{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:07:50Z","timestamp":1776276470876,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["407625\/2013-5"],"award-info":[{"award-number":["407625\/2013-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","doi-asserted-by":"publisher","award":["193.001.202\/2016"],"award-info":[{"award-number":["193.001.202\/2016"]}],"id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bijzonder Onderzoeksfonds","award":["CELSA\/17\/047 \u2013 BOF\/ISP"],"award-info":[{"award-number":["CELSA\/17\/047 \u2013 BOF\/ISP"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Scorpion venoms are a complex mixture of components. Among them the most important are peptides, which presents the capacity to interact and modulate several ion channel subtypes, including voltage-gated sodium channels (NaV). Screening the activity of scorpion toxins on different subtypes of NaV reveals the scope of modulatory activity and, in most cases, low channel selectivity. Until now there are approximately 60 scorpion toxins experimentally assayed on NaV channels. However, the molecular bases of interaction between scorpion toxins and NaV channels are not fully elucidated. The activity description of new scorpion toxins is crucial to enhance the predictive strength of the structural\u2013function correlations of these NaV modulatory molecules. In the present work a new scorpion toxin (Tf1a) was purified from Tityus fasciolatus venom by RP-HPLC, and characterized using electrophysiological experiments on different types of voltage-gated sodium channels. Tf1a was able to modify the normal function of NaV tested, showing to be a typical \u03b2-NaScTx. Tf1a also demonstrated an unusual capability to alter the kinetics of NaV1.5.<\/jats:p>","DOI":"10.3390\/toxins10090339","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T03:42:37Z","timestamp":1534909357000},"page":"339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Subtype Specificity of \u03b2-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels"],"prefix":"10.3390","volume":"10","author":[{"given":"Daniel Oliveira da","family":"Mata","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neurofarmacologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo Vieira","family":"Tibery","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neurofarmacologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-5635","authenticated-orcid":false,"given":"Leandro Ambr\u00f3sio","family":"Campos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neurofarmacologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalita Soares","family":"Camargos","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio UDF, Bras\u00edlia 70390-045, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Peigneur","sequence":"additional","affiliation":[{"name":"Toxicology and Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven (KU Leuven), P.O. Box 922, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tytgat","sequence":"additional","affiliation":[{"name":"Toxicology and Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven (KU Leuven), P.O. Box 922, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-4055","authenticated-orcid":false,"given":"Elisabeth Ferroni","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neurofarmacologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"key":"ref_1","unstructured":"Brazil, T.K., and Porto, T.J. (2010). Os Escorpi\u00f5es, EDUFBA. 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