{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:58:49Z","timestamp":1788580729077,"version":"build-2803163510"},"reference-count":161,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Fibroblast growth factor 23 (FGF23) plays a key role in the complex network between the bones and other organs. Initially, it was thought that FGF23 exclusively regulated phosphate and vitamin D metabolism; however, recent research has demonstrated that an excess of FGF23 has other effects that may be detrimental in some cases. The understanding of the signaling pathways through which FGF23 acts in different organs is crucial to develop strategies aiming to prevent the negative effects associated with high FGF23 levels. FGF23 has been described to have effects on the heart, promoting left ventricular hypertrophy (LVH); the liver, leading to production of inflammatory cytokines; the bones, inhibiting mineralization; and the bone marrow, by reducing the production of erythropoietin (EPO). The identification of FGF23 receptors will play a remarkable role in future research since its selective blockade might reduce the adverse effects of FGF23. Patients with chronic kidney disease (CKD) have very high levels of FGF23 and may be the population suffering from the most adverse FGF23-related effects. The general population, as well as kidney transplant recipients, may also be affected by high FGF23. Whether the association between FGF23 and clinical events is causal or casual remains controversial. The hypothesis that FGF23 could be considered a therapeutic target is gaining relevance and may become a promising field of investigation in the future.<\/jats:p>","DOI":"10.3390\/toxins11030175","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T06:56:52Z","timestamp":1553497012000},"page":"175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["FGF23, Biomarker or Target?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-3840","authenticated-orcid":false,"given":"Cristian","family":"Rodelo-Haad","sequence":"first","affiliation":[{"name":"Nephrology Service, University Hospital Reina Sofia, 14005 Cordoba, Spain"},{"name":"Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)\/University of Cordoba, 14005 Cordoba, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2627-1445","authenticated-orcid":false,"given":"Rafael","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Nephrology Service, University Hospital Reina Sofia, 14005 Cordoba, Spain"},{"name":"Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)\/University of Cordoba, 14005 Cordoba, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-0724","authenticated-orcid":false,"given":"Juan R.","family":"Mu\u00f1oz-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Nephrology Service, University Hospital Reina Sofia, 14005 Cordoba, Spain"},{"name":"Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)\/University of Cordoba, 14005 Cordoba, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Victoria","family":"Pend\u00f3n-Ruiz de Mier","sequence":"additional","affiliation":[{"name":"Nephrology Service, University Hospital Reina Sofia, 14005 Cordoba, Spain"},{"name":"Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)\/University of Cordoba, 14005 Cordoba, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Martin-Malo","sequence":"additional","affiliation":[{"name":"Nephrology Service, University Hospital Reina Sofia, 14005 Cordoba, Spain"},{"name":"Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)\/University of Cordoba, 14005 Cordoba, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Nephrology Service, University Hospital Reina Sofia, 14005 Cordoba, Spain"},{"name":"Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)\/University of Cordoba, 14005 Cordoba, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"ref_1","first-page":"302","article-title":"Spanish Society of Nephrology document on KDIGO guidelines for the assessment and treatment of chronic kidney disease","volume":"34","author":"Gorostidi","year":"2014","journal-title":"Nefrologia"},{"key":"ref_2","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group (2009). KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney. Int. Suppl., 113, S1\u2013S130."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.atherosclerosis.2009.01.001","article-title":"Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community","volume":"205","author":"Mirza","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1093\/ndt\/gfr208","article-title":"The potential roles of FGF23 and Klotho in the prognosis of renal and cardiovascular diseases","volume":"26","author":"Bernheim","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast Growth Factor 23 and Risks of Mortality and End-Stage Renal Disease in Patients with Chronic Kidney Disease","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.kint.2017.04.006","article-title":"Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: Whats changed and why it matters","volume":"92","author":"Ketteler","year":"2017","journal-title":"Kidney Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.semnephrol.2014.02.007","article-title":"Laboratory abnormalities in CKD-MBD: Markers, predictors, or mediators of disease?","volume":"34","author":"Evenepoel","year":"2014","journal-title":"Semin. Nephrol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/sdi.12411","article-title":"Pathophysiology of Calcium, Phosphorus, and Magnesium Dysregulation in Chronic Kidney Disease","volume":"28","author":"Felsenfeld","year":"2015","journal-title":"Semin. Dial."},{"key":"ref_9","first-page":"275","article-title":"FGF23 and mineral metabolism, implications in CKD-MBD","volume":"32","author":"Rodriguez","year":"2012","journal-title":"Nefrologia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.atherosclerosis.2009.05.013","article-title":"Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population","volume":"207","author":"Mirza","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hill, N.R., Fatoba, S.T., Oke, J.L., Hirst, J.A., O\u2019Callaghan, C.A., Lasserson, D.S., and Hobbs, F.D.R. (2016). Global Prevalence of Chronic Kidney Disease\u2014A Systematic Review and Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158765"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.semnephrol.2016.05.008","article-title":"The Economic Burden of Chronic Kidney Disease and End-Stage Renal Disease","volume":"36","author":"Wang","year":"2016","journal-title":"Semin. Nephrol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s11914-018-0486-0","article-title":"CKD-MBD: From the Pathogenesis to the Identification and Development of Potential Novel Therapeutic Targets","volume":"16","author":"Elias","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/ki.2011.223","article-title":"Cardiovascular disease in chronic kidney disease. A clinical update from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"80","author":"Herzog","year":"2011","journal-title":"Kidney Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.nefro.2016.05.023","article-title":"Cardiovascular calcifications in chronic kidney disease: Potential therapeutic implications","volume":"36","author":"Bover","year":"2016","journal-title":"Nefrologia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1056\/NEJMoa043545","article-title":"Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis","volume":"353","author":"Wanner","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1681\/ASN.2015020117","article-title":"Rationale and Approaches to Phosphate and Fibroblast Growth Factor 23 Reduction in CKD","volume":"26","author":"Isakova","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1681\/ASN.2014101009","article-title":"Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study","volume":"27","author":"Chonchol","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance hemodialysis","volume":"15","author":"Block","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1681\/ASN.2017121334","article-title":"Fibroblast Growth Factor-23 and Risks of Cardiovascular and Noncardiovascular Diseases: A Meta-Analysis","volume":"29","author":"Marthi","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Rodelo-Haad, C., Rodr\u00edguez-Ortiz, M.E., Martin-Malo, A., Pendon-Ruiz de Mier, M.V., Ag\u00fcera, M.L., Mu\u00f1oz-Casta\u00f1eda, J.R., Soriano, S., Caravaca, F., Alvarez-Lara, M.A., and Felsenfeld, A. (2018). Phosphate control in reducing FGF23 levels in hemodialysis patients. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201537"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1210\/er.2012-1026","article-title":"The osteocyte: An endocrine cell\u2026 and more","volume":"34","author":"Dallas","year":"2013","journal-title":"Endocr. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev-physiol-030212-183727","article-title":"Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism","volume":"75","author":"Hu","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mce.2014.10.007","article-title":"Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli","volume":"399","author":"Ito","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ki.2015.231","article-title":"Key role of the kidney in the regulation of fibroblast growth factor 23","volume":"88","author":"Mace","year":"2015","journal-title":"Kidney Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/kisup.2013.88","article-title":"A phosphate-centric paradigm for pathophysiology and therapy of chronic kidney disease","volume":"3","author":"Kuro","year":"2013","journal-title":"Kidney Int."},{"key":"ref_27","first-page":"1125","article-title":"Forging forward with 10 burning questions on FGF23 in kidney disease","volume":"10","author":"Hruska","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1111\/j.1523-1755.2004.00604.x","article-title":"FGF-23 in patients with end-stage renal disease on hemodialysis","volume":"65","author":"Imanishi","year":"2004","journal-title":"Kidney Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/ndt\/gfs050","article-title":"FGF23 and PTH\u2014Double agents at the heart of CKD","volume":"27","author":"Silver","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41581-018-0087-2","article-title":"Renal and extrarenal effects of fibroblast growth factor 23","volume":"15","author":"Vervloet","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jbmr.2606","article-title":"FGF23 Regulates Bone Mineralization in a 1,25(OH)2D3 and Klotho-Independent Manner","volume":"31","author":"Murali","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11154-017-9421-4","article-title":"Secondary Hyperparthyroidism: Pathogenesis, Diagnosis, Preventive and Therapeutic Strategies","volume":"18","author":"Portillo","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1517\/14656566.2015.1061994","article-title":"Advances in pharmacotherapy for secondary hyperparathyroidism","volume":"16","year":"2015","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/MNH.0b013e328362141e","article-title":"New insights in regulation of calcium homeostasis","volume":"22","author":"Felsenfeld","year":"2013","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_36","first-page":"346","article-title":"Fuller Albright and our current understanding of calcium and phosphorus regulation and primary hyperparathyroidism","volume":"31","author":"Felsenfeld","year":"2011","journal-title":"Nefrologia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1046\/j.1523-1755.1998.00221.x","article-title":"Effect of serum phosphate on parathyroid hormone secretion during hemodialysis","volume":"54","author":"Cobo","year":"1998","journal-title":"Kidney Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1046\/j.1523-1755.2003.00331.x","article-title":"Proliferation in hyperplastic human and normal rat parathyroid glands: Role of phosphate, calcitriol, and gender","volume":"64","author":"Almaden","year":"2003","journal-title":"Kidney Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/ki.1991.315","article-title":"Calcemic response to parathyroid hormone in renal failure: Role of calcitriol and the effect of parathyroidectomy","volume":"40","author":"Rodriguez","year":"1991","journal-title":"Kidney Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1038\/ki.2011.26","article-title":"Phosphate and Klotho","volume":"79","author":"Kuro","year":"2011","journal-title":"Kidney Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1210\/me.2003-0048","article-title":"Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system","volume":"17","author":"Tsujikawa","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1681\/ASN.2007060673","article-title":"Postprandial mineral metabolism and secondary hyperparathyroidism in early CKD","volume":"19","author":"Isakova","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2215\/CJN.06040710","article-title":"Secondary Hyperparathyroidism: Pathogenesis, Disease Progression, and Therapeutic Options","volume":"6","author":"Cunningham","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fendo.2015.00154","article-title":"Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy","volume":"6","author":"Itoh","year":"2015","journal-title":"Front. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/wdev.176","article-title":"The Fibroblast Growth Factor signaling pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physrev.00002.2011","article-title":"Regulation and function of the FGF23\/klotho endocrine pathways","volume":"92","author":"Martin","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tig.2004.08.007","article-title":"Evolution of the Fgf and Fgfr gene families","volume":"20","author":"Itoh","year":"2004","journal-title":"Trends Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00424-007-0231-5","article-title":"Biological activity of FGF-23 fragments","volume":"454","author":"Berndt","year":"2007","journal-title":"Pflugers Arch."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/jbmr.3197","article-title":"Therapeutic Effects of FGF23 c-tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption","volume":"32","author":"Johnson","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/01.mnh.0000447020.74593.6f","article-title":"Coupling fibroblast growth factor 23 production and cleavage: Iron deficiency, rickets, and kidney disease","volume":"23","author":"Wolf","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1681\/ASN.2007010068","article-title":"How fibroblast growth factor 23 works","volume":"18","author":"Liu","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00424-018-2231-z","article-title":"Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi)","volume":"471","author":"Jacquillet","year":"2019","journal-title":"Pflugers Arch."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1247\/csf.29.91","article-title":"Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice","volume":"29","author":"Li","year":"2004","journal-title":"Cell Struct. Funct."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Matsumura","year":"1997","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1096\/fj.201700006R","article-title":"Differential regulation of renal Klotho and FGFR1 in normal and uremic rats","volume":"31","author":"Herencia","year":"2017","journal-title":"FASEB J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3389\/fendo.2018.00189","article-title":"FGF23 Actions on Target Tissues-With and Without Klotho","volume":"9","author":"Richter","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_58","first-page":"4003","article-title":"The parathyroid is a target organ for FGF23 in rats","volume":"117","author":"Galitzer","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/ki.2011.107","article-title":"Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo","volume":"80","author":"Lopez","year":"2011","journal-title":"Kidney Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1681\/ASN.2009040427","article-title":"FGF23 fails to inhibit uremic parathyroid glands","volume":"21","author":"Canalejo","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1523-1755.2005.00184.x","article-title":"Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients","volume":"67","author":"Nakanishi","year":"2005","journal-title":"Kidney Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1006\/bbrc.2000.4226","article-title":"Severely reduced production of klotho in human chronic renal failure kidney","volume":"280","author":"Koh","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1681\/ASN.2009121311","article-title":"Klotho deficiency causes vascular calcification in chronic kidney disease","volume":"22","author":"Hu","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"29134","DOI":"10.1074\/jbc.M112.342980","article-title":"Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor","volume":"287","author":"Goetz","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature25451","article-title":"\u03b1-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling","volume":"553","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41581-018-0078-3","article-title":"The Klotho proteins in health and disease","volume":"15","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1681\/ASN.2014040325","article-title":"Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate","volume":"26","author":"Xie","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ncomms2240","article-title":"Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart","volume":"3","author":"Xie","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.2215\/CJN.02160212","article-title":"FGF-23 and the progression of coronary arterial calcification in patients new to dialysis","volume":"7","author":"Khan","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"F1212","DOI":"10.1152\/ajprenal.00169.2010","article-title":"Fibroblast growth factor 23 production in bone is directly regulated by 1{alpha},25-dihydroxyvitamin D, but not PTH","volume":"299","author":"Saji","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2215\/CJN.03270314","article-title":"Effect of Cinacalcet and Vitamin D Analogs on Fibroblast Growth Factor-23 during the Treatment of Secondary Hyperparathyroidism","volume":"10","author":"Sprague","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1681\/ASN.2016010066","article-title":"Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D","volume":"28","author":"Karaplis","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41574-018-0076-3","article-title":"Role of phosphate sensing in bone and mineral metabolism","volume":"14","author":"Chande","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1210\/en.2005-0777","article-title":"Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice","volume":"146","author":"Perwad","year":"2005","journal-title":"Endocrinology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1093\/ndt\/gfn438","article-title":"PTH, FGF-23 and early CKD","volume":"23","author":"Rodriguez","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5414\/CN107764","article-title":"The effect of phosphate binders, calcium and lanthanum carbonate on FGF23 levels in chronic kidney disease patients","volume":"80","author":"Soriano","year":"2013","journal-title":"Clin. Nephrol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"F882","DOI":"10.1152\/ajprenal.00360.2010","article-title":"PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: A bone parathyroid feedback loop","volume":"299","author":"Wasserman","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/ki.2014.215","article-title":"Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription","volume":"86","author":"Meir","year":"2014","journal-title":"Kidney Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/sj.ki.5002622","article-title":"Bone mass does not correlate with the serum fibroblast growth factor 23 in hemodialysis patients","volume":"73","author":"Friedlander","year":"2008","journal-title":"Kidney Int."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1681\/ASN.2011101006","article-title":"Calcium Deficiency Reduces Circulating Levels of FGF23","volume":"23","author":"Lopez","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"F1088","DOI":"10.1152\/ajprenal.00474.2004","article-title":"Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism","volume":"289","author":"Shimada","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2215\/CJN.04730510","article-title":"Effects of dietary phosphate and calcium intake on fibroblast growth factor-23","volume":"6","author":"Vervloet","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"E310","DOI":"10.1152\/ajpendo.00460.2012","article-title":"Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo","volume":"304","author":"Quinn","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/CIRCULATIONAHA.114.013876","article-title":"Cinacalcet, Fibroblast Growth Factor-23, and Cardiovascular Disease in Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial","volume":"132","author":"Moe","year":"2015","journal-title":"Circulation"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.kint.2016.05.019","article-title":"Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease","volume":"90","author":"Singh","year":"2016","journal-title":"Kidney Int."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.kint.2016.10.021","article-title":"Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease","volume":"91","author":"Isakova","year":"2017","journal-title":"Kidney Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1046\/j.1523-1755.1999.00273.x","article-title":"Inflammation enhances cardiovascular risk and mortality in hemodialysis patients","volume":"55","author":"Zimmermann","year":"1999","journal-title":"Kidney Int."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Gutierrez","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ki.2015.290","article-title":"Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production","volume":"89","author":"David","year":"2016","journal-title":"Kidney Int."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/jbmr.1923","article-title":"Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women","volume":"28","author":"Wolf","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2215\/CJN.13281211","article-title":"Fibroblast growth factor 23 and Inflammation in CKD","volume":"7","author":"Isakova","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1096\/fj.201700667R","article-title":"Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia","volume":"32","author":"Agoro","year":"2018","journal-title":"FASEB J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"F132","DOI":"10.1152\/ajprenal.00081.2017","article-title":"Acute blood loss stimulates fibroblast growth factor 23 production","volume":"314","author":"Rabadi","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.kint.2017.11.018","article-title":"Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury","volume":"93","author":"Toro","year":"2018","journal-title":"Kidney Int."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Hanudel, M.R., Eisenga, M.F., Rappaport, M., Chua, K., Qiao, B., Jung, G., Gabayan, V., Gales, B., Ramos, G., and de Jong, M.A. (2018). Effects of erythropoietin on fibroblast growth factor 23 in mice and humans. Nephrol. Dial. Transplant., gfy189.","DOI":"10.1093\/ndt\/gfy189"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1681\/ASN.2012040414","article-title":"Adiponectin promotes functional recovery after podocyte ablation","volume":"24","author":"Rutkowski","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"F881","DOI":"10.1152\/ajprenal.00373.2007","article-title":"Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats","volume":"294","author":"Cammisotto","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cmet.2013.04.009","article-title":"Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1","volume":"17","author":"Kajimura","year":"2013","journal-title":"Cell Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.kint.2016.09.016","article-title":"Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression","volume":"91","author":"Rutkowski","year":"2017","journal-title":"Kidney Int."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.2337\/dc13-2235","article-title":"FGF23 in type 2 diabetic patients: Relationship with bone metabolism and vascular disease","volume":"37","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Hanks, L.J., Casazza, K., Judd, S.E., Jenny, N.S., and Guti\u00e9rrez, O.M. (2015). Associations of Fibroblast Growth Factor-23 with Markers of Inflammation, Insulin Resistance and Obesity in Adults. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122885"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1073\/pnas.1800160115","article-title":"Insulin suppresses the production of fibroblast growth factor 23 (FGF23)","volume":"115","author":"Feger","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/emmm.201303716","article-title":"FGF23 regulates renal sodium handling and blood pressure","volume":"6","author":"Andrukhova","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbrc.2016.01.034","article-title":"Up-regulation of FGF23 release by aldosterone","volume":"470","author":"Zhang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/ndt\/gfv393","article-title":"Fibroblast growth factor 23 correlates with volume status in haemodialysis patients and is not reduced by haemodialysis","volume":"31","author":"Humalda","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"E837","DOI":"10.1152\/ajpendo.2001.281.4.E837","article-title":"Analysis of recombinant Phex: An endopeptidase in search of a substrate","volume":"281","author":"Guo","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0272-6386(12)80670-6","article-title":"Determinants of left ventricular hypertrophy and systolic dysfunction in chronic renal failure","volume":"24","author":"Greaves","year":"1994","journal-title":"Am. J. Kidney Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kint.2018.03.024","article-title":"FGF23 effects on the heart-levels, time, source, and context matter","volume":"94","author":"Faul","year":"2018","journal-title":"Kidney Int."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.cmet.2015.09.002","article-title":"Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy","volume":"22","author":"Grabner","year":"2015","journal-title":"Cell Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1681\/ASN.2014050465","article-title":"Klotho and phosphate are modulators of pathologic uremic cardiac remodeling","volume":"26","author":"Hu","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1038\/s41598-018-32065-2","article-title":"Increased Phosphaturia Accelerates the Decline in Renal Function: A Search for Mechanisms","volume":"8","author":"Robles","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/ndt\/gfv421","article-title":"Induction of cardiac FGF23\/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease","volume":"31","author":"Flasbart","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/ndt\/gfx332","article-title":"Genetic background influences cardiac phenotype in murine chronic kidney disease","volume":"33","author":"Neuburg","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"64649","DOI":"10.18632\/oncotarget.11623","article-title":"FGF23 promotes myocardial fibrosis in mice through activation of \u03b2-catenin","volume":"7","author":"Hao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1038\/s41598-017-10140-4","article-title":"Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload","volume":"7","author":"Slavic","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/ndt\/gfy006","article-title":"Fibroblast growth factor 23 is induced by an activated renin-angiotensin-aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts","volume":"33","author":"Kirchhoff","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"E863","DOI":"10.1152\/ajpendo.00596.2012","article-title":"FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy","volume":"304","author":"Touchberry","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fendo.2018.00278","article-title":"Paracrine Effects of FGF23 on the Heart","volume":"9","author":"Haffner","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/me.2010-0142","article-title":"Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse","volume":"24","author":"Bookout","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/1873-3468.12040","article-title":"Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages","volume":"590","author":"Han","year":"2016","journal-title":"FEBS Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/1440-1681.12933","article-title":"The association of serum FGF23 and non-alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients","volume":"45","author":"He","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1053\/jren.2003.50018","article-title":"Interactions between inflammation, oxidative stress, and endothelial dysfunction in end-stage renal disease","volume":"13","author":"Stenvinkel","year":"2003","journal-title":"J. Ren. Nutr."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/ki.2012.176","article-title":"Update on fibroblast growth factor 23 in chronic kidney disease","volume":"82","author":"Wolf","year":"2012","journal-title":"Kidney Int."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1038\/s41598-017-02068-6","article-title":"FGF23\/FGFR4-mediated left ventricular hypertrophy is reversible","volume":"7","author":"Grabner","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1172\/JCI83470","article-title":"FGF23 signaling impairs neutrophil recruitment and host defense during CKD","volume":"126","author":"Rossaint","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/ki.2011.125","article-title":"Acute loss of renal function attenuates slow leukocyte rolling and transmigration by interfering with intracellular signaling","volume":"80","author":"Rossaint","year":"2011","journal-title":"Kidney Int."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00223-011-9501-5","article-title":"Fibroblast growth factor 23 (FGF23) and alpha-klotho stimulate osteoblastic MC3T3.E1 cell proliferation and inhibit mineralization","volume":"89","author":"Shalhoub","year":"2011","journal-title":"Calcif. Tissue Int."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.kint.2017.02.014","article-title":"Klotho expression in osteocytes regulates bone metabolism and controls bone formation","volume":"92","author":"Komaba","year":"2017","journal-title":"Kidney Int."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"9795","DOI":"10.1074\/jbc.M113.527150","article-title":"FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis","volume":"289","author":"Coe","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2215\/CJN.01290308","article-title":"Epidemiology of acute infections among patients with chronic kidney disease","volume":"3","author":"Dalrymple","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"C1036","DOI":"10.1152\/ajpcell.00215.2011","article-title":"Characterization of FGF receptor expression in human neutrophils and their contribution to chemotaxis","volume":"301","author":"Haddad","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/s41598-017-03210-0","article-title":"Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/jbmr.1740","article-title":"Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes","volume":"28","author":"Bacchetta","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.2215\/CJN.03950417","article-title":"Fibroblast Growth Factor 23 and Anemia in the Chronic Renal Insufficiency Cohort Study","volume":"12","author":"Mehta","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/jnc.13585","article-title":"Fibroblast growth factor 23 signaling in hippocampal cells: Impact on neuronal morphology and synaptic density","volume":"137","author":"Hensel","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2011.07.028","article-title":"Impairment of spatial learning and memory in transgenic mice overexpressing human fibroblast growth factor-23","volume":"1412","author":"Liu","year":"2011","journal-title":"Brain Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nrneph.2014.112","article-title":"Mechanisms of muscle wasting in chronic kidney disease","volume":"10","author":"Wang","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/jbmr.275","article-title":"Anti-FGF-23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice","volume":"26","author":"Aono","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1074\/jbc.M507440200","article-title":"Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway","volume":"281","author":"Zhao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"14388","DOI":"10.1038\/s41598-017-14811-0","article-title":"Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia","volume":"7","author":"Krick","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1165\/ajrcmb.22.1.3554","article-title":"Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life","volume":"22","author":"Suga","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/gerona\/glu170","article-title":"Klotho Prevents NF\u03baB Translocation and Protects Endothelial Cell from Senescence Induced by Uremia","volume":"70","author":"Carracedo","year":"2015","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s00424-016-1858-x","article-title":"Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells","volume":"468","author":"Richter","year":"2016","journal-title":"Pflugers Arch."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ki.2013.3","article-title":"Fibroblast growth factor 23 is not associated with and does not induce arterial calcification","volume":"83","author":"Scialla","year":"2013","journal-title":"Kidney Int."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.kint.2018.02.017","article-title":"The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk","volume":"94","author":"Gehring","year":"2018","journal-title":"Kidney Int."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrneph.2015.153","article-title":"Phosphate and FGF-23 homeostasis after kidney transplantation","volume":"11","author":"Baia","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.2215\/CJN.01880213","article-title":"Fibroblast Growth Factor 23 and Cardiovascular Mortality after Kidney Transplantation","volume":"8","author":"Baia","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1681\/ASN.2004070602","article-title":"Serum phosphate levels and mortality risk among people with chronic kidney disease","volume":"16","author":"Kestenbaum","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1161\/CIRCULATIONAHA.105.553198","article-title":"Relation between serum phosphate level and cardiovascular event rate in people with coronary disease","volume":"112","author":"Tonelli","year":"2005","journal-title":"Circulation"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1093\/ndt\/gfq191","article-title":"Relation between serum fibroblast growth factor-23 level and mortality in incident dialysis patients: Are gender and cardiovascular disease confounding the relationship?","volume":"25","author":"Olauson","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.2215\/CJN.04320709","article-title":"Coronary calcification in patients with chronic kidney disease and coronary artery disease","volume":"4","author":"Nakamura","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1212\/WNL.0000000000000410","article-title":"Plasma FGF23 and the risk of stroke: The Northern Manhattan Study (NOMAS)","volume":"82","author":"Wright","year":"2014","journal-title":"Neurology"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Kuczera, P., Adamczak, M., and Wiecek, A. (2016). Fibroblast Growth Factor-23-A Potential Uremic Toxin. Toxins, 8.","DOI":"10.3390\/toxins8120369"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1681\/ASN.2017070772","article-title":"Longitudinal FGF23 Trajectories and Mortality in Patients with CKD","volume":"29","author":"Isakova","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1681\/ASN.2018050517","article-title":"Fibroblast Growth Factor-23 May Follow Cardiovascular Disease Rather than Causing It in Chronic Kidney Disease","volume":"29","author":"Zhou","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1093\/ndt\/gfy005","article-title":"Effects of lower versus higher phosphate diets on fibroblast growth factor-23 levels in patients with chronic kidney disease: A systematic review and meta-analysis","volume":"33","author":"Tsai","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_157","first-page":"339","article-title":"The effects of tenapanor on serum fibroblast growth factor 23 in patients receiving hemodialysis with hyperphosphatemia","volume":"34","author":"Wolf","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Sprague, S.M., Ketteler, M., Rastogi, A., Walpen, S., Spinowitz, B., Rakov, V., Covic, A.C., and Floege, J. (2018). Effects of sucroferric oxyhydroxide and sevelamer carbonate on chronic kidney disease\u2013mineral bone disorder parameters in dialysis patients. Nephrol. Dial. Transplant.","DOI":"10.1093\/ndt\/gfy127"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"c74","DOI":"10.1159\/000319650","article-title":"Fibroblast growth factor 23 in hemodialysis patients: Effects of phosphate binder, calcitriol and calcium concentration in the dialysate","volume":"117","author":"Cancela","year":"2011","journal-title":"Nephron Clin. Pract."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1056\/NEJMoa1714641","article-title":"Burosumab Therapy in Children with X-Linked Hypophosphatemia","volume":"378","author":"Carpenter","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1172\/JCI61405","article-title":"FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality","volume":"122","author":"Shalhoub","year":"2012","journal-title":"J. Clin. 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