{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:33:56Z","timestamp":1774557236537,"version":"3.50.1"},"reference-count":129,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:00:00Z","timestamp":1522281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>This review explores current evidence to demonstrate that botulinum neurotoxins (BoNTs) exert antipruritic effects. Both experimental and clinical conditions in which botulinum neurotoxins have been applied for pruritus relief will be presented and significant findings will be highlighted. Potential mechanisms underlying antipruritic effects will also be discussed and ongoing challenges and unmet needs will be addressed.<\/jats:p>","DOI":"10.3390\/toxins10040143","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T12:51:56Z","timestamp":1522327916000},"page":"143","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antipruritic Effects of Botulinum Neurotoxins"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-3600","authenticated-orcid":false,"given":"Parisa","family":"Gazerani","sequence":"first","affiliation":[{"name":"Department of Health Science and Technology, Aalborg University, Frederik Bajers Vej 7A2, A2-208, 9220 Aalborg East, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1002\/(SICI)1097-4598(1997)6+<146::AID-MUS10>3.0.CO;2-4","article-title":"Botulinum toxin: Chemistry, pharmacology, toxicity, and immunology","volume":"6","author":"Brin","year":"1997","journal-title":"Muscle Nerve Suppl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1124\/pr.116.012658","article-title":"Botulinum neurotoxins: Biology, pharmacology, and toxicology","volume":"69","author":"Pirazzini","year":"2017","journal-title":"Pharmacol. 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