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s00056-017-0095-z","article-title":"Comparison of two treatment strategies for the early treatment of an anterior skeletal open bite","volume":"78","author":"Turkkahraman","year":"2017","journal-title":"J. Orofac. Orthop."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.ijom.2017.02.1275","article-title":"Anterior open bite correction by Le Fort I osteotomy with or without anterior segmentation: Which is more stable?","volume":"46","author":"Ismail","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.joms.2007.09.008","article-title":"Vertical ramus versus sagittal split osteotomies: Comparison of stability after mandibular setback","volume":"66","author":"Yoshioka","year":"2008","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00266-010-9582-y","article-title":"The stability of intraoral vertical ramus osteotomy and factors related to skeletal relapse","volume":"35","author":"Chen","year":"2011","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijom.2012.06.024","article-title":"Postoperative changes in mandibular prognathism surgically treated by intraoral vertical ramus osteotomy","volume":"42","author":"Nihara","year":"2013","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.joms.2015.09.035","article-title":"Intraoral vertical ramus osteotomy results in good long-term mandibular stability in patients with mandibular prognathism and anterior open bite","volume":"74","author":"Choi","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1016\/j.jcms.2012.12.003","article-title":"Stability after maxillary segmentation for correction of anterior open bite: A cohort study of 33 cases","volume":"41","author":"Silva","year":"2013","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/ejo\/cjn116","article-title":"Occlusal status and prevalence of occlusal malocclusion traits among 9-year-old schoolchildren","volume":"31","author":"Lux","year":"2009","journal-title":"Eur. J. Orthod."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/ejo\/cjs079","article-title":"Stability and relapse after orthodontic treatment of deep bite cases\u2014A long-term follow-up study","volume":"36","author":"Danz","year":"2012","journal-title":"Eur. J. Orthod."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jcms.2015.02.006","article-title":"3D analysis of condylar remodelling and skeletal relapse following bilateral sagittal split advancement osteotomies","volume":"43","author":"Xi","year":"2015","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0889-5406(99)70333-1","article-title":"Stability of orthodontic treatment outcome: Follow-up until 10 years postretention","volume":"115","year":"1999","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0278-2391(87)90019-X","article-title":"Postoperative infection following suprahyoid myotomy performed in conjunction with sagittal osteotomy of the mandible: Report of a case","volume":"45","author":"Papageorge","year":"1987","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bjoms.2004.10.007","article-title":"Three-dimensional finite element analysis used to compare methods of fixation after sagittal split ramus osteotomy: Setback surgery-posterior loading","volume":"43","author":"Erkmen","year":"2005","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_83","unstructured":"Shin, S.H., Kim, S.G., Park, Y.W., Kim, M.K., and Kweon, K.J. (2017, January 3\u20134). The effect of Botulinum toxin-A injection on patients with orthognathic surgery. Proceedings of the 56th Congress of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons, Seoul, Korea."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/(SICI)1097-4598(199910)22:10<1350::AID-MUS3>3.0.CO;2-8","article-title":"Myonuclear domains in muscle adaptation and disease","volume":"22","author":"Allen","year":"1999","journal-title":"Muscle Nerve"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1748-1716.2011.02350.x","article-title":"Voluntary resistance wheel exercise during post-natal growth in rats enhances skeletal muscle satellite cell and myonuclear content at adulthood","volume":"204","author":"Smith","year":"2012","journal-title":"Acta Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"10.e1","DOI":"10.1016\/j.ajodo.2007.12.022","article-title":"Evaluation of anterior open-bite treatment with occlusal adjustment","volume":"134","author":"Janson","year":"2008","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_87","first-page":"33","article-title":"Nonsurgical treatment of skeletal anterior open bite in adult patients: Posterior build-ups","volume":"87","year":"2016","journal-title":"Angle Orthod."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ajodo.2007.07.012","article-title":"Dentoskeletal changes associated with fixed and removable appliances with a crib in open-bite patients in the mixed dentition","volume":"133","author":"Giuntini","year":"2008","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Moimaz, S.A.S., Garbin, A.J.\u00cd., Lima, A.M.C., Lolli, L.F., Saliba, O., and Garbin, C.A.A.S. (2014). Longitudinal study of habits leading to malocclusion development in childhood. BMC Oral Health, 14.","DOI":"10.1186\/1472-6831-14-96"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ejo\/cjw005","article-title":"Effectiveness of open bite correction when managing deleterious oral habits in growing children and adolescents: A systematic review and meta-analysis","volume":"39","author":"Feres","year":"2017","journal-title":"Eur. J. Orthod."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Chun, B.Y., and Kim, S.Y. (2017). Acute visual loss after botulinum toxin A injection in the masseter muscle. Int. Ophthalmol., 1\u20134.","DOI":"10.1007\/s10792-017-0569-4"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/IOP.0b013e318032eb12","article-title":"Optic neuropathy associated with botulinum a toxin in thyroid-related orbitopathy","volume":"23","author":"Korn","year":"2007","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jaad.2005.06.011","article-title":"Botulinum toxin type A injections: Adverse events reported to the us food and drug administration in therapeutic and cosmetic cases","volume":"53","author":"Mohan","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0039-6257(04)00109-2","article-title":"Macular edema","volume":"49","author":"Tranos","year":"2004","journal-title":"Surv. Ophthalmol."},{"key":"ref_95","first-page":"34","article-title":"A single-blind, split-face, randomized, pilot study comparing the effects of intradermal and intramuscular injection of two commercially available botulinum toxin a formulas to reduce signs of facial aging","volume":"10","author":"Sapra","year":"2017","journal-title":"J. Clin. Aesthet. Dermatol."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/10\/1\/27\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:49:52Z","timestamp":1760194192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/10\/1\/27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,2]]},"references-count":95,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1]]}},"alternative-id":["toxins10010027"],"URL":"https:\/\/doi.org\/10.3390\/toxins10010027","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,2]]}}}