{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:49:40Z","timestamp":1791323380235,"version":"4.3.1"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>A retrospective case review study of viper envenomations collected by the Marseille\u2019s Poison Centre between 1996 and 2008 was performed. Results: 174 cases were studied (52 grade 1 = G1, 90 G2 and 32 G3). G1 patients received symptomatic treatments (average hospital stay 0.96 day). One hundred and six (106) of the G2\/G3 patients were treated with the antivenom Viperfav* (2.1+\/-0.9 days in hospital), while 15 of them received symptomatic treatments only (plus one immediate death) (8.1+\/-4 days in hospital, 2 of them died). The hospital stay was significantly reduced in the antivenom treated group (p &lt; 0.001), and none of the 106 antivenom treated patients had immediate (anaphylaxis) or delayed (serum sickness) allergic reactions. Conclusion: Viperfav* antivenom was safe and effective for treating asp viper venom-induced toxicity.<\/jats:p>","DOI":"10.3390\/toxins1020100","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T05:26:46Z","timestamp":1259126806000},"page":"100-112","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Asp Viper (Vipera aspis) Envenomation: Experience of the Marseille Poison Centre from 1996 to 2008"],"prefix":"10.3390","volume":"1","author":[{"given":"Luc","family":"De Haro","sequence":"first","affiliation":[{"name":"Centre Antipoison, h\u00f4pital Salvator, 249 boulevard Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Glaizal","sequence":"additional","affiliation":[{"name":"Centre Antipoison, h\u00f4pital Salvator, 249 boulevard Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Tichadou","sequence":"additional","affiliation":[{"name":"Centre Antipoison, h\u00f4pital Salvator, 249 boulevard Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Blanc-Brisset","sequence":"additional","affiliation":[{"name":"Centre Antipoison, h\u00f4pital Salvator, 249 boulevard Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryvonne","family":"Hayek-Lanthois","sequence":"additional","affiliation":[{"name":"Centre Antipoison, h\u00f4pital Salvator, 249 boulevard Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"key":"ref_1","first-page":"1131","article-title":"Les envenimations par les serpents de France et leur traitement","volume":"32","year":"2003","journal-title":"Presse M\u00e9d."},{"key":"ref_2","first-page":"1277","article-title":"Envenimation par vip\u00e8re d\u2019Orsini: 8 observations","volume":"27","author":"Orsini","year":"1998","journal-title":"Presse M\u00e9d."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0014-5793(02)03205-2","article-title":"Toxicity evolution of Vipera aspis aspis venom: Identification and molecular modeling of a novel phospholipase A2 heterodimer neurotoxin","volume":"527","author":"Jan","year":"2002","journal-title":"FEBS Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1046\/j.1432-1033.2003.03629.x","article-title":"Sequences and structural organization of phospholipase A2 genes from Vipera aspis aspis, V. aspis zinnikeri and Vipera berus berus venom","volume":"270","author":"Guillemin","year":"2003","journal-title":"Eur. 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