{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:45:44Z","timestamp":1790484344274,"version":"4.1.0"},"reference-count":129,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Non-transplanted and transplanted patients with chronic kidney disease (CKD) differ in terms of mortality and the risk of clinical events. This difference is probably due to the difference of both traditional and non-traditional risk factors. Uremic retention solutes may constitute important non-traditional risk factors in this population. In the present review, we selected a set of uremic toxins that have been associated with harmful effects, and are an appealing target for adjuvant therapy in CKD. For each toxin reviewed here, relevant studies were selected and the relationship with hard clinical outcomes of uremic toxins were compared between non-transplanted CKD patients and transplanted patients taking into account the level of glomerular filtration rate in these two situations.<\/jats:p>","DOI":"10.3390\/toxins10060229","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T11:04:46Z","timestamp":1528196686000},"page":"229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Uremic Toxins and Clinical Outcomes: The Impact of Kidney Transplantation"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5384-9006","authenticated-orcid":false,"given":"Sophie","family":"Liabeuf","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology and Clinical Research Department, Amiens University Medical Center, 80054 Amiens, France"},{"name":"EA 7517, MP3CV laboratory, CURS, Jules Verne University of Picardie, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Cheddani","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Ambroise Par\u00e9 University Medical Center, APHP, Boulogne Billancourt, 92100 Paris, France"},{"name":"INSERM U1018, Team 5, CESP (Centre de Recherche en \u00c9pid\u00e9miologie et Sant\u00e9 des Populations), Paris-Saclay University and Paris Ouest-Versailles-Saint-Quentin-en-Yvelines University (UVSQ), 94800 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad A.","family":"Massy","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Ambroise Par\u00e9 University Medical Center, APHP, Boulogne Billancourt, 92100 Paris, France"},{"name":"INSERM U1018, Team 5, CESP (Centre de Recherche en \u00c9pid\u00e9miologie et Sant\u00e9 des Populations), Paris-Saclay University and Paris Ouest-Versailles-Saint-Quentin-en-Yvelines University (UVSQ), 94800 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic Kidney Disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chronic Kidney Disease Prognosis Consortium, Matsushita, K., van der Velde, M., Astor, B.C., Woodward, M., Levey, A.S., de Jong, P.E., Coresh, J., and Gansevoort, R.T. 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